KEGG   ENZYME: 1.6.5.12
Entry
EC 1.6.5.12                 Enzyme                                 
Name
demethylphylloquinone reductase;
ndbB (gene name);
NDC1 (gene name);
demethylphylloquinone:NADPH oxidoreductase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
Sysname
NADPH:demethylphylloquinone oxidoreductase
Reaction(IUBMB)
demethylphylloquinone + NADPH + H+ = demethylphylloquinol + NADP+ [RN:R11061]
Reaction(KEGG)
R11061
Substrate
demethylphylloquinone [CPD:C13309];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
demethylphylloquinol [CPD:C21084];
NADP+ [CPD:C00006]
Comment
The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor.
History
EC 1.6.5.12 created 2015
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17872  demethylphylloquinone reductase
Genes
ATHAT5G08740(NDC1)
ALY9309449
CRB17882848
CSAT104708204 104734909 104769096
EUSEUTSA_v10013258mg
BRP103847188
BNA106419271 111212609
BOE106319430
RSZ108817949
THJ104819353
CPAP110816571
CIT102618551
CICCICLE_v10000807mg
PVY116105075 116106474
MINC123199089
TCC18611964
GRA105762580
GHI107930822 107931253
GAB108476577
DZI111316878
EGR104415973
GMX100795521
GSJ114413256
PVUPHAVU_002G275600g
VRA106769327
VAR108323929
VUN114174969
CCAJ109789425
APRC113854729
MTRMTR_8g094730
CAM101503757
LJALj4g3v2827910.1(Lj4g3v2827910.1) Lj4g3v2827910.2(Lj4g3v2827910.2)
ADU107480195
AIP107630920
AHF112733033 112791068
LANG109358669
FVE101308875
RCN112176025
PPER18777173
PMUM103337243
PAVI110753675
PDUL117628767
MDM103433086
PXB103952273
ZJU107425337 107425338
MNT21407825
CSV101223053
CMO103486095
BHJ120073875
MCHA111017844
CMAX111465980
CMOS111432564
CPEP111782254
RCU8282114
JCU105639437
HBR110657024 110660355
MESC110624194
POP7490188
PEU105124511
PALZ118043455
JRE108996371
QSU112019031
QLO115964007
TWL119990388
VVI100264660
VRI117918827
SLY101263978
SPEN107015022
SOT102581506
CANN107868106
NTA107796444 107800648
NSY104238606
NTO104085114
NAU109225159
INI109179495
ITR116012717
SIND105176066
OEU111365483 111409157
EGT105959868 105964861
SSPL121779817 121782608
HAN110873719
ECAD122581717
LSV111879295
CCAV112519684
DCR108219442
CSIN114307524
BVG104890540
SOE110800407
CQI110701317 110736653
NNU104587537
MING122063951 122069453 122081702
TSS122666642 122668851
PSOM113346448 113356398
NCOL116259399
OSA4340478
DOSAOs06t0214900-01(Os06g0214900)
OBR102715487
BDI100823745
ATS109746764
TDC119328641 119341753
TAES123148304 123161869 123164500
TUA125525340
SBI8080027
ZMA100282489
SITA101767448
SVS117852339
PVIR120669531 120703183
PHAI112889324
PDA103723780
EGU105034423
MUS103986928
DCT110115656
PEQ110035971
AOF109832866
ATR18429029
SMOSELMODRAFT_178273 SELMODRAFT_268023
PPP112277043
CRECHLRE_16g671000v5
VCNVOLCADRAFT_107672
MNGMNEG_6066
CSLCOCSUDRAFT_12331
APROF751_3208
OLUOSTLU_36839
OTAOT_ostta04g03900
BPGBathy08g03260
MISMICPUN_60345
MPPMICPUCDRAFT_47596
CMECYME_CMM178C
GSLGasu_20690
CCPCHC_T00004265001
FCYFRACYDRAFT_269458
EHXEMIHUDRAFT_461368 EMIHUDRAFT_470045
GPSC427_4635
OMEOLMES_1464
GPBHDN1F_02450
SYNslr1743(ndh)
SYZMYO_112180(ndh)
SYYSYNGTS_1207(ndh)
SYTSYNGTI_1207(ndh)
SYSSYNPCCN_1206(ndh)
SYQSYNPCCP_1206(ndh)
SYJD082_23110(ndbB)
SYOC7I86_06260
SYCsyc1598_c(ndbB)
SYUM744_03695
SYFSynpcc7942_2508
SYDSyncc9605_2310
SYESyncc9902_0383
SYGsync_2511
SYRSynRCC307_0389(ndh)
SYXSynWH7803_2175(ndh)
SYPSYNPCC7002_A2120(ndbB)
CYACYA_0862
CYBCYB_1748
SYNESyn6312_3456
SYNPSyn7502_00863
SYNKKR100_14260
SYNRKR49_07070
SYNDKR52_04635
SYHSyncc8109_2392
SYNWSynWH8103_02483
SYVAWQ23_10615
SYLAWQ21_10770
SYNCCB0101_14370
DSLDacsa_1246
SYWSYNW2165
CGCCyagr_1568
CYICBM981_3061
PMAPro_0096(ndh)
PMMPMM0082
PMTPMT_1625
PMNPMN2A_1446
PMIPMT9312_0085
PMBA9601_00951
PMCP9515_00921
PMFP9303_02581
PMGP9301_00941
PMHP9215_00951
PMJP9211_00911
PMENATL1_01471
PRCEW14_0102
PRMEW15_0164
CMPCha6605_1172 Cha6605_4090 Cha6605_6199
AMRAM1_2697
TVNNIES2134_101430(ndbB)
SLWBRW62_03875
TELtlr1136(ndbB)
THNNK55_02985(ndbB)
THECFFX45_12480
LEPLepto7376_3344
LENLEP3755_58200
LETO77CONTIG1_02936(ndh)
LBOLBWT_15670 LBWT_56400
KOVK9N68_15810
LSCKIK02_04980
LSKJ5X98_03075
HHGXM38_046090
PSEUPse7367_2005
PSERABRG53_2102
THEUHPC62_17325
GLPGlo7428_4351
GENGM3709_2091
GEEGM3708_3185
CHONNIES4102_17540
MARMAE_42940(ndbB2) MAE_62400(ndbB1)
MPKVL20_2143 VL20_2695
MIQB5D77_01060 B5D77_12325
MVZmyaer102_17350(ndbB2) myaer102_34460(ndbB1)
CANCyan10605_3058
CSNCyast_0025 Cyast_1396
CYLAA637_13705(ndh-2)
HAOPCC7418_2212
ENNFRE64_05310
CYUUCYN_05790
CYTcce_0154(ndbB) cce_4052 cce_4406
CWACwatDRAFT_3456 CwatDRAFT_6161
CYPPCC8801_0031 PCC8801_0681
CYHCyan8802_0029 Cyan8802_0708
CYCPCC7424_3107 PCC7424_4523
CYJCyan7822_0200 Cyan7822_1479 Cyan7822_5870
CYNCyan7425_1446
TERTery_3661 Tery_4096
ARPNIES39_C03210(ndbB)
PAGHNIES204_19420(ndbB)
PPSUNO713_01928(ndbB)
OXYHCG48_23500
MVAGD0A34_10010
LFSHFV01_11460
MICMic7113_3565
GEIGEI7407_1584 GEI7407_3314
OACOscil6304_3986
ONIOsc7112_2336
MPROBJP34_02545
PHORJWS08_08025 JWS08_21680
CEPCri9333_2861
GVIglr3503
GLJGKIL_0162(ndh) GKIL_1185(ndh) GKIL_3028(ndh) GKIL_3902(ndh)
GMLISF26_14955
ANAalr4094
NPUNpun_R1623
NOSNos7107_4485
NOPNos7524_0617
NONNOS3756_49290
NFLCOO91_00248
NOECLI64_02480 CLI64_23675 CLI64_28550
NSHGXM_05919
NEDHUN01_32080
AVAAva_0810
NAZAazo_4817
ANBANA_C11689(ndh)
ACYAnacy_2011 Anacy_4522
AWAAA650_17225
ANNEH233_20650 EH233_26120
CSGCylst_6117
RSINB6N60_02534 B6N60_04171
CALOCal7507_0568
CALTCal6303_0926
CALHIJ00_11250
RIVRiv7116_6852
FISFIS3754_01360
NSPHBDGGKGIB_01467(ndbB)
DOUBMF77_01764(ndh)
DFSHGD76_09485
CCURIAR63_12545
CRKL3I90_11710
AFLOHEQ12_16425
TOQHCG51_02065 HCG51_04960 HCG51_22050
NCNBZZ01_00515 BZZ01_00785 BZZ01_06725 BZZ01_13585 BZZ01_13645
CTHEChro_3291 Chro_5076
PLPPle7327_0734 Ple7327_4053
SCSSta7437_2980 Sta7437_3640
STANSTA3757_26730 STA3757_30400(ndbB) STA3757_35060
CEOETSB_0596(ndbB)
CERRGRSB_0558(ndbB)
KBSEPA93_46425
CTMCabther_B0793
CVLJ8C06_00670 J8C06_15040
CHLOJ8C02_00700 J8C02_12325
FACFACI_IFERC01G1802
FAIFAD_0773
THBN186_01975
TCBTCARB_1480
THFMA03_00395
THELIG193_06475
 » show all
Reference
1  [PMID:26023160]
  Authors
Fatihi A, Latimer S, Schmollinger S, Block A, Dussault PH, Vermaas WF, Merchant SS, Basset GJ
  Title
A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis.
  Journal
Plant Cell 27:1730-41 (2015)
DOI:10.1105/tpc.15.00103
  Sequence
[ath:AT5G08740] [syn:slr1743]
Other DBs
ExplorEnz - The Enzyme Database: 1.6.5.12
IUBMB Enzyme Nomenclature: 1.6.5.12
ExPASy - ENZYME nomenclature database: 1.6.5.12
BRENDA, the Enzyme Database: 1.6.5.12
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