KEGG   ENZYME: 1.6.5.12
Entry
EC 1.6.5.12                 Enzyme                                 
Name
demethylphylloquinone reductase;
ndbB (gene name);
NDC1 (gene name);
demethylphylloquinone:NADPH oxidoreductase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
Sysname
NADPH:demethylphylloquinone oxidoreductase
Reaction(IUBMB)
demethylphylloquinone + NADPH + H+ = demethylphylloquinol + NADP+ [RN:R11061]
Reaction(KEGG)
R11061
Substrate
demethylphylloquinone [CPD:C13309];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
demethylphylloquinol [CPD:C21084];
NADP+ [CPD:C00006]
Comment
The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor.
History
EC 1.6.5.12 created 2015
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17872  demethylphylloquinone reductase
Genes
ATH: AT5G08740(NDC1)
ALY: 9309449
CRB: 17882848
CSAT: 104708204 104734909 104769096
EUS: EUTSA_v10013258mg
BRP: 103847188
BNA: 106419271 111212609
BOE: 106319430
RSZ: 108817949
THJ: 104819353
CPAP: 110816571
CIT: 102618551
CIC: CICLE_v10000807mg
PVY: 116105075 116106474
MINC: 123199089
TCC: 18611964
GRA: 105762580
GHI: 107930822 107931253
GAB: 108476577
DZI: 111316878
EGR: 104415973
GMX: 100795521
GSJ: 114413256
PVU: PHAVU_002G275600g
VRA: 106769327
VAR: 108323929
VUN: 114174969
CCAJ: 109789425
APRC: 113854729
MTR: MTR_8g094730
CAM: 101503757
LJA: Lj4g3v2827910.1(Lj4g3v2827910.1) Lj4g3v2827910.2(Lj4g3v2827910.2)
ADU: 107480195
AIP: 107630920
AHF: 112733033 112791068
LANG: 109358669
FVE: 101308875
RCN: 112176025
PPER: 18777173
PMUM: 103337243
PAVI: 110753675
PDUL: 117628767
MDM: 103433086
PXB: 103952273
ZJU: 107425337 107425338
MNT: 21407825
CSV: 101223053
CMO: 103486095
BHJ: 120073875
MCHA: 111017844
CMAX: 111465980
CMOS: 111432564
CPEP: 111782254
RCU: 8282114
JCU: 105639437
HBR: 110657024 110660355
MESC: 110624194
POP: 7490188
PEU: 105124511
PALZ: 118043455
JRE: 108996371
QSU: 112019031
QLO: 115964007
TWL: 119990388
VVI: 100264660
VRI: 117918827
SLY: 101263978
SPEN: 107015022
SOT: 102581506
CANN: 107868106
NTA: 107796444 107800648
NSY: 104238606
NTO: 104085114
NAU: 109225159
INI: 109179495
ITR: 116012717
SIND: 105176066
OEU: 111365483 111409157
EGT: 105959868 105964861
SSPL: 121779817 121782608
HAN: 110873719
ECAD: 122581717
LSV: 111879295
CCAV: 112519684
DCR: 108219442
CSIN: 114307524
BVG: 104890540
SOE: 110800407
CQI: 110701317 110736653
NNU: 104587537
MING: 122063951 122069453 122081702
TSS: 122666642 122668851
PSOM: 113346448 113356398
NCOL: 116259399
OSA: 4340478
DOSA: Os06t0214900-01(Os06g0214900)
OBR: 102715487
BDI: 100823745
ATS: 109746764
TDC: 119328641 119341753
TAES: 123148304 123161869 123164500
TUA: 125525340
SBI: 8080027
ZMA: 100282489
SITA: 101767448
SVS: 117852339
PVIR: 120669531 120703183
PHAI: 112889324
PDA: 103723780
EGU: 105034423
MUS: 103986928
DCT: 110115656
PEQ: 110035971
AOF: 109832866
ATR: 18429029
SMO: SELMODRAFT_178273 SELMODRAFT_268023
PPP: 112277043
CRE: CHLRE_16g671000v5
VCN: VOLCADRAFT_107672
MNG: MNEG_6066
CSL: COCSUDRAFT_12331
APRO: F751_3208
OLU: OSTLU_36839
OTA: OT_ostta04g03900
BPG: Bathy08g03260
MIS: MICPUN_60345
MPP: MICPUCDRAFT_47596
CME: CYME_CMM178C
GSL: Gasu_20690
CCP: CHC_T00004265001
FCY: FRACYDRAFT_269458
EHX: EMIHUDRAFT_461368 EMIHUDRAFT_470045
GPS: C427_4635
OME: OLMES_1464
GPB: HDN1F_02450
SYN: slr1743(ndh)
SYZ: MYO_112180(ndh)
SYY: SYNGTS_1207(ndh)
SYT: SYNGTI_1207(ndh)
SYS: SYNPCCN_1206(ndh)
SYQ: SYNPCCP_1206(ndh)
SYJ: D082_23110(ndbB)
SYO: C7I86_06260
SYC: syc1598_c(ndbB)
SYU: M744_03695
SYF: Synpcc7942_2508
SYD: Syncc9605_2310
SYE: Syncc9902_0383
SYG: sync_2511
SYR: SynRCC307_0389(ndh)
SYX: SynWH7803_2175(ndh)
SYP: SYNPCC7002_A2120(ndbB)
CYA: CYA_0862
CYB: CYB_1748
SYNE: Syn6312_3456
SYNP: Syn7502_00863
SYNK: KR100_14260
SYNR: KR49_07070
SYND: KR52_04635
SYH: Syncc8109_2392
SYNW: SynWH8103_02483
SYV: AWQ23_10615
SYL: AWQ21_10770
SYNC: CB0101_14370
DSL: Dacsa_1246
SYW: SYNW2165
CGC: Cyagr_1568
CYI: CBM981_3061
PMA: Pro_0096(ndh)
PMM: PMM0082
PMT: PMT_1625
PMN: PMN2A_1446
PMI: PMT9312_0085
PMB: A9601_00951
PMC: P9515_00921
PMF: P9303_02581
PMG: P9301_00941
PMH: P9215_00951
PMJ: P9211_00911
PME: NATL1_01471
PRC: EW14_0102
PRM: EW15_0164
CMP: Cha6605_1172 Cha6605_4090 Cha6605_6199
AMR: AM1_2697
TVN: NIES2134_101430(ndbB)
SLW: BRW62_03875
TEL: tlr1136(ndbB)
THN: NK55_02985(ndbB)
THEC: FFX45_12480
LEP: Lepto7376_3344
LEN: LEP3755_58200
LET: O77CONTIG1_02936(ndh)
LBO: LBWT_15670 LBWT_56400
KOV: K9N68_15810
LSC: KIK02_04980
LSK: J5X98_03075
HHG: XM38_046090
PSEU: Pse7367_2005
PSER: ABRG53_2102
THEU: HPC62_17325
GLP: Glo7428_4351
GEN: GM3709_2091
GEE: GM3708_3185
CHON: NIES4102_17540
MAR: MAE_42940(ndbB2) MAE_62400(ndbB1)
MPK: VL20_2143 VL20_2695
MIQ: B5D77_01060 B5D77_12325
MVZ: myaer102_17350(ndbB2) myaer102_34460(ndbB1)
CAN: Cyan10605_3058
CSN: Cyast_0025 Cyast_1396
CYL: AA637_13705(ndh-2)
HAO: PCC7418_2212
ENN: FRE64_05310
CYU: UCYN_05790
CYT: cce_0154(ndbB) cce_4052 cce_4406
CWA: CwatDRAFT_3456 CwatDRAFT_6161
CYP: PCC8801_0031 PCC8801_0681
CYH: Cyan8802_0029 Cyan8802_0708
CYC: PCC7424_3107 PCC7424_4523
CYJ: Cyan7822_0200 Cyan7822_1479 Cyan7822_5870
CYN: Cyan7425_1446
TER: Tery_3661 Tery_4096
ARP: NIES39_C03210(ndbB)
PAGH: NIES204_19420(ndbB)
PPSU: NO713_01928(ndbB)
OXY: HCG48_23500
MVAG: D0A34_10010
LFS: HFV01_11460
MIC: Mic7113_3565
GEI: GEI7407_1584 GEI7407_3314
OAC: Oscil6304_3986
ONI: Osc7112_2336
MPRO: BJP34_02545
PHOR: JWS08_08025 JWS08_21680
CEP: Cri9333_2861
GVI: glr3503
GLJ: GKIL_0162(ndh) GKIL_1185(ndh) GKIL_3028(ndh) GKIL_3902(ndh)
GML: ISF26_14955
ANA: alr4094
NPU: Npun_R1623
NOS: Nos7107_4485
NOP: Nos7524_0617
NON: NOS3756_49290
NFL: COO91_00248
NOE: CLI64_02480 CLI64_23675 CLI64_28550
NSH: GXM_05919
NED: HUN01_32080
AVA: Ava_0810
NAZ: Aazo_4817
ANB: ANA_C11689(ndh)
ACY: Anacy_2011 Anacy_4522
AWA: AA650_17225
ANN: EH233_20650 EH233_26120
CSG: Cylst_6117
RSIN: B6N60_02534 B6N60_04171
CALO: Cal7507_0568
CALT: Cal6303_0926
CALH: IJ00_11250
RIV: Riv7116_6852
FIS: FIS3754_01360
NSPH: BDGGKGIB_01467(ndbB)
DOU: BMF77_01764(ndh)
DFS: HGD76_09485
CCUR: IAR63_12545
CRK: L3I90_11710
AFLO: HEQ12_16425
TOQ: HCG51_02065 HCG51_04960 HCG51_22050
NCN: BZZ01_00515 BZZ01_00785 BZZ01_06725 BZZ01_13585 BZZ01_13645
CTHE: Chro_3291 Chro_5076
PLP: Ple7327_0734 Ple7327_4053
SCS: Sta7437_2980 Sta7437_3640
STAN: STA3757_26730 STA3757_30400(ndbB) STA3757_35060
CEO: ETSB_0596(ndbB)
CER: RGRSB_0558(ndbB)
KBS: EPA93_46425
CTM: Cabther_B0793
CVL: J8C06_00670 J8C06_15040
CHLO: J8C02_00700 J8C02_12325
FAC: FACI_IFERC01G1802
FAI: FAD_0773
THB: N186_01975
TCB: TCARB_1480
THF: MA03_00395
THEL: IG193_06475
 » show all
Reference
1  [PMID:26023160]
  Authors
Fatihi A, Latimer S, Schmollinger S, Block A, Dussault PH, Vermaas WF, Merchant SS, Basset GJ
  Title
A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis.
  Journal
Plant Cell 27:1730-41 (2015)
DOI:10.1105/tpc.15.00103
  Sequence
[ath:AT5G08740] [syn:slr1743]
Other DBs
ExplorEnz - The Enzyme Database: 1.6.5.12
IUBMB Enzyme Nomenclature: 1.6.5.12
ExPASy - ENZYME nomenclature database: 1.6.5.12
BRENDA, the Enzyme Database: 1.6.5.12
LinkDB

DBGET integrated database retrieval system