KEGG   ENZYME: 1.6.5.12
Entry
EC 1.6.5.12                 Enzyme                                 
Name
demethylphylloquinone reductase;
ndbB (gene name);
NDC1 (gene name);
demethylphylloquinone:NADPH oxidoreductase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
Sysname
NADPH:demethylphylloquinone oxidoreductase
Reaction(IUBMB)
demethylphylloquinone + NADPH + H+ = demethylphylloquinol + NADP+ [RN:R11061]
Reaction(KEGG)
R11061
Substrate
demethylphylloquinone [CPD:C13309];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
demethylphylloquinol [CPD:C21084];
NADP+ [CPD:C00006]
Comment
The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor.
History
EC 1.6.5.12 created 2015
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17872  demethylphylloquinone reductase
Genes
ATH: AT5G08740(NDC1)
ALY: 9309449
CRB: 17882848
CSAT: 104708204 104734909 104769096
EUS: EUTSA_v10013258mg
BRP: 103847188
BNA: 106419271 111212609
BOE: 106319430
RSZ: 108817949
THJ: 104819353
CPAP: 110816571
CIT: 102618551
CIC: CICLE_v10000807mg
PVY: 116105075 116106474
MINC: 123199089
TCC: 18611964
GRA: 105762580
GHI: 107930822 107931253
GAB: 108476577
HSYR: 120144484 120147677
DZI: 111316878
EGR: 104415973
RARG: 115725984
GMX: 100795521
GSJ: 114413256
PVU: 137812511
VRA: 106769327
VAR: 108323929
VUN: 114174969
VUM: 124834409
CCAJ: 109789425
APRC: 113854729
MTR: 11437509
TPRA: 123916097
CAM: 101503757
PSAT: 127104529
VVO: 131602889 131602909
LJA: 130711806
ADU: 107480195
AIP: 107630920
AHF: 112733033 112791068
LANG: 109358669
PCIN: 129307686
QSA: O6P43_030251
FVE: 101308875
AANS: 126794709
RCN: 112176025
PPER: 18777173
PMUM: 103337243
PAVI: 110753675
PDUL: 117628767
MDM: 103433086
MSYL: 126617742
PXB: 103952273
PCOX: 137722936
ZJU: 107425337
MNT: 21407825
CSAV: 115714294
HLP: 133800088
CSV: 101223053
CMO: 103486095
BHJ: 120073875
MCHA: 111017844
CMAX: 111465980
CMOS: 111432564
CPEP: 111782254
RCU: 8282114
MEAN: 126682116
JCU: 105639437
HBR: 110657024 110660355
MESC: 110624194
POP: 7490188
PEU: 105124511
PALZ: 118043455
PNZ: 133672396
JRE: 108996371
CILL: 122303325
CAVE: 132165495
AGLU: 133856533 133861420
QSU: 112019031
QLO: 115964007
CSAA: 142630499
TWL: 119990388
VVI: 100264660
VRI: 117918827
SLY: 101263978
SPEN: 107015022
SOT: 102581506
SSTN: 125859518
SDUL: 129894231
SVER: 125810406
CANN: 107868106
LBB: 132617261
NTA: 107796444 107800648
NSY: 104238606
NTO: 104085114
NAU: 109225159
INI: 109179495
ITR: 116012717
SIND: 105176066
OEU: 111365483 111409157
EGT: 105959868 105964861
SSPL: 121779817 121782608
SMIL: 131008639
SHIS: 125213312
APAN: 127257388
PEBU: 140806000
PTAB: 142549563
CARB: 113700214 113702250
HAN: 110873719
BHW: 143536592 143557779 143615714
ECAD: 122581717
LSV: 111879295
CCAV: 112519684
DCR: 108219442
AGRV: 141711680
CSIN: 114307524
RVL: 131315804
AEW: 130785265
DLT: 127800706
BVG: 104890540
SOE: 110800407
CQI: 110701317 110736653
ATRI: 130828174
SLAF: 141657595
MOF: 131160634
NNU: 104587537
MING: 122063951 122069453 122081702
TSS: 122666642 122668851
PSOM: 113346448 113356398
OSA: 4340478
DOSA: Os06g0214900
OBR: 102715487
OGL: 127776414
BDI: 100823745
ATS: 109746764
TDC: 119328641 119341753
TAES: 123148304 123161869 123164500
TUA: 125525340
HVG: 123407346
LPER: 127317730
LRD: 124685253
SBI: 8080027
ZMA: 100282489
MFLO: 136520228 136529278
SITA: 101767448
SVS: 117852339
PVIR: 120669531 120703183
PHAI: 112889324
PAUA: 133930622
TANG: 140760060
PDA: 103723780
EGU: 105034423
MUS: 103986928
ZOF: 122008689 122016738
DCT: 110115656
PEQ: 110035971
AOF: 109832866
MSIN: 131242549
ACAK: 137941485
NCOL: 116259399
ATR: 18429029
CJF: 131076973
SMO: SELMODRAFT_178273 SELMODRAFT_268023
PPP: 112277043
CRE: CHLRE_16g671000v5
VCN: VOLCADRAFT_107672
MNG: MNEG_6066
CSL: COCSUDRAFT_12331
APRO: F751_3208
OLU: OSTLU_36839
OTA: OT_ostta04g03900
BPG: Bathy08g03260
MIS: MICPUN_60345
MPP: MICPUCDRAFT_47596
CME: CYME_CMM178C
GSL: Gasu_20690
CCP: CHC_T00004265001
EHX: EMIHUDRAFT_461368 EMIHUDRAFT_470045
PMAW: MACH26_20330(yjlD)
CTM: Cabther_B0793
CVL: J8C06_15040
CHLO: J8C02_12325
SYN: slr1743(ndh)
SYZ: MYO_112180(ndh)
SYY: SYNGTS_1207(ndh)
SYT: SYNGTI_1207(ndh)
SYS: SYNPCCN_1206(ndh)
SYQ: SYNPCCP_1206(ndh)
SYJ: D082_23110(ndbB)
SYO: C7I86_06260
SYNH: HTZ78_00290
SYNS: OLK001_05590(ndbB)
SYC: syc1598_c(ndbB)
SYU: M744_03695
SYF: Synpcc7942_2508
SYD: Syncc9605_2310
SYE: Syncc9902_0383
SYG: sync_2511
SYR: SynRCC307_0389(ndh)
SYX: SynWH7803_2175(ndh)
CYA: CYA_0862
CYB: CYB_1748
SYNE: Syn6312_3456
SYNK: KR100_14260
SYNR: KR49_07070
SYND: KR52_04635
SYH: Syncc8109_2392
SYNW: SynWH8103_02483
SYNC: CB0101_14370
SYNY: BM449_09305
SYNZ: H8F24_08990
SYNL: KJJ24_08810
SYNO: LY254_05810
SYNU: SynWH8101_2510
SYW: SYNW2165
CGC: Cyagr_1568
CYI: CBM981_3061
PMA: Pro_0096(ndh)
PMM: PMM0082
PMT: PMT_1625
PMN: PMN2A_1446
PMI: PMT9312_0085
PMB: A9601_00951
PMC: P9515_00921
PMF: P9303_02581
PMG: P9301_00941
PMH: P9215_00951
PMJ: P9211_00911
PME: NATL1_01471
PRC: EW14_0102
PRM: EW15_0164
WNA: KA717_28445
CMP: Cha6605_4090
CYN: Cyan7425_1446
CEP: Cri9333_2861
TVN: NIES2134_101430(ndbB)
SLW: BRW62_03875
TEL: tlr1136(ndbB)
THN: NK55_02985(ndbB)
THEC: FFX45_12480
THEY: JW907_12640
TSQ: D3A95_02310
AMR: AM1_2697
ACAM: HRE53_10465
TSZ: OOK60_00830
LEN: LEP3755_58200
LET: O77CONTIG1_02936(ndh)
LBO: LBWT_15670
LEPB: GFS31_02270 GFS31_29590
LEPI: EDM05_021460
KOV: K9N68_15810
LSC: KIK02_04980
LSK: J5X98_03075
SFRI: RBJ76_08930
HHG: XM38_046090
DSL: Dacsa_1246
PSEU: Pse7367_2005
PSER: ABRG53_2102
PGX: OA858_09790
SYNP: Syn7502_00863
THEU: HPC62_17325
TOG: HNI00_21205
TSIN: OXH18_01100
GLP: Glo7428_4351
CHON: NIES4102_17540
GDU: P0S91_11105
GEN: GM3709_2091
GEE: GM3708_3185
CAN: Cyan10605_3058
CSN: Cyast_0025
CYL: AA637_13705(ndh-2)
CYR: A5482_001705
CYD: Dongsha4_14335
SYP: SYNPCC7002_A2120(ndbB)
SYV: AWQ23_10615
SYL: AWQ21_10770
LEP: Lepto7376_3344
SYNN: NIES970_15700(ndbB)
PIP: FEK30_14865
MAR: MAE_42940(ndbB2) MAE_62400(ndbB1)
MPK: VL20_2143 VL20_2695
MIQ: B5D77_01060 B5D77_12325
MVZ: myaer102_17350(ndbB2) myaer102_34460(ndbB1)
MIBL: ACE3JL_04070 ACE3JL_18935
MICD: ACQY1Y_09055 ACQY1Y_09495
MPRC: ACQY1X_09090 ACQY1X_09530
HAO: PCC7418_2212
ENN: FRE64_05310
CYU: UCYN_05790
CYT: cce_0154(ndbB) cce_4052
CWA: CwatDRAFT_6161
CYP: PCC8801_0031 PCC8801_0681
CYH: Cyan8802_0029 Cyan8802_0708
CYC: PCC7424_3107 PCC7424_4523
CYJ: Cyan7822_0200 Cyan7822_1479
TER: Tery_3661 Tery_4096
PAGH: NIES204_19420(ndbB)
PPSU: NO713_01928(ndbB)
PRUN: PCC7821_02333(ndbB)
MVAG: D0A34_10010
LFS: HFV01_11460
LIX: H2674_14435
ARP: NIES39_C03210(ndbB)
CSAU: ACL6C3_00415 ACL6C3_15695
OXY: HCG48_23500
OAC: Oscil6304_3986
PHOR: JWS08_08025 JWS08_21680
PYH: NEA10_04525 NEA10_10525
ONI: Osc7112_2336
MIC: Mic7113_3565
MPRO: BJP34_02545
GEI: GEI7407_1584 GEI7407_3314
GVI: glr3503
GLJ: GKIL_1185(ndh)
GML: ISF26_14955
ANA: alr4094
NPU: Npun_R1623
NOS: Nos7107_4485
NOP: Nos7524_0617
NON: NOS3756_49290
NFL: COO91_00248
NOE: CLI64_02480
NSH: GXM_05919
NED: HUN01_32080
NPZ: ACX27_21560
NLK: NIES25_04320
NCW: NIES2107_52160
NCF: ANSO36C_20050(ndbB)
NOST: GJB62_05215
NOSU: JYQ62_15225
NOSQ: PQG02_27320
NOSZ: WKK05_29270
NOSC: L6494_07130
AVA: Ava_0810
NAZ: Aazo_4817
ANB: ANA_C11689(ndh)
ACY: Anacy_2011 Anacy_4522
AWA: AA650_17225
ANN: EH233_26120
CSG: Cylst_6117
RSIN: B6N60_02534
HBQ: QI031_04880
NSPH: BDGGKGIB_01467(ndbB)
AEE: IM676_10380
ALIH: ACQFX9_15345
CALO: Cal7507_0568
CALT: Cal6303_0926
CALH: IJ00_11250
CALN: NIES2098_10340
CALS: NIES3974_46320
RIV: Riv7116_6852
MDP: NIES3275_61010
FIS: FIS3754_01360
DOU: BMF77_01764(ndh)
DFS: HGD76_09485
DCM: NIES806_23650
DOT: EZY12_21140
DOZ: HEP80_10300
DOC: HEQ26_10745
CRK: L3I90_11710
AFLO: HEQ12_16425
STOQ: K2F26_06975
SKV: NIES73_16600
RCS: NIES932_30470
CCUR: IAR63_12545
OCF: WJM97_17810 WJM97_19335
TOQ: HCG51_22050
TTQ: NIES37_05970
TOI: HG267_11560
TOZ: HGR01_07115
ALAX: NIES50_13870
SCYT: SAMD_01460
SCYS: NIES4073_27090
BSEN: DP114_00300
BOX: DP113_00300
NCN: BZZ01_13585
CTHE: Chro_5076
PLP: Ple7327_0734 Ple7327_4053
SCS: Sta7437_2980 Sta7437_3640
STAN: STA3757_26730 STA3757_30400(ndbB)
GLT: GlitD10_0470(ndh)
GCY: LQF76_14055
CEO: ETSB_0596(ndbB)
CER: RGRSB_0558(ndbB)
CEEC: P3F56_02900
MEAE: QEN48_05755
 » show all
Reference
1  [PMID:26023160]
  Authors
Fatihi A, Latimer S, Schmollinger S, Block A, Dussault PH, Vermaas WF, Merchant SS, Basset GJ
  Title
A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis.
  Journal
Plant Cell 27:1730-41 (2015)
DOI:10.1105/tpc.15.00103
  Sequence
[ath:AT5G08740] [syn:slr1743]
Other DBs
ExplorEnz - The Enzyme Database: 1.6.5.12
IUBMB Enzyme Nomenclature: 1.6.5.12
ExPASy - ENZYME nomenclature database: 1.6.5.12
BRENDA, the Enzyme Database: 1.6.5.12
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