KEGG   ENZYME: 1.8.4.13
Entry
EC 1.8.4.13                 Enzyme                                 
Name
L-methionine (S)-S-oxide reductase;
fSMsr;
methyl sulfoxide reductase I and II;
acetylmethionine sulfoxide reductase;
methionine sulfoxide reductase;
L-methionine:oxidized-thioredoxin S-oxidoreductase;
methionine-S-oxide reductase;
free-methionine (S)-S-oxide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
Sysname
L-methionine:thioredoxin-disulfide S-oxidoreductase
Reaction(IUBMB)
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin [RN:R07606]
Reaction(KEGG)
R07606;
(other) R02025
Substrate
L-methionine [CPD:C00073];
thioredoxin disulfide [CPD:C00343];
H2O [CPD:C00001]
Product
L-methionine (S)-S-oxide [CPD:C15999];
thioredoxin [CPD:C00342]
Comment
Requires NADPH [2]. The reaction occurs in the opposite direction to that given above. Dithiothreitol can replace reduced thioredoxin. L-Methionine (R)-S-oxide is not a substrate [see EC 1.8.4.14, L-methionine (R)-S-oxide reductase].
History
EC 1.8.4.13 created 1984 as EC 1.8.4.5, part transferred 2006 to EC 1.8.4.13
Pathway
ec00270  Cysteine and methionine metabolism
Reference
1
  Authors
Black S, Harte EM, Hudson B, Wartofsky L.
  Title
A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides.
  Journal
J Biol Chem 235:2910-2916 (1960)
Reference
2  [PMID:37234]
  Authors
Ejiri SI, Weissbach H, Brot N.
  Title
Reduction of methionine sulfoxide to methionine by Escherichia coli.
  Journal
J Bacteriol 139:161-4 (1979)
DOI:10.1128/JB.139.1.161-164.1979
Reference
3  [PMID:6999943]
  Authors
Ejiri SI, Weissbach H, Brot N.
  Title
The purification of methionine sulfoxide reductase from Escherichia coli.
  Journal
Anal Biochem 102:393-8 (1980)
DOI:10.1016/0003-2697(80)90173-6
Reference
4  [PMID:15680228]
  Authors
Weissbach H, Resnick L, Brot N.
  Title
Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.
  Journal
Biochim Biophys Acta 1703:203-12 (2005)
DOI:10.1016/j.bbapap.2004.10.004
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.13
IUBMB Enzyme Nomenclature: 1.8.4.13
ExPASy - ENZYME nomenclature database: 1.8.4.13
BRENDA, the Enzyme Database: 1.8.4.13
LinkDB

KEGG   REACTION: R02025
Entry
R02025                      Reaction                               
Name
L-methionine:oxidized-thioredoxin S-oxidoreductase
Definition
L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin
Equation
C00073 + C00343 + C00001 <=> C02989 + C00342
Comment
two distinct enzymes
L-methionine (S)-S-oxide specific (ec 1.8.4.13, see R07606)
L-methionine (R)-S-oxide specific (ec 1.8.4.14, see R07608)
Reaction class
RC00013  C00342_C00343
RC00639  C00073_C02989
Enzyme
1.8.4.13        1.8.4.14
Pathway
rn00270  Cysteine and methionine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.8  Acting on a sulfur group of donors
   1.8.4  With a disulfide as acceptor
    1.8.4.13
     R02025  L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin
    1.8.4.14
     R02025  L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin
Orthology
K08968  L-methionine (R)-S-oxide reductase [EC:1.8.4.14]
LinkDB

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