KEGG   ENZYME: 1.8.5.8
Entry
EC 1.8.5.8                  Enzyme                                 
Name
eukaryotic sulfide quinone oxidoreductase;
SQR;
SQOR;
SQRDL (gene name)
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a quinone or similar compound as acceptor
Sysname
sulfide:glutathione,quinone oxidoreductase
Reaction(IUBMB)
hydrogen sulfide + glutathione + a quinone = S-sulfanylglutathione + a quinol [RN:R11929]
Reaction(KEGG)
R11929
Substrate
hydrogen sulfide [CPD:C00283];
glutathione [CPD:C00051];
quinone [CPD:C15602]
Product
S-sulfanylglutathione [CPD:C17267];
quinol [CPD:C15603]
Comment
Contains FAD. This eukaryotic enzyme, located at the inner mitochondrial membrane, catalyses the first step in the metabolism of sulfide. While both sulfite and glutathione have been shown to act as sulfane sulfur acceptors in vitro, it is thought that the latter acts as the main acceptor in vivo. The electrons are transferred via FAD and quinones to the electron transfer chain. Unlike the bacterial homolog (EC 1.8.5.4, bacterial sulfide:quinone reductase), which repeats the catalytic cycle without releasing the product, producing a polysulfide, the eukaryotic enzyme transfers the persulfide to an acceptor at the end of each catalytic cycle.
History
EC 1.8.5.8 created 2017
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K22470  eukaryotic sulfide quinone oxidoreductase
Genes
HSA58472(SQOR)
PTR453405(SQOR)
PPS100984085(SQOR)
GGO101146608(SQOR)
PON100452776(SQOR)
NLE100589960(SQOR)
MCC713699(SQOR)
MCF101926271(SQOR)
CSAB103245691(SQRDL)
CATY105588190(SQRDL)
PANU101005963(SQOR)
TGE112627482(SQOR)
RRO104674037(SQOR)
RBB108530119(SQRDL)
TFN117070710(SQOR)
CJC100410241(SQRDL)
SBQ101039585(SQRDL)
CSYR103271193(SQOR)
MMUR105872566(SQRDL)
OGA100946734(SQOR)
MMU59010(Sqor)
MCAL110312539(Sqor)
MPAH110319011(Sqor)
RNO691966(Sqor)
MCOC116090833(Sqor)
MUN110553250(Sqor)
CGE100770919(Sqor)
PLEU114699614(Sqor)
NGI103747009(Sqrdl)
HGL101725445(Sqrdl)
CPOC100735471(Sqor)
CCAN109676782(Sqrdl)
DORD105981212(Sqrdl)
DSP122114642(Sqor)
OCU100357085(SQRDL)
OPI101525399(SQOR)
TUP102491065(SQRDL)
CFA478289(SQOR)
VVP112920034(SQOR)
VLG121484044(SQOR)
AML100466768(SQOR)
UMR103656586(SQRDL)
UAH113269573(SQOR)
UAR123801940(SQOR)
ELK111161095
LLV125091604 125104844
MPUF101681233(SQRDL)
ORO101363149(SQRDL)
EJU114226525(SQOR)
ZCA113910189(SQOR)
MLX118003465(SQOR)
FCA101085805(SQOR)
PYU121041650(SQOR)
PBG122468686(SQOR)
PTG102956665(SQRDL)
PPAD109263034(SQRDL)
AJU106986292(SQOR)
HHV120243835(SQOR)
BTA507858(SQOR)
BOM102272805(SQRDL)
BIU109565157(SQRDL)
BBUB102390525(SQOR)
CHX102183520(SQRDL)
OAS101113498(SQOR)
ODA120852946(SQOR) 120853154
CCAD122443642(SQOR)
SSC100154990(SQOR)
CFR102506338(SQOR)
CBAI105076997(SQRDL)
CDK105104934(SQOR)
VPC102545691(SQOR)
BACU103020738(SQRDL)
LVE103075323(SQRDL)
OOR101282852(SQRDL)
DLE111181631(SQOR)
PCAD102986038(SQOR)
PSIU116749215(SQOR)
ECB100070480(SQOR)
EPZ103554021(SQRDL)
EAI106834984(SQOR)
MYB102250577(SQRDL)
MYD102773979(SQRDL)
MMYO118651361(SQOR)
MLF102436321(SQOR)
MNA107536227(SQRDL)
PKL118721856(SQOR)
HAI109396647(SQRDL)
DRO112311815(SQOR)
SHON118992588(SQOR)
AJM119057628(SQOR)
PDIC114492424(SQOR)
PHAS123808876(SQOR)
MMF118629792(SQOR)
RFQ117023877(SQOR)
PALE102892873(SQOR)
PGIG120622682(SQOR)
PVP105288724(SQOR)
RAY107514961(SQRDL)
MJV108400241(SQRDL)
TOD119238586(SQOR)
SARA101546804(SQRDL)
LAV100659861(SQOR)
TMU101352821
DNM101424944(SQOR)
MDO100013567(SQRDL)
GAS123237873(SQOR)
SHR100935171(SQOR)
PCW110223654(SQOR)
OAA100088843(SQOR)
PCOC116225329(SQOR)
MGP100551322(SQOR)
CJO107318739(SQOR)
NMEL110404052(SQOR)
APLA101794247(SQOR)
ACYG106033801(SQRDL)
AFUL116493434(SQOR)
TGU100220597(SQOR)
LSR110474252(SQOR)
SCAN103816028(SQOR)
PMOA120508903(SQOR)
OTC121343465(SQOR)
PRUF121354370(SQOR)
GFR102036352(SQRDL)
FAB101814680(SQRDL)
PHI102105060(SQRDL)
PMAJ107209455(SQRDL)
CCAE111934099(SQOR)
CCW104683982(SQOR)
ETL114059945(SQOR)
ZAB102069227(SQOR)
FPG101922842(SQRDL)
FCH102052821(SQOR)
CLV102097058(SQOR)
EGZ104130927(SQRDL)
NNI104017121(SQRDL)
ACUN113484015(SQOR)
TALA104355573(SQOR)
PADL103922742(SQRDL)
ACHC115341495(SQOR)
AAM106496523(SQRDL)
AROW112963525(SQOR)
NPD112952873(SQOR)
DNE112995969(SQOR)
ASN102370416(SQOR)
AMJ102565876(SQRDL)
CPOO109309059(SQRDL)
GGN109288575(SQRDL)
PSS102450989(SQOR)
CMY102937523(SQOR)
CPIC101942158(SQOR)
TST117883568(SQOR)
CABI116830917(SQOR)
MRV120374016(SQOR)
ACS100559421(sqrdl)
PVT110077232(SQOR)
SUND121933579(SQOR)
PBI103062542(SQOR)
PMUR107282915(SQOR)
TSR106543411(SQRDL)
PGUT117675728(SQOR)
VKO123027705(SQOR)
PMUA114584461(SQOR)
ZVI118092667(SQOR)
GJA107124460(SQRDL)
XLA379770(sqor.L) 380565(sqor.S)
XTR549710(sqor)
NPR108796990(SQRDL)
RTEM120931313(SQOR)
BBUF120985846(SQOR)
BGAR122929631(SQOR)
DRE550580(sqor)
SRX107712522 107739076
SANH107662445 107662477 107688928
SGH107557991 107589329
CCAR109109435
CAUA113043523 113043524 113067036
IPU100304964(sqor)
PHYP113530085(sqor)
SMEO124392476(sqor)
AMEX103025164(sqor)
EEE113581769(sqor)
TRU101067169 101067390
TNGGSTEN00025595G001
LCO104940596(sqor)
NCC104960093(sqrdl)
CGOB115009417 115009485
ELY117262838(sqor)
PLEP121949948(sqor)
SLUC116038361(sqor)
ECRA117941029(sqor)
PFLV114559539(sqor)
GAT120808894(sqor)
PPUG119196450(sqor)
MSAM119894398 119894399
CUD121514748(sqor) 121514749
MZE101475715(sqor)
ONL100694767(sqor)
OAU116332636(sqor)
OLA101171573(sqor)
OML112152270(sqor)
XMA102221794(sqor)
XCO114136958(sqor)
XHE116710467(sqor)
PRET103466434(sqrdl)
PFOR103131460(sqrdl)
PLAI106935787(sqrdl)
PMEI106932639(sqrdl)
GAF122835902(sqor)
CVG107096715(sqrdl)
CTUL119787374(sqor)
GMU124860329(sqor)
NFU107395505(sqrdl)
KMR108230035(sqor)
ALIM106526844(sqrdl)
NWH119416356(sqor)
AOCE111577707 111577712(sqor)
CSEM103380463(sqrdl)
POV109624534(sqrdl)
SSEN122775508 122775509
HHIP117763172(sqor)
LCF108876667(sqrdl)
SDU111229570(sqor)
SLAL111658550(sqor)
XGL120793799(sqor)
HCQ109507584(sqrdl)
BPEC110169311(sqor)
MALB109954036 109972679 109972685
SASA106561757 106584721
OTW112251440(sqor) 112265884
OMY110500795 110521223
OGO124031848 124037502
ONE115117275 115124975
SALP111972037 112071120
SNH120052334(sqor) 120066765
ELS105018365(sqor)
SFM108942041(sqor)
PKI111846664(sqor)
AANG118215461(sqor)
LOC102682967(sqrdl)
PSPA121294822 121304433
ARUT117429902 117963045
LCM102357687(SQRDL)
CMK103186591(sqor)
RTP109915700(sqor)
BFO118407755
BBEL109468972
CIN100175914
SCLV120332784
SPU105446119
APLC110989700
SKO100378456
DMEDmel_CG14997(CG14997)
DER6543723
DSE6610747
DSIDsimw501_GD13825(Dsim_GD13825)
DYADyak_GE21427
DAN6493435
DSR110183569
DPODpse_GA13414
DPE6601902
DMN108153404
DWI6645221
DGR6558606
DMODmoj_GI16584
DAZ108612500
DNV115563131
DHE111597424
DVI6624264
CCAT101449399
BOD106622942
MDE101897148
SCAC106090500
LCQ111678673
AGAAgaP_AGAP003142
ACOZ120949931
AARA120895334
AAG5573581
AALB109429124 115261402
CQUCpipJ_CPIJ004284
CPII120421774
CNS116342451
AME100577145
ACER108004428
ALAB122715582
BIM100743158
BBIF117217277
BVK117243089
BVAN117155263
BTER100642939
BPYO122575197
CCAL108627651
OBB114874199
MGEN117226186
NMEA116428931
CGIG122405437
SOC105196811
MPHA105839154
AEC105150250
ACEP105624256
PBAR105430605
VEM105569030
HST105189411
DQU106742065
CFO105258448
FEX115240951
LHU105669764
PGC109855915
OBO105284522
PCF106794019
PFUC122521376
VPS122635495
NVI100119840
CSOL105366595
TPRE106650055
MDL103578628
CGLO123269926
FAS105272027
DAM107040890
AGIF122847398
CCIN107264972
TCA659301
DPA109536361
SOY115889783
ATD109595800
CSET123306486
AGB108917721
LDC111507162
NVL108557478
APLN108744482
PPYR116159940
OTU111422828 111423941 111424030 111424058
BMOR101740027
BMAN114245409
MSEX115444820
DPLKGM_210821
BANY112050508 112050512
PMAC106708022 106713348
PPOT106107436
PRAP111000149 111000150
ZCE119832441 119832523
HAW110372031
TNL113494746
OFU114354394 114354412
PXY105395554
API103309578
DNX107173529
AGS114122914
RMD113559336
BTAB109034965
DCI103519581
CLEC106669712
HHAL106685215
NLU111062732
PHUPhum_PHUM008330
FOC113204160
ZNE110833128
CSEC111864841
FCD110862606
DPXDAPPUDRAFT_306714
PVM113812921 113827780
PJA122251733
HAME121857525
PCLA123769225
PTRU123507919 123507920
HAZT108665981
EAF111714216
ISCIscW_ISCW010340
DSV119455590
RSAN119376612 119394827
RMP119172112
VDE111253701
VJA111263539
TUT107365002
DPTE113790845
DFR124497067
CSCU111635210
PTEP107444346
SDM118198449
CELCELE_F02H6.5(sqrd-1) CELE_Y9C9A.16(Y9C9A.16)
CBRCBG_18746 CBG_18748
NAINECAME_19587
TSPTsp_10064
HROHELRODRAFT_73394
LGILOTGIDRAFT_234113
PCAN112556938
BGT106071872
GAE121373219 121373313
HRF124116678
HRJ124279073
CRG105342276 117686866
MYI110448710
PMAX117315362
MMER123524296
OBI106871235
OSN115219975
LAK106172774 106174519 106174571
SMMSmp_062070.1
SHXMS3_0020764
OVIT265_09176
NVE5498317 5522176
EPA110240088
ATEN116300013 116300014
ADF107340797
AMIL114966384
PDAM113670775
SPIS111324356
DGT114522863
XEN124450714
HMG100214548
TADTRIADDRAFT_49680
AQU100642085
MNGMNEG_8172
NCRNCU07112
NTENEUTE1DRAFT68211(NEUTE1DRAFT_68211)
SMPSMAC_07747
PANPODANSg563
TTTTHITE_2116481
MTMMYCTH_2309471
CTHRCTHT_0049480
MGRMGG_10087
TMNUCRPA7_3713 UCRPA7_4975
FGRFGSG_03259
FPUFPSE_08477
FVRFVEG_08543
FOXFOXG_09969
NHENECHADRAFT_105688
TRETRIREDRAFT_76215
TRRM419DRAFT_122477
MAWMAC_08700
MAJMAA_07763 MAA_09663
CMTCCM_03171 CCM_04152
PLJVFPFJ_00055
VALVDBG_02786
VDAVDAG_03703
CFJCFIO01_09380
SAPOSAPIO_CDS9428
ELAUCREL1_8913
PFYPFICI_06662 PFICI_07567
SSLSS1G_12373
BFUBCIN_08g00090 BCIN_12g05950
ANIAN1825.2 AN8346.2
AFMAFUA_7G00350
ACTACLA_067380
NFINFIA_112890
AORAO090023000140
ANGANI_1_1300034(An03g03640)
AFVAFLA_006504
ALUCAKAW2_50762S
ACHEACHE_70622S
APUUAPUU_10971S APUU_61420A
PCSPc16g05560
PDPPDIP_06540
TMFPMAA_014910
TRGTRUGW13939_00947
PNOSNOG_12870(SNOG_12869)
PTEPTT_02546 PTT_18870
BZECOCCADRAFT_30189 COCCADRAFT_85909
BSCCOCSADRAFT_158390 COCSADRAFT_346259
BORCOCMIDRAFT_37021 COCMIDRAFT_9950
AALTCC77DRAFT_1099663 CC77DRAFT_951339
NPAUCRNP2_6363 UCRNP2_7437
SPOSPBC2G5.06c(hmt2)
CNECNK03140
CNBCNBK0340
CGICGB_K0460W
TMSTREMEDRAFT_70514
TVSTRAVEDRAFT_63977
DSQDICSQDRAFT_97269
PCOPHACADRAFT_120746
SHSSTEHIDRAFT_74259
HIRHETIRDRAFT_32066(sqor)
PSQPUNSTDRAFT_53732
ADLAURDEDRAFT_180625
FMEFOMMEDRAFT_104425
GTRGLOTRDRAFT_114639
LBCLACBIDRAFT_188129
MPRMPER_06239
MRRMoror_6516
CCICC1G_04280
SCMSCHCODRAFT_51805
ABPAGABI1DRAFT111296(AGABI1DRAFT_111296)
ABVAGABI2DRAFT190518(AGABI2DRAFT_190518)
CPUTCONPUDRAFT_139667 CONPUDRAFT_79894
SLASERLADRAFT_443941 SERLADRAFT_480763
WSEWALSEDRAFT_33204
WICJ056_003533
UMAUMAG_01195
PFPPFL1_02837
MGLMGL_1275
MRTMRET_2870
MSYMMSY001_0631
MBRMONBRDRAFT_35901
SREPTSG_09564 PTSG_09600
DDIDDB_G0292250(sqrdl)
DPPDICPUDRAFT_56106
DFADFA_07169(sqrdl)
TETTTHERM_01513260
PTMGSPATT00025988001 GSPATT00030239001 GSPATT00033070001
SMINv1.2.018790.t1(symbB.v1.2.018790.t1)
EHXEMIHUDRAFT_224838 EMIHUDRAFT_310574
 » show all
Reference
1  [PMID:10224084]
  Authors
Vande Weghe JG, Ow DW
  Title
A fission yeast gene for mitochondrial sulfide oxidation.
  Journal
J Biol Chem 274:13250-7 (1999)
DOI:10.1074/jbc.274.19.13250
  Sequence
Reference
2  [PMID:18494801]
  Authors
Hildebrandt TM, Grieshaber MK
  Title
Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria.
  Journal
FEBS J 275:3352-61 (2008)
DOI:10.1111/j.1742-4658.2008.06482.x
Reference
3  [PMID:22852582]
  Authors
Jackson MR, Melideo SL, Jorns MS
  Title
Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite.
  Journal
Biochemistry 51:6804-15 (2012)
DOI:10.1021/bi300778t
  Sequence
[hsa:58472]
Reference
4  [PMID:25225291]
  Authors
Libiad M, Yadav PK, Vitvitsky V, Martinov M, Banerjee R
  Title
Organization of the human mitochondrial hydrogen sulfide oxidation pathway.
  Journal
J Biol Chem 289:30901-10 (2014)
DOI:10.1074/jbc.M114.602664
  Sequence
[hsa:58472]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.5.8
IUBMB Enzyme Nomenclature: 1.8.5.8
ExPASy - ENZYME nomenclature database: 1.8.5.8
BRENDA, the Enzyme Database: 1.8.5.8
LinkDB

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