KEGG ENZYME: 2.1.1.12

ENZYME: 2.1.1.12

Entry

EC 2.1.1.12                 Enzyme

Name

methionine S-methyltransferase;
S-adenosyl methionine:methionine methyl transferase;
methionine methyltransferase;
S-adenosylmethionine transmethylase;
S-adenosylmethionine-methionine methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:L-methionine S-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine [RN:R00649]

Reaction(KEGG)

R00649;
(other) R04772

Substrate

S-adenosyl-L-methionine [CPD:C00019];
L-methionine [CPD:C00073]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
S-methyl-L-methionine [CPD:C03172]

Comment

Requires Zn2+ or Mn2+

History

EC 2.1.1.12 created 1972

Pathway

ec00450

Selenocompound metabolism

ec01100

Metabolic pathways

Orthology

K08247

methionine S-methyltransferase

Genes

ATH:	AT5G49810(MMT)

ALY:

9301833

CRB:

17876741

CSAT:

104724368 104725483 104760968

EUS:	EUTSA_v10028379mg

BRP:

103852205

BNA:	106347003 106405635

BOE:

106327035

RSZ:

108842566

THJ:	104800334 104809041

CPAP:

110807371

CIT:

102615293

CIC:	CICLE_v10000109mg

PVY:

116107076

MINC:

123213762

TCC:

18595236

GRA:	105768013 105773006

GHI:	107902056 107906306 107958524 107961729

GAB:	108483023 108486208

HSYR:

120131801 120195829

DZI:

111281309

EGR:

104452450

GMX:	100800262(MMT1) 100803724(MMT2)

GSJ:	114379085 114391292

PVU:	PHAVU_006G221800g

VRA:

106775847

VAR:

108343150

VUN:

114187894

VUM:

124843441

CCAJ:

109803429

APRC:

113870518

MTR:

11434316

TPRA:

123910516 123910781

CAM:

101489113

PSAT:

127086303

VVO:

131640840

LJA:

130739390

ADU:

107476174

AIP:

107626365

AHF:	112728804 112758316

LANG:

109329628

PCIN:

129285003 129305780

QSA:	O6P43_012107

FVE:

101312937

RCN:

112180942

PPER:

18792170

PMUM:

103318942

PAVI:

110765687

PDUL:

117613254

MDM:	103411068 103416410

MSYL:

126601492 126630917

PXB:

103946414

ZJU:

107408781

MNT:

21399522

CSAV:

115712430

CSV:

101211867

CMO:

103493292

BHJ:

120091213

MCHA:

111008456

CMAX:

111477986 111482961

CMOS:

111436008 111447458

CPEP:

111798048 111810225

RCU:

8276899

MEAN:

126660293

JCU:

105631576

HBR:	110634724 110667562

MESC:

110619702 110624929

POP:

18098376

PEU:	105117735 105128447

PALZ:

118031094

JRE:

108988904

CILL:

122309998

CAVE:

132177856

QSU:

111989581

QLO:

115977664

TWL:

120003965

VVI:

100264437

VRI:	117923073 117926799

SLY:

101254039

SPEN:

107006489

SOT:

102601157

SSTN:

125863793

SDUL:

129885957

CANN:

107839818

LBB:

132598588

NTA:	107773392 107775022

NSY:

104242875

NTO:

104090720

NAU:

109242132

INI:

109185637

ITR:

116007022

SIND:

105169043 105172497

OEU:	111381917 111410756

EGT:	105960616 105962568

SSPL:

121741889 121754196 121805839 121807050

SMIL:

131002915 131014335 131023667

SHIS:

125189221 125196144 125223350

APAN:

127252443 127261018

HAN:	110910665 110936629

ECAD:

122591307

LSV:

111891651

CCAV:

112501857

DCR:

108204565

CSIN:

114299531 114317228

RVL:

131306346

AEW:	130759208 130774460 130778990 130784234

BVG:

104896997

SOE:

110803107

CQI:	110688317 110712320

ATRI:

130820729

MOF:

131164573

NNU:

104593907

MING:

122068746

TSS:

122666986

PSOM:

113347274

OSA:

4337554

OBR:

102710302

OGL:

127773737

BDI:

100836641

ATS:	109757810 109772098

TDC:	119310317 119315685 119327467 119358163

TAES:

123083372 123083898 123086846 123096129 123103256 123113658 123152706 123179822 123185184

TUA:	125531180 125542316 125550642

LPER:

127299903 127340890

LRD:	124697686 124700876 124708024

SBI:

8066591

ZMA:

541786

MFLO:

136508641 136512708 136514259

SITA:

101760501

SVS:

117848562

PVIR:

120667105 120697149

PHAI:

112884997

PDA:

103720822

EGU:

105051560

MUS:	103971204 103994727

ZOF:	121980283 121984194

AOF:

109837946

MSIN:

131236656

NCOL:

116250620

ATR:

18427820

SMO:	SELMODRAFT_132291

PPP:	112275594 112288761

» show all

Reference

1 [PMID:6078098]

Authors

Karr D, Tweto J, Albersheim P.

Title

S-adenosyl methionine: methionine methyl transferase from wheat germ.

Journal

Arch Biochem Biophys 121:732-8 (1967)
DOI:10.1016/0003-9861(67)90061-6

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.12

IUBMB Enzyme Nomenclature:

2.1.1.12

ExPASy - ENZYME nomenclature database:

2.1.1.12

BRENDA, the Enzyme Database:

2.1.1.12

CAS:

9027-77-4

LinkDB

DBGET integrated database retrieval system