Entry Name (S)-tetrahydroprotoberberine N-methyltransferase;
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine [RN:
R04716 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
(S)-7,8,13,14-tetrahydroprotoberberine [CPD:
C05204 ]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine [CPD:
C05318 ]
Comment Involved in the biosynthesis of isoquinoline alkaloids in plants.
History EC 2.1.1.122 created 1999
Pathway ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K13396 (S)-tetrahydroprotoberberine N-methyltransferase
Genes Taxonomy Reference 1
Authors Rueffer, M., Zumstein, G., Zenk, M.H.
Title Partial purification and characterization of S-adenosyl-L-methionine:(S)-tetrahydroprotoberberine cis-N-methyltransferase from suspension-cultured cells of Eschscholtzia and Corydalis.
Journal Phytochemistry 29:3727-3733 (1990)
Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.122
LinkDB All DBs
