| Entry |
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| Name |
(S)-coclaurine-N-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine [RN: R04692]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
(S)-coclaurine [CPD: C06161]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
(S)-N-methylcoclaurine [CPD: C05176]
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| Comment |
The enzyme is specific for the (S)-isomer of coclaurine. Norcoclaurine can also act as an acceptor.
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| History |
EC 2.1.1.140 created 2001
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| Pathway |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K13384 | (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase |
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| Genes |
| PSOM: | 113294670 113318496 |
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| Reference |
1 |
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| Authors |
Loeffler, S., Deus-Neumann, B. and Zenk, M.H. |
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| Title |
S-Adenosyl-L-methionine: (S)-coclaurine-N-methyltransferase from Tinospora cordifolia. |
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| Journal |
Phytochemistry 38:1387-1395 (1995) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.140 |
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| LinkDB |
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