KEGG   ENZYME: 2.1.1.147
Entry
EC 2.1.1.147                Enzyme                                 
Name
corydaline synthase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + palmatine + 2 NADPH + H+ = S-adenosyl-L-homocysteine + corydaline + 2 NADP+ [RN:R07241]
Reaction(KEGG)
R07241
Substrate
S-adenosyl-L-methionine [CPD:C00019];
palmatine [CPD:C05315];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
corydaline [CPD:C15530];
NADP+ [CPD:C00006]
Comment
Also acts on 7,8-dihydropalmatine.
History
EC 2.1.1.147 created 2002
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
Rueffer M, Bauer W, Zenk MH.
  Title
The formation of corydaline and related alkaloids in Corydalis cava in vivo and in vitro.
  Journal
Canad J Chem 72:170-175 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.147
IUBMB Enzyme Nomenclature: 2.1.1.147
ExPASy - ENZYME nomenclature database: 2.1.1.147
BRENDA, the Enzyme Database: 2.1.1.147
CAS: 155807-67-3
LinkDB

KEGG   REACTION: R07241
Entry
R07241                      Reaction                               
Name
S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase
Definition
S-Adenosyl-L-methionine + Palmatine + 2 NADPH <=> S-Adenosyl-L-homocysteine + Corydaline + 2 NADP+
Equation
Reaction class
RC00001  C00005_C00006
RC00003  C00019_C00021
RC01955  C05315_C15530
Enzyme
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.147
     R07241  S-Adenosyl-L-methionine + Palmatine + 2 NADPH <=> S-Adenosyl-L-homocysteine + Corydaline + 2 NADP+
Other DBs
RHEA: 14776
LinkDB

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