Entry
Name
cobalt-precorrin-5B (C1)-methyltransferase;
cobalt-precorrin-6A synthase;
CbiD
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:cobalt-precorrin-5B C1-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cobalt-precorrin-5B = S-adenosyl-L-homocysteine + cobalt-precorrin-6A [RN:
R07773 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
cobalt-precorrin-5B
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
cobalt-precorrin-6A
Comment
This enzyme catalyses the C-1 methylation of cobalt-precorrin-5B in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis. See EC
2.1.1.152 , precorrin-6A synthase (deacetylating), for the C1-methyltransferase that participates in the aerobic cobalamin biosynthesis pathway.
History
EC 2.1.1.195 created 2010
Pathway
Orthology
K02188 cobalt-precorrin-5B (C1)-methyltransferase
Genes
SEM : STMDT12_C20540(cbiD)
SETC : CFSAN001921_06625(cbiD)
SEEN : SE451236_16370(cbiD)
SENH : CFSAN002069_21660(cbiD)
SEEH : SEEH1578_19440(cbiD)
SENJ : CFSAN001992_01275(cbiD)
SEEC : CFSAN002050_17120(cbiD)
SEEB : SEEB0189_009305(cbiD)
SENC : SEET0819_17305(cbiD)
BUF : D8682_20840 D8682_24215
BAGE : BADSM9389_15300(cbiD)
BFT : MNO13_05060(cbiD) MNO13_08195(cbiD)
BSEL : RHD99_04865(cbiD) RHD99_08230(cbiD)
METY : MRY16398_18660(cbiD)
OPO : DSM2777_13890(cbiD) DSM2777_20810(cbiD)
PAEB : NCGM1900_3403(cbiD)
PPRC : PFLCHA0_c06620(cbiD)
PPUU : PputUW4_00535(cbiD)
PTW : TUM18999_08460(cbiD)
BMV : BMASAVP1_A1600(cbiD)
BPL : BURPS1106A_1970(cbiD)
BUE : BRPE67_BCDS06760(cbiD)
PDIO : PDMSB3_1859.1(cbiD)
MPT : Mpe_B0441(cbiD) Mpe_B0476(cbiD)
HHT : F506_09490 F506_13825
AZA : AZKH_4158(cbiD_cobF)
THAG : CKCBHOJB_02805(cbiD)
AGR : AGROH133_09247(cbiD)
AVV : RvVAT039_01090(cbiD)
AVF : RvVAR031_22270(cbiD)
NEN : NCHU2750_36530(cbiD)
BVL : BF3285c1_2111(cbiD2)
BIO : BR141012304_11399(cbiD)
MAQU : Maq22A_c09480(cbiD)
RMM : ROSMUCSMR3_00814(cbiD)
LVS : LOKVESSMR4R_01278(cbiD)
GBN : GEOBRER4_34640(cbiD)
PPOR : JCM14722_14210(cbiD)
BACI : B1NLA3E_01910(cbiD)
PARG : PspKH34_20140(cbiD)
LMOC : LMOSLCC5850_1184(cbiD)
LMW : LMOSLCC2755_1187(cbiD)
LMX : LMOSLCC2372_1191(cbiD)
LMZ : LMOSLCC2482_1235(cbiD)
LMON : LMOSLCC2376_1145(cbiD)
LMOS : LMOSLCC7179_1162(cbiD)
LMOO : LMOSLCC2378_1200(cbiD)
LMOY : LMOSLCC2479_1192(cbiD)
LMOT : LMOSLCC2540_1173(cbiD)
LMOA : LMOATCC19117_1194(cbiD)
PPQ : PPSQR21_047920(cbiD)
SMEN : SAMEA4412692_0356(cbiD)
LRU : HMPREF0538_20906(cbiD)
AUR : HMPREF9243_1740(cbiD)
AMIT : DBT49_0001530(cbiD)
CCOH : SAMEA4530647_0617(cbiD)
CGEL : psyc5s11_38550(cbiD)
DDL : Desdi_0492 Desdi_1018
DED : DHBDCA_p1192 DHBDCA_p2939(cbiD)
DEC : DCF50_p1258 DCF50_p2943(cbiD)
BPRO : PMF13cell1_04268(cbiD)
BLUI : Blut17040_11470(cbiD)
CSCI : HDCHBGLK_00124(cbiD)
CHYL : CE91St63_25820(cbiD)
ACEL : acsn021_39700(cbiD)
ACHT : bsdcttw_22290(cbiD)
CBAR : PATL70BA_0230(cbiD)
AMIC : Ami3637_15810(cbiD)
ABUT : Ami103574_09205(cbiD)
ETM : CE91St48_21160(cbiD)
PDF : CD630DERM_34290(cbiD)
PHX : KGNDJEFE_00481(cbiD)
EAC : EAL2_808p01000(cbiD)
NCD : ACONDI_00693(ecfA3_1)
DHO : Dia5BBH33_07600(cbiD)
SLE : sle_07930(sle_07930)
SGM : GCM10017557_05190(cbiD)
BALA : DSM104299_01723(cbiD)
SYR : SynRCC307_0048(cbiD)
SYX : SynWH7803_0047(cbiD)
SYH : Syncc8109_0051(cbiD)
SYNW : SynWH8103_00047(cbiD)
MVZ : myaer102_50560(cbiD)
PAGH : NIES204_38450(cbiD)
PRUN : PCC7821_04584(cbiD)
CALN : NIES2098_15980(cbiD)
NSPH : BDGGKGIB_03096(cbiD)
PPIO : CE91St28_12040(cbiD)
PCRE : NCTC12858_01484(cobK)
PCAG : NCTC12856_00422(cobK)
TVO : TVG0972668(TVG0972668)
SACR : SacRon12I_01950(cbiD)
» show all
Taxonomy
Reference
Authors
Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ.
Title
The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway.
Journal
Reference
Authors
Roessner CA, Williams HJ, Scott AI
Title
Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin.
Journal
Reference
Authors
Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ
Title
Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.195
LinkDB
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