Entry
Name
[methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase;
methyltransferase 2 (ambiguous);
mtaA (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
methylated methanol-specific corrinoid protein:CoM methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) methanol-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) methanol-specific corrinoid protein] [RN:
R10000 ]
Reaction(KEGG)
Substrate
[methyl-Co(III) methanol-specific corrinoid protein];
CoM [CPD:
C03576 ]
Product
methyl-CoM [CPD:
C03920 ];
[Co(I) methanol-specific corrinoid protein]
Comment
The enzyme, which is involved in methanogenesis from methanol, catalyses the transfer of a methyl group from a corrinoid protein (see EC
2.1.1.90 , methanol---corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to CoM, forming the substrate for EC
2.8.4.1 , coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis. Free methylcob(I)alamin can substitute for the corrinoid protein in vitro [5].
History
EC 2.1.1.246 created 2012
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K14080 [methyl-Co(III) methanol/glycine betaine-specific corrinoid protein]:coenzyme M methyltransferase
Genes
DTI : Desti_0877 Desti_2036 Desti_3217 Desti_5361
DKU : Desku_0050 Desku_0055 Desku_0060
FWA : DCMF_12445 DCMF_12460
TJR : TherJR_0470 TherJR_0979 TherJR_0982
MST : Msp_0112(mtaA2) Msp_0182(mtaA4) Msp_0761(mtaA1) Msp_0774(mtaA3)
METB : AW729_02405 AW729_06195 AW729_10490
MEIS : PXD04_02420(mtaA) PXD04_04500 PXD04_04505 PXD04_04790 PXD04_08395
MBA : Mbar_A1054 Mbar_A1688 Mbar_A3639
MBY : MSBRM_2354 MSBRM_2991 MSBRM_3313
MBW : MSBRW_1093 MSBRW_3045 MSBRW_3668
MBAR : MSBR2_2320 MSBR2_2952 MSBR2_3267
MBAK : MSBR3_1746 MSBR3_2381 MSBR3_3262
MAC : MA_0779(cmtM) MA_1615(cmtM) MA_2163(cmtM) MA_3613(cmtM) MA_4379(mtaA) MA_4559(cmtM)
MMA : MM_0176(mtaA) MM_0505 MM_1070(mtaA) MM_1932(mtbA)
MMAZ : MmTuc01_0522 MmTuc01_1102 MmTuc01_2009
MMJ : MSMAS_0231 MSMAS_0801 MSMAS_1125 MSMAS_2752
MMAC : MSMAC_0237 MSMAC_0779 MSMAC_1671 MSMAC_2485
MVC : MSVAZ_0217 MSVAZ_0373 MSVAZ_1364
MEK : MSKOL_0211 MSKOL_0358 MSKOL_1307
MLS : MSLAZ_0369 MSLAZ_1228 MSLAZ_1379 MSLAZ_2322 MSLAZ_2965
METM : MSMTP_0087 MSMTP_0267 MSMTP_1139 MSMTP_1438 MSMTP_1905 MSMTP_1916 MSMTP_2416 MSMTP_2659
MEF : MSWH1_0532 MSWH1_1021 MSWH1_1747 MSWH1_2472 MSWH1_2627
MEQ : MSWHS_0547 MSWHS_1092 MSWHS_1568 MSWHS_2411 MSWHS_2572
MSJ : MSSAC_0718 MSSAC_1597 MSSAC_1859 MSSAC_2001 MSSAC_3198 MSSAC_4064 MSSAC_4242
MSZ : MSSIH_0662 MSSIH_1027 MSSIH_1186 MSSIH_2365 MSSIH_3600 MSSIH_3745
MSW : MSSIT_0690 MSSIT_1074 MSSIT_1253 MSSIT_2316 MSSIT_2424 MSSIT_3653 MSSIT_3824
MTHR : MSTHT_0082 MSTHT_1209 MSTHT_1754
MTHE : MSTHC_0648 MSTHC_1535 MSTHC_2085
MHOR : MSHOH_0293 MSHOH_0908 MSHOH_1347 MSHOH_1564 MSHOH_3370 MSHOH_3435
MFZ : AOB57_002025 AOB57_007965 AOB57_010270
MHAB : RSJ42_00660(mtaA) RSJ42_03615(mtaA) RSJ42_11610(mtaA) RSJ42_14700(mtaA)
METW : AAY43_02680 AAY43_07435 AAY43_07610
MBU : Mbur_0452(mtaA) Mbur_0808 Mbur_1005(mtaA)
MMET : MCMEM_0940 MCMEM_1137 MCMEM_2051
MELO : J7W08_02985 J7W08_04245
MMH : Mmah_0008 Mmah_0518 Mmah_0901 Mmah_0970 Mmah_1478
MHAZ : BHR79_00830 BHR79_03425 BHR79_08720 BHR79_09050
MPOT : BKM01_04990 BKM01_07580 BKM01_08935 BKM01_10485
MEV : Metev_0012 Metev_0013 Metev_0942
MZH : Mzhil_0011 Mzhil_0619 Mzhil_1798 Mzhil_1957
MZI : HWN40_04040 HWN40_06230 HWN40_07880
MMAV : RE476_03530(mtaA) RE476_06210(mtaA) RE476_06905(mtaA)
MSEB : RE474_02320(mtaA) RE474_11785(mtaA) RE474_13240(mtaA)
MHZ : Metho_0761 Metho_0776 Metho_1260
MEHF : MmiHf6_01690(hemE_2) MmiHf6_11380(hemE_6)
MEES : MmiEs2_08220(hemE_2) MmiEs2_14070(hemE_5)
MEAM : MU439_00860 MU439_01115 MU439_01140(mtaA) MU439_02360 MU439_05065(mtaA)
MEAE : QEN48_01425(mtaA) QEN48_01460 QEN48_03630 QEN48_05100(mtaA) QEN48_07910
TAR : TALC_00463 TALC_00742
MAX : MMALV_03890 MMALV_05210 MMALV_09620
MER : MMINT_07210 MMINT_13560 MMINT_15760
MEUZ : KRP56_02065 KRP56_04335
MARC : AR505_1035 AR505_1063 AR505_1404 AR505_1575
» show all
Taxonomy
Reference
Authors
LeClerc GM, Grahame DA
Title
Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression.
Journal
Sequence
Reference
Authors
Harms U, Thauer RK
Title
Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli.
Journal
Sequence
Reference
Authors
Sauer K, Thauer RK
Title
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Zinc dependence and thermodynamics of the methanol:cob(I)alamin methyltransferase reaction.
Journal
Reference
Authors
Sauer K, Harms U, Thauer RK
Title
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Purification, properties and encoding genes of the corrinoid protein MT1.
Journal
Reference
Authors
Sauer K, Thauer RK
Title
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.246
LinkDB
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