Entry
Name
cobalt-precorrin-4 methyltransferase;
CbiF;
S-adenosyl-L-methionine:cobalt-precorrin-4 11-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:cobalt-precorrin-4 C11-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cobalt-precorrin-4 = S-adenosyl-L-homocysteine + cobalt-precorrin-5A [RN:
R05810 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
cobalt-precorrin-4 [CPD:
C11540 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
cobalt-precorrin-5A [CPD:
C16242 ]
Comment
This enzyme, which participates in the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway, catalyses the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A. See EC
2.1.1.133 , precorrin-4 C11-methyltransferase, for the equivalent enzyme that participates in the aerobic cobalamin biosynthesis pathway.
History
EC 2.1.1.271 created 2013
Pathway
Orthology
K05936 precorrin-4/cobalt-precorrin-4 C11-methyltransferase
Genes
SETC : CFSAN001921_06640(cbiF)
SEEN : SE451236_16355(cbiF)
SENH : CFSAN002069_21675(cbiF)
SEEH : SEEH1578_19425(cbiF)
SENJ : CFSAN001992_01290(cbiF)
SEEC : CFSAN002050_17105(cbiF)
SEEB : SEEB0189_009320(cbiF)
SENC : SEET0819_17290(cbiF)
KIE : NCTC12125_04866(cbiF)
BUF : D8682_20855 D8682_24230
BFT : MNO13_05075 MNO13_08210
BSEL : RHD99_04880 RHD99_08245
METY : MRY16398_18690(cbiF)
OPO : DSM2777_13900(cbiF) DSM2777_20795(cbiF)
PAEB : NCGM1900_3360(cobM)
PAEU : BN889_03295(cobM_1)
PVD : CFBP1590__3056(cobM)
PPRC : PFLCHA0_c37010(cobM)
PMUD : NCTC8068_02676(cobM)
PFW : PF1751_v1c23300(cobM)
PPUU : PputUW4_02357(cobM)
PTRT : HU722_0013180(cobM)
PTW : TUM18999_08600(cobM)
PTAE : NCTC10697_02112(cobM)
MDN : JT25_008960 JT25_023585
TFRI : Thiofri_02454(cbiF)
GAI : IMCC3135_08965(cobM)
HAAH : HALA3H3_800145(cobM)
BMV : BMASAVP1_A1598(cobM)
BML : BMA10229_A0259(cobM)
BPM : BURPS1710b_2117(cobM)
BPL : BURPS1106A_1972(cobM)
PDIO : PDMSB3_1857.1(cobM)
PLG : NCTC10937_02524(cobM)
MPT : Mpe_B0438(cobM) Mpe_B0473(cobM)
AZA : AZKH_4155(cbiF_cobM)
THAG : CKCBHOJB_02808(cbiF)
MESU : LHFGNBLO_003265(cobM)
SMEL : SM2011_c03187(cobM)
SFD : USDA257_c53910(cobM)
SAME : SAMCFNEI73_Ch3347(cobM)
AGR : AGROH133_09248(cobM)
ALF : CFBP5473_01410(cobM)
ASAL : CFBP5507_12780(cobM)
RPUS : CFBP5875_12400(cobM)
ALEG : CFBP4996_12800(cobM)
REC : RHECIAT_PA0000372(cobM)
REL : REMIM1_PD00472(cobM)
REP : IE4803_PA00408(cobM)
REI : IE4771_PC00421(cobM)
RTR : RTCIAT899_PC07020(cobM)
RHL : LPU83_pLPU83d0181(cobM)
RGA : RGR602_PC01210(cobM)
RPHA : AMC79_PB00381(cobM)
RLW : RlegWSM1455_31570(cobM)
RBW : RLCC275e_30585(cobM)
NEN : NCHU2750_36520(cobM)
BSEP : HAP48_0032395(cobM)
BCAN : BcanWSM471_15580(cobM)
MAQU : Maq22A_c09465(cobM)
MMES : MMSR116_15270(cobM)
MTUN : MTUNDRAET4_2081(cobM)
FIL : BN1229_v1_3168(cobM)
FIY : BN1229_v1_2754(cobM)
RLI : RLO149_c006250(cobM)
PHP : PhaeoP97_00776(cobM)
PPIC : PhaeoP14_00731(cobM)
SINL : DSM14862_03165(cobM)
SPSE : SULPSESMR1_02796(cobM)
RMM : ROSMUCSMR3_03056(cobM)
AHT : ANTHELSMS3_02553(cobM)
LVS : LOKVESSMR4R_00338(cobM)
GEH : HYN69_05185(cobM) HYN69_20045(cobM)
AALK : LGT41_0000205(cobM)
GEC : GEO60473_24170(cobM)
GBN : GEOBRER4_34610(cbiF)
GSB : GSUB_01380(cbiF) GSUB_08625
GHC : L9S41_04740(cobM) L9S41_12145
PCA : Pcar_0473(cbiF) Pcar_0851 Pcar_1059
PEF : A7E78_05730 A7E78_06200
DVE : DESUT3_08150(cbiF) DESUT3_18050(cobM)
DES : DSOUD_0628(cbiF) DSOUD_2051
PPOR : JCM14722_14350(cobM)
DOV : DSCO28_10540(cbiF_1) DSCO28_28820(cbiF_2)
DWD : DSCW_27450(cobM) DSCW_34020
DMM : dnm_047300(cobM) dnm_086570 dnm_086580
DAX : FDQ92_10645 FDQ92_11360(cobM)
LMAY : DPV73_18165(cobM) DPV73_19655(cobM)
PARG : PspKH34_20110(cbiF)
LMOC : LMOSLCC5850_1187(cbiF)
LMW : LMOSLCC2755_1190(cbiF)
LMX : LMOSLCC2372_1194(cbiF)
LMZ : LMOSLCC2482_1238(cbiF)
LMON : LMOSLCC2376_1148(cbiF)
LMOS : LMOSLCC7179_1165(cbiF)
LMOO : LMOSLCC2378_1203(cbiF)
LMOY : LMOSLCC2479_1195(cbiF)
LMOT : LMOSLCC2540_1176(cbiF)
LMOA : LMOATCC19117_1197(cbiF)
BAYD : BSPP4475_15685(cobM)
PPQ : PPSQR21_047890(cobM)
PCHI : PC41400_25700(cobM)
SMEN : SAMEA4412692_0359(cobM)
LRU : HMPREF0538_20903(cobM)
AUR : HMPREF9243_1737(cobM)
CTYK : CTK_C09480(cbiF_cobM)
CCOH : SAMEA4530647_0620(cbiF)
CGEL : psyc5s11_38510(cbiF_cobM)
BIE : RFF05_08595(cobM) RFF05_11335(cobM)
BPRO : PMF13cell1_04266(cbiF)
CSCI : HDCHBGLK_00122(cbiF)
ACEL : acsn021_39690(cbiF)
ACHT : bsdcttw_22300(cbiF)
CBAR : PATL70BA_0226(cbiF)
AMIC : Ami3637_15815(cobM)
ABUT : Ami103574_09200(cobM)
ETM : CE91St48_21140(cbiF)
PDF : CD630DERM_34260(cbiF)
PHX : KGNDJEFE_00484(cbiF)
EAC : EAL2_808p01040(cbiF)
PIV : NCTC13079_00691(cbiF)
VRM : 44547418_01213(cbiF)
VDN : NCTC11831_00750(cbiF)
SELM : TAMA11512_14920(cobM)
MANA : MAMMFC1_04004(cbiF)
PFAC : PFJ30894_01759(cbiF)
MBO : BQ2027_MB2097C(cobM)
MAVM : MAA44156_01805(cobM)
MMAE : MMARE11_29760(cobM)
MBAI : MB901379_02832(cobM)
MHEK : JMUB5695_02271(cobM)
MKY : IWGMT90018_27280(cobM)
MPHL : MPHLCCUG_02702(cobM)
MTHN : 4412656_01953(cobM)
MAUU : NCTC10437_00338(cobM)
MFLV : NCTC10271_02114(cobM)
MGO : AFA91_20115 AFA91_20675
MSAL : DSM43276_01909(cobM)
MTER : 4434518_03151(cobM)
CDIP : ERS451417_01235(cobM)
COI : CPCIP5297_05340(cobM)
CUN : Cul210932_1138(cobM)
CUQ : Cul210931_1090(cobM)
CUJ : CUL131002_1122c(cobM)
NFR : ERS450000_04863(cobM)
NAD : NCTC11293_06410(cobM)
NWL : NWFMUON74_64260(cobM)
NSPU : IFM12276_04840(cobM)
RPY : Y013_10510 Y013_14630
RCR : NCTC10994_03356(cobM)
RANT : RHODO2019_04725(cobM)
TPUL : TPB0596_24010(cobM)
SGRF : SGFS_088280 SGFS_096380
SCB : SCAB_90891 SCAB_9861(cobM)
SAMB : SAM23877_1927(cbiF)
STRF : ASR50_09000 ASR50_31615
SLE : sle_52780(sle_52780)
SALW : CP975_27605(cobM) CP975_34365
SGM : GCM10017557_05200(cobM)
SCOE : CP976_10540(cobM) CP976_34760(cobM)
SGOB : test1122_02370(cobM)
SXT : KPP03845_105802(cobM)
SCT : SCAT_1053(cbiF) SCAT_p1402(cobM)
SCY : SCATT_10470 SCATT_p03250
DCO : SAMEA4475696_1936(cobM)
PAK : HMPREF0675_3454(cobM)
CGRN : 4412665_00755(cbiF)
PAUS : NCTC13651_00949(cbiF)
PPC : HMPREF9154_0397(cobM)
TEZ : BKM78_01670 BKM78_05770
TLA : TLA_TLA_00340(cobM) TLA_TLA_01167(cbiF)
RAIN : Rai3103_07550(cobM)
BROO : brsh051_09610(cobM)
NAQU : ENKNEFLB_00278(cobM_1) ENKNEFLB_01625(cobM_2)
AGRA : AGRA3207_000941(cobM)
APRE : CNX65_08870(cobM) CNX65_28745
SESP : BN6_25790(cobM) BN6_70180
SSYI : EKG83_11625(cobM) EKG83_39335
KUT : JJ691_59050 JJ691_93650(cysG_1)
KPHY : AOZ06_33715 AOZ06_44415
LED : BBK82_22405 BBK82_26155
SACE : GIY23_16860(cobM) GIY23_16920
CROS : N8J89_31495(cobM) N8J89_33310
UME : RM788_12815(cobM) RM788_16385
MSAG : GCM10017556_51680(cobM)
ACTR : Asp14428_65750(cobM)
BALA : DSM104299_01722(cbiF)
PARQ : DSM112329_00632(cobM)
SYR : SynRCC307_0701(cobM)
SYX : SynWH7803_1853(cobM)
SYH : Syncc8109_0684(cobM)
SYNW : SynWH8103_02099(cobM)
TVN : NIES2134_108260(cobM)
LET : O77CONTIG1_04802(cbiF_2)
MVZ : myaer102_02410(cobM)
PAGH : NIES204_08180(cobM)
PRUN : PCC7821_03415(cbiF)
NSPH : BDGGKGIB_03573(cbiF)
DFO : Dform_01779(cobM|cbiF)
FPOL : ERS445057_01272(cbiF)
MFEG : GCM10025860_06630 GCM10025860_24730(cbiF)
TVO : TVG0970612(TVG0970612)
» show all
Taxonomy
Reference
Authors
Raux E, Schubert HL, Woodcock SC, Wilson KS, Warren MJ
Title
Cobalamin (vitamin B12) biosynthesis--cloning, expression and crystallisation of the Bacillus megaterium S-adenosyl-L-methionine-dependent cobalt-precorrin-4 transmethylase CbiF.
Journal
Sequence
Reference
Authors
Schubert HL, Wilson KS, Raux E, Woodcock SC, Warren MJ
Title
The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase.
Journal
Reference
Authors
Kajiwara Y, Santander PJ, Roessner CA, Perez LM, Scott AI
Title
Genetically engineered synthesis and structural characterization of cobalt-precorrin 5A and -5B, two new intermediates on the anaerobic pathway to vitamin B12: definition of the roles of the CbiF and CbiG enzymes.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.271
LinkDB
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