Entry
Name
(-)-pluviatolide 4-O-methyltransferase;
OMT3 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(-)-pluviatolide 4-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (-)-pluviatolide = S-adenosyl-L-homocysteine + (-)-bursehernin [RN:
R11230 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
(-)-pluviatolide [CPD:
C21191 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
(-)-bursehernin [CPD:
C21183 ]
Comment
The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
History
EC 2.1.1.323 created 2016
Pathway
ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
Orthology
K21203 (-)-pluviatolide 4-O-methyltransferase
Reference
Authors
Lau W, Sattely ES
Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.323
LinkDB
All DBs