KEGG   ENZYME: 2.1.1.323
Entry
EC 2.1.1.323                Enzyme                                 
Name
(-)-pluviatolide 4-O-methyltransferase;
OMT3 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(-)-pluviatolide 4-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (-)-pluviatolide = S-adenosyl-L-homocysteine + (-)-bursehernin [RN:R11230]
Reaction(KEGG)
R11230
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(-)-pluviatolide [CPD:C21191]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(-)-bursehernin [CPD:C21183]
Comment
The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
History
EC 2.1.1.323 created 2016
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21203  (-)-pluviatolide 4-O-methyltransferase
Reference
1  [PMID:26359402]
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.323
IUBMB Enzyme Nomenclature: 2.1.1.323
ExPASy - ENZYME nomenclature database: 2.1.1.323
BRENDA, the Enzyme Database: 2.1.1.323
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