KEGG   ENZYME: 2.1.1.325
Entry
EC 2.1.1.325                Enzyme                                 

Name
juvenile hormone-III synthase;
farnesoic acid methyltransferase;
juvenile hormone acid methyltransferase;
JHAMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(2E,6E)-farnesoate O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + (2E,6E)-farnesoate = S-adenosyl-L-homocysteine + methyl (2E,6E)-farnesoate [RN:R08147];
(2) S-adenosyl-L-methionine + juvenile hormone III acid = S-adenosyl-L-homocysteine + juvenile hormone III [RN:R08151]
Reaction(KEGG)
R08147 R08151
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(2E,6E)-farnesoate [CPD:C16502];
juvenile hormone III acid [CPD:C16504]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methyl (2E,6E)-farnesoate [CPD:C16503];
juvenile hormone III [CPD:C09694]
Comment
The enzyme, found in insects, is involved in the synthesis of juvenile hormone III, a sesquiterpenoid that regulates several processes including embryonic development, metamorphosis, and reproduction, in many insect species.
History
EC 2.1.1.325 created 2016
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K10718  juvenile hormone-III synthase
K22546  juvenile hormone-III synthase
Genes
BFO: 118403346 118404249 118405827 118409862 118413724 118415847 118422267 118424899 118430371 118431045
SPU: 105440269 105446656
APLC: 110973357 110973358 110975845 110989548
SKO: 102800802 102803287 102805153 102805273
DME: Dmel_CG17330(jhamt)
DER: 6547578
DSE: 6613700
DSI: Dsimw501_GD29004(Dsim_GD29004)
DYA: Dyak_GE13105
DAN: 6507586
DSR: 110181192
DPE: 6589341
DMN: 108161394
DWI: 6643814
DAZ: 108611017
DNV: 115563239
DHE: 111594183
DVI: 6627699
LCQ: 111683712
AAG: 5567710
AME: 724216
BIM: 100748241
BTER: 100649865
CCAL: 108623758
OBB: 114877883
PCF: 106792460
CSOL: 105364772
MDL: 103579048
TCA: 100141982(Mt1) 100142187(Mt2) 662961(Tcjhamt)
DPA: 109537726
PMAC: 106714896
PXY: 105388451
ZNE: 110830587
PVM: 113819003
LAK: 106153710
ALY: 9313440
CRB: 17887228
BRP: 103837883
BOE: 106310155
LHA: LHA_0531
 » show all
Reference
1  [PMID:14530389]
  Authors
Shinoda T, Itoyama K
  Title
Juvenile hormone acid methyltransferase: a key regulatory enzyme for insect metamorphosis.
  Journal
Proc Natl Acad Sci U S A 100:11986-91 (2003)
DOI:10.1073/pnas.2134232100
  Sequence
[bmor:692445]
Reference
2  [PMID:21195763]
  Authors
Defelipe LA, Dolghih E, Roitberg AE, Nouzova M, Mayoral JG, Noriega FG, Turjanski AG
  Title
Juvenile hormone synthesis: "esterify then epoxidize" or "epoxidize then esterify"? Insights from the structural characterization of juvenile hormone acid methyltransferase.
  Journal
Insect Biochem Mol Biol 41:228-35 (2011)
DOI:10.1016/j.ibmb.2010.12.008
  Sequence
[aag:5567710]
Reference
3  [PMID:24657668]
  Authors
Van Ekert E, Heylen K, Rouge P, Powell CA, Shatters RG Jr, Smagghe G, Borovsky D
  Title
Aedes aegypti juvenile hormone acid methyl transferase, the ultimate enzyme in the biosynthetic pathway of juvenile hormone III, exhibits substrate control.
  Journal
J Insect Physiol 64:62-73 (2014)
DOI:10.1016/j.jinsphys.2014.03.001
  Sequence
[aag:5567710]
Reference
4  [PMID:25893162]
  Authors
Van Ekert E, Shatters RG Jr, Rouge P, Powell CA, Smagghe G, Borovsky D
  Title
Cloning and expressing a highly functional and substrate specific farnesoic acid  o-methyltransferase from the Asian citrus psyllid (Diaphorina citri Kuwayama).
  Journal
FEBS Open Bio 5:264-75 (2015)
DOI:10.1016/j.fob.2015.03.012
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.325
IUBMB Enzyme Nomenclature: 2.1.1.325
ExPASy - ENZYME nomenclature database: 2.1.1.325
BRENDA, the Enzyme Database: 2.1.1.325
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