KEGG ENZYME: 2.1.1.376

ENZYME: 2.1.1.376

Entry

EC 2.1.1.376                Enzyme

Name

glycine betaine---corrinoid protein Co-methyltransferase;
mtgB (gene name);
glycine betaine methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

glycine betaine:[Co(I) glycine betaine-specific corrinoid protein] Co-methyltransferase

Reaction(IUBMB)

glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] = N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein] [RN:R12787]

Reaction(KEGG)

R12787

Substrate

glycine betaine [CPD:C00719];
[Co(I) glycine betaine-specific corrinoid protein]

Product

N,N-dimethylglycine [CPD:C01026];
[methyl-Co(III) glycine betaine-specific corrinoid protein]

Comment

The enzyme, which catalyses the transfer of a methyl group from glycine betaine to a glycine betaine-specific corrinoid protein (MtgC), is involved in methanogenesis from glycine betaine in some methanogenic archaea, and in glycine betaine degradation in some bacteria. Unlike similar enzymes involved in methanogenesis from methylated C1 compounds, this enzyme does not contain the unusual amino acid L-pyrrolysine.

History

EC 2.1.1.376 created 2021

Pathway

ec00260

Glycine, serine and threonine metabolism

ec01100

Metabolic pathways

Orthology

K25220

glycine betaine---corrinoid protein Co-methyltransferase

Genes

PBIZ:

LWC08_01290

DBK:	DGMP_29310

DEK:	DSLASN_08550

CACE:

CACET_c34470(mttB)

GFE:	Gferi_19940

BLIQ:

INP51_05155 INP51_12235 INP51_14665

WHJ:	H9Q79_07380 H9Q79_08790 H9Q79_08880 H9Q79_14845

TEB:	T8CH_0245 T8CH_0486 T8CH_1979 T8CH_2735 T8CH_2737

CALK:

HUE98_00750 HUE98_00760 HUE98_08960

DSY:

DSY3156

DHD:

Dhaf_4326

DDH:	Desde_3695

DOR:	Desor_0412

DMI:	Desmer_0448

FWA:	DCMF_23125 DCMF_26765

AACX:

DEACI_1208 DEACI_1210 DEACI_1255 DEACI_1256 DEACI_1266 DEACI_1268 DEACI_1278 DEACI_1681 DEACI_4248

TJR:	TherJR_2945

AWO:	Awo_c07540(mttB10)

AWI:	CHL1_002430 CHL1_003003(mtgB)

ETM:	CE91St48_00670(mttB_1) CE91St48_00770 CE91St48_05970 CE91St48_09680 CE91St48_13000 CE91St48_22250(mttB_3) CE91St48_22260(mttB_4) CE91St48_31720 CE91St48_31730(mttB_5)