KEGG   ENZYME: 2.1.1.376
Entry
EC 2.1.1.376                Enzyme                                 
Name
glycine betaine---corrinoid protein Co-methyltransferase;
mtgB (gene name);
glycine betaine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
glycine betaine:[Co(I) glycine betaine-specific corrinoid protein] Co-methyltransferase
Reaction(IUBMB)
glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] = N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein] [RN:R12787]
Reaction(KEGG)
R12787
Substrate
glycine betaine [CPD:C00719];
[Co(I) glycine betaine-specific corrinoid protein]
Product
N,N-dimethylglycine [CPD:C01026];
[methyl-Co(III) glycine betaine-specific corrinoid protein]
Comment
The enzyme, which catalyses the transfer of a methyl group from glycine betaine to a glycine betaine-specific corrinoid protein (MtgC), is involved in methanogenesis from glycine betaine in some methanogenic archaea, and in glycine betaine degradation in some bacteria. Unlike similar enzymes involved in methanogenesis from methylated C1 compounds, this enzyme does not contain the unusual amino acid L-pyrrolysine.
History
EC 2.1.1.376 created 2021
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K25220  glycine betaine---corrinoid protein Co-methyltransferase
Genes
PBIZLWC08_01290
DBKDGMP_29310
DEKDSLASN_08550
CACECACET_c34470(mttB)
GFEGferi_19940
BLIQINP51_05155 INP51_12235 INP51_14665
WHJH9Q79_07380 H9Q79_08790 H9Q79_08880 H9Q79_14845
TEBT8CH_0245 T8CH_0486 T8CH_1979 T8CH_2735 T8CH_2737
CALKHUE98_00750 HUE98_00760 HUE98_08960
DSYDSY3156
DHDDhaf_4326
DDHDesde_3695
DORDesor_0412
DMIDesmer_0448
FWADCMF_23125 DCMF_26765
AACXDEACI_1208 DEACI_1210 DEACI_1255 DEACI_1256 DEACI_1266 DEACI_1268 DEACI_1278 DEACI_1681 DEACI_4248
TJRTherJR_2945
AWOAwo_c07540(mttB10)
AWICHL1_000711 CHL1_002430 CHL1_003003(mtgB)
ETMCE91St48_00670(mttB_1) CE91St48_00770 CE91St48_05970 CE91St48_09680 CE91St48_13000 CE91St48_22250(mttB_3) CE91St48_22260(mttB_4) CE91St48_31720 CE91St48_31730(mttB_5)
NCDACONDI_01179 ACONDI_01398 ACONDI_01399 ACONDI_01401 ACONDI_02393 ACONDI_03100
AARAcear_1049 Acear_1222
STEDSPTER_06970(mtgB_3)
ALAMRT761_00980 RT761_01750
MELOJ7W08_01665
MEUZKRP56_05670
 » show all
Reference
1  [PMID:25313086]
  Authors
Ticak T, Kountz DJ, Girosky KE, Krzycki JA, Ferguson DJ Jr.
  Title
A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase.
  Journal
Proc Natl Acad Sci U S A 111:E4668-76 (2014)
DOI:10.1073/pnas.1409642111
  Sequence
[dsy:DSY3156]
Reference
2  [PMID:31787957]
  Authors
Creighbaum AJ, Ticak T, Shinde S, Wang X, Ferguson DJ Jr.
  Title
Examination of the Glycine Betaine-Dependent Methylotrophic Methanogenesis Pathway: Insights Into Anaerobic Quaternary Amine Methylotrophy.
  Journal
Front Microbiol 10:2572 (2019)
DOI:10.3389/fmicb.2019.02572
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.376
IUBMB Enzyme Nomenclature: 2.1.1.376
ExPASy - ENZYME nomenclature database: 2.1.1.376
BRENDA, the Enzyme Database: 2.1.1.376
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