| Entry |
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| Name |
caffeate O-methyltransferase;
caffeate methyltransferase;
caffeate 3-O-methyltransferase;
S-adenosyl-L-methionine:caffeic acid-O-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate [RN: R03366]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
3,4-dihydroxy-trans-cinnamate [CPD: C01197]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
3-methoxy-4-hydroxy-trans-cinnamate [CPD: C01494]
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| Comment |
3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but more slowly.
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| History |
EC 2.1.1.68 created 1984
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| Pathway |
| ec00940 | Phenylpropanoid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K13066 | caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase |
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| Genes |
| ALY: | 9302094 9302099 9303555 9303558 |
| CSAT: | 104703789 104717445 104722135 104725937 104729294 104730586 104730602 104752845 104761441 |
| EUS: | EUTSA_v10013896mg EUTSA_v10013897mg EUTSA_v10013908mg EUTSA_v10025520mg EUTSA_v10025522mg EUTSA_v10027501mg |
| BRP: | 103844876 103844878 103851985 103857055 103861716 103868698 |
| BNA: | 106356003 106373206 106374490 106385406 106392944 106409594 106418605 106434499 106434512 106437143 106437536 106444684 111205367 |
| BOE: | 106296210 106304347 106314910 106318901 106326817 106332463 106336119 |
| RSZ: | 108840420 108842003 108847745 108849034 108855334 108855432 130500633 130507220 |
| THJ: | 104799941 104799942 104799943 104802099 104804741 104811887 104813820 |
| CIT: | 102609664 102609976 102610562 102610871 102611981 102612475 102613152 102619425 102620276 102620338 102620533 102622352 102623037 102623705 102625353 102626016 102627175 102629858 102630049 102630642 127898632 127900384 127901112 127901145 127901524 127901780 127901800 127902074 |
| CIC: | CICLE_v10001555mg CICLE_v10001661mg CICLE_v10003323mg CICLE_v10003428mg CICLE_v10003737mg CICLE_v10005230mg CICLE_v10005251mg CICLE_v10012042mg CICLE_v10013542mg CICLE_v10015685mg CICLE_v10017649mg CICLE_v10017683mg CICLE_v10018226mg CICLE_v10018306mg CICLE_v10020377mg CICLE_v10020761mg CICLE_v100208142m CICLE_v10020820mg CICLE_v10020821mg CICLE_v10020828mg CICLE_v10020870mg CICLE_v10020873mg CICLE_v10020874mg CICLE_v10020875mg CICLE_v10020880mg CICLE_v10021670mg CICLE_v10021888mg CICLE_v10023568mg CICLE_v10023965mg CICLE_v10023994mg CICLE_v10024037mg CICLE_v10024239mg CICLE_v10024389mg CICLE_v10026359mg CICLE_v10026361mg CICLE_v10031949mg CICLE_v10031951mg CICLE_v10031952mg CICLE_v10031953mg |
| PVY: | 116109069 116109124 116109126 116111931 116111937 116116119 116116634 116117203 116120218 116120219 116121824 116125659 116128982 116129819 116135367 |
| MINC: | 123193589 123193590 123201620 123203759 123206967 123207172 123207173 123207175 123209138 123210223 123215322 123215323 123228814 123228972 123228974 123229057 123229059 123230013 123230022 |
| TCC: | 108661886 108663133 18507240 18587033 18589881 18589884 18592353 18599823 18599828 18601594 18605869 18605934 |
| GRA: | 105765366 105765367 105765368 105765408 105767646 105777756 105778083 105778084 105782479 105786164 105791250 105792628 105792629 105799382 |
| GHI: | 107889315 107889317 107891421 107893152 107895385 107895907 107909353 107915194 107915880 107922183 107929569 107929578 107929579 107929580 107936289 107936296 107937281 107937285 107939017 107940407 107940417 107947186 107948794 121203455 121222500 121224358 |
| GAB: | 108454744 108454946 108456843 108458089 108462551 108462554 108462612 108463104 108468573 108468574 108468576 108470190 108476615 108478631 108478815 108481968 108487847 |
| HSYR: | 120116151 120116152 120116153 120117320 120117322 120120356 120120801 120133965 120151502 120164932 120164933 120172230 120178119 120178120 120178126 120178154 120179105 120179119 120179148 120186881 120186895 120199752 120207175 120211258 120211268 |
| DZI: | 111277023 111277024 111279472 111279932 111289581 111294125 111295573 111296804 111297033 111298242 111302720 111302721 |
| EGR: | 104415145 104415146 104416154 104416158 104416159 104417513 104424243 104424567 104429247 104429250 104430810 104430849 104437195 104437201 104437219 104444139 104445600 104445601 104449485 104449526 104449528 104450510 104452413 104455705 104456234 120286470 120286481 120286487 120286488 120286492 120286495 120286498 120286501 120286509 120290357 |
| GMX: | 100777636 100780100 100788873 100803633 100805999(IMT1) 100806525 |
| GSJ: | 114400750 114410222 114415629 114415631 114415633 114418253 |
| PVU: | PHAVU_009G044400g PHAVU_009G258700g PHAVU_009G258800g PHAVU_009G258900g PHAVU_009G259000g PHAVU_009G259100g PHAVU_009G259200g PHAVU_009G259300g PHAVU_009G259500g PHAVU_L008600g |
| VRA: | 106760166 106760167 106764425 |
| VAR: | 108322235 108322321 108331569 108332176 108337604 108347163 |
| VUN: | 114162415 114162417 114164317 114166549 114167305 114193513 |
| VUM: | 124822830 124834297 124843151 124844039 |
| CCAJ: | 109789134 109794407 109797532 109817907 |
| APRC: | 113848006 113851065 113861533 113865423 113874611 |
| MTR: | 11417290 11421675 11428411 11428747 25481245 25501422 25501425 25501426 25501428 25501432 |
| TPRA: | 123889523 123908912 123909020 123909021 123913580 123924507 123924511 |
| CAM: | 101489645 101499314 101499972 |
| PSAT: | 127074970 127081194 127117487 127117488 127117489 127132054 127132084 |
| VVO: | 131610788 131615633 131645931 131645933 131645955 131650899 131661230 |
| LJA: | 130731442 130732879 130747059 130749119 |
| AHF: | 112698013 112715717 112784538 |
| LANG: | 109328338 109338233 109343467 109345737 109359349 109359350 |
| PCIN: | 129288030 129288417 129303975 129304011 129304160 129313942 129313943 129314378 |
| QSA: | O6P43_014915 O6P43_018511 O6P43_018512 O6P43_020016 O6P43_027443 O6P43_027444 O6P43_027445 O6P43_027447 O6P43_027450 O6P43_031488 |
| FVE: | 101294295 101296734 101308514 |
| RCN: | 112173018 112174337 112177138 112177243 112178673 112184684 112186762 112187184 112195792 112199890 |
| PPER: | 18776084 18784868 18786300 18786738 18786962 18787303 18790301 |
| PMUM: | 103319810 103322531 103333559 103342357 103342358 103342359(OMT1) 103342360 103343871 |
| PAVI: | 110749562 110750598 110754534 110754543 110758861 110764012 110764013 110764014 110764015 110764024 110764059 110772009 |
| PDUL: | 117613038 117615943 117617464 117619155 117620318 117625659 117625687 117628001 |
| MDM: | 103405809 103406240 103406241 103410332 103416926 103420798 103421923 103422036 103426499 103426529 103428516 103431087 103433538 103439452 103439955 103439956 103439958 103444340 114821537 |
| MSYL: | 126587406 126587408 126602260 126602261 126602960 126617782 126622479 126622651 126624198 126625233 126625250 126629573 126629826 126630014 126630015 126630016 126630017 126630193 126633822 126633858 |
| PXB: | 103927980 103927981 103927983 103935025 103935026 103943352 103943506 103951568 103951571 103951572 103951578 103956347 |
| ZJU: | 107414981 107418645 107418646 107418657 107418658 107418659 107423786 107423795 107423799 107423818 107429761 107434023 |
| MNT: | 21386163 21396224 21399503 21402552 21402554 21402556 21406195 |
| CSAV: | 115703695 115703767 115704150 115704696 115706436 115706437 115706439 115706440 115706441 115708263 115708264 115716367 115716906 115721930 115723302 |
| CSV: | 101204109 101205290 101214675 101214916 |
| CMO: | 103491014 103501180 103503246 107990280 |
| BHJ: | 120069086 120089696 120090274 120090551 120091798 |
| MCHA: | 111011723 111013374 111013400 111021443 |
| CMAX: | 111467633 111498431 |
| CMOS: | 111443843 111443858 111443866 111443875 111443892 111443897 111443906 111443926 111450048 |
| CPEP: | 111800838 111800840 111800841 111802251 |
| RCU: | 8262723 8270912 8270961 8270962 8282965 8285506 8288877 |
| MEAN: | 126656431 126664634 126685798 126686904 126686906 126686907 |
| JCU: | 105631282 105631656 105632993 105635946 105636072 105639044 105639046 105646425 105646969 110009243 |
| HBR: | 110633210 110634239 110634596 110634655 110635655 110637255 110646402 110650778 110651119 110660998 110663184 110666566 110666571 110667200 110667558 110668193 110668919 110668933 |
| MESC: | 110606332 110606366 110609830 110620427 110620573 110621614 110621616 110625885 110625905 110626912 110627924 |
| POP: | 112326165 7455369 7464476 7486809 7487746 7489078 7491420 7493466 |
| PEU: | 105110074 105116664 105126241 105135039 105135998 105136006 105136824 105139125 |
| PALZ: | 118037805 118040848 118041177 118041178 118042464 118043955 118043959 118063366 118063469 118063471 |
| JRE: | 108981438 108984504 108984894 108988282 108988354 108996985 108997950 109001928 109007527 109016296 109017756 109019627 109019628 118343751 |
| CILL: | 122289564 122289961 122289963 122309408 122309409 122309719 122310509 122312420 122312428 122312450 122312461 122312469 122312475 122312484 122312578 122313249 122313358 122313359 122313360 122313584 122313895 122313907 |
| CAVE: | 132169418 132173707 132184044 132184054 132184268 132184521 132185620 132185634 132186245 132186637 132186751 132186918 132186982 132187356 132187372 132187934 132187935 132188334 132188393 132190131 132190319 |
| QSU: | 111984638 111986891 111998091 111999738 112003971 112004110 112008529 112008537 112008542 112008545 112010443 112022960 112024712 112025116 112034364 112039311 |
| QLO: | 115954874 115954921 115956983 115956988 115957251 115958367 115958535 115959905 115960109 115960477 115960695 115961310 115965516 115974993 115975154 115975406 115975407 115977818 115977827 115983734 115994059 |
| TWL: | 119980326 119991969 119992484 119993419 119993421 119993422 120003335 120004090 120004360 120017161 120017162 |
| VVI: | 100232862 100232921 100242108 100253843 100255690 100260649 100260763 100260786 100265976 100265990 100854172 132253142 |
| VRI: | 117905577 117905995 117906164 117928551 117931761 117931763 117931793 117932682 117932824 117934093 117934121 |
| SLY: | 101247834 101251452 101258157 101261963(CTOMT1) 101262824 |
| SPEN: | 107002798 107015050 107021224 107022387 107022691 107023557 107023901 |
| SOT: | 102580081 102590869 102598963 102599285 102599938 102601059 102601955 107058365 |
| SSTN: | 125850018 125858515 125864991 125872242 125874005 125874309 125874334 125874421 125874422 125874423 125874424 125874437 |
| SDUL: | 129877139 129894354 129900050 129900634 129900817 |
| CANN: | 107845577 107862991 107873006 107874581 107874582 107875336 124893919 |
| LBB: | 132604937 132607228 132626646 132626663 132631985 132632002 132632190 |
| NTA: | 107781704 107786249 107788038 107793948 107795225(OMT) 107808034 107809583 |
| NSY: | 104210365 104213493 104220105 104220510 104232532 104247907 104247909 |
| NTO: | 104093759 104102219 104112840 104113085 |
| NAU: | 109207707 109213341 109214785 109216530 109225432 109238560 |
| INI: | 109150685 109165820 109165828 109169365 109169372 109169378 109169387 109194027 |
| ITR: | 115995564 115997239 116000356 116027462 116027469 116027475 |
| SIND: | 105155389 105155459 105155461 105156074 105160270 105166789 105166790 105166792 105166793 105171204 105176053 |
| EGT: | 105948694 105958797 105959984 105963647 105964561 105964570 105964613 105964669 |
| SSPL: | 121755989 121781296 121792982 121793860 |
| SMIL: | 130993304 130999983 131016166 |
| SHIS: | 125197435 125209845 125212956 125217723 |
| APAN: | 127246917 127256425 |
| HAN: | 110872993 110872994 110872995 110872997 110880491 110880664 110883877 110883878 110883913 110883919 110883923 110883924 110910235 110910237 110918544 110935947 110935949 110937336 110939393 110941106 110941120 |
| ECAD: | 122580299 122584671 122585007 122587186 122603167 122604332 122605064 122605407 122606653 122606654 122606655 122606657 122607521 |
| LSV: | 111885575 111885585 111903002 111903004 111903396 111920419 |
| CCAV: | 112502160 112517955 112518480 112524515 |
| DCR: | 108210405 108213212 108213412 108214102 108214103 108214345 108215346 108215347 108215577 108215829 108221040 108223084 |
| CSIN: | 114256533 114258943 114263502 114279920 114281109 114289828 114298482 114299270 114311917 114318633 114318652 114318654 114319246 |
| RVL: | 131297882 131300318 131300492 131306389 131306397 131312075 131324320 |
| AEW: | 130752610 130757246 130760883 130766806 130766817 130766826 130790222 130791401 130793849 |
| BVG: | 104887972 104888149 104888150 104888557 104897755 104901566 104901641 104901795 104901881 104901967 104902057 104902142 104902234 |
| SOE: | 110778083 110780238 110784083 110784177 110784196 110785731 110785749 110797580 110797596 110797628 110801392 |
| CQI: | 110685492 110690251 110692919 110692921 110693058 110697403 110697782 110713433 110713990 110713992 110724195 110727557 110727590 110727597 110729489 110729654 110731660 110731662 |
| ATRI: | 130806644 130809948 130809949 130824825 130825451 130825452 130825453 130825454 130825773 |
| NNU: | 104585771 104590656 104596816 104601399 104604834 |
| MING: | 122057048 122057467 122061057 122061385 122061940 122062008 122067123 122069568 122070346 122073509 122074748 122080840 122081123 122084343 122084344 122084345 122084682 122084701 122084795 122084796 122084797 122084798 122084988 122085017 122086214 122088518 122089414 122090996 122091141 |
| TSS: | 122642835 122643491 122643587 122643817 122643818 122645703 122646398 122648296 122649077 122649107 122657823 122657849 122658914 122658915 122660412 122660839 122662261 122663263 122663693 122664474 122667447 122667449 122667450 122667452 122671618 |
| PSOM: | 113286544 113288498 113326813 113332502 113341805 113346262 113346520 |
| TDC: | 119270800 119279020 119280848 119305126 119305127 119306746 119319175 119324413 119334749 119336376 119341366 119361971 119361975 |
| TAES: | 123177153 123178260 |
| MFLO: | 136476450 136476470 |
| PVIR: | 120658570 120680242 120711449 |
| PDA: | 103696092 103706414 103716997 |
| EGU: | 105037617 105042923 105054950 105054951 105054994 |
| MUS: | 103971944 103973932 103974740 103974741 103975177 103978658 103980348 103982815 103998763 |
| ZOF: | 122000275 122032468 122032830 122034804 |
| DCT: | 110098174 110100929 110101663 110101682 110108293 110108304 |
| PEQ: | 110020850 110023022 110023954 110023969 110026827 110031091 110034484 110039323 |
| AOF: | 109820654 109821887 109822249 109837170 109837171 109838501 |
| MSIN: | 131218596 131233500 131234034 131234035 131235354 131248689 131248693 131248696 131248697 131257761 131257772 131257773 131257774 131257780 |
| NCOL: | 116252484 116253190 116253193 116253194 116260880 116262254 116262255 116263147 |
| SMO: | SELMODRAFT_450944(COMT1-1) SELMODRAFT_450945(COMT1-2) |
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| Reference |
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| Authors |
Ebel J, Schaller-Hekeler B, Knobloch KH, Wellman E, Grisebach H, Hahlbrock K. |
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| Title |
Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures. |
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| Journal |
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| Reference |
|
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| Authors |
Poulton JE, Butt VS. |
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| Title |
Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L). |
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| Journal |
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| Reference |
3 |
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| Authors |
Shimada M, Kuroda H, Higuchi T. |
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| Title |
Evidence for the formation of methoxyl groups of ferulic and sinapic acid in Bambusa by the same O-methyltransferase. |
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| Journal |
Phytochemistry 12:2873-2875 (1973) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.68 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.68 |
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| LinkDB |
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