KEGG   ENZYME: 2.1.1.68
Entry
EC 2.1.1.68                 Enzyme                                 

Name
caffeate O-methyltransferase;
caffeate methyltransferase;
caffeate 3-O-methyltransferase;
S-adenosyl-L-methionine:caffeic acid-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate [RN:R03366]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3,4-dihydroxy-trans-cinnamate [CPD:C01197]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-4-hydroxy-trans-cinnamate [CPD:C01494]
Comment
3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but more slowly.
History
EC 2.1.1.68 created 1984
Pathway
ec00940  Phenylpropanoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13066  caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase
Genes
ATH: AT5G54160(OMT1)
ALY: 9302094 9302099 9303555 9303558
CRB: 17876808 17896611
CSAT: 104703789 104717445 104722135 104725937 104729294 104730586 104730602 104752845 104761441
EUS: EUTSA_v10013896mg EUTSA_v10013897mg EUTSA_v10013908mg EUTSA_v10025520mg EUTSA_v10025522mg EUTSA_v10027501mg
BRP: 103844876 103844878 103851985 103857055 103861716 103868698
BNA: 106356003 106373206 106374490 106383910 106385406 106392944 106409594 106418605 106432400 106434499 106434512 106437132 106437143 106437536 106444684 111205367
BOE: 106296210 106304347 106314910 106318901 106326817 106332463 106336119
RSZ: 108840420 108842003 108847745 108849034 108855334
THJ: 104799941 104799942 104799943 104802099 104804741 104811887 104813820
CPAP: 110823164
LJA: Lj1g3v1079700.1(Lj1g3v1079700.1) Lj1g3v5060810.2(Lj1g3v5060810.2) Lj2g3v3339490.1(Lj2g3v3339490.1)
ADU: 107470102
AIP: 107622793
OSA: 4344702
DOSA: Os08t0157500-01(Os08g0157500)
OBR: 102717362
SBI: 8069622
ZMA: 100125646(comt)
SITA: 101765311
PHAI: 112897072
ATR: 18424568
SMO: SELMODRAFT_450944(COMT1-1) SELMODRAFT_450945(COMT1-2)
 » show all
Reference
1  [PMID:4472044]
  Authors
Ebel J, Schaller-Hekeler B, Knobloch KH, Wellman E, Grisebach H, Hahlbrock K.
  Title
Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures.
  Journal
Biochim Biophys Acta 362:417-24 (1974)
DOI:10.1016/0304-4165(74)90137-8
Reference
2  [PMID:241400]
  Authors
Poulton JE, Butt VS.
  Title
Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L).
  Journal
Biochim Biophys Acta 403:301-14 (1975)
DOI:10.1016/0005-2744(75)90060-1
Reference
3
  Authors
Shimada, M., Kuroda, H. and Higuchi, T.
  Title
Evidence for the formation of methoxyl groups of ferulic and sinapic acid in Bambusa by the same O-methyltransferase.
  Journal
Phytochemistry 12:2873-2875 (1973)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.68
IUBMB Enzyme Nomenclature: 2.1.1.68
ExPASy - ENZYME nomenclature database: 2.1.1.68
BRENDA, the Enzyme Database: 2.1.1.68
CAS: 50936-45-3
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