KEGG   ENZYME: 2.1.1.89
Entry
EC 2.1.1.89                 Enzyme                                 
Name
tetrahydrocolumbamine 2-O-methyltransferase;
tetrahydrocolumbamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine [RN:R04077]
Reaction(KEGG)
R04077
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5,8,13,13a-tetrahydrocolumbamine [CPD:C04118]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
tetrahydropalmatine [CPD:C02890]
Comment
Involved in the biosynthesis of the berberine alkaloids.
History
EC 2.1.1.89 created 1989
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
Beecher, C.W.W. and Kelleher, W.J.
  Title
Enzymatic study of the late stages of protoberberine alkaloid biosynthesis.
  Journal
Tetrahedron Lett 25:4595-4598 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.89
IUBMB Enzyme Nomenclature: 2.1.1.89
ExPASy - ENZYME nomenclature database: 2.1.1.89
BRENDA, the Enzyme Database: 2.1.1.89
CAS: 93792-09-7
LinkDB

KEGG   REACTION: R04077
Entry
R04077                      Reaction                               
Name
S-Adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase
Definition
S-Adenosyl-L-methionine + Isocorypalmine <=> S-Adenosyl-L-homocysteine + Tetrahydropalmatine
Equation
Reaction class
RC00003  C00019_C00021
RC00392  C02890_C04118
Enzyme
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Other DBs
RHEA: 22539
LinkDB

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