KEGG   ENZYME: 2.1.2.7
Entry
EC 2.1.2.7                  Enzyme                                 
Name
D-alanine 2-hydroxymethyltransferase;
2-methylserine hydroxymethyltransferase
Class
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
Sysname
5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase
Reaction(IUBMB)
5,10-methylenetetrahydrofolate + D-alanine + H2O = tetrahydrofolate + 2-methylserine [RN:R01225]
Reaction(KEGG)
R01225
Substrate
5,10-methylenetetrahydrofolate [CPD:C00143];
D-alanine [CPD:C00133];
H2O [CPD:C00001]
Product
tetrahydrofolate [CPD:C00101];
2-methylserine [CPD:C02115]
Comment
Also acts on 2-hydroxymethylserine.
History
EC 2.1.2.7 created 1972
Pathway
ec00670  One carbon pool by folate
ec01100  Metabolic pathways
Reference
1  [PMID:14001018]
  Authors
WILSON EM, SNELL EE.
  Title
Metabolism of alpha-methylserine. I. alpha-Methylserine hydroxymethyltransferase.
  Journal
J Biol Chem 237:3171-9 (1962)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.2.7
IUBMB Enzyme Nomenclature: 2.1.2.7
ExPASy - ENZYME nomenclature database: 2.1.2.7
BRENDA, the Enzyme Database: 2.1.2.7
CAS: 9075-76-7
LinkDB

KEGG   REACTION: R01225
Entry
R01225                      Reaction                               
Name
5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase
Definition
5,10-Methylenetetrahydrofolate + D-Alanine + H2O <=> Tetrahydrofolate + 2-Methylserine
Equation
C00143 + C00133 + C00001 <=> C00101 + C02115
Reaction class
RC00022  C00101_C00143
RC00472  C00133_C02115
Enzyme
2.1.2.7
Pathway
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.7
     R01225  5,10-Methylenetetrahydrofolate + D-Alanine + H2O <=> Tetrahydrofolate + 2-Methylserine
Other DBs
RHEA: 10067
LinkDB

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