KEGG ENZYME: 2.1.5.1

ENZYME: 2.1.5.1

Entry

EC 2.1.5.1                  Enzyme

Name

sesamin methylene transferase;
sesA (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methylenetransferases

Sysname

(+)-sesamin:tetrahydrofolate N-methylenetransferase

Reaction(IUBMB)

(1) (+)-sesamin + tetrahydrofolate = (+)-demethylpiperitol + 5,10-methylenetetrahydrofolate [RN:R11955];
(2) (+)-demethylpiperitol + tetrahydrofolate = (+)-didemethylpinoresinol + 5,10-methylenetetrahydrofolate [RN:R11956]

Reaction(KEGG)

R11955 R11956

Substrate

(+)-sesamin [CPD:C10882];
tetrahydrofolate [CPD:C00101];
(+)-demethylpiperitol [CPD:C21801]

Product

(+)-demethylpiperitol [CPD:C21801];
5,10-methylenetetrahydrofolate [CPD:C00143];
(+)-didemethylpinoresinol [CPD:C21802]

Comment

This enzyme was characterized from the bacterium Sinomonas sp. No.22. It catalyses a cleavage of a methylene bridge, followed by the transfer of the methylene group to tetrahydrofolate. The enzyme is also active with (+)-episesamin, (-)-asarinin, (+)-sesaminol, (+)-sesamolin, and piperine.

History

EC 2.1.5.1 created 2018

Orthology

K22578

sesamin methylene transferase

Reference

1 [PMID:27444012]

Authors

Kumano T, Fujiki E, Hashimoto Y, Kobayashi M

Title

Discovery of a sesamin-metabolizing microorganism and a new enzyme.

Journal