KEGG   ENZYME: 2.2.1.11
Entry
EC 2.2.1.11                 Enzyme                                 
Name
6-deoxy-5-ketofructose 1-phosphate synthase;
DKFP synthase
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
Sysname
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Reaction(IUBMB)
(1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10049];
(2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10050]
Reaction(KEGG)
R10049 R10050
Substrate
2-oxopropanal [CPD:C00546];
D-fructose 1,6-bisphosphate [CPD:C00354];
D-fructose 1-phosphate [CPD:C01094]
Product
D-glyceraldehyde 3-phosphate [CPD:C00118];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.11 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16305  fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Genes
SSEIFJR45_02715
EGDGS424_017090
AHATADCFC_22570
RTSCE91St31_04870
MKCkam1_189
BVOPan97_15820(fbaB)
ASACATHSA_0473
MJAMJ_1585
MFEMefer_0658
MVUMetvu_0368
MFSMFS40622_0194
MIFMetin_0355
MJHJH146_0289
MESGMLAUSG7_0763
MESAMLASG1_0429
MIGMetig_0068
MMPMMP0293
MMQMmarC5_1380
MMXMmarC6_0660
MMZMmarC7_1296
MMDGYY_01500
MMAKMMKA1_03000(fba)
MMAOMMOS7_03270(fba)
MMADMMJJ_07650(fbaB)
MAEMaeo_0690
MVNMevan_1304
MVOMvol_1341
MOKMetok_1121
MBAMbar_A0176 Mbar_A2224
MBYMSBRM_2208 MSBRM_2781
MBWMSBRW_0821 MSBRW_2524
MBARMSBR2_2738
MBAKMSBR3_2683
MACMA_2666 MA_3889
MMAMM_0714
MMAZMmTuc01_0735
MMJMSMAS_0603
MMACMSMAC_0605
MVCMSVAZ_0963
MEKMSKOL_0932
MLSMSLAZ_0625
METMMSMTP_0658
MEFMSWH1_0770
MEQMSWHS_0822
MSJMSSAC_1781 MSSAC_3626
MSZMSSIH_3164
MSWMSSIT_3238
MTHRMSTHT_2315
MTHEMSTHC_0965
MHORMSHOH_0711
MFZAOB57_003890
MPYMpsy_1203
MZIHWN40_02565
MHZMetho_0427
MTPMthe_0380
MHIMhar_2267
MHUMhun_1466
MRTJKHC33_07445
MLAMlab_1135
MEMMemar_1367
MBGBN140_2246
MEMAMMAB1_2969
MCHKMchiMG62_15630
MPIMpet_1339
MPLMpal_0799
 » show all
Reference
1  [PMID:17014089]
  Authors
White RH, Xu H
  Title
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
  Journal
Biochemistry 45:12366-79 (2006)
DOI:10.1021/bi061018a
  Sequence
[mja:MJ_1585]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.11
IUBMB Enzyme Nomenclature: 2.2.1.11
ExPASy - ENZYME nomenclature database: 2.2.1.11
BRENDA, the Enzyme Database: 2.2.1.11
LinkDB

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