KEGG ENZYME: 2.2.1.11

ENZYME: 2.2.1.11

Entry

EC 2.2.1.11                 Enzyme

Name

6-deoxy-5-ketofructose 1-phosphate synthase;
DKFP synthase

Class

Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases

Sysname

2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase

Reaction(IUBMB)

(1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10049];
(2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10050]

Reaction(KEGG)

R10049 R10050

Substrate

2-oxopropanal [CPD:C00546];
D-fructose 1,6-bisphosphate [CPD:C00354];
D-fructose 1-phosphate [CPD:C01094]

Product

D-glyceraldehyde 3-phosphate [CPD:C00118];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848];
D-glyceraldehyde [CPD:C00577]

Comment

The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.

History

EC 2.2.1.11 created 2012

Pathway

ec00400

Phenylalanine, tyrosine and tryptophan biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K16305

fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase

Genes

AAEO:

BJI67_06825

AFY:	BW247_04500

TIN:

Tint_0447

THI:

THI_0524

AFR:

AFE_1802

AFE:	Lferr_1479

ACU:

Atc_1531

ACZ:	Acaty_c1299

AFI:	Acife_0795 Acife_2018

AFJ:	AFERRID_27730

AFP:	K1Y48_06025 K1Y48_10460

ACIY:

MQE22_05275

SUA:

Saut_0463

SPAL:

FM071_05630

SSEI:

FJR45_02715

HYO:

NNO_1235

HCJ:

HCR_00780

NSA:	Nitsa_0969

SUN:	SUN_1211(fbaB)

SLH:	YH65_05870

NIS:

NIS_0927

NAP:	C3L23_03955

CPAF:

C6V80_04545

DPS:

DP2457

AAUT:

ACETAC_00835

CCU:	Ccur_03540

SHI:	Shel_19790

ELE:

Elen_2983

EYY:	EGYY_28100

EGD:	GS424_017090

AEQ:

AEQU_1983

AHAT:

ADCFC_22570

DDT:	AAY81_07945

CBAC:

JI75_01080

BWA:	HLV38_04495

RTS:	CE91St31_04870

EBZ:	J7S26_07675

MIN:	Minf_2129(fbaB)

MKC:

kam1_189

MFH:

MFUM_0234

MCAO:

IT6_05205

MEAP:

MTHMO_0280(fba)

BVO:	Pan97_15820(fbaB)

GAX:	Pan161_52870(fbaB)

HYA:	HY04AAS1_0176

HHO:	HydHO_0183

HYS:	HydSN_0190

ASAC:

ATHSA_0473

LFC:

LFE_2179

LFI:	LFML04_1323

LFP:	Y981_06425

LEG:	ABH19_06865

FBN:	HY931_01465

MJA:

MJ_1585

MFE:	Mefer_0658

MVU:	Metvu_0368

MFS:	MFS40622_0194

MIF:	Metin_0355

MJH:	JH146_0289

MESG:

MLAUSG7_0763

MESA:

MLASG1_0429

MIG:	Metig_0068

MMP:

MMP0293

MMQ:	MmarC5_1380

MMX:	MmarC6_0660

MMZ:	MmarC7_1296

MMD:

GYY_01500

MMAK:

MMKA1_03000(fba)

MMAO:

MMOS7_03270(fba)

MMAD:

MMJJ_07650(fbaB)

MAE:

Maeo_0690

MVN:	Mevan_1304

MVO:

Mvol_1341

MOK:	Metok_1121

MBA:	Mbar_A0176 Mbar_A2224

MBY:	MSBRM_2208 MSBRM_2781

MBW:	MSBRW_0821 MSBRW_2524

MBAR:

MSBR2_2738

MBAK:

MSBR3_2683

MAC:	MA_2666 MA_3889

MMA:

MM_0714

MMAZ:

MmTuc01_0735

MMJ:	MSMAS_0603

MMAC:

MSMAC_0605

MVC:	MSVAZ_0963

MEK:	MSKOL_0932

MLS:	MSLAZ_0625

METM:

MSMTP_0658

MEF:	MSWH1_0770

MEQ:	MSWHS_0822

MSJ:	MSSAC_1781 MSSAC_3626

MSZ:	MSSIH_3164

MSW:	MSSIT_3238

MTHR:

MSTHT_2315

MTHE:

MSTHC_0965

MHOR:

MSHOH_0711

MFZ:	AOB57_003890

MPY:

Mpsy_1203

MZI:	HWN40_02565

MMAV:

RE476_07655

MSEB:

RE474_03950

MHZ:	Metho_0427

MEHF:

MmiHf6_17900(fbaB)

MEES:

MmiEs2_09970(fbaB)

MTP:

Mthe_0380

MHI:

Mhar_2267

MHU:

Mhun_1466

MRTJ:

KHC33_07445

MLA:

Mlab_1135

MEM:	Memar_1367

MBG:	BN140_2246

MEMA:

MMAB1_2969

MCHK:

MchiMG62_15630

MSUM:

OH143_01060

MPI:

Mpet_1339

MEND:

L6E24_12595

MEFW:

F1737_04070

MAQE:

RJ40_00525

MFK:	E2N92_01880

MOU:	OU421_10940

MESB:

L1S32_02930

MANQ:

L1994_04885

MPL:

Mpal_0799

» show all

Reference

1 [PMID:17014089]

Authors

White RH, Xu H

Title

Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.

Journal

Biochemistry 45:12366-79 (2006)
DOI:10.1021/bi061018a

Sequence

[mja:MJ_1585]

Reference

2 [PMID:18318840]

Authors

Samland AK, Wang M, Sprenger GA

Title

MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.

Journal

FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x