KEGG   ENZYME: 2.3.1.169
Entry
EC 2.3.1.169                Enzyme                                 
Name
CO-methylating acetyl-CoA synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:corrinoid protein O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] [RN:R08433]
Reaction(KEGG)
R08433;
(other) R09317 R10243
Substrate
acetyl-CoA [CPD:C00024];
[Co(I) corrinoid Fe-S protein]
Product
CO [CPD:C00237];
CoA [CPD:C00010];
[methyl-Co(III) corrinoid Fe-S protein]
Comment
Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2.
History
EC 2.3.1.169 created 2003, modified 2015
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00193  acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit beta
K14138  acetyl-CoA synthase
Genes
GEFFO488_05725
DSFUWK_03162
DAKDaAHT2_0825
DBKDGMP_17890
DOLDole_3184
DMLDmul_30850(cdhC)
DALDalk_0681
DATHRM2_16660(cdhC)
DTOTOL2_C11810(cdhC)
DOVDSCO28_59730
DWDDSCW_28530
DALKDSCA_26720
DLIdnl_32610(cdhC)
DMMdnm_013320(cdhC)
DEKDSLASN_16760
DAODesac_1967
DTIDesti_0231
SFUSfum_2565
DAXFDQ92_06240(cdhC)
DBRDeba_0240
DHRLGS26_01915(cdhC)
CLJCLJU_c37550
CAHCAETHG_1608(acsB)
CSQCSCA_4551
CACECACET_c10320(acsB)
CCKCcar_18785
CFMBJL90_11135
CDRKB9W14_22250
CLOSDMR38_18720(cdhC)
AMTAmet_2028
GFEGferi_06315
PBIFKXZ80_13900(cdhC)
BYLA4V09_05460
BHANCGC63_07970(cdhC)
BLAUDQQ01_09725(cdhC)
BPROPMF13cell1_04283
BLABEYS05_16725(cdhC)
BLIQINP51_05955(cdhC)
QDOH9Q78_01470(cdhC)
WHJH9Q79_03155(cdhC)
CDFCD630_07280
PDCCDIF630_00844(cdhC)
CDCCD196_0674
CDLCDR20291_0655
PDFCD630DERM_07280
CSTCLOST_1171
PSORRSJ16_15710
ROCHF520_11260(cdhC)
TEMJW646_10895(cdhC)
TGCL0P85_16865(acsB)
TEBT8CH_0661
CALKHUE98_15620(cdhC)
DSYDSY1652
DHDDhaf_2797
DDHDesde_2255
DDLDesdi_1921
DMTDESME_07330
DORDesor_3273
DAIDesaci_2974
DMIDesmer_2535
DEDDHBDCA_p224
DECDCF50_p284
DRSDEHRE_00705
DAEDtox_1271 Dtox_3781
DKUDesku_1491 Desku_2149
DAUDaud_0111 Daud_0871
FWADCMF_05865
AACXDEACI_2512
TJRTherJR_1158
DGIDesgi_0523 Desgi_1186 Desgi_2051
ELMELI_3601
EMTCPZ25_018715(cdhC)
ELIMB2M23_08410
AWOAwo_c10760(acsB1) Awo_c33680(acsB2)
AWICHL1_001322(cdhC) CHL1_002701(cdhC)
ALKAJ0B03_11240(cdhC) J0B03_11265(cdhC)
CTHMCFE_1665
TKITKV_c19820(acsB)
CHYCHY_1222(acsB)
MTAMoth_1202
MTHOMOTHE_c11780
MTHZMOTHA_c12650
ADGAdeg_0336
TPZTph_c15170(acsA)
TEPTepRe1_0561
TAETepiRe1_0613
TOCToce_0813
NCDACONDI_02971
AARAcear_1304
MANAMAMMFC1_00476
STEDSPTER_05160 SPTER_13680
DETDET0666 DET0700
DEHcbdbA652(codH)
DEBDehaBAV1_0635
DEVDhcVS_604(cdhC)
DEGDehalGT_0597
DMCbtf_622(acsB)
DMDdcmb_668(acsB)
DMGGY50_0591(cdhC)
DMXX792_03230
DMYX793_02975
DMZX794_02725
DUCUCH007_05840(acsB)
DLYDehly_0817
DEWDGWBC_1386
DFODform_00887(acsB) Dform_00914(acsB)
DETHHX448_06200(cdhC)
KSTKSMBR1_1325(codh_acsB)
BROCIPI25_11080(cdhC)
BPITBPIT_02250
JETL3J17_07150(cdhC)
VAIBU251_01290
TPITREPR_3067
TAZTREAZ_1648
TYETHEYE_A1470
DTPJZK55_05480
TIDThein_2183
TOPTOPB45_0394
TCMHL41_07625
THETF1847_08575(cdhC)
CTHITHC_1762
TAVG4V39_01655(cdhC)
TMAIFVE67_00230(cdhC)
MJAMJ_0152 MJ_0156
MFEMefer_0200
MVUMetvu_0967 Metvu_1184
MFSMFS40622_0117 MFS40622_0121
MIFMetin_0081 Metin_1228
MJHJH146_0001 JH146_0005
MESGMLAUSG7_0548(cdhC) MLAUSG7_1300(cdhC)
MESAMLASG1_0247(cdhC) MLASG1_0900(cdhC)
MIGMetig_1378 Metig_1382
MMPMMP0983(cdhB)
MMQMmarC5_0803
MMXMmarC6_1675
MMZMmarC7_0225
MMDGYY_05740
MMAKMMKA1_11390(cdhC)
MMAOMMOS7_10750(cdhC)
MMADMMJJ_00080
MAEMaeo_1171
MVNMevan_0309
MOKMetok_0742 Metok_0743
METFCFE53_00285(cdhC) CFE53_03765(cdhC)
MTHMTH_1710
MMGMTBMA_c02890(cdhC)
MWOMWSIV6_0251(cdhC)
METCMTCT_1563
METEtca_01657
METKFVF72_03115(cdhC)
MTHMFZP57_01135(cdhC)
METJFZP68_06140(cdhC)
MAROMarbSA_08790
MELMetbo_0464
MEWMSWAN_1932
METHMBMB1_1563(cdhC)
MFCBRM9_0799(cdhC)
MFIDSM1535_0761(cdhC)
MCUBMCBB_1819(cdhC)
MSUBBK009_06800
METNBK008_02445
METTCIT01_07280(cdhC)
METOCIT02_10130(cdhC)
MEMEHYG87_07910(cdhC)
MFVMfer_0525
MKAMK0720(cdhC)
AFUAF_0379
AFGAFULGI_00003790
AVEArcve_1123
ASTAsulf_02027 Asulf_02202
FPLFerp_0733 Ferp_0929
GACGACE_0357 GACE_1720
GAHGAH_00919 GAH_01141
MBAMbar_A0202 Mbar_A0432
MBYMSBRM_0626 MSBRM_2757
MBWMSBRW_0569 MSBRW_0794
MBARMSBR2_1752 MSBR2_2715
MBAKMSBR3_2713 MSBR3_2953
MACMA_1014(cdhC) MA_3862(cdhC)
MMAMM_0686 MM_2087
MMAZMmTuc01_0702
MMJMSMAS_0628 MSMAS_2598
MMACMSMAC_0630 MSMAC_1822
MVCMSVAZ_0993 MSVAZ_3015
MEKMSKOL_0965 MSKOL_3022
MLSMSLAZ_0647
METMMSMTP_0685 MSMTP_0693
MEFMSWH1_0794
MEQMSWHS_0846
MSJMSSAC_3456 MSSAC_3599
MSZMSSIH_2984 MSSIH_3139
MSWMSSIT_3042 MSSIT_3210
MTHRMSTHT_2338
MTHEMSTHC_0942
MHORMSHOH_0737 MSHOH_3262
MFZAOB57_003745(cdhC)
MBUMbur_0860
MMETMCMEM_0992
MELOJ7W08_03310(cdhC)
MMHMmah_1168
MHAZBHR79_07695
MEVMetev_0424
MZHMzhil_1135
MPYMpsy_2893
MZIHWN40_08235(cdhC)
MHZMetho_0977
MTPMthe_0290
MCJMCON_1330(cdhC) MCON_1942(cdhC)
MHIMhar_0791 Mhar_2326
MHUMhun_0688
MRTJKHC33_09840(cdhC)
MBGBN140_2375(acsB)
MEMAMMAB1_3162
MCHKMchiMG62_09140
MBNMboo_1196 Mboo_1371
MFOMetfor_1453 Metfor_1719
MPLMpal_0803
RCILRC459(cdhC)
MELUMTLP_05360
MERMMINT_19140
BARCAOA65_0452(cdhC2)
BARBAOA66_1430(cdhC2)
 » show all
Reference
1  [PMID:2984190]
  Authors
Ragsdale SW, Wood HG.
  Title
Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.
  Journal
J Biol Chem 260:3970-7 (1985)
Reference
2  [PMID:12386327]
  Authors
Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL
  Title
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.
  Journal
Science 298:567-72 (2002)
DOI:10.1126/science.1075843
  Sequence
[mta:Moth_1202]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.169
IUBMB Enzyme Nomenclature: 2.3.1.169
ExPASy - ENZYME nomenclature database: 2.3.1.169
BRENDA, the Enzyme Database: 2.3.1.169
CAS: 176591-19-8
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