KEGG ENZYME: 2.3.1.169

ENZYME: 2.3.1.169

Entry

EC 2.3.1.169                Enzyme

Name

CO-methylating acetyl-CoA synthase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:corrinoid protein O-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] [RN:R08433]

Reaction(KEGG)

R08433;
(other) R09317 R10243

Substrate

acetyl-CoA [CPD:C00024];
[Co(I) corrinoid Fe-S protein]

Product

CO [CPD:C00237];
CoA [CPD:C00010];
[methyl-Co(III) corrinoid Fe-S protein]

Comment

Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2.

History

EC 2.3.1.169 created 2003, modified 2015

Pathway

ec00720

Other carbon fixation pathways

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00193

acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit beta

K14138

acetyl-CoA synthase

Genes

GEF:	FO488_05725

DSF:

UWK_03162

DLM:	DPPLL_26590

DAK:	DaAHT2_0825

DBK:	DGMP_17890

DDU:

GF1_14210

ECOM:

QTN59_00700(acsB)

EAJ:	Q3M24_13030(acsB)

DOL:

Dole_3184

DAL:

Dalk_0681

DAT:	HRM2_16660(cdhC)

DTO:	TOL2_C11810(cdhC)

DOV:	DSCO28_59730

DWD:	DSCW_28530

DALK:

DSCA_26720

DESB:

BuS5_02608

DML:	Dmul_30850(cdhC)

DLI:	dnl_32610(cdhC)

DMM:	dnm_013320(cdhC)

DEK:	DSLASN_16760

DAO:	Desac_1967

DTI:	Desti_0231

SFU:

Sfum_2565

DAX:	FDQ92_06240(cdhC)

DBR:

Deba_0240

DMP:

FAK_42010

TID:	Thein_2183

TOP:	TOPB45_0394

TCM:	HL41_07625

THET:

F1847_08575(cdhC)

CTHI:

THC_1762

TAV:	G4V39_01655(cdhC)

TMAI:

FVE67_00230(cdhC)

DHR:	LGS26_01915(cdhC)

CLJ:	CLJU_c37550

CAH:	CAETHG_1608(acsB)

CSQ:

CSCA_4551

CACE:

CACET_c10320(acsB)

CCK:	Ccar_18785

CFM:	BJL90_11135

CDRK:

B9W14_22250

CLOS:

DMR38_18720(cdhC)

RGV:	NQ502_01500(acsB)

DSY:

DSY1652

DHD:

Dhaf_2797

DDH:	Desde_2255

DDL:	Desdi_1921

DMT:	DESME_07330

DOR:	Desor_3273

DAI:	Desaci_2974

DMI:	Desmer_2535

DED:	DHBDCA_p224

DEC:	DCF50_p284

DRS:	DEHRE_00705

DAE:	Dtox_1271 Dtox_3781

DKU:	Desku_1491 Desku_2149

DAU:	Daud_0111 Daud_0871

FWA:	DCMF_05865

AACX:

DEACI_2512

TJR:	TherJR_1158

DGI:	Desgi_0523 Desgi_1186 Desgi_2051

ELM:

ELI_3601

EMT:	CPZ25_018715(cdhC)

ELIM:

B2M23_08410

AWO:	Awo_c10760(acsB1) Awo_c33680(acsB2)

AWI:	CHL1_001322(cdhC) CHL1_002701(cdhC)

ALKA:

J0B03_11240(cdhC) J0B03_11265(cdhC)

CTHM:

CFE_1665

BYL:	A4V09_05460

BHAN:

CGC63_07970(cdhC)

BLAU:

DQQ01_09725(cdhC)

BPRO:

PMF13cell1_04283

BLAB:

EYS05_16725(cdhC)

BLIQ:

INP51_05955(cdhC)

BWX:	NQ550_13510(acsB) NQ550_13515(acsB)

BMAS:

LK422_06255(cdhC)

BLAR:

LC508_02765(cdhC) LC508_10480(cdhC)

BLUI:

Blut17040_19210(acsB_1) Blut17040_19220(acsB_2)

BCOC:

BLCOC_33110

BHV:	BLHYD_15400 BLHYD_15410 BLHYD_31730

QDO:	H9Q78_01470(cdhC)

WHJ:	H9Q79_03155(cdhC)

MFOR:

NQ534_19150(acsB)

AMT:

Amet_2028

GFE:	Gferi_06315

PBIF:

KXZ80_13900(cdhC)

PSOR:

RSJ16_15710

CDF:	CD630_07280

PDC:	CDIF630_00844(cdhC)

CDC:	CD196_0674

CDL:	CDR20291_0655

PDF:	CD630DERM_07280

ROC:	HF520_11260(cdhC)

RIL:

CRIB_2159

RHOM:

FRIFI_2466

TEM:	JW646_10895(cdhC)

TGC:	L0P85_16865(acsB)

TMY:	TEMA_26050(acsB)

TPET:

TPHSE_37280(acsB)

TEB:

T8CH_0661

THYR:

P4S50_13870(acsB)

IBR:	NQ514_13085(acsB)

CST:	CLOST_1171

TKI:	TKV_c19820(acsB)

CHY:	CHY_1222(acsB)

ADG:

Adeg_0336

TPZ:	Tph_c15170(acsA)

AAUT:

ACETAC_10535(cdhC)

MTA:

Moth_1202

MTHO:

MOTHE_c11780

MTHZ:

MOTHA_c12650

DBC:	MFMK1_002343(cdhC)

TEP:	TepRe1_0561

TAE:	TepiRe1_0613

BACG:

D2962_12355(cdhC)

TOC:

Toce_0813

NCD:	ACONDI_02971

AAR:	Acear_1304

MANA:

MAMMFC1_00476

STED:

SPTER_05160 SPTER_13680

SSPH:

SPSPH_008490 SPSPH_013880

SOVA:

SOV_05410 SOV_12190 SOV_14250

SSID:

SPSIL_006410 SPSIL_019320

CALK:

HUE98_15620(cdhC)

DET:	DET0666 DET0700

DEH:	cbdbA652(codH)

DEB:	DehaBAV1_0635

DEV:	DhcVS_604(cdhC)

DEG:	DehalGT_0597

DMC:	btf_622(acsB)

DMD:	dcmb_668(acsB)

DMG:	GY50_0591(cdhC)

DMX:	X792_03230

DMY:	X793_02975

DMZ:	X794_02725

DUC:	UCH007_05840(acsB)

DLY:	Dehly_0817

DEW:	DGWBC_1386

DFO:	Dform_00887(acsB) Dform_00914(acsB)

DETH:

HX448_06200(cdhC)

KST:	KSMBR1_1325(codh_acsB)

BROC:

IPI25_11080(cdhC)

BPIT:

BPIT_02250

JET:	L3J17_07150(cdhC)

VAI:	BU251_01290

TPI:	TREPR_3067

TAZ:	TREAZ_1648

TYE:	THEYE_A1470

DTP:	JZK55_05480

MJA:	MJ_0152 MJ_0156

MFE:	Mefer_0200

MVU:	Metvu_0967 Metvu_1184

MFS:	MFS40622_0117 MFS40622_0121

MIF:	Metin_0081 Metin_1228

MJH:	JH146_0001 JH146_0005

MESG:

MLAUSG7_0548(cdhC) MLAUSG7_1300(cdhC)

MESA:

MLASG1_0247(cdhC) MLASG1_0900(cdhC)

MIG:	Metig_1378 Metig_1382

MMP:	MMP0983(cdhB)

MMQ:	MmarC5_0803

MMX:	MmarC6_1675

MMZ:	MmarC7_0225

MMD:

GYY_05740

MMAK:

MMKA1_11390(cdhC)

MMAO:

MMOS7_10750(cdhC)

MMAD:

MMJJ_00080

MAE:

Maeo_1171

MVN:	Mevan_0309

MOK:	Metok_0742 Metok_0743

METF:

CFE53_00285(cdhC) CFE53_03765(cdhC)

MTH:

MTH_1710

MMG:	MTBMA_c02890(cdhC)

MWO:	MWSIV6_0251(cdhC)

METC:

MTCT_1563

METE:

tca_01657

METK:

FVF72_03115(cdhC)

MTHM:

FZP57_01135(cdhC)

METJ:

FZP68_06140(cdhC)

MARO:

MarbSA_08790

MEL:	Metbo_0464

MEW:	MSWAN_1932

METH:

MBMB1_1563(cdhC)

MFC:	BRM9_0799(cdhC)

MFI:	DSM1535_0761(cdhC)

MCUB:

MCBB_1819(cdhC)

MSUB:

BK009_06800

METN:

BK008_02445

METT:

CIT01_07280(cdhC)

METO:

CIT02_10130(cdhC)

MEME:

HYG87_07910(cdhC)

MFEG:

GCM10025860_01010

MEER:

NKF70_04630(cdhC)

MFV:

Mfer_0525

MKA:	MK0720(cdhC)

AFU:

AF_0379

AFG:	AFULGI_00003790

AVE:	Arcve_1123

AST:	Asulf_02027 Asulf_02202

FPL:	Ferp_0733 Ferp_0929

GAC:	GACE_0357 GACE_1720

GAH:	GAH_00919 GAH_01141

MBA:	Mbar_A0202 Mbar_A0432

MBY:	MSBRM_0626 MSBRM_2757

MBW:	MSBRW_0569 MSBRW_0794

MBAR:

MSBR2_1752 MSBR2_2715

MBAK:

MSBR3_2713 MSBR3_2953

MAC:	MA_1014(cdhC) MA_3862(cdhC)

MMA:	MM_0686 MM_2087

MMAZ:

MmTuc01_0702

MMJ:	MSMAS_0628 MSMAS_2598

MMAC:

MSMAC_0630 MSMAC_1822

MVC:	MSVAZ_0993 MSVAZ_3015

MEK:	MSKOL_0965 MSKOL_3022

MLS:	MSLAZ_0647

METM:

MSMTP_0685 MSMTP_0693

MEF:	MSWH1_0794

MEQ:	MSWHS_0846

MSJ:	MSSAC_3456 MSSAC_3599

MSZ:	MSSIH_2984 MSSIH_3139

MSW:	MSSIT_3042 MSSIT_3210

MTHR:

MSTHT_2338

MTHE:

MSTHC_0942

MHOR:

MSHOH_0737 MSHOH_3262

MFZ:	AOB57_003745(cdhC)

MBU:

Mbur_0860

MMET:

MCMEM_0992

MELO:

J7W08_03310(cdhC)

MMH:

Mmah_1168

MHAZ:

BHR79_07695

MPOT:

BKM01_03940

MEV:	Metev_0424

MZH:	Mzhil_1135

MPY:

Mpsy_2893

MZI:	HWN40_08235(cdhC)

MMAV:

RE476_02135(cdhC)

MSEB:

RE474_12030(cdhC)

MHZ:	Metho_0977

MEHF:

MmiHf6_01230

MEES:

MmiEs2_08400

MTP:

Mthe_0290

MCJ:	MCON_1330(cdhC) MCON_1942(cdhC)

MHI:	Mhar_0791 Mhar_2326

MHU:

Mhun_0688

MRTJ:

KHC33_09840(cdhC)

MBG:	BN140_2375(acsB)

MEMA:

MMAB1_3162

MCHK:

MchiMG62_09140

MRC:	R6Y96_05880(acsB)

MFK:	E2N92_11690(cdhC)

MBN:	Mboo_1196 Mboo_1371

MFO:	Metfor_1453 Metfor_1719

MPL:

Mpal_0803

RCI:	LRC459(cdhC)

MELU:

MTLP_05360

MER:	MMINT_19140

BARC:

AOA65_0452(cdhC2)

BARB:

AOA66_1430(cdhC2)

LOB:	NEF87_001879

» show all

Reference

1 [PMID:2984190]

Authors

Ragsdale SW, Wood HG.

Title

Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.

Journal

J Biol Chem 260:3970-7 (1985)

Reference

2 [PMID:12386327]

Authors

Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL

Title

A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.

Journal

Science 298:567-72 (2002)
DOI:10.1126/science.1075843

Sequence

[mta:Moth_1202]