KEGG ENZYME: 2.3.1.170

ENZYME: 2.3.1.170

Entry

EC 2.3.1.170                Enzyme

Name

6'-deoxychalcone synthase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing)

Reaction(IUBMB)

3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O [RN:R06568]

Reaction(KEGG)

Substrate

malonyl-CoA [CPD:C00083];
4-coumaroyl-CoA [CPD:C00223];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Product

CoA [CPD:C00010];
isoliquiritigenin [CPD:C08650];
CO2 [CPD:C00011];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Comment

Isoliquiritigenin is the precursor of liquiritigenin, a 5-deoxyflavanone.

History

EC 2.3.1.170 created 2004

Pathway

Flavonoid biosynthesis

Biosynthesis of secondary metabolites

Reference

1 [PMID:3355160]

Authors

Ayabe S, Udagawa A, Furuya T.

Title

NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract.

Journal

Arch Biochem Biophys 261:458-62 (1988)
DOI:10.1016/0003-9861(88)90362-1

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:	114308-23-5

LinkDB

DBGET integrated database retrieval system