Entry
Name
UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase;
WbpD;
WlbB
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [RN:
R10100 ]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:
C00024 ];
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate [CPD:
C20359 ]
Product
CoA [CPD:
C00010 ];
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD:
C19725 ]
Comment
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.
History
EC 2.3.1.201 created 2012
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
ec00541 O-Antigen nucleotide sugar biosynthesis
Orthology
K13018 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase
Genes
AVT : NCTC3438_01789(dapH)
PAZO : AYR47_15425 AYR47_15470
PSET : THL1_1978 THL1_5262
COLA : DBO93_01230 DBO93_03740
PLZ : S4054249_18585 S4054249_18595
PVB : J5X90_03250 J5X90_03340
LSS : NCTC12082_00068(lpxD_1)
TLR : Thiosp_00143(wbpD_1) Thiosp_04202(wbpD_2)
TWG : Thiowin_03345(wbpD_2) Thiowin_03356(wbpD_3) Thiowin_03362(wbpD_4) Thiowin_03365(wbpD_5)
TNI : TVNIR_0689(dapH_[H])
NZO : SAMEA4504057_0085(dapH)
NANI : NCTC12227_01673(dapH)
NBA : CUN60_00255 CUN60_00310
CHAE : CH06BL_04750(wlbB) CH06BL_39680(bplB)
LMIR : NCTC12852_00301(dapH)
BTRM : SAMEA390648701341(bplB)
AXX : ERS451415_06024(dapH)
OUE : I6G29_01400 I6G29_01500(wbpD)
CTES : O987_08015 O987_25132
PKT : AT984_02050 AT984_09175
SMIO : CATMQ487_00150(wlbB)
MLIR : LPB04_23370 LPB04_23905
RBS : RHODOSMS8_00381(wbpD)
MIV : C4E04_12585 C4E04_13640 C4E04_13730
SPLM : BXU08_19405 BXU08_19460
DVN : HQ394_05635 HQ394_13380
HAD : CDV25_01310 CDV25_08050
SULG : FJR48_02535 FJR48_03720
ASUI : ASUIS_2000 ASUIS_2071
GME : Gmet_1324(fdtC_fdtA)
GNT : KP003_11595 KP003_11675
DHY : DESAM_20918 DESAM_20954
AMAU : DSM26151_08940(wbpD)
AIL : FLP10_03350 FLP10_11915
CRY : B7495_15240 B7495_15245
GMN : GMOLON4_2041(wbpD) GMOLON4_2063(wlbB)
AAQ : AOC05_10710 AOC05_10805
AAGI : NCTC2676_1_02021(dapH)
GNC : QQS42_06775 QQS42_07155
JME : EEW87_010855 EEW87_014570
DCO : SAMEA4475696_2256(dapH)
HALT : IM660_13995 IM660_14140
AMYZ : HUW46_03205(fdtC) HUW46_05836(lpxD)
ACTS : ACWT_3003 ACWT_7611
ACTL : L3i22_069480 L3i22_100770
TBW : NCTC13354_00628(dapH)
AHW : NCTC11636_02344(dapH)
ASLA : NCTC11923_02579(dapH)
AVC : NCTC10951_01536(dapH)
FSL : EJO69_00875 EJO69_11385
SYNW : SynWH8103_00501(wlbB)
RRS : RoseRS_1724 RoseRS_4429
CAG : Cagg_0038 Cagg_1971 Cagg_1985
CAP : CLDAP_36230 CLDAP_40370
WCH : wcw_0167(wbbJ) wcw_1824(wblC)
RUL : UC8_09450(fdtC) UC8_50380(wbpD)
AHEL : Q31a_30440(fdtC) Q31a_44990(wbpD)
LCRE : Pla8534_69430(wbpD)
SPER : EW093_13220 EW093_13505
TPX : Turpa_0311 Turpa_0323
ABA : Acid345_1080 Acid345_3315
BCEL : BcellWH2_04368(fdtC)
PFAI : NXY11_13215 NXY11_15690
DORI : FH5T_08995 FH5T_09090
ANF : AQPE_0347 AQPE_0481 AQPE_3062
PGIN : FRZ67_02955 FRZ67_17870
PSN : Pedsa_2803 Pedsa_3222 Pedsa_3232
PHG : KCTC32516_00991(wbpD)
TMP : F9Y86_04685 F9Y86_08560
KAN : IMCC3317_17150(fdtC)
AQA : D1815_20980 D1815_22025
SPON : HME9304_01539(wbpD)
CIO : CEQ15_13540 CEQ15_19885
CHRS : EAG08_06130 EAG08_09355
CHRJ : CHRYMOREF3P_1891(wbpD)
CFLU : ODZ84_09125 ODZ84_15755
CHYD : H4K34_02505 H4K34_02645
PTAN : CRYO30217_03203(wbpD)
BBAU : AEM51_03805 AEM51_05405 AEM51_08000
AVE : Arcve_0556 Arcve_0563
PYC : TQ32_02930 TQ32_02975
THEI : K1720_02880 K1720_03060
» show all
Taxonomy
Reference
Authors
Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS
Title
Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa.
Journal
Sequence
Reference
Authors
Larkin A, Imperiali B
Title
Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.201
LinkDB
All DBs