KEGG   ENZYME: 2.3.1.203
Entry
EC 2.3.1.203                Enzyme                                 
Name
UDP-N-acetylbacillosamine N-acetyltransferase;
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase;
pglD (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + UDP-N-acetylbacillosamine = CoA + UDP-N,N'-diacetylbacillosamine [RN:R10099]
Reaction(KEGG)
R10099
Substrate
acetyl-CoA [CPD:C00024];
UDP-N-acetylbacillosamine [CPD:C04630]
Product
CoA [CPD:C00010];
UDP-N,N'-diacetylbacillosamine [CPD:C20357]
Comment
The product, UDP-N,N'-diacetylbacillosamine, is an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [1,2] and O-linked glycosylation of certain L-serine residues in Neisseria species [3].
History
EC 2.3.1.203 created 2012, modified 2013
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K15913  UDP-N-acetylbacillosamine N-acetyltransferase
Genes
VQICCZ37_12405
COLWA3Q33_07445
COLADBO93_00785
CBERB5D82_08985
FPMLA56_930
FNAOOM_0807
FNLM973_08250
AHAAHA_2896
ADHCK627_11330
NAWLVJ86_05665
USULVJ78_05080
UTELVJ83_05805
SKUSulku_2411
CJECj1123c(pglD)
CJBBN148_1123c(pglD)
CJJCJJ81176_1140(pglD)
CJUC8J_1063(pglD)
CJNICDCCJ07001_1078
CJICJSA_1065(pglD)
CJMCJM1_1101(pglD)
CJSCJS3_1169
CJPA911_05440
CJEJN564_01091
CJEUN565_01134
CJENN755_01127
CJEIN135_01160
CJERH730_06585
CJVMTVDSCj20_1126(pglD)
CJYQZ67_01200(pglD)
CJQUC78_1080(pglD)
CJLPJ17_05755
CJWPJ18_05570
CJRCJE1265(pglD)
CJDJJD26997_0598(pglD)
CJZM635_01320
CJXBN867_11140
CFFCFF8240_1380
CFTCFF04554_1395(pglD)
CFVCFVI03293_1418(pglD)
CFXCFV97608_1518(pglD)
CFZCSG_15170
CAMPCFT03427_1343(pglD)
CFPCR44_06795
CCVCCV52592_1210(pglD)
CHACHAB381_0951
CCOCCC13826_0449(pglD)
CCOCCCON33237_1462(pglD)
CLACLA_1256(pglD)
CLRUPTC16701_1239(pglD)
CLMUPTC16712_1257(pglD)
CLQUPTC4110_1241(pglD)
CLNUPTC3659_1476(pglD)
CLLCONCH_1207(pglD)
CCOLBN865_10060
CCCG157_03320
CCQN149_1064(pglD)
CCFYSQ_03355
CCYYSS_06080
CCOIYSU_03390
CCOFVC76_05510(pglD)
CCOOATE51_01358(pglD_3)
CAJCIG1485E_1389(pglD)
CISCINS_1221(pglD)
CVOCVOL_1235(pglD)
CPELCPEL_1362(pglD)
CAMRCAQ16704_1267(pglD)
CSMCSUB8521_1443(pglD)
CSFCSUB8523_1539(pglD)
CGRACGRAC_1487(pglD)
CURECUREO_1371(pglD)
CHYOCHH_0380(pglD)
CHVCHELV3228_0557(pglD)
CSPFCSF_0890(pglD)
CPINCPIN18020_0865(pglD)
CCUNCCUN_1174(pglD)
CLXCLAN_0357(pglD)
CAVICAV_0413(pglD)
CHWA2J15_001365
CAMZCVIC12175_1319(pglD)
CAMYCSUIS_0202(pglD)
COJCORN_1326(pglD)
CUXCUP3940_1134(pglD)
CRXCRECT_1673(pglD)
CGEOCGEO_1571(pglD)
CCORCCORG_0296(pglD)
CARMCARM_1289(pglD)
CMUCCMCT_0320(pglD)
CSHOCSHOW_1515(pglD)
CINFCINF_0566(pglD)
CNVCNZW441b_1126(pglD)
AFCAFAEC_1299
AHSAHALO_0832
AMARAMRN_0897
HBVABIV_0885
SINUIMZ28_10320
RALRumal_3864
DRMDred_3128
EBMSG0102_22700
PSNPedsa_3203
ALMAO498_13855
GRLLPB144_06680
MARTBTR34_08465
MARBCJ263_08145
MHUMhun_2125
 » show all
Reference
1  [PMID:17087520]
  Authors
Olivier NB, Chen MM, Behr JR, Imperiali B
  Title
In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.
  Journal
Biochemistry 45:13659-69 (2006)
DOI:10.1021/bi061456h
  Sequence
[cje:Cj1123c]
Reference
2  [PMID:18198901]
  Authors
Rangarajan ES, Ruane KM, Sulea T, Watson DC, Proteau A, Leclerc S, Cygler M, Matte A, Young NM
  Title
Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter  jejuni.
  Journal
Biochemistry 47:1827-36 (2008)
DOI:10.1021/bi702032r
  Sequence
[cje:Cj1123c]
Reference
3  [PMID:21542610]
  Authors
Hartley MD, Morrison MJ, Aas FE, Borud B, Koomey M, Imperiali B
  Title
Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine.
  Journal
Biochemistry 50:4936-48 (2011)
DOI:10.1021/bi2003372
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.203
IUBMB Enzyme Nomenclature: 2.3.1.203
ExPASy - ENZYME nomenclature database: 2.3.1.203
BRENDA, the Enzyme Database: 2.3.1.203
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