KEGG   ENZYME: 2.3.1.221
Entry
EC 2.3.1.221                Enzyme                                 
Name
noranthrone synthase;
polyketide synthase A (ambiguous);
PksA (ambiguous);
norsolorinic acid anthrone synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:hexanoate malonyltransferase (norsolorinic acid anthrone-forming)
Reaction(IUBMB)
7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O [RN:R10239]
Reaction(KEGG)
R10239
Substrate
malonyl-CoA [CPD:C00083];
hexanoyl-[acyl-carrier protein] [CPD:C05749]
Product
CoA [CPD:C00010];
norsolorinic acid anthrone [CPD:C20453];
[acyl-carrier protein] [CPD:C00229];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A multi-domain polyketide synthase involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase [1].
History
EC 2.3.1.221 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15316  noranthrone synthase
Genes
PAN: PODANSg8570
PBEL: QC761_207410
PPSD: QC762_207410
PPSP: QC763_207410
PPSA: QC764_207410
MBRN: 26247918(FSR1_2)
PTKZ: JDV02_010040
GLZ: GLAREA_01150
ANI: ANIA_07825
AOR: AO090026000009
AFV: AFLA_006311
APUU: APUU_20037A
CIM: CIMG_08569
CPW: CPC735_062240
FFU: CLAFUR5_14164
CBET: CB0940_02994
BCOM: BAUCODRAFT_62024
 » show all
Reference
1  [PMID:18403714]
  Authors
Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA
  Title
Deconstruction of iterative multidomain polyketide synthase function.
  Journal
Science 320:243-6 (2008)
DOI:10.1126/science.1154711
Reference
2  [PMID:19847268]
  Authors
Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA
  Title
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization.
  Journal
Nature 461:1139-43 (2009)
DOI:10.1038/nature08475
Reference
3  [PMID:20332208]
  Authors
Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC
  Title
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 107:6246-51 (2010)
DOI:10.1073/pnas.0913531107
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.221
IUBMB Enzyme Nomenclature: 2.3.1.221
ExPASy - ENZYME nomenclature database: 2.3.1.221
BRENDA, the Enzyme Database: 2.3.1.221
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