KEGG   ENZYME: 2.3.1.26
Entry
EC 2.3.1.26                 Enzyme                                 
Name
sterol O-acyltransferase;
cholesterol acyltransferase;
sterol-ester synthase;
acyl coenzyme A-cholesterol-O-acyltransferase;
acyl-CoA:cholesterol acyltransferase;
ACAT;
acylcoenzyme A:cholesterol O-acyltransferase;
cholesterol ester synthase;
cholesterol ester synthetase;
cholesteryl ester synthetase;
SOAT1 (gene name);
SOAT2 (gene name);
ARE1 (gene name);
ARE2 (gene name);
acyl-CoA:cholesterol O-acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
long-chain acyl-CoA:sterol O-acyltransferase
Reaction(IUBMB)
a long-chain acyl-CoA + a sterol = CoA + a long-chain 3-hydroxysterol ester [RN:R12496]
Reaction(KEGG)
R12496 > R01461
Substrate
long-chain acyl-CoA [CPD:C02843];
sterol [CPD:C00370]
Product
CoA [CPD:C00010];
long-chain 3-hydroxysterol ester [CPD:C22215]
Comment
The enzyme catalyses the formation of sterol esters from a sterol and long-chain fatty acyl-coenzyme A. The enzyme from yeast, but not from mammals, prefers monounsaturated acyl-CoA. In mammals the enzyme acts mainly on cholesterol and forms cholesterol esters that are stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol. In macrophages, the accumulation of cytosolic droplets of cholesterol esters results in the formation of `foam cells', a hallmark of early atherosclerotic lesions. In hepatocytes and enterocytes, cholesterol esters can be incorporated into apolipoprotein B-containing lipoproteins for secretion from the cell.
History
EC 2.3.1.26 created 1972, modified 2019
Pathway
ec00100  Steroid biosynthesis
Orthology
K00637  sterol O-acyltransferase
Genes
HSA6646(SOAT1) 8435(SOAT2)
PTR457553(SOAT1) 737291(SOAT2)
PPS100990991(SOAT1) 100991938(SOAT2)
GGO101137508(SOAT1) 101143800(SOAT2)
PON100436698(SOAT1) 100443060(SOAT2)
NLE100590480(SOAT1) 100591122(SOAT2)
MCC701171(SOAT2) 716989(SOAT1)
MCF102121286(SOAT1) 102135925(SOAT2)
CSAB103230515(SOAT1) 103238380(SOAT2)
CATY105580285(SOAT2) 105580775(SOAT1)
PANU100998458(SOAT1) 101012402(SOAT2)
TGE112627146(SOAT1) 112635341(SOAT2)
RRO104670609(SOAT2) 104672006(SOAT1)
RBB108521617(SOAT2) 108539887(SOAT1)
TFN117076693(SOAT1) 117090055(SOAT2)
PTEH111541702(SOAT2) 111555313(SOAT1)
CJC100387443(SOAT1) 100412165(SOAT2)
SBQ101047229(SOAT1) 101052421(SOAT2)
CSYR103267545(SOAT1) 103269719(SOAT2)
MMUR105870615(SOAT2) 105875493(SOAT1)
OGA100962874(SOAT2) 100965917(SOAT1)
MMU20652(Soat1) 223920(Soat2)
MCAL110301596(Soat1) 110310293(Soat2)
MPAH110321652(Soat1) 110335070(Soat2)
RNO266770(Soat2) 81782(Soat1)
MCOC116082223(Soat2) 116101816(Soat1)
MUN110552319(Soat2) 110563339(Soat1)
CGE100689317(Soat1) 100752385(Soat2)
PLEU114696635(Soat2)
NGI103728004(Soat1) 103738463(Soat2)
HGL101718579(Soat2) 101725301(Soat1)
CPOC100716750(Soat1) 100728450(Soat2)
CCAN109684043(Soat2) 109693443(Soat1)
DORD105985111(Soat1) 105997917(Soat2)
DSP122103891(Soat1) 122124220(Soat2)
NCAR124961744 124976730 124983098
OCU100009537(SOAT1) 100349393(SOAT2)
OPI101522712(SOAT2) 101524678(SOAT1)
TUP102485090(SOAT1) 102501974(SOAT2)
CFA486511(SOAT2) 490325(SOAT1)
VVP112921168(SOAT2) 112921836(SOAT1)
VLG121480399(SOAT2) 121494712(SOAT1)
AML100464310(SOAT1) 100466845(SOAT2)
UMR103668575(SOAT1) 103675666(SOAT2)
UAH113257567(SOAT2) 113262770(SOAT1)
UAR123794617(SOAT2) 123801346(SOAT1)
ELK111150910 111157987
LLV125085747 125107568
MPUF101687685(SOAT2) 101693044(SOAT1)
ORO101372404(SOAT2) 101377194(SOAT1)
EJU114222870(SOAT1) 114225688(SOAT2)
ZCA113922052(SOAT2) 113931946(SOAT1)
MLX118008807(SOAT2) 118014416(SOAT1)
FCA101081271(SOAT1) 101099223(SOAT2)
PYU121011872(SOAT1) 121038507(SOAT2)
PBG122473464(SOAT2) 122476340(SOAT1)
PTG102951570(SOAT2) 102951637(SOAT1)
PPAD109249185(SOAT2) 109253480(SOAT1)
AJU106977936(SOAT1) 106986455(SOAT2)
HHV120247273(SOAT2) 120247467(SOAT1)
BTA504287(SOAT1) 513554(SOAT2)
BOM102266586(SOAT1) 102286882(SOAT2)
BIU109559050(SOAT2) 109570627(SOAT1)
BBUB102395575(SOAT2) 102403392(SOAT1)
CHX102181472(SOAT2) 102186791(SOAT1)
OAS101107179(SOAT2) 101121363(SOAT1) 114117342
ODA120858285(SOAT2) 120880520(SOAT1)
CCAD122427255(SOAT2) 122452089(SOAT1)
SSC100515544(SOAT2) 100628166(SOAT1)
CFR102509905(SOAT2) 102517625(SOAT1)
CBAI105068919(SOAT1) 105076275(SOAT2)
CDK105094576(SOAT2) 105099977(SOAT1)
VPC102525768(SOAT2) 102544460(SOAT1)
BACU103005265(SOAT2) 103019063(SOAT1)
LVE103074467(SOAT1) 103078608(SOAT2)
OOR101283408(SOAT1) 101288997(SOAT2)
DLE111165675(SOAT1) 111173958(SOAT2)
PCAD102977521(SOAT2) 102985612(SOAT1)
PSIU116759682(SOAT1) 116761048(SOAT2)
ECB100050551(SOAT1) 100146367(SOAT2)
EPZ103559415(SOAT2) 103566918(SOAT1)
EAI106833928(SOAT1) 106835276(SOAT2)
MYB102251864(SOAT1) 102258914(SOAT2)
MYD102752811(SOAT2) 102760492(SOAT1)
MMYO118651668(SOAT2) 118673106(SOAT1)
MLF102418054(SOAT2) 102428466(SOAT1) 102443306
MNA107528134(SOAT2) 107531050(SOAT1)
PKL118721361(SOAT1) 118730166(SOAT2)
HAI109384905(SOAT1) 109391779(SOAT2)
DRO112298110(SOAT1) 112318616(SOAT2)
SHON118979108(SOAT1)
AJM119043504(SOAT2) 119049583(SOAT1)
PDIC114511879(SOAT1) 114513415(SOAT2)
PHAS123813033(SOAT2) 123818366(SOAT1)
MMF118624235(SOAT2) 118637878(SOAT1)
RFQ117014674(SOAT1) 117029355(SOAT2)
PALE102897908(SOAT1) 102897972(SOAT2)
PGIG120602128(SOAT2) 120617615(SOAT1)
PVP105292844(SOAT1) 105302667(SOAT2)
RAY107509023(SOAT1) 107509777(SOAT2)
MJV108391159(SOAT1) 108402966(SOAT2)
TOD119241232(SOAT1) 119247978(SOAT2)
SARA101547112(SOAT2) 101552737(SOAT1)
LAV100666457(SOAT1) 100670395(SOAT2)
TMU101352609 101353901
DNM101415761(SOAT2) 101424051 101439724(SOAT1) 101443584 101447432
MDO100022219(SOAT1)
GAS123247969(SOAT1) 123250227(SOAT2)
SHR100920315(SOAT1) 100933677(SOAT2)
PCW110194139(SOAT2) 110206808(SOAT1)
OAA100081816(SOAT2) 100085367(SOAT1)
GGA424424(SOAT1)
PCOC116230442(SOAT1)
MGP100544187(SOAT1)
CJO107317265(SOAT1)
NMEL110402509(SOAT1)
APLA101790922(SOAT1)
ACYG106042512(SOAT1)
AFUL116492028(SOAT1)
TGU100223763(SOAT1)
LSR110478939(SOAT1)
SCAN103814788(SOAT1)
PMOA120512224(SOAT1)
OTC121344266(SOAT1)
PRUF121359796(SOAT1)
GFR102041188(SOAT1)
FAB101815412(SOAT1)
PHI102102644(SOAT1)
PMAJ107208206(SOAT1)
CCAE111932597(SOAT1)
CCW104693579(SOAT1)
ETL114062572(SOAT1)
ZAB102068817(SOAT1)
FPG101919752(SOAT1)
FCH102060236(SOAT1)
CLV102098103(SOAT1)
EGZ104132041(SOAT1)
NNI104011338(SOAT1)
ACUN113483059(SOAT1)
TALA104359540(SOAT1)
PADL103914031(SOAT1)
ACHC115349189(SOAT1)
AAM106484966(SOAT1)
AROW112975091(SOAT1)
NPD112947695(SOAT1)
DNE112983702(SOAT1)
ASN102373020(SOAT1) 102378548 102379056
AMJ102568578(SOAT1) 102573699
CPOO109307171(SOAT1)
GGN109286970(SOAT1)
PSS102448344(SOAT1) 102450944(SOAT2)
CMY102934330(SOAT2) 102943858(SOAT1)
CPIC101940194(SOAT2) 101944538(SOAT1)
TST117881322(SOAT1) 117889003(SOAT2)
CABI116828547(SOAT2) 116834217(SOAT1)
MRV120370550(SOAT1) 120391259(SOAT2)
ACS100556270(soat1) 100559804 100567184 100567378 107982384
PVT110077048(SOAT1)
SUND121920463 121920466(SOAT2) 121928759(SOAT1)
PBI103048435 103064093(SOAT1)
PMUR107283372(SOAT1) 107288520 107288521 107288522 107288523 107288524 114922654
TSR106544465(SOAT1) 106557336
PGUT117661157(SOAT1) 117666479
VKO123027911(SOAT1)
PMUA114586205(SOAT2) 114598569 114598570 114598594
ZVI118076791(SOAT2) 118077703 118088264 118088449 118089157
STOW125432919(SOAT1)
XLA108708653 108714368(soat1.L) 446863(soat1.S) 779411(soat2.S)
XTR100145286(soat1) 100216296(soat2) 101730739
NPR108786819(SOAT2) 108800649(SOAT1)
RTEM120929304 120929305 120929306 120945640(SOAT1)
BBUF120978476(SOAT1) 120993919 120993920 120996087(SOAT2)
BGAR122931422 122931423 122932620 122943182(SOAT1)
DRE564424(soat1) 564868(soat2)
SRX107707573(soat1) 107734612 107758003
SANH107657858 107681296 107700347
SGH107549691 107566412(soat2) 107599004(soat1)
CCAR109059086 109059087 109072620
CAUA113050186 113076346 113078370
PPRM120464561(soat2) 120472593(soat1)
MAMB125273400(soat2) 125279535(soat1)
IPU108265920(soat1) 108272126(soat2)
PHYP113535230(soat1) 113540941
SMEO124400361(soat1) 124402877(soat2)
TFD113642643(soat1) 113643245(soat2)
AMEX103034708 103042750 111197020
EEE113571647
TRU101072139 101077060 105417935(soat1)
TNGGSTEN00013578G001 GSTEN00028839G001
LCO104919967 104929343(soat1)
NCC104966663
CGOB115007559(soat1) 115007732
ELY117253487(soat1) 117257034(soat2)
PLEP121941376(soat1) 121957287(soat2)
SLUC116051366(soat2) 116055456(soat1)
ECRA117942651(soat2) 117950136(soat1)
PFLV114554740 114562037(soat1)
GAT120823793(soat1) 120834696(soat2)
PPUG119216929(soat1) 119229555(soat2)
MSAM119885539(soat2) 119900719(soat1)
CUD121507035(soat2) 121511848(soat1)
MZE101475426 101487179(soat1)
ONL100697439 100706988(soat1)
OAU116320715(soat2) 116323167(soat1)
OLA101162519 101164716(soat1)
OML112144903(soat2) 112150835(soat1)
XMA102229353(soat1) 102229837
XCO114136210 114150622(soat1)
XHE116711257(soat2) 116725326(soat1)
PRET103464078(soat1) 103464407
PFOR103135830(soat2) 103138480(soat1)
PLAI106951090(soat1) 106956632(soat2)
PMEI106906815(soat1) 106928441(soat2)
GAF122834468(soat2) 122838042(soat1)
CVG107100648(soat1) 107103130
CTUL119780837(soat1) 119790317(soat2)
GMU124856666(soat2) 124874467(soat1)
NFU107385327 107393145(soat1)
KMR108230591(soat1) 108231501(soat2)
ALIM106512175(soat1) 106514738(soat2)
NWH119407832(soat1) 119412417(soat2)
AOCE111563899(soat1) 111583785
CSEM103386401 103393235(soat1)
POV109625295(soat1) 109635497
SSEN122767836(soat2) 122781268(soat1)
HHIP117759962(soat1) 117762290(soat2)
LCF108881364(soat1) 108884835
SDU111223955 111231092(soat1)
SLAL111651858(soat1) 111659793
XGL120791280(soat1) 120806976(soat2)
HCQ109510620 109532427(soat1)
BPEC110154556 110160201(soat1)
MALB109954616 109967403(soat1)
SASA106566146 106613907(soat1)
OTW112251021(soat1) 112262720(soat2)
OMY110494785(soat2) 110524440(soat1)
OGO123996939(soat1) 124003974(soat2)
ONE115108434
SALP111975891(soat1) 112069696
SNH120054864(soat1) 120057880(soat2)
ELS105007362 105026366(soat1)
SFM108919079(soat1) 108928332
PKI111835303(soat2) 111848971(soat1)
AANG118210915(soat2) 118226300(soat1)
LOC102683439 102692222(soat1)
PSPA121308925 121330530(soat1)
ARUT117401130 117412248(soat1) 117967106
LCM102351870(SOAT1) 102367356(SOAT2)
CMK103179969(soat1) 103189932(soat2)
RTP109927029(soat1)
BFO118424040
BBEL109486598
SPU583194
APLC110974464
DMEDmel_CG8112(CG8112)
DER6552441
DSE6607223
DSIDsimw501_GD18564(Dsim_GD18564)
DYADyak_GE25896
DAN6500959
DSR110188757
DPODpse_GA20833
DPE6594563
DMN108155015
DWI6647984
DGR6564030
DMODmoj_GI24769
DAZ108621893
DNV108660378
DHE111601473
DVI6629264
CCAT101451980 110117796
BOD106626744 106626771
MDE101888385 101888553 101888657
SCAC106088722 106090130
LCQ111677357
AGAAgaP_AGAP012216 AgaP_AGAP012217
ACOZ120958112 120958113
AARA120899616 120899617
AAG5572188
AALB109414895
CQUCpipJ_CPIJ002958 CpipJ_CPIJ002959 CpipJ_CPIJ019799
CPII120415133 120415150 120418140
AME552313
ACER107994543
ALAB122719619
BIM100740568
BBIF117210741
BVK117231158
BVAN117166502
BTER100647632
BPYO122572532
CCAL108625512
OBB114873905
MGEN117225204
NMEA116425360
CGIG122397367
SOC105197438 105197445 105197466 105197475 105200298 105204780
MPHA105831194 105833666 105836642
AEC105150715 105150716 105150717 105151440
ACEP105621768 105621834
PBAR105426039
VEM105561384
HST105189309
DQU106742888
CFO105249109 105258340 112639984 112639992
FEX115233029 115233030 115238810 115238828 115242059
LHU105673784
PGC109860842
OBO105279911
PCF106787777
PFUC122523461
VPS122629732
NVI100122384
CSOL105364083
TPRE106651706
MDL103570127
CGLO123270202
FAS105265222 105265223
DAM107042461 107042462 107042470
CCIN107266592
TCA658068 658748
DPA109542077
SOY115878857
ATD109602527 109602539
CSET123313911 123314184
AGB108910891 108910892
LDC111513203 111515739
NVL108562027
APLN108733598
PPYR116177681 116177682 116177749 116177750 116178333 116178705 116178872 116178989 116178991
OTU111414247 111414328 111414346 111414424
BMOR101740142
BMAN114250606
MSEX115443132
DPLKGM_205051
BANY112053868
PMAC106710838
PPOT106109072
PXU106128493
PRAP110996350
ZCE119835008
HAW110375674
TNL113504657
SLIU111352082
OFU114355532
PHUPhum_PHUM045410
FOC113205675 113212022 113212023
ZNE110828545
CSEC111873548
FCD110846328
DPXDAPPUDRAFT_40502
DMK116925270
PVM113813586
PJA122250809
PCHN125026217
HAME121873321
PCLA123745246
PTRU123508683
HAZT108682478
ISCIscW_ISCW007924
DSV119434536 119436658
RSAN119398639
RMP119161465
TUT107364500
DPTE113795447 113797138 113797938 113797945
DFR124493577 124493920 124493923 124498527
CSCU111627895 111641665
PTEP107437856 107447646
SDM118197968 118203916
CELCELE_B0395.2(mboa-1)
CBRCBG_16409
NAINECAME_05183
TSPTsp_07565
HROHELRODRAFT_114186
LGILOTGIDRAFT_172306
PCAN112563801
BGT106063279
GAE121380781
HRF124110534
HRJ124279265
CRG105344142
MYI110446400
PMAX117343927
MMER123531201
OBI106877085
OSN115211603
LAK106150577 106151044
SMMSmp_134390
SHXMS3_0013870
OVIT265_01192
EGLEGR_03337
NVE5521639
EPA110232256
ATEN116304971
ADF107331943
AMIL114961555
PDAM113664737
SPIS111333509
DGT114516569
XEN124439814
TADTRIADDRAFT_22890
AQU100639150 100639276 105312507
QSU111983552 111991223 112020324 112020675
CMECYME_CME100C
SCEYCR048W(ARE1) YNR019W(ARE2)
SEUBDI49_0798 DI49_4754
SPAOSPAR_C01020 SPAR_N03210
AGOAGOS_AAR065C
ERCEcym_2101
KLAKLLA0_C09152g
KMXKLMA_30485(ARE2)
LTHKLTH0A06204g
VPOKpol_1027p14
ZROZYRO0D08734g
CGRCAGL0C02981g CAGL0M10571g
NCSNCAS_0A04580(NCAS0A04580) NCAS_0D04420(NCAS0D04420)
NDINDAI_0I00520(NDAI0I00520) NDAI_0K01630(NDAI0K01630)
TPFTPHA_0H02220(TPHA0H02220)
TBLTBLA_0F04000(TBLA0F04000) TBLA_0I02260(TBLA0I02260)
TDLTDEL_0A07320(TDEL0A07320)
TGBHG536_0A08890
KAFKAFR_0F00800(KAFR0F00800) KAFR_0J02490(KAFR0J02490)
KNGKNAG_0D00500(KNAG0D00500) KNAG_0I02600(KNAG0I02600)
ZMKHG535_0A07180
PPAPAS_chr3_0467
DHADEHA2F24222g DEHA2F24244g
PICPICST_33115(ARE2)
PGUPGUG_00464
SPAASPAPADRAFT_54917
LELLELG_02432
CALCAALFM_C206940CA(ARE2)
CTPCTRG_01764 CTRG_01765
COTCORT_0C06130
CDUCD36_21230
CTENCANTEDRAFT_113635
YLIYALI0F06578g
CLUCLUG_05837
CLUSA9F13_05g01133
CAURCJI97_002862
SLBAWJ20_1276(ARE2)
PKZC5L36_0A02310
BNNFOA43_003406
BBRXBRETT_004256
OPAHPODL_02962
NCRNCU03991 NCU04144
NTENEUTE1DRAFT127291(NEUTE1DRAFT_127291) NEUTE1DRAFT87893(NEUTE1DRAFT_87893)
SMPSMAC_04443 SMAC_06169
PANPODANSg8191 PODANSg903
TTTTHITE_2108121 THITE_2110877
MTMMYCTH_2301957 MYCTH_2307471
CTHRCTHT_0068350
MGRMGG_06765
PPEIPpBr36_07254
TMNUCRPA7_2776 UCRPA7_8403
SSCKSPSK_04973
FGRFGSG_02016 FGSG_09863
FPUFPSE_10216 FPSE_10942
FVRFVEG_02575 FVEG_07471
FOXFOXG_04347 FOXG_05564
NHENECHADRAFT_41716 NECHADRAFT_85955
TRETRIREDRAFT_50607
TRRM419DRAFT_102202
MAWMAC_00801 MAC_01953
MAJMAA_04727 MAA_08231
CMTCCM_07840
PLJVFPFJ_09596
VALVDBG_09403
VDAVDAG_04641
CFJCFIO01_00425 CFIO01_08515
CHIGCH63R_09453 CH63R_13093
SAPOSAPIO_CDS0513 SAPIO_CDS8551
ELAUCREL1_1079 UCREL1_758
PFYPFICI_07207 PFICI_11190
SSLSS1G_07371 SS1G_10590
BFUBCIN_04g01080 BCIN_10g05780
MBEMBM_00195 MBM_07979
PSCOLY89DRAFT_610053 LY89DRAFT_749752
GLZGLAREA_04618 GLAREA_07902
ANIAN4208.2
AFMAFUA_1G06040
ACTACLA_028560
NFINFIA_018690
AORAO090009000480
ANGANI_1_628164(An18g04660)
AFVAFLA_010885
ALUCAKAW2_31133A
ACHEACHE_11056S
APUUAPUU_60437A
PCSPc13g01800 Pc13g05460
PDPPDIP_69720
TMFPMAA_024150
TRGTRUGW13939_03791
CIMCIMG_03839
CPWCPC735_004930
UREUREG_02086
PBLPAAG_01841
PBNPADG_00520
ABEARB_05568
TVETRV_06840
AJEHCAG_00155
BGHBDBG_07403
PNOSNOG_02790 SNOG_11748
PTEPTT_18164 PTT_20058
BZECOCCADRAFT_104696 COCCADRAFT_5418
BSCCOCSADRAFT_158622 COCSADRAFT_244117
BORCOCMIDRAFT_23450 COCMIDRAFT_79731
AALTCC77DRAFT_1017866 CC77DRAFT_370839
ZTRMYCGRDRAFT_41169 MYCGRDRAFT_44439(ARE1)
PFJMYCFIDRAFT_184454 MYCFIDRAFT_208180
FFUCLAFUR5_01809 CLAFUR5_08804
BCOMBAUCODRAFT_61588 BAUCODRAFT_71776
NPAUCRNP2_3303 UCRNP2_4061
TMLGSTUM_00000025001 GSTUM_00001327001
SPOSPAC13G7.05(are1) SPCP1E11.05c(are2)
CNECNF01130
CNBCNBF3580
CNGCNAG_05860
CGICGB_F5190W
TMSTREMEDRAFT_34263
TVSTRAVEDRAFT_148341
DSQDICSQDRAFT_153227
PCOPHACADRAFT_178226
SHSSTEHIDRAFT_125940
HIRHETIRDRAFT_387282
PSQPUNSTDRAFT_66632
ADLAURDEDRAFT_61665
FMEFOMMEDRAFT_16175
GTRGLOTRDRAFT_115574
LBCLACBIDRAFT_188091
MRRMoror_7033
MOREE1B28_007332
CCICC1G_00886
SCMSCHCODRAFT_53724
ABPAGABI1DRAFT105226(AGABI1DRAFT_105226)
ABVAGABI2DRAFT185966(AGABI2DRAFT_185966)
CPUTCONPUDRAFT_59491
SLASERLADRAFT_350480
WSEWALSEDRAFT_32831
UMAUMAG_05355
PFPPFL1_05361
MGLMGL_2868
MRTMRET_3462
PGRPGTG_16235
ACANACA1_031610
TGOTGME49_263710(ACAT1A)
TETTTHERM_00046980 TTHERM_00895740
PTMGSPATT00019987001 GSPATT00022217001
PIFPITG_12278
PSOJPHYSODRAFT_350290
 » show all
Reference
1  [PMID:42927]
  Authors
Spector AA, Mathur SN, Kaduce TL.
  Title
Role of acylcoenzyme A: cholesterol o-acyltransferase in cholesterol metabolism.
  Journal
Prog Lipid Res 18:31-53 (1979)
DOI:10.1016/0163-7827(79)90003-1
Reference
2  [PMID:389289]
  Authors
Taketani S, Nishino T, Katsuki H.
  Title
Characterization of sterol-ester synthetase in Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 575:148-55 (1979)
DOI:10.1016/0005-2760(79)90140-1
Reference
3  [PMID:9717734]
  Authors
Lee O, Chang CC, Lee W, Chang TY
  Title
Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines.
  Journal
J Lipid Res 39:1722-7 (1998)
Reference
4  [PMID:9020103]
  Authors
Yang H, Cromley D, Wang H, Billheimer JT, Sturley SL
  Title
Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity.
  Journal
J Biol Chem 272:3980-5 (1997)
DOI:10.1074/jbc.272.7.3980
Reference
5  [PMID:9857049]
  Authors
Chang CC, Lee CY, Chang ET, Cruz JC, Levesque MC, Chang TY
  Title
Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner.
  Journal
J Biol Chem 273:35132-41 (1998)
DOI:10.1074/jbc.273.52.35132
Reference
6  [PMID:18480028]
  Authors
Das A, Davis MA, Rudel LL
  Title
Identification of putative active site residues of ACAT enzymes.
  Journal
J Lipid Res 49:1770-81 (2008)
DOI:10.1194/jlr.M800131-JLR200
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.26
IUBMB Enzyme Nomenclature: 2.3.1.26
ExPASy - ENZYME nomenclature database: 2.3.1.26
BRENDA, the Enzyme Database: 2.3.1.26
CAS: 9027-63-8
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