KEGG   ENZYME: 2.3.1.268
Entry
EC 2.3.1.268                Enzyme                                 
Name
ethanol O-acetyltransferase;
eat1 (gene name);
ethanol acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:ethanol O-acetyltransferase
Reaction(IUBMB)
ethanol + acetyl-CoA = ethyl acetate + CoA [RN:R11957]
Reaction(KEGG)
R11957
Substrate
ethanol [CPD:C00469];
acetyl-CoA [CPD:C00024]
Product
ethyl acetate [CPD:C00849];
CoA [CPD:C00010]
Comment
The enzyme, characterized from the yeast Wickerhamomyces anomalus, is responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts. It is only distantly related to enzymes classified as EC 2.3.1.84, alcohol O-acetyltransferase. The enzyme also possesses thioesterase and esterase activities, which are inhibited by high ethanol concentrations.
History
EC 2.3.1.268 created 2018
Orthology
K22586  ethanol O-acetyltransferase
Genes
SCE: YGR015C(EAT1)
SEUB: DI49_1979
SPAO: SPAR_G02460
ERC: Ecym_7076
KLA: KLLA0_C17963g KLLA0_E24421g
KMX: KLMA_10805 KLMA_40050
LTH: KLTH0E08866g
VPO: Kpol_1062p36
ZRO: ZYRO0G11264g
CGR: 2887884(GVI51_F08415)
NCS: NCAS_0A05240(NCAS0A05240)
NDI: NDAI_0K02570(NDAI0K02570)
TPF: TPHA_0K01380(TPHA0K01380)
TGB: HG536_0C03940
TDL: TDEL_0D03000(TDEL0D03000)
KAF: KAFR_0F03480(KAFR0F03480)
KNG: KNAG_0D03600(KNAG0D03600)
ZMK: HG535_0E03520
SLUD: SCDLUD_001453 SCDLUD_002055
 » show all
Reference
1  [PMID:28356220]
  Authors
Kruis AJ, Levisson M, Mars AE, van der Ploeg M, Garces Daza F, Ellena V, Kengen SWM, van der Oost J, Weusthuis RA
  Title
Ethyl acetate production by the elusive alcohol acetyltransferase from yeast.
  Journal
Metab Eng 41:92-101 (2017)
DOI:10.1016/j.ymben.2017.03.004
  Sequence
[ag:A0A1E3P8S6]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.268
IUBMB Enzyme Nomenclature: 2.3.1.268
ExPASy - ENZYME nomenclature database: 2.3.1.268
BRENDA, the Enzyme Database: 2.3.1.268
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