| Entry |
|
|---|
| Name |
(13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase;
AT1 (gene name)
|
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
|
|---|
| Sysname |
acetyl-CoA:(13S,14R)-1,13-dihydroxy-cis-N-methylcanadine O-acetyltransferase
|
|---|
| Reaction(IUBMB) |
acetyl-CoA + (13S,14R)-1,13-dihydroxy-cis-N-methylcanadine = (13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine + CoA [RN: R11689]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
acetyl-CoA [CPD: C00024];
(13S,14R)-1,13-dihydroxy-cis-N-methylcanadine [CPD: C21587]
|
|---|
| Product |
(13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine [CPD: C21588];
CoA [CPD: C00010]
|
|---|
| Comment |
The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.
|
|---|
| History |
EC 2.3.1.285 created 2019
|
|---|
| Pathway |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
| K22095 | (13S,14R)-1,13-dihydroxy-N-methylcandine 13-O-acetyltransferase |
|
|---|
| Genes |
| PSOM: | 113273664 113303870 113322791 |
|
|---|
| Reference |
|
|---|
| Authors |
Dang TT, Chen X, Facchini PJ |
|---|
| Title |
Acetylation serves as a protective group in noscapine biosynthesis in opium poppy. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke CD |
|---|
| Title |
Complete biosynthesis of noscapine and halogenated alkaloids in yeast. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.285 |
|
|---|
| LinkDB |
|
|---|
