Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acyl-CoA:aromatic amino acid N-acetyltransferase
Reaction(IUBMB)
(1) an acyl-CoA + L-tryptophan = an N-acyl-L-tryptophan + CoA [RN:R13676];
(2) an acyl-CoA + L-tyrosine = an N-acyl-L-tyrosine + CoA [RN:R13677];
(3) an acyl-CoA + L-phenylalanine = an N-acyl-L-phenylalanine + CoA [RN:R13678]
N-acyl-L-tryptophan [CPD:C23151];
CoA [CPD:C00010];
N-acyl-L-tyrosine [CPD:C23152];
N-acyl-L-phenylalanine [CPD:C23153]
Comment
The enzyme catalyses the first step in the biosynthesis of oxazolone compounds (phenazolones, tyrazolones, and tryptazolones), which have been reported from Gram-negative as well as Gram-positive bacteria. The enzymes from different organisms have different specificity for the amino acid substrate, as well as for the length of the acyl-CoA tail.
