KEGG ENZYME: 2.3.1.6

ENZYME: 2.3.1.6

Entry

EC 2.3.1.6                  Enzyme

Name

choline O-acetyltransferase;
choline acetylase;
choline acetyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:choline O-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + choline = CoA + O-acetylcholine [RN:R01023]

Reaction(KEGG)

R01023

Substrate

acetyl-CoA [CPD:C00024];
choline [CPD:C00114]

Product

CoA [CPD:C00010];
O-acetylcholine [CPD:C01996]

Comment

Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.

History

EC 2.3.1.6 created 1961

Pathway

ec00564

Glycerophospholipid metabolism

Orthology

K00623

choline O-acetyltransferase

Genes

HSA:	1103(CHAT)

PTR:	450451(CHAT)

PPS:	100976056(CHAT)

GGO:	101129095(CHAT)

PON:	100444631(CHAT)

PPYG:

129006060(CHAT)

NLE:	100584675(CHAT)

HMH:	116479318(CHAT)

SSYN:

129480276(CHAT)

MCC:	709977(CHAT)

MCF:	102146741(CHAT)

MTHB:

126963211

MNI:	105486642(CHAT)

CSAB:

103215827(CHAT)

CATY:

105591468(CHAT)

PANU:

101013111(CHAT)

TGE:	112631519(CHAT)

MLEU:

105547378(CHAT)

RRO:	104677712(CHAT)

RBB:	108537812(CHAT)

TFN:	117082451(CHAT)

PTEH:

111554547(CHAT)

CANG:

105517717(CHAT)

CJC:	100391258(CHAT)

SBQ:	101042797(CHAT)

CIMI:

108286694(CHAT)

ANAN:

105734592(CHAT)

CSYR:

103257512(CHAT)

MMUR:

105860108(CHAT)

LCAT:

123649791(CHAT)

PCOQ:

105825962(CHAT)

OGA:	100945012(CHAT)

MMU:	12647(Chat)

MCAL:

110309681(Chat)

MPAH:

110325356(Chat)

RNO:	290567(Chat)

MCOC:

116084493(Chat)

ANU:	117706056(Chat)

MUN:	110561617(Chat)

CGE:	100756785(Chat)

MAUA:

101829899(Chat)

PROB:

127235330(Chat)

PLEU:

114699355(Chat)

MORG:

121455245(Chat)

MFOT:

126500589

AAMP:

119827085(Chat)

NGI:	103735013(Chat)

HGL:	101711939(Chat)

CPOC:

100718930(Chat)

CCAN:

109683982(Chat)

DORD:

106001017(Chat)

DSP:	122122332(Chat)

PLOP:

125345031(Chat)

NCAR:

124985917

MMMA:

107153454(Chat)

OCU:	100342226 127488395

OPI:	101517234(CHAT)

TUP:	102490742(CHAT)

GVR:	103588316(CHAT)

CFA:	486775(CHAT)

CLUD:

112671986(CHAT)

VVP:	112921044(CHAT)

VLG:	121485195(CHAT)

NPO:	129523001(CHAT)

AML:	105240673(CHAT)

UMR:	103668061(CHAT)

UAH:	113243089(CHAT)

UAR:	123800334(CHAT)

ELK:

111145252

LLV:

125085282

MPUF:

101678414(CHAT)

MNP:	132015293(CHAT)

MLK:	131830310(CHAT)

NVS:	122898953(CHAT)

ORO:	101377526(CHAT)

EJU:	114205453(CHAT)

ZCA:	113918493(CHAT)

MLX:	118020652(CHAT)

NSU:	110589356(CHAT)

LWW:	102743973(CHAT)

FCA:	751512(CHAT)

PYU:	121036935(CHAT)

PCOO:

112854528(CHAT)

PBG:	122492973(CHAT)

PVIV:

125148128(CHAT)

LRUF:

124506677

PTG:	102955228(CHAT)

PPAD:

109264566(CHAT)

PUC:

125932792

AJU:

106989815

HHV:	120232817(CHAT)

BTA:	524732(CHAT)

BOM:	102275818(CHAT)

BIU:	109553654(CHAT)

BBUB:

102401542(CHAT)

BBIS:

104999014(CHAT)

CHX:	102182280(CHAT)

OAS:	101117817(CHAT)

BTAX:

128048768(CHAT)

ODA:	120865504(CHAT)

CCAD:

122446180(CHAT)

MBEZ:

129555999(CHAT)

SSC:	396896(CHAT)

CFR:	102512463(CHAT)

CBAI:

105075619(CHAT)

CDK:	105093435(CHAT)

VPC:	102526500(CHAT)

BACU:

103017639(CHAT)

BMUS:

118882792(CHAT)

LVE:	103087947(CHAT)

OOR:	101288890(CHAT)

DLE:	111169892(CHAT)

PCAD:

102973373(CHAT)

PSIU:

116741646(CHAT)

NASI:

112395740(CHAT)

ECB:	100062632(CHAT)

EPZ:	103552164(CHAT)

EAI:	106824271(CHAT)

MYB:	102248169(CHAT) 102255670

MYD:	102773878(CHAT)

MMYO:

118679371(CHAT)

MLF:	102422909(CHAT)

MDT:	132214726(CHAT)

PKL:	118732120(CHAT)

EFUS:

103292828(CHAT)

MNA:	107527946(CHAT)

DRO:	112305557(CHAT)

SHON:

118994131(CHAT)

AJM:	119047680(CHAT)

PDIC:

114497439(CHAT)

PHAS:

123821002(CHAT)

MMF:	118632117(CHAT)

PPAM:

129069661(CHAT)

HAI:	109389479(CHAT)

RFQ:	117035757(CHAT)

PALE:

102879671(CHAT)

PGIG:

120609738(CHAT)

PVP:	105288947(CHAT)

RAY:	107508908(CHAT)

MJV:	108390141(CHAT)

TOD:	119233714(CHAT)

SARA:

101549017(CHAT)

SETR:

126033770(CHAT)

LAV:	100662470(CHAT)

TMU:

101347293

ETF:	101659176(CHAT)

DNM:	101432614(CHAT)

MDO:	100019640(CHAT)

GAS:	123236373(CHAT)

SHR:	116421926(CHAT)

AFZ:

127546947

PCW:	110215361(CHAT)

TVP:	118829313(CHAT)

OAA:	100077991(CHAT)

GGA:	395314(CHAT)

PCOC:

116234793(CHAT)

MGP:	100543253(CHAT)

CJO:	107315570(CHAT)

TPAI:

128078010(CHAT)

LMUT:

125693486(CHAT)

NMEL:

110400574(CHAT)

APLA:

101793965(CHAT)

ACYG:

106032106(CHAT)

CATA:

118245204(CHAT)

AFUL:

116491475(CHAT)

TGU:	100231848(CHAT)

LSR:	110473541(CHAT)

SCAN:

103814032(CHAT)

PMOA:

120507266(CHAT)

OTC:	121336139(CHAT)

PRUF:

121357563(CHAT)

GFR:	102039969(CHAT)

FAB:	101817021(CHAT)

OMA:	130254821(CHAT)

PHI:	102110760(CHAT)

PMAJ:

107206533(CHAT)

CCAE:

111931590(CHAT)

CCW:	104690200(CHAT)

CBRC:

103623672(CHAT)

ETL:	114063577(CHAT)

ZAB:	102071390(CHAT)

ZLE:	135449632(CHAT)

ACHL:

103799667(CHAT)

SVG:	106854194(CHAT)

MMEA:

130576628(CHAT)

HRT:	120756198(CHAT)

SATI:

136364573(CHAT)

FPG:	101920651(CHAT)

FCH:	102047610(CHAT)

CCRI:

104157567(CHAT)

NNT:	104399001(CHAT)

SHAB:

115608904(CHAT)

ACUN:

113481929(CHAT)

TALA:

104355590(CHAT)

ACHC:

115348381(CHAT)

HALD:

104316829(CHAT)

HLE:	104831939(CHAT)

AGEN:

126042523

GCL:

127017983

CSTI:

104555700(CHAT)

LDI:	104340305(CHAT)

MNB:	103779892(CHAT)

DPUB:

104301344(CHAT)

AVIT:

104274923(CHAT)

BRHI:

104497819(CHAT)

EGZ:	104122701(CHAT)

NNI:	104013529(CHAT)

PCAO:

104046858(CHAT)

PADL:

103925840(CHAT)

AFOR:

103901934(CHAT)

FGA:	104069763(CHAT)

GSTE:

104250949(CHAT)

CLV:	102093477(CHAT)

MUI:	104546528(CHAT)

PGUU:

104462706(CHAT)

PLET:

104613624(CHAT)

EHS:	104512445(CHAT)

CMAC:

104480497(CHAT)

CUCA:

104065088(CHAT)

TEO:	104370525(CHAT)

BREG:

104632108(CHAT)

OHA:	104338470(CHAT)

ACAR:

104529733(CHAT)

CPEA:

104391794(CHAT)

CVF:	104293536(CHAT)

RTD:	128911838(CHAT)

AAM:	106499858(CHAT)

AROW:

112968080(CHAT)

NPD:	112950528(CHAT)

TGT:	104566969(CHAT)

DNE:	112993305(CHAT)

SCAM:

104151035(CHAT)

ASN:	102377196(CHAT)

AMJ:	102569949(CHAT)

CPOO:

109324367(CHAT)

GGN:	109287315(CHAT)

PSS:	102449796(CHAT)

CMY:	102935845(CHAT)

CCAY:

125639820(CHAT)

DCC:	119858801(CHAT)

CPIC:

101946401(CHAT)

TST:	117880976(CHAT)

CABI:

116839114(CHAT)

MRV:	120369091(CHAT)

ACS:	100558883(chat)

ASAO:

132771243(CHAT)

PVT:	110080700(CHAT)

SUND:

121924819(CHAT)

PBI:	103061793 103065039

PMUR:

107293833(CHAT)

CTIG:

120307983(CHAT)

TSR:	106557099(CHAT)

PGUT:

117675770(CHAT)

APRI:

131200774(CHAT)

PTEX:

113445394(CHAT)

NSS:	113415369(CHAT)

VKO:	123018257(CHAT)

PMUA:

114596702(CHAT)

PRAF:

128413823(CHAT)

ZVI:	118096392(CHAT)

HCG:	128349459(CHAT)

GJA:	107124840(CHAT)

STOW:

125438075(CHAT)

EMC:	129332560(CHAT)

XLA:	108696296(chat.L) 108703349(chat.S)

XTR:	100485221(chat)

NPR:	108788608(CHAT)

RTEM:

120909089(CHAT)

BBUF:

121005635(CHAT)

BGAR:

122942079(CHAT)

MUO:	115471282(CHAT)

GSH:	117360022(CHAT)

DRE:	100170938(chata)

SRX:	107707518 107716339 107746756 107756945

SANH:

107673961 107674393 107683741 107684585

SGH:	107569502 107585314 107588646

CCAR:

109064142 109073168 109073723 109086229 109094778 109108215

CAUA:

113056521 113096127 113112394

CGIB:

127969928 127969937 128025606 128026655

PTET:

122333464 122356171(chata)

LROH:

127173758 127175067(chata)

OMC:	131551315 131552331(chata)

PPRM:

120479301(chata) 120487114

RKG:	130076544 130077609(chata)

MAMB:

125255784 125276994(chata)

CIDE:

127523200 127525430

CERY:

137007999 137020090(chata)

MASI:

127411788 127414022 127423233 127427014

TROS:

130559189(chata) 130568931

TDW:	130431417(chata) 130438699

MANU:

129416807(chata) 129421495

IPU:	108262900(chata) 108273528

IFU:	128605668(chata) 128617250

PHYP:

113527245 113544018(chat)

SMEO:

124388469 124394734(chata)

TFD:	113639946(chata) 113652229

TVC:	132846698(chata) 132858840

TRN:	134315292(chata) 134321695

AMEX:

103043285 103044316(chata)

CMAO:

118809935(chata)

EEE:	113581952(chat) 113588411

CHAR:

105895983 105909460(chata)

TRU:	101061555 101076861

TFS:	130533638(chata) 130533844

TNG:	GSTEN00016461G001 GSTEN00035908G001

LCO:	104930374(chat) 109136882

NCC:	104942458 104960833(chat) 104962666

TBEN:

117473303 117499730(chata)

CGOB:

115020276 115024188

PGEO:

117460031(chata) 117464491

GACU:

117538160(chata) 117544716

EMAC:

134858978(chata) 134870491

ELY:	117246700 117248790(chata)

EFO:	125881098 125903176(chata)

PLEP:

121954585(chata) 121959181

SLUC:

116054475(chata) 116061426

ECRA:

117936737 117960760(chata)

ESP:	116670761 116705238

PFLV:

114548684 114572552(chat)

GAT:	120819616 120820971(chata)

PPUG:

119213280 119214551(chata)

AFB:	129091686 129092733(chata)

CLUM:

117744197(chata) 117749113

PSWI:

130204101 130207146

MSAM:

119916239 119916892(chata)

SCHU:

122867343 122884212(chata)

CUD:	121511366(chata) 121528919

ALAT:

119009317 119034043(chata)

MZE:	101468574 101474042

ONL:	100690211 100700808

OAU:	116316601(chata) 116327444

OLA:	101156191 101173179

OML:	112154589 112162239(chata)

CSAI:

133418919 133463357(chata)

XMA:	102218840 102227259(chat)

XCO:	114137419(chat) 114152345

XHE:	116713855(chat) 116727462

PRET:

103476855(chat) 103481435

PFOR:

103142275 103147747(chat)

PLAI:

106954049 106959776(chat)

PMEI:

106904705(chat) 106931138

GAF:	122823272 122843031(chata)

PPRL:

129360197(chata) 129368185

CVG:	107089365 107089989

CTUL:

119774973 119788592(chata)

GMU:	124858764(chata) 124875759

NFU:	107375923(chat) 107387807

KMR:	108245700(chata) 108246008

ALIM:

106515353 106516582

NWH:	119419445(chata) 119423717

AOCE:

111564396 111582227

MCEP:

125018898(chata) 125022842

CSEM:

103381961 103387214

POV:	109626669 109630809(chat)

SSEN:

122759702 122781895(chata)

HHIP:

117752876 117775367(chata)

HSP:	118100677 118119151(chata)

PPLT:

128427069 128453693(chata)

SMAU:

118283407(chata) 118288072

LCF:	108880384(chata) 108899013

SDU:	111219604 111235159(chat)

SLAL:

111654634(chat) 111660222

XGL:	120794584 120796682(chata)

HCQ:	109509950 109523969(chat)

SSCV:

125978832 125990959

SBIA:

133496006 133509414(chata)

PEE:	133395226 133410070(chata)

PTAO:

133469148 133486107(chata)

BPEC:

110159153(chat) 110166454

MALB:

109961990(chat) 109962946

BSPL:

114842057(chata) 114845889

SJO:	128372522(chata) 128381510

SASA:

106589926 106609157

STRU:

115153558 115201731

OTW:	112239448 112258237 121840769

OMY:	110499558 110502837

OGO:	124037291 124039388

ONE:	115112945 115123577

OKI:	109883100 109899962

OKE:	118361003 118377116

SALP:

111978578(chat)

SNH:	120029340 120045988

CCLU:

121547759 121576447

ELS:	105009941(chat)

SFM:

108939585

PKI:	111859565(chat)

AANG:

118217564 118219722

LOC:	102697876(chat)

PSPA:

121322124 121326107

ARUT:

117416158 117418604

PSEX:

120519060(chata)

LCM:	102347699(CHAT)

CMK:	103181719(chata)

RTP:	109926257(chata)

CPLA:

122541875(chata)

HOC:	132834924(chata)

LERI:

129712908(chata)

PMRN:

116945026(CHAT)

LRJ:	133341901(CHAT)

BFO:	118412577 118424121 118427325

BBEL:

109478329

CIN:	445622(chat)

SCLV:

120344451

SPU:

574696

LPIC:

129281748

APLC:

110986841

ARUN:

117303738

AJC:

117109905

SKO:

100369252

DME:	Dmel_CG12345(ChAT)

DER:

6553866

DSE:

6613725

DSI:	Dsimw501_GD19246(Dsim_GD19246)

DYA:	Dyak_GE25557

DAN:

6499911

DSR:

110186314

DPO:

4801339

DPE:

6588486

DMN:

108153961

DWI:

6650420

DGR:

6567386

DMO:	Dmoj_GI10809

DAZ:

108621686

DNV:

108659621

DHE:

111602640

DVI:

6634979

CCAT:

101451626

BOD:

106623800

BDR:

105222102

RZE:

108364020

AOQ:

129235849

TDA:

119682396

MDE:

101889931

SCAC:

106091888

LCQ:

111681257

LSQ:

119602903

GFS:	119635064 119643395

ECOE:

129942734

CLON:

129611329

HIS:

119658483

AGA:

1273593

ACOZ:

120947360

AARA:

120896360

AMER:

121587610

ASTE:

118502852

AFUN:

125762987

AMOU:

128299530

AALI:

118461597

AAG:

5573378

ASUA:

134204473

CQU:	CpipJ_CPIJ001609

CPII:

120422544

CNS:

116338183

BCOO:

119068511

AME:

408934

ACER:

107993140

ADR:

102679795

BIM:

100746556

BBIF:

117215585

BVK:

117242175

BVAN:

117159906

BTER:

100650308

BAFF:

126929009

BPYO:

122571475

BPAS:

132908688

OBB:

114879061

MGEN:

117229688

NMEA:

116434666

CGIG:

122402217

AEC:

105143074

ACEP:

105623295

PBAR:

105427135

VEM:

105569893

HST:

109504566

DQU:

106741916

CFO:

105252134

LHU:	105672719(ChAT)

PGC:

109853390

OBO:

105279745

PCF:

106786480

PFUC:

122513656

VPS:

122635523

VCRB:

124428770

VVE:

124955830

NVI:

100121638

CSOL:

105368480

LBD:

127284532

CGLO:

123264461

FAS:

105266500

DAM:

107045444

AGIF:

122859102

CINS:

118065572

VCAN:

122419524

CCIN:

107264510

DSM:

124406446

NPT:

124214883

NFB:

124178472

NLO:

107222789

NVG:

124300829

AROA:

105692246

TCA:

664403

DPA:

109542904

SOY:

115891136

AGRG:

126734648

ATD:

109593867

CSET:

123318199

AGB:

108903777

LDC:

111510047

DVV:

114331012

APLN:

108737878 112904479

PPYR:

116166618

OTU:

111413325

MSEX:

115442233 119190107

DPL:	KGM_210548

BANY:

112050460

MJU:

123869110

NIQ:

126772986

VCD:

124535216

MCIX:

123657969

PMAC:

106709632 106709640

PXU:

106116978

ZCE:

119837575

CCRC:

123695169

HZE:

124634718

TNL:

113493189

SLIU:

111356288

ATRA:

106134789

GMW:

113519082

PGW:

126369949

LGLY:

125234644

CFEL:

113377696

CCRN:

123305003

API:

100159222

DNX:

107162847

RMD:

113550929

ACOO:

126835435

DVT:

126901838

BTAB:

109040044

DCI:

103516828

CLEC:

106664013

HHAL:

106679902(ChAT)

NLU:	111047838 120355827

HVI:

124359353

MQU:

128983426

PHU:	Phum_PHUM569800

FOC:

113210661

TPAL:

117643867

BROR:

134528235

IEL:

124160161

FCD:

110862640

DPX:	DAPPUDRAFT_45346

DMK:	116932575 123476919

DPZ:

124350554

PVM:

113820314

PJA:

122254991

PCHN:

125036397

PMOO:

119592355

HAME:

121855707

PCLA:

123759656

CQD:

128698613

PTRU:

123510419

ESN:

127000295

MNZ:

135198070

HAZT:

108681745

EAF:

111700202

LSM:

121126814

TCF:

131891947

PPOI:

119104615

DSV:

119436395

RMP:

119162362

VDE:

111245845

VJA:

111267853

TUT:

107366463

DPTE:

113797206

DFR:

124496979

CSCU:

111617375 111620797 111622737 111623493 111623495 111623912 111624353 111624972 111624987 111625007 111625354 111625365 111625375 111625394 111637170 111641253

CVS:	136973088 136973200 136975030 136976077(VAChT) 136978283 136978427 136978445 136978446 136980252 136986243 136990916

PTEP:

107445027

ABRU:

129975166

UDV:

129228655

SDM:

118183671

PMEO:

129591546

CEL:	CELE_CHA-1(cha-1)

CBR:	CBG_08305(Cbr-cha-1)

CRQ:	GCK72_015032

BMY:	BM_BM7387(Bma-cha-1)

LOA:	LOAG_12141

HRO:	HELRODRAFT_84274

LGI:	LOTGIDRAFT_107011

PVUL:

126811076

PCAN:

112572327

BGT:

106060968

GAE:

121379781

HRF:

124113721

HRJ:

124277725

CRG:

105343100

CANU:

128166499

CVN:

111122081

OED:

125670770

MYI:

110441481

PMAX:

117328266

MCAF:

127708775

MMER:

123564475

RPHI:

132756763

DPOL:

127866029 127866059

MAEA:

128246264

OBI:

106867711

LJP:	135468564 135468645

LAK:

106155833

SMM:	Smp_146910

SHX:	MS3_00003817

OVI:	T265_06479

EGL:

EGR_03641

LLON:

135487480

NVE:

5497657

EPA:

110245622

ATEN:

116293491 116300862

ACAN:

ACA1_069830

» show all

Reference

1 [PMID:13115440]

Authors

BERMAN R, WILSON IB, NACHMANSOHN D.

Title

Choline acetylase specificity in relation to biological function.

Journal

Biochim Biophys Acta 12:315-24 (1953)
DOI:10.1016/0006-3002(53)90150-4

Reference

2 [PMID:13799882]

Authors

BERRY JF, WHITTAKER VP.

Title

The acyl-group specificity of choline acetylase.

Journal

Biochem J 73:447-58 (1959)
DOI:10.1042/bj0730447

Reference

3 [PMID:14299645]

Authors

FRITZ IB, SCHULTZ SK.

Title

CARNITINE ACETYLTRANSFERASE. II. INHIBIITON BY CARNITINE ANALOGUES AND BY SULFHYDRYL REAGENTS.

Journal

J Biol Chem 240:2188-92 (1965)

Reference

Authors

Schuberth J.

Title

Choline acetyltransferase. Purification and effect of salts on the mechanism of the enzyme-catalysed reaction.

Journal

Biochim Biophys Acta 122:470-481 (1966)

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.6

IUBMB Enzyme Nomenclature:

2.3.1.6

ExPASy - ENZYME nomenclature database:

2.3.1.6

BRENDA, the Enzyme Database:

2.3.1.6

CAS:

9012-78-6

LinkDB

DBGET integrated database retrieval system