KEGG   ENZYME: 2.3.3.12
Entry
EC 2.3.3.12                 Enzyme                                 
Name
3-propylmalate synthase;
3-(n-propyl)-malate synthase;
3-propylmalate glyoxylate-lyase (CoA-pentanoylating);
beta-n-propylmalate synthase;
n-propylmalate synthase
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
Sysname
pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)
Reaction(IUBMB)
pentanoyl-CoA + H2O + glyoxylate = 3-propylmalate + CoA [RN:R03040]
Reaction(KEGG)
R03040
Substrate
pentanoyl-CoA [CPD:C00888];
H2O [CPD:C00001];
glyoxylate [CPD:C00048]
Product
3-propylmalate [CPD:C02123];
CoA [CPD:C00010]
History
EC 2.3.3.12 created 1972 as EC 4.1.3.11, transferred 2002 to EC 2.3.3.12
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
Reference
1  [PMID:14085361]
  Authors
IMAI K, REEVES HC, AJL SJ.
  Title
N-PROPYLMALATE SYNTHETASE.
  Journal
J Biol Chem 238:3193-8 (1963)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.12
IUBMB Enzyme Nomenclature: 2.3.3.12
ExPASy - ENZYME nomenclature database: 2.3.3.12
BRENDA, the Enzyme Database: 2.3.3.12
CAS: 37290-62-3
LinkDB

KEGG   REACTION: R03040
Entry
R03040                      Reaction                               
Name
3-propylmalate glyoxylate-lyase (CoA-pentanoylating)
Definition
3-Propylmalate + CoA <=> Pentanoyl-CoA + H2O + Glyoxylate
Equation
C02123 + C00010 <=> C00888 + C00001 + C00048
Comment
possibly intermediate
Reaction class
RC00004  C00010_C00888
RC00311  C00048_C02123
Enzyme
2.3.3.12
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.12
     R03040  3-Propylmalate + CoA <=> Pentanoyl-CoA + H2O + Glyoxylate
Other DBs
RHEA: 14460
LinkDB

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