KEGG   ENZYME: 2.3.3.3
Entry
EC 2.3.3.3                  Enzyme                                 
Name
citrate (Re)-synthase;
(R)-citrate synthase;
Re-citrate-synthase;
citrate oxaloacetate-lyase [(pro-3R)-CH2COO-->acetyl-CoA]
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
Sysname
acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]
Reaction(IUBMB)
acetyl-CoA + H2O + oxaloacetate = citrate + CoA [RN:R00351]
Reaction(KEGG)
R00351
Substrate
acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
oxaloacetate [CPD:C00036]
Product
citrate [CPD:C00158];
CoA [CPD:C00010]
Comment
This enzyme is inactivated by oxygen and is found in some anaerobes. Its stereospecificity is opposite to that of EC 2.3.3.1, citrate (Si)-synthase.
History
EC 2.3.3.3 created 1972 as EC 4.1.3.28, transferred 2002 to EC 2.3.3.3
Pathway
ec00020  Citrate cycle (TCA cycle)
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K05942  citrate (Re)-synthase
Genes
DVUDVU_0398
DVLDvul_2536
DVMDvMF_1549
DVGDeval_0360
DDSDdes_0102
DFIAXF13_13150
DPGDESPIGER_1798
DEFCNY67_00565
DTRRSDT_0090
DFLDFE_2759
DGGDGI_0640
DDEDde_0520
DMSE8L03_14670
DAFDesaf_0832
PBIZLWC08_11900
DRTDret_2092
SATSYN_02536
DAODesac_0563
DTIDesti_1258
SFUSfum_1009 Sfum_3301
DAXFDQ92_03340
DHRLGS26_06275
CACCA_C0970
CAESMB_G0987(leuA1)
CAYCEA_G0981
CBOCBO0417
CBACLB_0450
CBHCLC_0483
CBYCLM_0496
CBLCLK_3619
CBBCLD_0326
CBICLJ_B0485
CBFCLI_0502
CBJH04402_00434
CKLCKL_0973
CKRCKR_0877
CLJCLJU_c06610
CLSCXIVA_23650
CLBClo1100_2583
CPASClopa_3429
CPATCLPA_c14670(leuA2)
CPAECPAST_c14670(leuA2)
CAHCAETHG_2751
CSQCSCA_3672
CLDCLSPO_c04550(leuA)
CCKCcar_22935
CTYKCTK_C06610
CEUA7L45_00865
CDRKB9W14_01275
CFERD4Z93_11375
CLOSDMR38_03150
CRWCROST_015140
CFBCLFE_015960
CAUNCLAUR_013860
CALEFDN13_13050
CTHCthe_3157
CTXClo1313_0708
HSCHVS_12360(leuA3)
CCECcel_2177
RHEREHE19_007700
CTHDCDO33_16290
BPBbpr_I1100
BHUbhn_I1070
CLEClole_1325
CEWEKH84_09195
RHORHOM_07875
RIXRO1_15050
RIMROI_22460
CCOMI6K69_00730
BYLA4V09_07810
BLAUDQQ01_09460
BPROPMF13cell1_03741(leuA_2)
CPYCphy_3097
CSCIHDCHBGLK_02924
HSDSD1D_0728
CPROCPRO_08880(leuA_1)
EHLEHLA_0853
ANRAna3638_18590
ACELacsn021_31200
ACHTbsdcttw_33920
RGNRGna_01435
DLOK5I24_01955
SINTK5I26_12450
WCPH9Q76_12100
SSUNH9Q77_07610
WHJH9Q79_04335
EREEUBREC_1970
ERTEUR_16330
ERAERE_32270
TEBT8CH_1272
EMTCPZ25_009790
ALKAJ0B03_06290
CMIUB1H56_14155
CBARPATL70BA_3279
MDVC5Q96_07845
ETMCE91St48_30720
EUUADJ67_03935
CSCCsac_0724 Csac_0746 Csac_2456
ATEAthe_0518 Athe_2226
COBCOB47_0468 COB47_2001
CHDCalhy_0541 Calhy_2133 Calhy_2151
COWCalow_0374 Calow_1908
CKICalkr_1788 Calkr_1803 Calkr_2241
CLCCalla_0210 Calla_1186 Calla_1202
CKNCalkro_0420 Calkro_2113 Calkro_2129
CCHAELD05_11145 ELD05_11265 ELD05_13070
CDIACaldiYA01_03730 CaldiYA01_19300 CaldiYA01_19440
NCDACONDI_00268
CADCuri_c11840
SPOAEQM13_05545
TURAT726_12005
TSGHLK68_12220
TBBJ0J69_02090
AGRAAGRA3207_001215
NOABKM31_02150
NOWGBF35_35840
NCXNocox_29105(leuA3)
NGNLCN96_40145
DVCDvina_45875
DETDET1614
DEHcbdbA1708
DEBDehaBAV1_1360
DEVDhcVS_1496
DEGDehalGT_1408
DMCbtf_1554
DMDdcmb_1500
DMGGY50_1509
DMXX792_08080
DMYX793_07435
DMZX794_07330
DUCUCH007_14830
DLYDehly_1331
DEWDGWBC_1793
DFODform_00040(nifV)
DETHHX448_01875
KBSEPA93_18005
DGEDgeo_2246
DPDDeipe_2367
DCHSY84_09405
DABAUC44_00415
DWUDVJ83_15890
DFCDFI_11390
DGADEGR_00790
KSTKSMBR1_2157(cimA)
BROCIPI25_11365
BPITBPIT_29110
JETL3J17_04545
ALUSSTSP2_00175(leuA_2)
VAIBU251_01105
SSMSpirs_2643
EMIEmin_0401
EPOEpro_0887
TYETHEYE_A1277
DTPJZK55_11680
TIDThein_0064
TOPTOPB45_1562
TCMHL41_01010
THETF1847_06305
CTHITHC_1672
TAVG4V39_07690
TMAIFVE67_06105
ALAMRT761_00877
MBAMbar_A0624
MBYMSBRM_3186
MBWMSBRW_0379
MBARMSBR2_3146
MBAKMSBR3_3141
MACMA_4264
MMAMM_1002
MMAZMmTuc01_1028
MMJMSMAS_0299
MMACMSMAC_0304
MVCMSVAZ_3196
MEKMSKOL_3167
MLSMSLAZ_2804
METMMSMTP_0335
MEFMSWH1_2897
MEQMSWHS_2095
MSJMSSAC_3820
MSZMSSIH_3354
MSWMSSIT_3423
MTHRMSTHT_1587
MTHEMSTHC_1702
MHORMSHOH_0397
MFZAOB57_007030
MBUMbur_1075
MMETMCMEM_1605
MELOJ7W08_06955
MMHMmah_0581
MHAZBHR79_00505
MEVMetev_0799
MZHMzhil_0635
MPYMpsy_1028
MZIHWN40_03320
MHZMetho_1936
MTPMthe_0336
MPDMCP_0446
MEZMtc_1389
RCIRCIX1793(leuA-3)
MELUMTLP_12040
MEAMMU439_04765
IHOIgni_0261
IISEYM_04445
IAGIgag_0936 Igag_1776
THGTCELL_0774
PDLPyrde_1539
CMACmaq_1917
VDIVdis_0198
VMOVMUT_1536
KCRKcr_0973
LOKILokiarch_26360(leuA_2) Lokiarch_35110(leuA_4)
 » show all
Reference
1  [PMID:5808294]
  Authors
Dittbrenner S, Chowdhury AA, Gottschalk G.
  Title
The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate.
  Journal
Biochem Biophys Res Commun 36:802-8 (1969)
DOI:10.1016/0006-291X(69)90680-9
Reference
2  [PMID:4974734]
  Authors
Gottschalk G.
  Title
Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici.
  Journal
Eur J Biochem 7:301-6 (1969)
DOI:10.1111/j.1432-1033.1969.tb19607.x
Reference
3  [PMID:5958189]
  Authors
Gottschalk G, Barker HA.
  Title
Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase.
  Journal
Biochemistry 5:1125-33 (1966)
DOI:10.1021/bi00868a003
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.3
IUBMB Enzyme Nomenclature: 2.3.3.3
ExPASy - ENZYME nomenclature database: 2.3.3.3
BRENDA, the Enzyme Database: 2.3.3.3
CAS: 9077-70-7
LinkDB

DBGET integrated database retrieval system