KEGG   ENZYME: 2.4.1.14
Entry
EC 2.4.1.14                 Enzyme                                 
Name
sucrose-phosphate synthase;
UDP-glucose---fructose-phosphate glucosyltransferase;
sucrosephosphate---UDP glucosyltransferase;
UDP-glucose-fructose-phosphate glucosyltransferase;
SPS;
uridine diphosphoglucose-fructose phosphate glucosyltransferase;
sucrose 6-phosphate synthase;
sucrose phosphate synthetase;
sucrose phosphate-uridine diphosphate glucosyltransferase;
sucrose phosphate synthase;
UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-alpha-D-glucose + D-fructose 6-phosphate = UDP + sucrose 6F-phosphate [RN:R00766 R06073]
Reaction(KEGG)
R00766 R06073(G)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
D-fructose 6-phosphate [CPD:C00085]
Product
UDP [CPD:C00015];
sucrose 6F-phosphate [CPD:C02591]
Comment
Requires Mg2+ or Mn2+ for maximal activity [2]. The enzyme from Synechocystis sp. strain PCC 6803 is not specific for UDP-glucose as it can use ADP-glucose and, to a lesser extent, GDP-glucose as substrates [2]. The enzyme from rice leaves is activated by glucose 6-phosphate but that from cyanobacterial species is not [2]. While the reaction catalysed by this enzyme is reversible, the enzyme usually works in concert with EC 3.1.3.24, sucrose-phosphate phosphatase, to form sucrose, making the above reaction essentially irreversible [3]. The F in sucrose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.
History
EC 2.4.1.14 created 1961, modified 2008
Pathway
ec00500  Starch and sucrose metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00696  sucrose-phosphate synthase
Genes
ATHAT1G04920(SPS3F) AT4G10120(ATSPS4F) AT5G11110(SPS2F) AT5G20280(SPS1F)
ALY9307526 9310055 9310678 9328314
CRB111829932 17881554 17884088 17900430
CSAT104705376 104706379 104707307 104721265 104736104 104737013 104737937 104739022 104754635 104762737 104769326 104770411
EUSEUTSA_v10006639mg EUTSA_v10012540mg EUTSA_v10012643mg EUTSA_v10028384mg
BRP103844199 103845691 103851339 103853568 103855902 103874391
BNA106348525 106366768 106370972 106371763 106377423 106397279 106399433 106407297 106410155 106425833 106430056 106439492 111210345
BOE106307062 106318106 106327013 106327645 106328688 106343737
RSZ108817601 108832089 108842455 108842585 108842662 108843725 108847230 108847612 108850228
THJ104799636 104801022 104824613
CPAP110806438 110808418 110811933 110815619
CIT102614911 102618138 102624502 102630462
CICCICLE_v10004221mg CICLE_v10007311mg CICLE_v10007312mg CICLE_v100186551m
PVY116106627 116107458 116107849 116108366 116113477 116128988 116138026
MINC123194371 123201077 123205772 123211161 123229541
TCC18587764 18588834 18592795 18602682
GRA105769920 105773682 105777501 105782791 105793014
GHI107897149 107914058 107914804 107940066 107948694 107959558 107962903 121212592 121218323 121225232
GAB108464000 108465223 108467712 108477118 108484177
DZI111276696 111279832 111284186 111286073 111299386 111303296 111307848
EGR104437014 104445410 104449786 104456017
GMX100127429 100786531 100798787 100806543 100807527 100813168
GSJ114377082 114383700 114393926 114395909 114417471 114423351
PVUPHAVU_003G170100g PHAVU_005G002600g PHAVU_006G031700g
VRA106762335 106768365 106779669
VAR108334080 108343111 108344383
VUN114179600 114189190 114195859
CCAJ109805846 109811244 109816247 109816562
APRC113846990 113848265 113855239
MTRMTR_3g047380 MTR_4g115620 MTR_5g091340
CAM101493995 101499894 101506259
LJALj0g3v0058449.1(Lj0g3v0058449.1) Lj2g3v3101760.1(Lj2g3v3101760.1) Lj3g3v1955590.1(Lj3g3v1955590.1) Lj4g3v1893200.1(Lj4g3v1893200.1)
ADU107461295 107482790
AIP107638448 107640447
AHF112701590 112723321 112741002 112795700
LANG109341631 109345880 109354648
FVE101292871 101298507 101307526 101310276
RCN112169498 112169745 112185776 112196398
PPER18768098 18771657 18789554 18790710
PMUM103319718 103322685 103336553 103341128
PAVI110746034 110752667 110755941 110763790
PDUL117614681 117615054 117633910 117637877
MDM103400066 103411875 103443444 103444513 103447799 103456219(SPS)
PXB103932736 103932737 103937917 103946723 103949182 103952486 103953884 103956574
ZJU107410852 107422272 107422414 107427961
MNT21388866 21391872 21395843
CSV101208942 101220898 101221022
CMO103485403 103487408 103496894
BHJ120070979 120075610 120092858
MCHA111005729 111006848 111009771 111020244
CMAX111476601 111485105 111489806 111494894 111496997 111499039
CMOS111437230 111443549 111445569 111459930 111461522 111464322
CPEP111778331 111779763 111792846 111797285 111807059 111808523
RCU8259425 8272223 8280623 8281336
JCU105633156 105637611 105640094 105641278
HBR110636212 110646478 110650924 110672696
MESC110602239 110602984 110604864 110606036 110609238 110630655
POP18099919 18107084 18111090 7458381 7461652 7477753
PEU105115760 105121058 105122656 105134043 105137770 105140471
PALZ118032603 118034487 118048694 118051254 118052067 118055228
JRE108986051 108995651 109001391 109002797 109003426
QSU111984301 112016314 112017458
QLO115959955 115961052 115974921 115977118
TWL119997875 120002169 120005548 120005626 120011885
VVI100232974 100241955 100244135 100262385
VRI117905325 117907982 117912407 117913756 117914242 117924951
SLY101055573 101055611 101256154 543516(sps)
SPEN107004626 107025839 107028888 107031272
SOT102577833(SPS) 102581151 102604041 102604080
SSTN125845570 125870373 125878036 125878275
CANN107864313 107877734
NTA107761563 107766133(SPSA) 107780355 107785687 107789345 107802224 107805820 107826329(SPSC)
NSY104224363 104227396 104234884 104247669
NTO104095849 104101876 104106492 104110702
NAU109216583 109234218 109241833 109243985
INI109148848 109176232 109178772
ITR116002183 116011867 116016475
SIND105162148 105166439 105172946 105174736 105179612
OEU111373117 111392573 111399373 111403073 111408561
EGT105949818 105963576 105964664 105974295
SSPL121748656 121751659 121781701 121796179 121799662 121799921 121804469 121806350 121807650 121810008
HAN110893891 110898571 110912341 110928688 110941362
ECAD122579489 122584911 122595990 122598998 122604031
LSV111877807 111881846 111893900 111895225 111908812
CCAV112501211 112514403 112516508 112518594 112519393 112521073
DCR108193934 108214238 108218718 108220526 108226543
CSIN114289014 114291008 114322208
BVG104901950(SBSPS1) 104909043
SOE110777402 110801165
CQI110705371 110708009 110725575 110733612
NNU104586143 104590896 104592518 104593975 104602206
MING122066018 122066728 122069816 122071855 122088483
TSS122651663 122655556 122667329 122667610 122669730
PSOM113271575 113281149 113282757 113282998 113296752 113303738 113355868
NCOL116247930 116252430 116255426
OSA4324364 4328527 4341642 4345220 4350151
DOSAOs01t0919400-00(Os01g0919400) Os02t0184400-01(Os02g0184400) Os06t0643800-01(Os06g0643800) Os08t0301500-01(Os08g0301500) Os11t0236100-01(Os11g0236100)
OBR102699820 102704296 102710502 102716755 102718101
BDI100825323 100828234 100831622 100843974 100844859
ATS109738481 109762784 109780026 109780714 109787086
TDC119266644 119270082 119274305 119278137 119286552 119295218 119316235 119322957 119330970 119339893
TAES123063086 123071986 123076775 123086738 123091244 123136523 123144023 123149544 123171116 123172359 542867 542872 542873 542958 543405
TUA125516743 125523678 125542318 125545737 125550787
SBI8067709 8071544 8074599 8079417 8079789
ZMA100275248 100384028 100384650 100501516 103626734 103650849 542711
SITA101752535 101759319 101760433 101761271 101781780
SVS117834187 117837615 117852965 117857684 117860446
PVIR120644018 120654875 120671280 120672924 120676459 120680159 120685802 120700739 120704034 120709064 120712039
PHAI112873537 112889701 112893063 112896580 112902630
PDA103704794 103706486 103710588 103710846 103711479
EGU105039053 105049657 105050124 105051141
MUS103980733 103981780(SPS) 103988055 103998686
DCT110094355 110103949 110108196
PEQ110024800 110031244
AOF109824717 109830237 109837222 109841155
ATR18427768 18442593 18447493
SMOSELMODRAFT_148419(Sps2) SELMODRAFT_81492(Sps1) SELMODRAFT_91988(Sps3)
PPP112286574 112292429
VCNVOLCADRAFT_57787
CSLCOCSUDRAFT_48006
CVRCHLNCDRAFT_36181
APROF751_1987
GSLGasu_03810
SDKKHX94_14080
SYKKDN34_13255
SAVIJYB87_15195
MARQMARGE09_P3578
MMTMetme_0591
MDNJT25_011210
METLU737_05520
MAHMEALZ_0614(sps)
MBUREQU24_03045
MESLKKZ03_07365
TCXTcr_1794
HTREPV75_09710
HMARHVMH_0656(sps)
THIOAYJ59_03310 AYJ59_04280
MEJQ7A_1564
MECQ7C_247
MPINLGT42_010360
THIGFE785_04520
TXAHQN79_07950
TIBTHMIRHAM_21760(sps)
TZOTHMIRHAT_22260(sps)
THISHZT40_13735
TLOJ9253_00770
TANIJ8380_02210
TWNL2Y54_08615
NOCNoc_3069
NHLNhal_3941
NWANwat_3124
NWRE3U44_04210
ALVAlvin_0252
TVIThivi_1158
TMBThimo_1348
MPURMARPU_12205
TEETel_08340
THIPN838_02220
THIMKFB96_10540
TBOGLT988_06535
HHCM911_07515
EBSECTOBSL9_1499
TGRTgr7_0708
TKMTK90_2312
TNITVNIR_0279(mfpsA_[H])
TTITHITH_16115
TVRTVD_01115
APRSBI364_15095
HNAHneap_0227
HAZA9404_10345
WMAWM2015_745
GAIIMCC3135_06955(mfpsA_2)
GHLGM160_01005
TTCFOKN1_0257
THICTspCOW1_24840(sps)
HOLHORIV_03730
PAURFGL86_10595
EPSL0Y14_07680
RACRA876_16685
NEUNE1213(sps)
NETNeut_1080
NITNAL212_0460
NIINit79A3_2496
NMUNmul_A2267
NLCEBAPG3_014535
MFAMfla_2610
MEIMsip34_2763
MEPMPQ_2706
MEUACJ67_09825
MPAUZMTM_14650(sps)
SPLBSFPGR_05670(sps)
SNIVSFSGTM_16970(sps)
DEUDBW_2297(mfpsA)
DBADbac_2912
DSFUWK_00548
DAKDaAHT2_1337
DOLDole_0650
DMLDmul_00730
DATHRM2_24290(spsA)
DOVDSCO28_19360(sps)
DWDDSCW_13100(sps)
DALKDSCA_04260(sps)
DLIdnl_43730
MEAMex_1p0091
MDIMETDI0081
MEXMext_0200
MCHMchl_0143
MPOMpop_0284
MZAB2G69_08380
MORMOC_0555
METAY590_00410
MAQUMaq22A_1p31500(rfaG)
MPHYMCBMB27_05495
MEEDA075_19325
METDC0214_00935
METXA3862_28905
MMESMMSR116_31330
MINDmvi_56290(sps)
AUAM673_16940
AALAIGS74_12200
AALMLUX29_14090
SUAMBOO69_20920
SULDB5M07_05835
SPOTG6548_17000
SINLDSM14862_02294(ss2)
MARUFIU81_08605(mfpsA1)
LSALKBK07_09885
PYEA6J80_01145
PARREOJ32_16725
PLIAE4191_09880
PMAUCP157_03500(ss2)
MONG8E03_17040
FAPGR316_12205
SNJA7E77_00920
SMYBJP26_09930
SPLKAV944_13210
SPAUDRN02_006105
SARIH5J25_14425
ANHA6F65_02402(mfpsA)
CMANA9D14_15710
EGNBMF35_b0162
EFVCHH26_13865
QCINCF85_12190
PNSA9D12_00015
ABGAsbog_02203
LCKHN018_05115
MGMMmc1_3516
AFRAFE_1551
AFELferr_1267
ACUAtc_1728
ACZAcaty_c1478
AFIAcife_1677
AFJAFERRID_23690
ATXGCD22_01375(sps1)
AFPK1Y48_11380
MAESGa0123461_1718
HORHore_18210
HASHalsa_0772
HPKHprae_0492
HHLHalha_1826
AFTBBF96_05250
MBJKQ51_01499(mfpsA)
RTXTI83_07365
RTCAPU90_09710
RUBGBA63_05610
SYNsll0045(sps)
SYZMYO_128450(sps)
SYYSYNGTS_2819(sps)
SYTSYNGTI_2818(sps)
SYSSYNPCCN_2817(sps)
SYQSYNPCCP_2817(sps)
SYJD082_07330(spsA)
SYOC7I86_14725
SYCsyc0730_d(sps)
SYUM744_12710
SYFSynpcc7942_0808
SYDSyncc9605_2689
SYESyncc9902_2315
SYGsync_2936
SYRSynRCC307_2529(sps)
SYXSynWH7803_2527
SYPSYNPCC7002_A0888(spsA)
SYNESyn6312_2695
SYNKKR100_00785
SYNRKR49_08880
SYNDKR52_02500
SYHSyncc8109_2757(spsA)
SYNWSynWH8103_02908(sps_sds)
SYVAWQ23_04600
SYLAWQ21_05185
SYNCCB0101_08175
SYNYBM449_05040
SYWSYNW2520(sps)
CGCCyagr_0980
CYICBM981_2458
PMAPro_1880(rfaG)
PMMPMM1711(sps)
PMTPMT_2268
PMNPMN2A_1322
PMIPMT9312_1803
PMBA9601_19201
PMCP9515_19021
PMFP9303_30171(sps)
PMGP9301_19011
PMHP9215_19831
PMJP9211_18491
PMENATL1_21951(sps)
PRCEW14_2080
PRMEW15_2282
TVNNIES2134_108440(sps)
SLWBRW62_04370
TELtlr0582(sps)
THNNK55_11890(sps)
THECFFX45_12875
LETO77CONTIG1_00929(mfpsA_1)
THEUHPC62_22465
GENGM3709_1827
GEEGM3708_1775
OXYHCG48_12990
MICMic7113_0591
OACOscil6304_3321
MPROBJP34_19305
NPUNpun_F4709
NOSNos7107_1808
NOPNos7524_3554
NFLCOO91_00241
NOECLI64_14590
NSHGXM_05878
ANBANA_C12881
ACYAnacy_5147
AWAAA650_11585
CSGCylst_1866
CALTCal6303_0199
CALNNIES2098_03320 NIES2098_11100(sps)
NSPBMF81_01068
NSPHBDGGKGIB_03304(ss2)
DOUBMF77_04107(mfpsA_3)
DFSHGD76_18580
AFLOHEQ12_02350
TOQHCG51_31840
SOAG3M56_005245
RBARB5197(sps)
PIRVN12_23145(mfpsA_3)
RULUC8_59090(mfpsA_2)
RMLFF011L_55410(mfpsA)
MFFMFFC18_51400(mfpsA)
ROLCA51_34360(mfpsA)
AHELQ31a_17940(mfpsA_1)
BVOPan97_31820(mfpsA_2)
RLCK227x_26780(mfpsA)
AMUCPan181_07020(mfpsA_2)
PNDPla175_04860(mfpsA_1)
PLMPlim_3683
PBSPlabr_0007 Plabr_3287
FMRFuma_03286(mfpsA_2)
GMRGmarT_26600(mfpsA)
GIMF1728_01675
GPNPan110_25120(mfpsA)
MRIMal4_00740(mfpsA_2)
SDYNMal52_36180(mfpsA)
PLONPla110_00640(mfpsA)
VBLL21SP4_02013
TAERGT409_01100
OCKEXM22_16825
SASSMUG09_15995
NSONIASO_06600
NIAA8C56_09200
LBYLbys_0264
RSIRunsl_4419
FJOFjoh_3967
FJGBB050_03561(mfpsA)
FCRHYN56_19040
FFLHYN86_15915
FENJ0383_21685
MROMROS_1315
TMETmel_0533
TAFTHA_1341
THPBG95_06130
THERY592_06205
TFEJYK00_00680
FNOFnod_0446
FPEFerpe_0508
FIANA23_02855
OCYOSSY52_08760
PMOPmob_1867
DTNDTL3_0896
KOLKole_1069
KPFIX53_06510
MPGTheba_2030
MINFMESINF_0949
ASACATHSA_1493
DINSelin_2400
DAPDacet_2943
NLIG3M70_12405
 » show all
Reference
1  [PMID:13769376]
  Authors
MENDICINO J.
  Title
Sucrose phosphate synthesis in wheat germ and green leaves.
  Journal
J Biol Chem 235:3347-52 (1960)
Reference
2  [PMID:9852031]
  Authors
Curatti L, Folco E, Desplats P, Abratti G, Limones V, Herrera-Estrella L, Salerno G
  Title
Sucrose-phosphate synthase from Synechocystis sp. strain PCC 6803: identification of the spsA gene and characterization of the enzyme expressed in Escherichia coli.
  Journal
J Bacteriol 180:6776-9 (1998)
DOI:10.1128/JB.180.24.6776-6779.1998
  Sequence
[syn:sll0045]
Reference
3  [PMID:15012296]
  Authors
Huber SC, Huber JL
  Title
ROLE AND REGULATION OF SUCROSE-PHOSPHATE SYNTHASE IN HIGHER PLANTS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 47:431-444 (1996)
DOI:10.1146/annurev.arplant.47.1.431
Reference
4  [PMID:12062401]
  Authors
Cumino A, Curatti L, Giarrocco L, Salerno GL
  Title
Sucrose metabolism: Anabaena sucrose-phosphate synthase and sucrose-phosphate phosphatase define minimal functional domains shuffled during evolution.
  Journal
FEBS Lett 517:19-23 (2002)
DOI:10.1016/S0014-5793(02)02516-4
Reference
5  [PMID:18424616]
  Authors
Chua TK, Bujnicki JM, Tan TC, Huynh F, Patel BK, Sivaraman J
  Title
The structure of sucrose phosphate synthase from Halothermothrix orenii reveals its mechanism of action and binding mode.
  Journal
Plant Cell 20:1059-72 (2008)
DOI:10.1105/tpc.107.051193
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.14
IUBMB Enzyme Nomenclature: 2.4.1.14
ExPASy - ENZYME nomenclature database: 2.4.1.14
BRENDA, the Enzyme Database: 2.4.1.14
CAS: 9030-06-2
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