KEGG   ENZYME: 2.4.1.147
Entry
EC 2.4.1.147                Enzyme                                 
Name
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III;
uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase;
mucin core 3 beta3-GlcNAc-transferase;
Core 3beta-GlcNAc-transferase;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] = UDP + O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] [RN:R05909]
Reaction(KEGG)
R05909(G);
(other) R03513
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
Product
UDP [CPD:C00015];
O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
Comment
The product of the enzyme is known as core 3, one of the eight core structures of mucin-type O-glycans. O-Linked glycans are polysaccharides or oligosaccharides that are linked to a protein via the oxygen atom in the side chain of an L-serine or L-threonine residue.
History
EC 2.4.1.147 created 1984, modified 2015
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00739  acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
Genes
HSA192134(B3GNT6)
PTR451437(B3GNT6)
PPS100976514(B3GNT6)
GGO101135837(B3GNT6)
PON100447110(B3GNT6)
NLE100590559(B3GNT6)
MCC697946(B3GNT6)
MCF102140679(B3GNT6)
CSAB103248086(B3GNT6)
CATY105578707(B3GNT6)
PANU101011849(B3GNT6)
TGE112606758(B3GNT6)
RRO104665081(B3GNT6)
RBB108543201(B3GNT6)
TFN117081617(B3GNT6)
PTEH111540809(B3GNT6)
CJC100395512(B3GNT6)
MMUR105860361(B3GNT6)
OGA100952122(B3GNT6)
MMU272411(B3gnt6)
MCAL110299476(B3gnt6)
MPAH110338661(B3gnt6)
RNO292325(B3gnt6)
MCOC116100654(B3gnt6)
MUN110547309(B3gnt6)
CGE100768656(B3gnt6)
PLEU114698641(B3gnt6)
NGI103743061(B3gnt6)
HGL101709961(B3gnt6)
CPOC100734343(B3gnt6)
CCAN109688563(B3gnt6)
DORD105984027(B3gnt6)
DSP122115782(B3gnt6)
NCAR124960679
OCU100351306(B3GNT6)
OPI101527232(B3GNT6)
TUP102471967(B3GNT6)
CFA485176(B3GNT6)
VVP112928597(B3GNT6)
VLG121476367(B3GNT6)
AML100477436(B3GNT6)
UAH113269347(B3GNT6)
UAR123804248(B3GNT6)
ELK111140080
MPUF106007350(B3GNT6)
ORO101364432(B3GNT6)
EJU114218719(B3GNT6)
ZCA113915359(B3GNT6)
MLX118004086(B3GNT6)
FCA101088357(B3GNT6)
PYU121039524(B3GNT6)
PBG122482547(B3GNT6)
PPAD109267243(B3GNT6)
AJU113593724(B3GNT6)
HHV120229600(B3GNT6)
BTA540848(B3GNT6)
BOM102281875(B3GNT6)
BIU109569036(B3GNT6) 109569038
BBUB102404962(B3GNT6)
CHX102177179(B3GNT6)
OAS101110268(B3GNT6)
ODA120876811(B3GNT6)
CCAD122450216(B3GNT6)
SSC100524328(B3GNT6)
CFR102514253(B3GNT6)
CBAI105083615(B3GNT6)
CDK105098256(B3GNT6)
VPC102525895(B3GNT6)
BACU103008870(B3GNT6)
LVE103070939(B3GNT6)
PCAD102977665(B3GNT6)
ECB100146508(B3GNT6)
EPZ103548238(B3GNT6)
EAI106840415(B3GNT6)
MJV108387058(B3GNT6)
LAV100655490(B3GNT6)
TMU101342607
DNM101417985(B3GNT6)
OAA100074637(B3GNT6)
PSS102450449
CPIC101948298
PBI112542604
XLA108703688
DPXDAPPUDRAFT_111641 DAPPUDRAFT_46063
DMK116916560 116916565 116919278 116935951
RSAN119400953
DFR124490907
HRF124140568 124150821
CRG105325144
 » show all
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr Res 120:3-16 (1983)
DOI:10.1016/0008-6215(83)88002-1
Reference
2  [PMID:3160388]
  Authors
Brockhausen I, Matta KL, Orr J, Schachter H
  Title
Mucin synthesis. UDP-GlcNAc:GalNAc-R beta 3-N-acetylglucosaminyltransferase and UDP-GlcNAc:GlcNAc beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from pig and rat colon mucosa.
  Journal
Biochemistry 24:1866-74 (1985)
DOI:10.1021/bi00329a010
Reference
3  [PMID:7655172]
  Authors
Vavasseur F, Yang JM, Dole K, Paulsen H, Brockhausen I
  Title
Synthesis of O-glycan core 3: characterization of UDP-GlcNAc: GalNAc-R beta 3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines.
  Journal
Glycobiology 5:351-7 (1995)
DOI:10.1093/glycob/5.3.351
  Sequence
[hsa:192134]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.147
IUBMB Enzyme Nomenclature: 2.4.1.147
ExPASy - ENZYME nomenclature database: 2.4.1.147
BRENDA, the Enzyme Database: 2.4.1.147
CAS: 87927-96-6
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