KEGG   ENZYME: 2.4.1.214
Entry
EC 2.4.1.214                Enzyme                                 
Name
glycoprotein 3-alpha-L-fucosyltransferase;
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase;
GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase;
GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase;
GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-beta-L-fucose:N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] 3-alpha-L-fucosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-beta-L-fucose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein] [RN:R06015]
Reaction(KEGG)
R06015(G) > R09318(G);
(other) R11318(G)
Substrate
GDP-beta-L-fucose [CPD:C00325];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
Product
GDP [CPD:C00035];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
Comment
Requires Mn2+. The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue. This enzyme catalyses a reaction similar to that of EC 2.4.1.68, glycoprotein 6-alpha-L-fucosyltransferase, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,3-linkage rather than an alpha1,6-linkage. The {iupac/misc/glycp#3.5::N-glycan} products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea).
History
EC 2.4.1.214 created 2001
Pathway
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00753  glycoprotein 3-alpha-L-fucosyltransferase
Genes
ZVI118078576
BFO118405950 118406257 118411908 118412045 118412254 118412440 118413693 118425677 118426531 118426592 118426593 118429660 118430705 118432514 118432653
BBEL109461731 109462467 109466362 109467558 109467559 109468794 109470793 109472650 109473253 109485218
SCLV120325783 120325811 120326252 120326253 120326461 120327132 120330128 120332423 120335441 120335442 120336318 120343945
SPU100890299 100892875 105437757 105440751 105443584 105445519 115921346 115922540 115922761 115925446 115925447 115925451 115925452 115926808 115929731 574917 575118 579774 582389 588755 753114
APLC110976930 110977799 110978133 110978134 110980446 110981755 110989209 110989340 110990202 110990203
DMEDmel_CG6869(FucTA)
DER6544519
DSE6605753
DSIDsimw501_GD14528(Dsim_GD14528)
DYADyak_GE22226
DAN6506328
DSR110176209
DPODpse_GA19918 Dpse_GA25723 Dpse_GA25724
DPE113565816 6588690 6596938
DMN108151409 108162167 108162168
DWI6645794
DGR6557543
DMODmoj_GI13099
DAZ108613431
DNV108651431
DHE111595062
DVI6622988
CCAT101458318 101459389
BOD106614885
MDE101901412
SCAC106092729
LCQ111685167
AGAAgaP_AGAP003191
ACOZ120953373
AARA120896316
AAG5575371
AALB109414185
CQUCpipJ_CPIJ013202
CPII120423217
CNS116338840 116341884 116342793 116346121 116351383
AME100578168
ACER107999065
ALAB122719808
BIM100748078
BBIF117204097
BVK117235687
BVAN117159518
BTER100642198
BPYO122567151
CCAL108633042
OBB114874284
MGEN117220654
NMEA116427819
CGIG122405483
SOC105194752
MPHA105830600
AEC105151786
ACEP105627764
PBAR105425145
VEM105569385
HST105182309
DQU106741312
CFO105253014
FEX115244899
LHU105673879
PGC109853983
OBO105281195
PCF106789776
PFUC122517406
VPS122629353
NVI100116394
CSOL105360968
TPRE106653918
MDL103572507
CGLO123264394
FAS105269410
DAM107041910
AGIF122854943 122855072
CCIN107265253
TCA655857
DPA109534786 109537899 109537932
SOY115887868 115887927
ATD109599039
CSET123311867
AGB108917080
LDC111510682 111510683
NVL108558702
APLN108745025
PPYR116171534 116171751
OTU111424370
BMOR101742412
BMAN114243659
MSEX115447326
DPLKGM_204991
BANY112054928
PMAC106715499
PPOT106104327
PXU106116844
PRAP110992454
ZCE119829157
HAW110377270
TNL113499332
SLIU111348804
OFU114351547
PXY105397575
API100161726 100163995 100165601 100167629 100168794 100574117
DNX107162725 107172392 107173073 107173609
AGS114123584 114128008 114128010 114128011
RMD113548005 113548044 113558478 113560434 113560693
BTAB109033726
DCI103504944 103519010
CLEC106668184
HHAL106685390
NLU111049328 111052441 111055726 111059937 111060313 120355815 120356429
PHUPhum_PHUM491860
FOC113206592
ZNE110832335
CSEC111867708
FCD110843011 110843249 110844424 110849065 110850423 110852611 110852612 110852710
DMK116926825 116931878
PVM113828366
PJA122254487
PCHN125033198
HAME121861134
PCLA123773963
PTRU123512710
HAZT108668289 108669370 108671073 108671074 108676301 108677119
EAF111696777 111701449 111707210
ISCIscW_ISCW000880 IscW_ISCW003580 IscW_ISCW005012
DSV119434812 119448844 119450320 119450510 119450512
RSAN119381841 119381842 119383418 119383601 119390909
RMP119169683 119169686 119169687 119170382
VDE111246813
VJA111263712
TUT107360881 107367044
DPTE113791393
DFR124493723
CSCU111616856 111622473 111622475 111628209 111630055
PTEP107436083 107450737
SDM118187669 118201057
CELCELE_K12H6.3(fut-4)
CBRCBG_19588(Cbr-fut-4)
TSPTsp_00082 Tsp_02347a Tsp_02348
HROHELRODRAFT_123182 HELRODRAFT_166201 HELRODRAFT_84937 HELRODRAFT_86301
LGILOTGIDRAFT_129140 LOTGIDRAFT_152652
PCAN112555025 112555027 112556484 112560468 112562523
GAE121378023 121378119 121380440
HRF124114396 124117155 124119071 124119078 124119416 124119753 124120868 124121687 124124454 124126776 124130905 124130907 124137964 124140233 124140289 124143524 124146870
HRJ124252815 124252818 124257511 124260813 124268700 124281133 124285760 124287142
CRG105319931 105326742 105340008 117683259
MYI110443530 110450259 110456621 110456628 110456630 110456631 110459974 110464928
PMAX117316783 117317092 117326151 117326152 117336016 117342927
MMER123528191 123535574 123535747 123535763 123539200 123559052 123559810 123560140 123560509 123562117 123562511 123562846 123565607
OBI106876232 106876522 106877376 106882619
OSN115211825 115226009 115226011 115226504 115226505 115226509 115227328 115230711 115230712 118768515
LAK106150569 106150572 106156269 106158251 106159224 106160406 106163945 106166124 106166131 106171537 106172080 106172205 106172987 106173676 106174364 106176482 106179391 112042190
SMMSmp_054300 Smp_129750 Smp_154410 Smp_211180
EGLEGR_05896 EGR_10466
NVE116619801 5507414 5512058 5512165 5513806 5514645
EPA110233868 110238636 110240352 110248499 110254859
AMIL114973995 114976855
PDAM113665367 113675673 113675680 113676257 113676359
SPIS111323780 111330794
DGT114527812
HMG100197515 100199046 100215619 105848080
TADTRIADDRAFT_20532 TRIADDRAFT_3614
ATHAT1G49710(FUT12) AT3G19280(FUT11)
ALY9321371 9330274
CRB17892669 17899764
CSAT104742504 104746313 104758303 104765792 104777890
EUSEUTSA_v10011402mg EUTSA_v10022257mg
BRP103832922 103869473 103871397
BNA106346129 106406562 106416618 106418732 106428330 106439064 111204765 111216211
BOE106301123 106307787 106343405
RSZ108813729 108823121 108857666
THJ104798796 104803455
CPAP110813783
CIT102617014
CICCICLE_v10028212mg
PVY116140879
MINC123214610
TCC18607941
GRA105762819 105773248 105782696
GHI107894268 107928817 107934110 107937965 107953397
GAB108462114 108476746 108482200 108485473
DZI111296230 111308938
EGR104418734
GMX100776065 100792811
GSJ114388547 114419694
PVUPHAVU_003G292000g
VRA106768760
VAR108343376
VUN114178538
CCAJ109793169
APRC113858078
MTRMTR_4g086010
CAM101502044
LJALj4g3v0598850.1(Lj4g3v0598850.1)
ADU107469717
AIP107623116
AHF112715584 112782732
LANG109331404 109333305 109349444
FVE101293079
RCN112172265
PPER18766662
PMUM103335356
PAVI110771695
MDM103421796 103436488
PXB103937988
ZJU107427081
MNT21410140
CSV101202837 101205170
CMO103495239 103496162
BHJ120077948 120091536
MCHA111007907 111017732
CMAX111470944 111482907
CMOS111430616 111455575
CPEP111810161 111811265
RCU8275299
JCU105629829
HBR110634690 110638983
MESC110619657
POP7457535
PEU105108067
PALZ118059215
JRE108988882
QSU112025720
QLO115968668
TWL119982721 120002716
VVI100255469
VRI117911323
SLY101251424 101264378
SPEN107002790 107004595
SOT102592560 102599085
CANN107840277 107855995
NTA107766938 107767349(FucT) 107797347 107830046
NSY104213968 104237589
NTO104106034 104113469
NAU109233483 109235654
INI109154539 109161366 109165387
ITR116028671 116028672 116030067 116032462
SIND105169541 105172719
OEU111389108 111410807 111412885
EGT105957556
SSPL121753942 121757044 121809982
HAN110917016 110938245
ECAD122594402
LSV111877656 111880602 111895636
CCAV112500611 112507506
DCR108201987 108222779 108225732
CSIN114277040
BVG104904482
SOE110778319
CQI110698592 110704959
NNU104601780 104606410
MING122060511 122079687
TSS122658527 122661235
PSOM113289512 113297777
NCOL116262080
OSA4345809
DOSAOs08t0472600-01(Os08g0472600)
OBR102709390
BDI100834636
ATS109765104
TDC119328007 119340643
TAES123154940 123156180 543033
SBI8056895
ZMA100273557 778434
SITA101766834
SVS117861390
PVIR120678853 120712625
PHAI112897037
PDA103718299 103719837
EGU105041363 105060901
MUS103968374 103968680 103977535
DCT110092524 110100572 110113811
PEQ110029537
AOF109849943
ATR18421358
SMOSELMODRAFT_452935(FucTA)
PPP112288886
CSLCOCSUDRAFT_37671
DPPDICPUDRAFT_157080
SMINv1.2.020659.t1(symbB.v1.2.020659.t1)
 » show all
Reference
1  [PMID:11420147]
  Authors
Wilson IB, Rendic D, Freilinger A, Dumic J, Altmann F, Mucha J, Muller S, Hauser MT.
  Title
Cloning and expression of cDNAs encoding alpha1,3-fucosyltransferase homologues from Arabidopsis thaliana.
  Journal
Biochim Biophys Acta 1527:88-96 (2001)
DOI:10.1016/S0304-4165(01)00151-9
  Sequence
[ath:AT3G19280]
Reference
2  [PMID:11382750]
  Authors
Fabini G, Freilinger A, Altmann F, Wilson IB
  Title
Identification of core alpha 1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseadish peroxidase epitope.
  Journal
J Biol Chem 276:28058-67 (2001)
DOI:10.1074/jbc.M100573200
  Sequence
Reference
3  [PMID:10419500]
  Authors
Leiter H, Mucha J, Staudacher E, Grimm R, Glossl J, Altmann F.
  Title
Purification, cDNA cloning, and expression of GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase from mung beans.
  Journal
J Biol Chem 274:21830-9 (1999)
DOI:10.1074/jbc.274.31.21830
  Sequence
[vra:106768760]
Reference
4  [PMID:10567717]
  Authors
van Tetering A, Schiphorst WE, van den Eijnden DH, van Die I.
  Title
Characterization of a core alpha1-->3-fucosyltransferase from the snail Lymnaea stagnalis that is involved in the synthesis of complex-type N-glycans.
  Journal
FEBS Lett 461:311-4 (1999)
DOI:10.1016/S0014-5793(99)01489-1
Reference
5  [PMID:1868856]
  Authors
Staudacher E, Altmann F, Glossl J, Marz L, Schachter H, Kamerling JP, Hard K, Vliegenthart JF.
  Title
GDP-fucose: beta-N-acetylglucosamine (Fuc to (Fuc alpha 1----6GlcNAc)-Asn-peptide)alpha 1----3-fucosyltransferase activity in honeybee (Apis mellifica) venom glands. The difucosylation of asparagine-bound N-acetylglucosamine.
  Journal
Eur J Biochem 199:745-51 (1991)
DOI:10.1111/j.1432-1033.1991.tb16179.x
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.214
IUBMB Enzyme Nomenclature: 2.4.1.214
ExPASy - ENZYME nomenclature database: 2.4.1.214
BRENDA, the Enzyme Database: 2.4.1.214
CAS: 68247-53-0
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