KEGG   ENZYME: 2.4.1.217
Entry
EC 2.4.1.217                Enzyme                                 
Name
mannosyl-3-phosphoglycerate synthase;
MPG synthase;
GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-mannose:3-phospho-D-glycerate 3-alpha-D-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate [RN:R05768]
Reaction(KEGG)
R05768
Substrate
GDP-mannose [CPD:C00096];
3-phospho-D-glycerate [CPD:C00197]
Product
GDP [CPD:C00035];
2-(alpha-D-mannosyl)-3-phosphoglycerate [CPD:C11516]
Comment
Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.
History
EC 2.4.1.217 created 2002
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K05947  mannosyl-3-phosphoglycerate synthase
Genes
NCRNCU05700
NTENEUTE1DRAFT100267(NEUTE1DRAFT_100267)
SMPSMAC_02065
PANPODANSg2537
TTTTHITE_2120465
MTMMYCTH_2303166
CTHRCTHT_0072260
PPEIPpBr36_05480
TMNUCRPA7_732
CFJCFIO01_04083
ELAUCREL1_10936
PNOSNOG_14776
PTEPTT_11203
ACTNL083_6965
AFSAFR_36880
PLABC6361_25375
PLATC6W10_13480
PFLAPflav_085120
PSUUPsuf_048030
PRYPrubr_39070
NHYJQS43_18785
CCAZCOUCH_07620(mpgS)
DETDET1363(mpgSP)
DEHcbdbA1314
DEBDehaBAV1_1174
DEVDhcVS_1144
DMCbtf_1241
DMDdcmb_1222
DMGGY50_1201(mngA)
DMXX792_06380
DMYX793_06240
DMZX794_05800
DUCUCH007_11250
DLYDehly_0877
DEWDGWBC_0701
DFODform_01049
TTHTT_C0588
TTJTTHA0954(TTHA0954)
TTSThthe16_0950
TTLTtJL18_1098
MHDMarky_0082
RMRRmar_0502
RMGRhom172_0500
MTEEMTTB_02910
MFVMfer_0544
APOArcpr_0588
AVEArcve_0995 Arcve_1326
PFUPF0591
PFIPFC_02085
PHOPH0927(PH0927)
PABPAB0816
PYNPNA2_1454
PYAPYCH_06950
PYSPy04_0855
PYCTQ32_02365
TGATGAM_0817
TSITSIB_0251
TBATERMP_00005
THATAM4_785
TLTOCC_09696
THSTES1_0131
TNUBD01_0152
THVADU37_CDS01910
TCHCHITON_0969
TCEA3L02_00525
TBSA3L01_01795
THHCDI07_01770
TTDA3L14_03245
TRLA3L10_04690
THYA3L12_01820
PPACPAP_01435
APEAPE_0889.1(mpgs)
ACJACAM_0578(mpgs)
SMRSmar_0498
SHCShell_0304
PDLPyrde_0369
NGANgar_c16030(mngA1) Ngar_c27190(mngA2)
NVNNVIE_006110(mngA)
NEVNTE_01978
TAANMY3_00972 NMY3_02751
NFNNFRAN_0350(mngA) NFRAN_1965(mngA)
NCVNCAV_1295(mngA)
 » show all
Reference
1  [PMID:11562374]
  Authors
Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS
  Title
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.
  Journal
J Biol Chem 276:43580-8 (2001)
DOI:10.1074/jbc.M108054200
  Sequence
[pho:PH0927]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.217
IUBMB Enzyme Nomenclature: 2.4.1.217
ExPASy - ENZYME nomenclature database: 2.4.1.217
BRENDA, the Enzyme Database: 2.4.1.217
CAS: 393512-63-5
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