KEGG   ENZYME: 2.4.1.225
Entry
EC 2.4.1.225                Enzyme                                 
Name
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase;
N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase;
heparan glucuronyltransferase II
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan [RN:R07335]
Reaction(KEGG)
R07335 > R05935(G) R10138(G)
Substrate
UDP-alpha-D-glucuronate [CPD:C00167];
N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
Product
UDP [CPD:C00015];
beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
Comment
Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the human enzyme (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (EC 2.4.1.224) activity required for the synthesis of the heparan sulfate disaccharide repeats.
History
EC 2.4.1.225 created 2002
Pathway
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ec01100  Metabolic pathways
Orthology
K02366  glucuronyl/N-acetylglucosaminyl transferase EXT1
K02367  glucuronyl/N-acetylglucosaminyl transferase EXT2
Genes
HSA2131(EXT1) 2132(EXT2)
PTR107976420(EXT1) 451140(EXT2)
PPS100975712(EXT2) 100985695(EXT1)
GGO101130563(EXT2) 109025298(EXT1)
PON100172450(EXT1) 100436160(EXT2)
NLE100597702(EXT1) 100604250(EXT2)
MCC701488(EXT1) 715975(EXT2)
MCF101926231(EXT1) 102136104(EXT2)
CSAB103236980 103237338(EXT1)
CATY105584539(EXT1) 105586840(EXT2)
PANU100137439(EXT1) 101019229(EXT2) 116272456 116272614
TGE112606187(EXT2) 112629920(EXT1)
RRO104658897(EXT1) 104673882(EXT2)
RBB108519255(EXT2) 108536176(EXT1)
TFN117079472(EXT1) 117081393(EXT2)
PTEH111544934(EXT2) 111551020(EXT1)
CJC100386964(EXT1) 100400679(EXT2)
SBQ101039408(EXT2) 101053444(EXT1)
CSYR103260803 103263660 103264178 103272774
MMUR105863703(EXT1) 105885490(EXT2)
OGA100943601(EXT1) 100949922(EXT2)
MMU14042(Ext1) 14043(Ext2)
MCAL110310432(Ext1) 110311448(Ext2)
MPAH110317782(Ext2) 110334870(Ext1)
RNO299907(Ext1) 311215(Ext2)
MCOC116082489(Ext1) 116090518(Ext2)
MUN110540376(Ext2) 110559447 110559448
CGE100689334(Ext1) 100751585(Ext2)
PLEU114694845(Ext1) 114699729(Ext2)
NGI103738135(Ext1) 103751554(Ext2)
HGL101706257(Ext1) 101715817(Ext2)
CPOC100712625(Ext2) 100716132(Ext1)
CCAN109686418 109702003
DORD105996073(Ext2) 105997725(Ext1)
DSP122100734(Ext2) 122102360(Ext1)
NCAR124960112 124981119
OCU100343697(EXT2) 100351235(EXT1)
OPI101535829(EXT1) 101536088(EXT2)
TUP102467803(EXT1) 102487057(EXT2)
CFA475989(EXT2) 482024(EXT1)
VVP112915941(EXT1) 112924118(EXT2)
VLG121498758(EXT1) 121501521(EXT2)
AML100465258(EXT1) 105242037(EXT2)
UMR103661582(EXT1) 103672344(EXT2)
UAH113252791(EXT1) 113265011(EXT2)
UAR123797768(EXT1) 123799595(EXT2)
ELK111146555 111150031
LLV125078631 125097162
MPUF101672930(EXT2) 101691546(EXT1)
ORO101366478(EXT2) 101382133(EXT1)
EJU114199089(EXT1) 114215287(EXT2)
ZCA113914556(EXT2) 113931105(EXT1)
MLX118015150(EXT1) 118015783(EXT2)
FCA101081362(EXT1) 101083620(EXT2)
PYU121042894(EXT1) 121043515(EXT2)
PBG122483728(EXT2) 122495739(EXT1)
PTG102964333(EXT2) 102968916(EXT1)
PPAD109273237(EXT1) 109279210 109279211(EXT2)
AJU106975536(EXT1) 106978049(EXT2)
HHV120228461(EXT2) 120228668(EXT1)
BTA281151(EXT2) 538602(EXT1)
BOM102275740(EXT2) 102280308(EXT1)
BIU109568471(EXT1) 109569634(EXT2)
BBUB102389161(EXT2) 102407802(EXT1)
CHX102182243(EXT2) 102182809(EXT1)
OAS101110867(EXT2) 101114877(EXT1)
ODA120860718 120876908(EXT2) 120878901(EXT1)
CCAD122449196(EXT2) 122450981(EXT1)
SSC100157655(EXT1) 100522362(EXT2)
CFR102508456(EXT1) 102514905(EXT2)
CBAI105076487(EXT2) 105082972(EXT1)
CDK105096148(EXT1) 105106838(EXT2)
VPC102535018(EXT1) 102542570(EXT2)
BACU102999728(EXT2) 103019432(EXT1)
LVE103078738(EXT1) 103091009(EXT2)
OOR101280958(EXT2) 101286251(EXT1)
DLE111165183(EXT1) 111184011(EXT2)
PCAD102979294 102980097(EXT1)
PSIU116742524(EXT1) 116758175(EXT2)
ECB100055879(EXT2) 100056983(EXT1)
EPZ103549478(EXT1) 103556459(EXT2)
EAI106839736(EXT1) 106843971(EXT2)
MYB102238781(EXT2) 102244714(EXT1)
MYD102765321(EXT1) 102767712(EXT2)
MMYO118665109(EXT2) 118670761(EXT1)
MLF102422014(EXT2) 102441376(EXT1)
MNA107525491(EXT2) 107533185(EXT1)
PKL118712503 118718227(EXT1)
HAI109382533 109391972(EXT2)
DRO112303473(EXT2) 112315333(EXT1)
SHON118988619(EXT1) 119002984(EXT2)
AJM119051826(EXT1) 119064418(EXT2)
PDIC114499874(EXT2) 114514407(EXT1)
PHAS123810129(EXT2) 123833269(EXT1)
MMF118627865(EXT2) 118631561(EXT1)
RFQ117029882(EXT2) 117033795(EXT1)
PALE102890634(EXT2) 102891150(EXT1)
PGIG120595391(EXT1) 120606317
PVP105290068(EXT2) 105292239(EXT1)
RAY107507149(EXT1) 107511887(EXT2)
MJV108386769 108394755(EXT2) 108399086(EXT1) 108399399
TOD119238592 119255341(EXT2)
SARA101538625(EXT1) 101551336(EXT2)
LAV100656016(EXT2) 100657623(EXT1)
TMU101361975 101362012
DNM101436351(EXT1) 101436915(EXT2)
MDO100010947(EXT2) 100025396(EXT1)
GAS123241026(EXTL1) 123241182(EXT1) 123252570 123252571
SHR100929895(EXT1) 105750949(EXT2)
PCW110200303(EXT1) 110223945(EXT2)
OAA100078206(EXT1) 100079286(EXT2)
GGA100858205(EXT1) 100859367(EXTL1) 425859(EXT2)
PCOC116227694(EXT1) 116229130(EXT2) 116230047(EXTL1)
MGP100542119(EXT1) 100545109 100551486(EXTL1)
CJO107310492(EXT1) 107314816(EXT2) 107324063(EXTL1)
NMEL110387476(EXTL1) 110395119(EXT1) 110401311(EXT2)
APLA101790687(EXT2) 101792373(EXT1)
ACYG106037911(EXTL1) 106038456(EXT1) 106044125(EXT2)
AFUL116485915(EXT1) 116489660(EXT2) 116498028(EXTL1)
TGU100227900(EXT1) 100231605(EXT2) 115498288(EXTL1)
LSR110472037(EXT2) 110472893(EXTL1) 110479282(EXT1)
SCAN103814231(EXT1) 103823579(EXTL1) 103826716(EXT2)
PMOA120505159(EXT1) 120512558(EXT2) 120513889(EXTL1)
OTC121333361(EXT2) 121337462(EXT1) 121342741(EXTL1)
PRUF121349516(EXT2) 121351215(EXTL1) 121355356(EXT1)
GFR102035022(EXTL1) 102040196(EXT2) 102043948(EXT1)
FAB101814666(EXT2) 101816822(EXT1) 101818678(EXTL1)
PHI102099981(EXT1) 102107359(EXT2) 102111356(EXTL1)
PMAJ107200137(EXT1) 107205846(EXT2) 107213996(EXTL1)
CCAE111925064(EXT1) 111930141(EXT2)
CCW104692676(EXT1) 104695274(EXT2)
ETL114057979(EXT1) 114064860(EXT2) 114070342(EXTL1)
ZAB102062154(EXT2) 102067827(EXT1)
FPG101919384(EXT1) 101922176(EXTL1) 101923547(EXT2)
FCH102049940(EXT1) 102054426(EXT2) 102056866(EXTL1)
CLV102084082(EXTL1) 102085197(EXT2) 102091811(EXT1)
EGZ104123693(EXT1) 104134053(EXT2) 104134955(EXTL1)
NNI104017847(EXTL1) 104018021(EXT1) 104019563(EXT2)
ACUN113476897(EXT1) 113480641(EXT2) 113488189(EXTL1)
TALA104365235(EXT1) 104367927(EXT2) 116964263(EXTL1)
PADL103914958(EXT1) 103921685(EXT2)
ACHC115333408(EXT2) 115340329(EXT1) 115351760(EXTL1)
AAM106485009 106496271(EXT1) 106498294(EXT2) 106499622
AROW112960952(EXT1) 112964418(EXTL1) 112972955 112978433(EXT2)
NPD112943491(EXT2) 112948502(EXT1) 112950897(EXTL1)
DNE112979229(EXT2) 112982032(EXTL1) 112989149(EXT1)
ASN102370729(EXT1) 102376854(EXTL1) 102379048(EXT2)
AMJ102560415(EXT1) 102562202(EXT2) 102575942(EXTL1)
CPOO109318544(EXTL1) 109321140(EXT2) 109321481(EXT1)
GGN109294162(EXTL1) 109298936(EXT2) 109299004(EXT1)
PSS102444477(EXT1) 102446763(EXT2)
CMY102929859(EXTL1) 102938478(EXT2) 102939595(EXT1)
CPIC101946173(EXT1) 101949276(EXT2) 101953823(EXTL1) 103307378
TST117868243(EXTL1) 117873767(EXT1) 117876973(EXT2)
CABI116818811(EXT1) 116830766(EXT2) 116837997(EXTL1)
MRV120389310(EXTL1) 120398808(EXT1) 120404543(EXT2)
ACS100553800(extl1) 100555771(ext2) 100567014(ext1)
PVT110076972(EXT1) 110081549(EXT2) 110084159(EXTL1)
SUND121915625(EXTL1) 121928875(EXT1) 121933481(EXT2)
PBI103048904 103054708 103062807(EXT2) 103067611(EXTL1)
PMUR107292260 107295666(EXTL1) 107302595(EXT2)
TSR106538947 106539688(EXTL1) 106545012(EXT2)
PGUT117663388(EXTL1) 117665492(EXT2) 117668371(EXT1)
VKO123019173(EXT1) 123025901(EXTL1) 123026241(EXT2)
PMUA114596253(EXT2) 114601312(EXT1) 114601546(EXTL1)
ZVI118085381(EXT2) 118086449(EXTL1) 118089708(EXT1)
GJA107110827(EXTL1) 107113379 107122615(EXT2)
XLA380140(ext2.L) 398214(ext1.L) 398750(ext2.S) 399115(ext1.S)
XTR100151709(ext2) 448393(ext1)
NPR108786158(EXT2) 108790563(EXT1)
RTEM120917049(EXT2) 120941479(EXT1)
BBUF120980295(EXT2) 121001066(EXT1)
BGAR122920720(EXT2) 122938154(EXT1)
DRE101885478 493780(ext2) 497279(ext1a) 497280(ext1b) 497281(ext1c)
SRX107706235(extl1) 107706241 107711539 107715577 107727350 107733302 107750554 107754264 107754269 107754691
SANH107654722 107654729 107659874 107671371 107671458 107683605 107685778 107688159(ext2) 107688215 107688378 107696533
SGH107558762 107562300 107586005 107592048(extl1) 107592050 107592164 107592487 107592940 107592945 107593432
CCAR109050531 109056569 109059721 109072430 109074535(ext2) 109075419 109075422 109093562 109106263 109109198 109109965 109111718
CAUA113052033 113062235 113062294 113062301 113063437 113073234 113083119 113105758 113115689 113119245 113119254 113121224
PPRM120468007(ext2) 120469966(ext1c) 120479262(ext1b) 120491188(ext1a) 120493730
IPU108256617(ext1a) 108257122(ext1b) 108257140 108271344(ext2) 108275270
PHYP113529295 113532714 113535947 113535988 113536365(ext2)
SMEO124375785(ext1b) 124375938 124390802(ext2) 124401370 124403868(ext1a)
TFD113643961(ext1c) 113649722(ext1a) 113654795 113661608(ext1b) 113663258(ext2)
AMEX103026919 103031914 103040053 103046596(ext2) 103047171 111197650
EEE113575759(ext2) 113578814 113588018(ext1) 113591568 113591687
TRU101065654 101066048(ext2) 101072426 101072822 101075972
TNGGSTEN00017827G001 GSTEN00032917G001 GSTEN00032935G001 GSTEN00035381G001 GSTEN00038113G001
LCO104919199(ext2) 104926220 104931682 104932462 104937142
NCC104945394 104949435 104961795(ext1) 104963025(ext2)
CGOB115003439 115006327(ext2) 115015568 115016180 115021154
ELY117258719(ext2) 117263289(ext1b) 117263650 117265950 117270842
PLEP121945585 121955317 121958010(ext1b) 121958038 121960250(ext2)
SLUC116034014(ext2) 116035281 116047237(ext1c) 116047249(ext1b) 116066120
ECRA117943850(ext2) 117946948 117956425(ext1b) 117956791 117961813 117961814
PFLV114553112(ext2) 114557177 114567744 114567814 114572953
GAT120807940 120808600(ext2) 120810156 120826358(ext1b) 120826673(ext1c)
PPUG119195167 119197352 119219177(ext1b) 119219200 119229335(ext2)
MSAM119890106(ext2) 119897919 119907162 119907458(ext1b) 119908630 119909485
CUD121513315 121513674(ext2) 121521338 121523384(ext1b) 121524170
MZE101464589 101473582(ext2) 101479111 101482519 101486492
ONL100695641(ext2) 100700775 100705583 100707723 109194193
OAU116309414 116318909 116318948(ext1b) 116322583 116327190(ext2)
OLA101163398(ext2) 101164181 101167217 101169374
OML112143494 112160904(ext2) 112162700(ext1b) 112162739(ext1c)
XMA102217307 102217354 102230266 102234444(ext2) 102237506
XCO114141516 114142777(ext2) 114155469 114156156 114159116
XHE116716748 116718349(ext2) 116731149 116731796 116734657
PRET103457265 103462432(ext2) 103472886(ext1) 103473086 103478346
PFOR103131421 103135121 103139431(ext2) 103151922 103154987 103155379(ext1)
PLAI106951280 106953583(ext1) 106958190(ext2) 106961006 106964918
PMEI106907411 106923397(ext1) 106926106(ext2) 106928852
GAF122821865(ext2) 122825094 122831600 122843906(ext1b) 122844227(ext1c)
CVG107082854 107085591(ext2) 107086154 107089629(ext1) 107094248 107094935
CTUL119772289(ext1c) 119775297 119777081 119778046(ext1b) 119782724(ext2)
GMU124865747 124866743(ext2) 124879655(ext1c) 124879738(ext1b) 124881887
NFU107377760 107378775 107381443(ext2) 107394502 107394966
KMR108228674(ext2) 108232308 108243943(ext1b) 108244864 108250176(ext1c)
ALIM106511501 106514225(ext1) 106527530 106530767(ext2) 106532427 106535689
NWH119418618 119425471 119425560(ext1c) 119427822(ext2)
AOCE111563665 111564587 111574611(ext2) 111580481 111589114(ext1)
CSEM103378751(ext2) 103381137 103388612(ext1) 103393992 103394040
POV109632177(ext1) 109636768(ext2) 109639984 109642456 109643173 109644500
SSEN122772353(ext2) 122774807 122784514 122786453 122786792
HHIP117758031 117758296(ext2) 117770077 117770079(ext1b) 117776501
LCF108888686 108889564 108889565 108889668(ext2) 108889677 108891202
SDU111222995 111223271 111227735 111237872 111238419(ext2)
SLAL111654812(ext2) 111658101 111671857 111671874 111672565
XGL120784183 120786451(ext1b) 120786592(ext1c) 120788958 120794269(ext2)
HCQ109514394(ext2) 109518055 109518060 109523479 109529689(ext1)
BPEC110153759 110156338 110171534 110172856(ext2) 110173279
MALB109952487 109958190 109958643 109958685 109965798(ext2) 109968834
SASA100306779(ext1c) 100380322(ext2) 106570050 106571404 106588496 106588504 106594121 106597672 106607809
OTW112217339 112229926 112229932 112247034 112250171 112264222 112264884 112264892 121844920
OMY110487634 110488385 110496112(ext1b) 110496808(ext1c) 110506669 110511734 110522229 110526537 110529611
OGO123990750 123995089 124012587 124012858(ext1b) 124017649 124033638 124035622 124043635 124043639
ONE115107751 115112435(ext2) 115128292 115128299 115131708 115131715 115139415
SALP111954432 111955132 111955294 111955814 111955850 111969484 111972462
SNH120019504 120022446 120022523 120024563 120027266 120027289 120040883 120049131
ELS105005807 105017786 105022258(ext2) 105023503 105027867
SFM108922050(ext1) 108928562 108931808 108934682(ext2) 108940524
PKI111836091 111840708(ext2) 111843930 111843931 111844061 111854291
AANG118215430(ext2) 118226079 118230580 118233246(ext1c) 118233844
LOC102688650 102688999(ext1) 102689027(ext2) 102698389
PSPA121294359 121303296 121308213 121313281 121314898 121315561 121317487 121329636
ARUT117394872 117400267 117402503 117411447 117412720 117414200 117432282 117435140 117964062
LCM102353460(EXT1) 102354369 102354854(EXTL1) 102363354(EXT2)
CMK103174976(ext2) 103179627 103184956 103185802
RTP109910890(ext2) 109930524 109932300
BFO118404100 118408274
BBEL109479557 109480278
CIN100176235 100185120
SCLV120335452 120335699
SPU100893938 115918716 577995
APLC110981069 110986223
SKO100313593 100372539 102809744
DMEDmel_CG10117(ttv) Dmel_CG8433(sotv)
DER6548926 6549168
DSE6609157 6609382
DSIDsimw501_GD11060(Dsim_GD11060) Dsimw501_GD25567(Dsim_GD25567)
DYADyak_GE13596 Dyak_GE14097
DAN6495892 6496091
DSR110177800 110178267
DPODpse_GA10084 Dpse_GA17244
DPE6590702 6590872
DMN108159562 108159662 117190510
DWI6640721 6640835
DGR6560884 6561214
DMODmoj_GI20737 Dmoj_GI20872
DAZ108615183 108615817
DNV108652943 115564114 115564922
DHE111600127 111602550
DVI6624746 6627192
CCAT101453656 101460876
BOD106617537 106618671
MDE101888783 101894872 101901385
SCAC106082419 106091369
LCQ111677016 111677307
AGAAgaP_AGAP000081 AgaP_AGAP010388
ACOZ120952216 120956752
AARA120901724 120906198
AAG5566768 5578353
AALB109397881 109411435 109416900 109428863 115254192
CQUCpipJ_CPIJ009765 CpipJ_CPIJ012734
CPII120424304 120429091
CNS116340037 116349472
AME408293 726216
ACER107997927 107999513
ALAB122711993 122714818
BIM100741317 100744382
BBIF117211962 117214192
BVK117232255 117239137
BVAN117156137 117166073
BTER100643223 100650849
BPYO122571366 122577021
CCAL108622677 108627221
OBB114871565 114871663 114880970
MGEN117220187 117224160
NMEA116429461 116432549
CGIG122399622 122404430
SOC105195910 105198634
MPHA105835292 105839250
AEC105150811 105153382
ACEP105619491 105627211
PBAR105425236 105427034
VEM105564271 105564746
HST105181013 105188235
DQU106742285 106750617
CFO105253055 105253243
FEX115235169 115240513
LHU105673709 105675813
PGC109854839 109863645
OBO105287638
PCF106790860 106791047
PFUC122518599 122523426
VPS122629883 122631850
NVI100114642 100120177
CSOL105364815 105366129
TPRE106653398
MDL103578696 103580382
CGLO123268665 123275072
FAS105265574 105268060
DAM107040372 107041901
AGIF122851929 122854354
CCIN107262845 107267679
TCA657388 659287
DPA109537981 109539467 109540738
SOY115875099 115885155
ATD109599451 109609672
CSET123316160 123321334
AGB108912966 108913506
LDC111502043 111509249
NVL108557086 108557670 108558174
APLN108740927 108743766
PPYR116163081 116164508 116166831
OTU111414203 111419426
BMOR101736061 101741346
BMAN114247002 114249440
MSEX115440710 115448364
DPLKGM_203672 KGM_214517
BANY112046889 112047335
PMAC106708978 106709701
PPOT106100685 106105805
PXU106121928 106124397
PRAP110993283 111003256
ZCE119829569 119834064
HAW110374076 110376090
TNL113496594 113505944
SLIU111353115 111357626
OFU114349767 114352413
PXY105389344 105394758 105394780
API100164685 100167795
DNX107161983 107174001
AGS114120422 114131437
RMD113556757 113560806
BTAB109034604 109035894
DCI103505288
CLEC106673227 106674189
HHAL106678975 106681771
NLU111055975 111056777
PHUPhum_PHUM455050 Phum_PHUM488440
FOC113211216 113216463
ZNE110827878 110831848
CSEC111866884 111872464
FCD110847436 110859221
DPXDAPPUDRAFT_304945 DAPPUDRAFT_307216
DMK116933752 116934955
PVM113802032 113819966 113824640
PJA122263365 122264403
PCHN125032085 125036743
HAME121864489 121869478
PCLA123758376 123769944
PTRU123501535 123501664
HAZT108671440 108677950
EAF111696021 111700775
ISCIscW_ISCW000326 IscW_ISCW021392
DSV119457583 119464578
RSAN119374094 119402119
RMP119165413 119167082
VDE111248228 111251828
VJA111265185 111268602
TUT107361403 107367244 107371591 107371607
DPTE113789732 113796479
DFR124491080 124498786
CSCU111630346 111639960
PTEP107437365 107450714
SDM118185853 118200215
CELCELE_F12F6.3(rib-1)
BMYBM_BM10349(Bma-rib-2) BM_BM3322(Bma-rib-1)
LOALOAG_05822 LOAG_08703
NAINECAME_01875 NECAME_04728
TSPTsp_04346
HROHELRODRAFT_119925 HELRODRAFT_186788
LGILOTGIDRAFT_124977 LOTGIDRAFT_199269
PCAN112561913 112565643
BGT106055537 106058680
GAE121372488 121376972
HRF124138230 124149462
HRJ124270731 124276925 124282773
CRG105324710 105325442 117690299
MYI110443488 110451580
PMAX117317139 117326975
MMER123539606 123552181
OBI106867259 106868410
OSN115223691 115230884
LAK106155252 106175986 106181741
SMMSmp_146320.1 Smp_172060
SHXMS3_0016615
OVIT265_05866 T265_05932
EGLEGR_02934
NVE5505005 5510789
EPA110240280 110241454 110241460
ATEN116298104 116307177
ADF107336652 107336815 107358713
AMIL114957442 114961284
PDAM113666284 113669827
SPIS111326534 111336973
DGT114528496 114537265
XEN124438051 124457859
HMG100208615 100212044
TADTRIADDRAFT_1026 TRIADDRAFT_24279
AQU100636774 100641175
SMOSELMODRAFT_23945 SELMODRAFT_24030
PPP112279610 112280248 112280650 112281934 112282628 112290993 112294684
FPUFPSE_06328
FVRFVEG_11257
FOXFOXG_13828
NHENECHADRAFT_84083
SREPTSG_07269 PTSG_10121
ACANACA1_335890 ACA1_393390
PTIPHATRDRAFT_11259
FCYFRACYDRAFT_160829 FRACYDRAFT_234481
TPSTHAPSDRAFT_263396
 » show all
Reference
1  [PMID:11256613]
  Authors
Senay C, Lind T, Muguruma K, Tone Y, Kitagawa H, Sugahara K, Lidholt K, Lindahl U, Kusche-Gullberg M.
  Title
The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.
  Journal
EMBO Rep 1:282-6 (2000)
DOI:10.1093/embo-reports/kvd045
  Sequence
[bta:281151]
Reference
2  [PMID:9756849]
  Authors
Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K
  Title
The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate.
  Journal
J Biol Chem 273:26265-8 (1998)
DOI:10.1074/jbc.273.41.26265
  Sequence
[bta:281151]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.225
IUBMB Enzyme Nomenclature: 2.4.1.225
ExPASy - ENZYME nomenclature database: 2.4.1.225
BRENDA, the Enzyme Database: 2.4.1.225
CAS: 145539-84-0
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