KEGG   ENZYME: 2.4.1.228
Entry
EC 2.4.1.228                Enzyme                                 
Name
lactosylceramide 4-alpha-galactosyltransferase;
Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase;
globotriaosylceramide/CD77 synthase;
histo-blood group Pk UDP-galactose;
UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl(1<->1)ceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03486 R05960]
Reaction(KEGG)
R03486 R05960(G);
(other) R11375(G) R11376(G) R11377(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]
Comment
For explanation of superscript II in systematic name, see {iupac/2carb/37#372::2-carb.37}.
History
EC 2.4.1.228 created 2002
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K01988  lactosylceramide 4-alpha-galactosyltransferase
Genes
HSA53947(A4GALT)
PTR470230(A4GALT)
PPS100981788(A4GALT)
GGO101148084(A4GALT)
PON100172807(A4GALT)
NLE100582945(A4GALT)
MCC710998(A4GALT)
MCF102134894(A4GALT)
CSAB103223426(A4GALT)
CATY105598322(A4GALT)
PANU101018834(A4GALT)
TGE112633684(A4GALT)
RRO104668998(A4GALT)
RBB108514019(A4GALT)
TFN117096373(A4GALT)
PTEH111548923(A4GALT)
CJC100399091 100399258(A4GALT)
SBQ101049376(A4GALT)
CSYR103252710(A4GALT)
MMUR105858530(A4GALT)
OGA100951617(A4GALT)
MMU239559(A4galt)
MCAL110310458(A4galt)
MPAH110335243(A4galt)
RNO63888(A4galt)
MCOC116076817(A4galt)
MUN110552095(A4galt)
CGE100770462(A4galt)
PLEU114686395(A4galt) 114702818
NGI103743444(A4galt)
HGL101717743(A4galt)
CPOC100721247(A4galt)
CCAN109693113(A4galt)
DORD105992037(A4galt)
DSP122123590(A4galt)
NCAR124983198
OCU100347783(A4GALT)
OPI101533509(A4GALT)
TUP102482240(A4GALT)
CFA481222(A4GALT)
VVP112934050(A4GALT)
VLG121491575(A4GALT)
AML100473471(A4GALT)
UMR103674056(A4GALT)
UAH113241688(A4GALT)
UAR123780737(A4GALT)
ELK111157575
LLV125107394
MPUF101692689(A4GALT)
ORO101378243(A4GALT)
EJU114218319(A4GALT)
ZCA113921737(A4GALT)
MLX117998600(A4GALT)
FCA101085732(A4GALT)
PYU121040228(A4GALT)
PBG122472858(A4GALT)
PTG102966914(A4GALT)
PPAD109265669(A4GALT)
AJU106967275(A4GALT)
HHV120235109(A4GALT)
BTA618369(A4GALT)
BOM102281081(A4GALT)
BIU109559887(A4GALT)
CHX102190112(A4GALT)
OAS101106675(A4GALT)
ODA120857564(A4GALT)
CCAD122423689(A4GALT)
SSC100524987(A4GALT)
CFR102519432(A4GALT)
CBAI105073047(A4GALT)
CDK105091872(A4GALT)
VPC102534670(A4GALT)
BACU103010830(A4GALT) 103013262
LVE103069366(A4GALT)
OOR101275372(A4GALT)
DLE111186415(A4GALT)
PCAD102992800(A4GALT)
PSIU116760331(A4GALT)
ECB102150730(A4GALT)
EPZ103560176(A4GALT)
EAI106845936(A4GALT)
MYB102242406(A4GALT)
MYD102751675(A4GALT)
MMYO118651428(A4GALT)
MNA107535002(A4GALT)
PKL118712046(A4GALT)
HAI109371482(A4GALT)
DRO112321863(A4GALT)
SHON118974919(A4GALT)
AJM119060201(A4GALT)
PDIC114513477(A4GALT)
PHAS123816155(A4GALT)
MMF118624674(A4GALT)
RFQ117029224(A4GALT)
PALE102884849(A4GALT)
PGIG120602920(A4GALT)
PVP105298021(A4GALT)
RAY107505557(A4GALT)
MJV108384701(A4GALT)
TOD119247181(A4GALT) 119251252 119251299
SARA101547961(A4GALT)
LAV100654825(A4GALT)
TMU101343100
DNM101434316(A4GALT)
MDO100017110(A4GALT)
GAS123250290(A4GALT)
SHR100925030(A4GALT)
PCW110205872(A4GALT)
OAA100090950(A4GALT)
GGA418223(A4GALT)
PCOC116231434(A4GALT)
MGP100550373(A4GALT)
CJO107317221(A4GALT)
NMEL110396623(A4GALT)
APLA101791613(A4GALT)
ACYG106038268(A4GALT)
AFUL116496629(A4GALT)
TGU100222013 100224928 100227822 116807715
LSR110475200(A4GALT)
SCAN103819578 103819579
PMOA120507702 120507714
OTC121332070(A4GALT)
PRUF121352094(A4GALT)
GFR102036341 102038089(A4GALT)
FAB101814853 101816816
PHI102110169(A4GALT) 106628858
PMAJ107204192 107205156
CCAE111929644 111929661
CCW104696146 120409617
ETL114068557(A4GALT)
ZAB106629206(A4GALT)
FPG101921227(A4GALT) 101921402
FCH102057844 102058020
CLV102083490 102086854 102098242 102098421 102098604 102098778 102098963
EGZ104133947 104135101 104135149
NNI104012683 104012684 104012685
ACUN113487299 113487324
TALA104369229(A4GALT)
PADL103924312(A4GALT) 103924314
ACHC115352503 115352504(A4GALT)
AAM106488964 106488984
AROW112967088
NPD112960148(A4GALT)
DNE112991535(A4GALT)
ASN102382036(A4GALT)
AMJ102568489(A4GALT)
CPOO109316363(A4GALT)
GGN109297044(A4GALT)
PSS102459009(A4GALT)
CMY102947245(A4GALT)
CPIC101950887(A4GALT)
TST117883679(A4GALT)
CABI116822229(A4GALT)
MRV120372162(A4GALT)
ACS100558212(a4galt)
PVT110087161(A4GALT)
SUND121932251(A4GALT)
VKO123033921(A4GALT)
PMUA114596898(A4GALT)
ZVI118096287(A4GALT)
GJA107120303(A4GALT)
STOW125435622(A4GALT)
XLA108710180(a4galt.L)
XTR100495236(a4galt)
NPR108804610(A4GALT)
RTEM120930880(A4GALT)
BBUF121004002(A4GALT)
BGAR122926600(A4GALT)
LCM102352578 102358135 102364135(A4GALT) 102367121
RTP109916623(a4galt)
DMEDmel_CG17223(alpha4GT1) Dmel_CG5878(alpha4GT2)
DER6541374 6554314
DSE6613189 6616976
DSIDsimw501_GD11999(Dsim_GD11999) Dsimw501_GD21237(Dsim_GD21237)
DYADyak_GE14957 Dyak_GE23622
DAN6497573 6499569
DSR110183976
DPODpse_GA14400 Dpse_GA26016 Dpse_GA30827
DPE113565738 6589409 6589411
DMN108161990 108161991 108161994
DWI6642353
DGR6562020 6562021 6566712 6566713
DMODmoj_GI17430 Dmoj_GI17680 Dmoj_GI21097 Dmoj_GI21107 Dmoj_GI21149
DAZ108609667 108611322 108612040 108620613
DNV115563365 115563959
DHE111603754 111603769 111605531 111605535 115483235
DVI6627856 6627857 6627858 6629103 6629105 6629107 6629280
CCAT101455647
BOD106622044
MDE101898147
SCAC106082269
LCQ111687695
AGAAgaP_AGAP008258 AgaP_AGAP008259 AgaP_AGAP008260 AgaP_AGAP008261
ACOZ120955836 120955837
AARA120903323 120903324
AAG5565850 5572805 5572806
AALB109402519 109427936
CQUCpipJ_CPIJ001089 CpipJ_CPIJ001090 CpipJ_CPIJ001091 CpipJ_CPIJ019406 CpipJ_CPIJ019517
CPII120425038 120425084 120425089 120425090 120429786 120432453
CNS116343366 116346147 116346148 116346177 116346186 116346203 116346455 116347549 116348214 116351290
AME107965795 727510
ACER108001242 108001243 114577964
ALAB122719560
BIM100740409
BBIF117204463
BVK117233190
BVAN117153713
BTER100650768
BPYO122569170
CCAL108621932 108625680 108625708 108625772 108627168
OBB114871060
MGEN117222510
NMEA116425188
CGIG122395080
SOC105196183
MPHA105835340
AEC105145775
ACEP105624197 105624198
PBAR105430148 105430149
VEM105565147 105565148
HST105190591
DQU106752134
CFO105257223 105257248
LHU105678152
PGC109860132
PCF106792676
PFUC122518159
VPS122627604
NVI100115564
CSOL105359116
TPRE106649743 106651197
MDL103571850 103573985
CGLO123266288 123271667
FAS105265524
DAM107036410 107036540 107036541
AGIF122852499 122852895 122857547
CCIN107268984
TCA658448
DPA109537807 109543422
SOY115879082 115879084 115879186 115879188 115879227 115879248 115886044 115887748
ATD109596701 109602899 109608855
CSET123317327
AGB108914028
LDC111506093
NVL108558122
APLN108735466
PPYR116158876 116158877 116178097 116178530
OTU111413822 111413825 111418750 111419359 111420801 111421634 111424365 111426133
BMOR101745697
MSEX115448675
DPLKGM_210837
PMAC106707989 106716470
PPOT106102281 106109867
PXU106114144 106121085
PRAP111002820 123689406
ZCE119832516 119832562
HAW110376515 110376518 110376525 110376528
TNL113493751 113494791 113494792 113494827 113495305 113500611
SLIU111348404 111359776 111361926 111361951
OFU114361973 114361975
API100570817 100571406
DNX107166115
AGS114120620
RMD113556895
BTAB109031587 109033354 109033359 109033413 109034972 109043166
DCI103505501
CLEC106661801 106667625
HHAL106685363 106687390
NLU111043264
PHUPhum_PHUM591580
FOC113213782
ZNE110839021 110839023 110839024 110839025
CSEC111861228 111864855 111864876 111864880
DPXDAPPUDRAFT_111182 DAPPUDRAFT_224373 DAPPUDRAFT_227867 DAPPUDRAFT_239739 DAPPUDRAFT_239742 DAPPUDRAFT_246526 DAPPUDRAFT_25035 DAPPUDRAFT_25102 DAPPUDRAFT_25188 DAPPUDRAFT_255611 DAPPUDRAFT_262661 DAPPUDRAFT_305581 DAPPUDRAFT_308011 DAPPUDRAFT_316974 DAPPUDRAFT_316981 DAPPUDRAFT_32452 DAPPUDRAFT_328228 DAPPUDRAFT_330627 DAPPUDRAFT_3999 DAPPUDRAFT_4146 DAPPUDRAFT_4415 DAPPUDRAFT_49127 DAPPUDRAFT_49182 DAPPUDRAFT_49282 DAPPUDRAFT_60032 DAPPUDRAFT_63609 DAPPUDRAFT_63673 DAPPUDRAFT_67050 DAPPUDRAFT_72860
DMK116920953 116920959 116920960 116921665 116921825 116925995 116926000 116926053 116926060 116926826 116926830 116926831 116926836 116927014 116927015 116927016 116927619 116928054 116928377 116929717 116931330 116931449 116931451 116934336 123470428 123470455
PVM113807137 113816148 113818701 113818702 113819942 113819943 113826491 113829410 113830013 113830017
PJA122243879 122244468 122245385 122250879 122255275 122257961 122261205 122261206 122261650 122266598
PCHN125027724 125027902 125028862 125028863 125028864 125029140 125030804 125036716 125041817 125042062 125045356 125045357 125045374
HAME121855370 121857490 121859462 121859625 121859627 121859892 121866305 121869219 121869248 121872466
PCLA123745013 123754537 123759876 123761833 123761896 123764871 123765081 123766994 123770274
PTRU123503072 123508246 123509868 123520790
HAZT108665092 108665095 108668098 108668121 108672808 108673948 108674159 108681092 108681331 108682791
EAF111696522 111697478 111700658
LSM121116576 121119628 121126163 121127713 121127888 121128732 121129184 121129702
ISCIscW_ISCW001764 IscW_ISCW006262 IscW_ISCW006436 IscW_ISCW016806 IscW_ISCW023632 IscW_ISCW024908
DSV119439938 119440329 119441742 119446311 119449037 119457468 119462340 119465378
RSAN119373375 119373936 119375628 119381862 119385731 119386032 119386579 119386902 119391167 119391206 119401768 119401778
RMP119164302 119167885 119175991 119177826 119178731 119185556
CSCU111619600 111624323 111633299 111633300 111633301 111634269 111637798 111637802 111637815 111641513
PTEP107445145
SDM118194672
DGT114528755
ATHAT1G61050 AT2G38150 AT2G38152 AT3G09020 AT5G01250
ALY110224139 9309087 9315797 9317634 9318666 9322635
CRB17883816 17887713 17888432 17892042 17892158 17895616
CSAT104703696 104708969 104714434 104725095 104734178 104745062 104748339 104752773 104760592 104764595 104768340 104771514 104782249 104785659 104785660 104788923 104789876 104792610 104792613 109128472
EUSEUTSA_v10015400mg EUTSA_v10016818mg EUTSA_v10017675mg EUTSA_v10022431mg EUTSA_v10023465mg
BRP103838463 103847504 103848331 103867132 103867134 103870568
BNA106361585 106375187 106377506 106401051 106427911 106429327(BNAC04G07180D) 106429349 106435157 106435158 106435867 106435876 106448995 106452139 111199955 111205128 111205401 111215554 111215802
BOE106292917 106297793 106316533 106317240 106328068 106338355 106339612 106341154
RSZ108807329 108807593 108809947 108809965 108810169 108810529 108818126 108826946 108850990 108850991 108861212
THJ104805842 104806605 104806606 104807017 104809572 104816211
CPAP110807709 110813036 110814024
CIT102611987 102612578 102613019 102619808 107177427 112498639
CICCICLE_v10011728mg CICLE_v10013378mg CICLE_v10013470mg CICLE_v10013606mg CICLE_v10013615mg CICLE_v10015246mg
PVY116108748 116119642 116119668 116133248 116133751 116133752
MINC123193698 123212707 123212780 123218616 123223281 123223316 123223542 123223569 123223594 123223678 123223723
TCC18596888 18597570 18597572 18597573
GRA105774702 105778472 105780720 105780980 105799938
GHI107889767 107890972 107899525 107899526 107924960 107930131 107930134 107937745 107963355
GAB108456221 108458268 108459467 108485691 108488674
DZI111278196 111294934 111295564 111297022 111297857 111311124 111311125 111318753
EGR104420130 104426383 104445309
GMX100781975 100789203 100809042 100812965
GSJ114375273 114388090 114415727 114419151
PVUPHAVU_006G188000g PHAVU_008G105700g PHAVU_010G003100g
VRA106770172 106775580
VAR108327324 108342513
VUN114167356 114184006 114189223
CCAJ109788418 109791649 109804301
APRC113850181 113852071 113862429
MTRMTR_2g013300 MTR_7g067510
CAM101490091 101507256
LJALj1g3v2311890.1(Lj1g3v2311890.1) Lj1g3v2311900.1(Lj1g3v2311900.1) Lj6g3v2044530.1(Lj6g3v2044530.1)
ADU107468484 107475176 107484863 107484864 107484865 107484866 107484867 107484868
AIP107619912 107622069 107625731 107636678 107637879 107637880 107637882 107639480 107639481
AHF112718119 112727967 112740477 112740478 112740483 112742850 112743612 112750088 112783364 112784177 112796992 112796993 112796995 112796996 112796997 112796998
LANG109329644
FVE101292321 101292329 101292620 101309514
RCN112166304 112193033 112193915 112194908
PPER18773272 18774761 18778355
PMUM103324721 103343036
PAVI110765067 110765068 110765069 110766754 110766813
PDUL117625067 117630533 117633120
MDM103433582 103434765 103450614 103450623
PXB103928093 103936603 103936613 103966356 103966366 103966368
ZJU107409623 107430777 107430781 107430783
MNT21395346 21398673 21398676
CSV101219707 101220697
CMO103486194 103486309
BHJ120090207 120091871
MCHA111010894 111014925
CMAX111470132 111481968 111495773
CMOS111434013 111441769 111452297
CPEP111790672 111800313
RCU8269398 8278556
JCU105646616 105649509
HBR110634787 110641684 110643007 110661946
MESC110604274 110620259 110622526
POP7485449 7487351 7487465 7494355
PEU105128072 105141779 105142080
PALZ118031690 118037451 118047339
JRE108981006 108982233 108994894 108995110
QSU112013126 112031691 112031696 112031697 112031698 112031710 112035503
QLO115952589 115953959 115965593 115992543
TWL119988360 119989915 120005245
VVI100247748 100853373 104878362
VRI117919693 117923299
SLY101250644 101265092 101267735
SPEN107001788 107010967 107029946
SOT102584175 102589435 102603042
CANN107846007 107859407
NTA107759048 107761292 107769309 107808382
NSY104235543 104241090
NTO104105601 104115402
NAU109207433 109232960
INI109159022 109159071
ITR116028636 116030528
SIND105161620 105167919 105174549 105175636
OEU111365245 111368426 111370115 111370560 111376052
EGT105951483 105953069 105969062 105970164
SSPL121742518 121769711 121790184 121798187 121802222 121809638
HAN110885588 110898814 110913099 110915918 110925514 110937858
ECAD122591662 122597107 122607652
LSV111890673 111891202 111891640 111903977
CCAV112512797 112518238 112523797 112526980
DCR108197433 108206582 108217871 108222688
CSIN114277353 114287504 114322533
BVG104900747 104904814 104905065
SOE110786576 110788017
CQI110685033 110693584 110706872
NNU104586450 104588792 104588883 104596957 104601237
MING122092467 122093560
TSS122640624 122670787
PSOM113306329 113310452 113323491
NCOL116252357 116254064
OSA4336475
DOSAOs04t0529700-01(Os04g0529700)
OBR102717891
BDI100831105
ATS109732097
TDC119359708 119361016
TAES123041651 123053927 123185722
SBI8082872
ZMA100283564
SITA101786409
SVS117863523
PVIR120642424
PHAI112899501
PDA103701621 103716220 103721120
EGU105042837 105042838 105053509 105055492
MUS103968640
DCT110109954
AOF109820034
ATR18423117 18437915
SMOSELMODRAFT_419460(GT32A2)
PPP112286443 112288960
 » show all
Reference
1  [PMID:3099784]
  Authors
Bailly P, Piller F, Cartron JP, Leroy Y, Fournet B.
  Title
Identification of UDP-galactose: lactose (lactosylceramide) alpha-4 and beta-3 galactosyltransferases in human kidney.
  Journal
Biochem Biophys Res Commun 141:84-91 (1986)
DOI:10.1016/S0006-291X(86)80338-2
Reference
2  [PMID:10747952]
  Authors
Steffensen R, Carlier K, Wiels J, Levery SB, Stroud M, Cedergren B, Nilsson Sojka B, Bennett EP, Jersild C, Clausen H.
  Title
Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.
  Journal
J Biol Chem 275:16723-9 (2000)
DOI:10.1074/jbc.M000728200
  Sequence
[hsa:53947]
Reference
3  [PMID:10748143]
  Authors
Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  Title
Molecular cloning of globotriaosylceramide/CD77 synthase, aglycosyltransferase that initiates the synthesis of globo seriesglycosphingolipids.
  Journal
J Biol Chem 275:15152-6 (2000)
DOI:10.1074/jbc.M909620199
  Sequence
[hsa:53947]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.228
IUBMB Enzyme Nomenclature: 2.4.1.228
ExPASy - ENZYME nomenclature database: 2.4.1.228
BRENDA, the Enzyme Database: 2.4.1.228
CAS: 52725-57-2
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