KEGG ENZYME: 2.4.1.228

ENZYME: 2.4.1.228

Entry

EC 2.4.1.228                Enzyme

Name

lactosylceramide 4-alpha-galactosyltransferase;
Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase;
globotriaosylceramide/CD77 synthase;
histo-blood group Pk UDP-galactose;
UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl(1<->1)ceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase

Reaction(IUBMB)

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03486 R05960]

Reaction(KEGG)

R03486 R05960(G);
(other) R11375(G) R11376(G) R11377(G)

Substrate

UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]

Product

UDP [CPD:C00015];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]

Comment

For explanation of superscript II in systematic name, see {iupac/2carb/37#372::2-carb.37}.

History

EC 2.4.1.228 created 2002

Pathway

ec00601

Glycosphingolipid biosynthesis - lacto and neolacto series

ec00603

Glycosphingolipid biosynthesis - globo and isoglobo series

ec01100

Metabolic pathways

Orthology

K01988

lactosylceramide 4-alpha-galactosyltransferase

Genes

HSA:	53947(A4GALT)

PTR:	470230(A4GALT)

PPS:	100981788(A4GALT)

GGO:	101148084(A4GALT)

PON:	100172807(A4GALT)

NLE:	100582945(A4GALT)

MCC:	710998(A4GALT)

MCF:	102134894(A4GALT)

CSAB:

103223426(A4GALT)

CATY:

105598322(A4GALT)

PANU:

101018834(A4GALT)

TGE:	112633684(A4GALT)

RRO:	104668998(A4GALT)

RBB:	108514019(A4GALT)

TFN:	117096373(A4GALT)

PTEH:

111548923(A4GALT)

CJC:	100399091 100399258(A4GALT)

SBQ:	101049376(A4GALT)

CSYR:

103252710(A4GALT)

MMUR:

105858530(A4GALT)

OGA:	100951617(A4GALT)

MMU:	239559(A4galt)

MCAL:

110310458(A4galt)

MPAH:

110335243(A4galt)

RNO:	63888(A4galt)

MCOC:

116076817(A4galt)

MUN:	110552095(A4galt)

CGE:	100770462(A4galt)

PLEU:

114686395(A4galt) 114702818

NGI:	103743444(A4galt)

HGL:	101717743(A4galt)

CPOC:

100721247(A4galt)

CCAN:

109693113(A4galt)

DORD:

105992037(A4galt)

DSP:	122123590(A4galt)

NCAR:

124983198

OCU:	100347783(A4GALT)

OPI:	101533509(A4GALT)

TUP:	102482240(A4GALT)

CFA:	481222(A4GALT)

VVP:	112934050(A4GALT)

VLG:	121491575(A4GALT)

AML:	100473471(A4GALT)

UMR:	103674056(A4GALT)

UAH:	113241688(A4GALT)

UAR:	123780737(A4GALT)

ELK:

111157575

LLV:

125107394

MPUF:

101692689(A4GALT)

ORO:	101378243(A4GALT)

EJU:	114218319(A4GALT)

ZCA:	113921737(A4GALT)

MLX:	117998600(A4GALT)

FCA:	101085732(A4GALT)

PYU:	121040228(A4GALT)

PBG:	122472858(A4GALT)

PTG:	102966914(A4GALT)

PPAD:

109265669(A4GALT)

AJU:	106967275(A4GALT)

HHV:	120235109(A4GALT)

BTA:	618369(A4GALT)

BOM:	102281081(A4GALT)

BIU:	109559887(A4GALT)

CHX:	102190112(A4GALT)

OAS:	101106675(A4GALT)

ODA:	120857564(A4GALT)

CCAD:

122423689(A4GALT)

SSC:	100524987(A4GALT)

CFR:	102519432(A4GALT)

CBAI:

105073047(A4GALT)

CDK:	105091872(A4GALT)

VPC:	102534670(A4GALT)

BACU:

103010830(A4GALT) 103013262

LVE:	103069366(A4GALT)

OOR:	101275372(A4GALT)

DLE:	111186415(A4GALT)

PCAD:

102992800(A4GALT)

PSIU:

116760331(A4GALT)

ECB:	102150730(A4GALT)

EPZ:	103560176(A4GALT)

EAI:	106845936(A4GALT)

MYB:	102242406(A4GALT)

MYD:	102751675(A4GALT)

MMYO:

118651428(A4GALT)

MNA:	107535002(A4GALT)

PKL:	118712046(A4GALT)

HAI:	109371482(A4GALT)

DRO:	112321863(A4GALT)

SHON:

118974919(A4GALT)

AJM:	119060201(A4GALT)

PDIC:

114513477(A4GALT)

PHAS:

123816155(A4GALT)

MMF:	118624674(A4GALT)

RFQ:	117029224(A4GALT)

PALE:

102884849(A4GALT)

PGIG:

120602920(A4GALT)

PVP:	105298021(A4GALT)

RAY:	107505557(A4GALT)

MJV:	108384701(A4GALT)

TOD:	119247181(A4GALT) 119251252 119251299

SARA:

101547961(A4GALT)

LAV:	100654825(A4GALT)

TMU:

101343100

DNM:	101434316(A4GALT)

MDO:	100017110(A4GALT)

GAS:	123250290(A4GALT)

SHR:	100925030(A4GALT)

PCW:	110205872(A4GALT)

OAA:	100090950(A4GALT)

GGA:	418223(A4GALT)

PCOC:

116231434(A4GALT)

MGP:	100550373(A4GALT)

CJO:	107317221(A4GALT)

NMEL:

110396623(A4GALT)

APLA:

101791613(A4GALT)

ACYG:

106038268(A4GALT)

AFUL:

116496629(A4GALT)

TGU:	100222013 100224928 100227822 116807715

LSR:	110475200(A4GALT)

SCAN:

103819578 103819579

PMOA:

120507702 120507714

OTC:	121332070(A4GALT)

PRUF:

121352094(A4GALT)

GFR:	102036341 102038089(A4GALT)

FAB:	101814853 101816816

PHI:	102110169(A4GALT) 106628858

PMAJ:

107204192 107205156

CCAE:

111929644 111929661

CCW:	104696146 120409617

ETL:	114068557(A4GALT)

ZAB:	106629206(A4GALT)

FPG:	101921227(A4GALT) 101921402

FCH:	102057844 102058020

CLV:	102083490 102086854 102098242 102098421 102098604 102098778 102098963

EGZ:	104133947 104135101 104135149

NNI:	104012683 104012684 104012685

ACUN:

113487299 113487324

TALA:

104369229(A4GALT)

PADL:

103924312(A4GALT) 103924314

ACHC:

115352503 115352504(A4GALT)

AAM:	106488964 106488984

AROW:

112967088

NPD:	112960148(A4GALT)

DNE:	112991535(A4GALT)

ASN:	102382036(A4GALT)

AMJ:	102568489(A4GALT)

CPOO:

109316363(A4GALT)

GGN:	109297044(A4GALT)

PSS:	102459009(A4GALT)

CMY:	102947245(A4GALT)

CPIC:

101950887(A4GALT)

TST:	117883679(A4GALT)

CABI:

116822229(A4GALT)

MRV:	120372162(A4GALT)

ACS:	100558212(a4galt)

PVT:	110087161(A4GALT)

SUND:

121932251(A4GALT)

VKO:	123033921(A4GALT)

PMUA:

114596898(A4GALT)

ZVI:	118096287(A4GALT)

GJA:	107120303(A4GALT)

STOW:

125435622(A4GALT)

XLA:	108710180(a4galt.L)

XTR:	100495236(a4galt)

NPR:	108804610(A4GALT)

RTEM:

120930880(A4GALT)

BBUF:

121004002(A4GALT)

BGAR:

122926600(A4GALT)

LCM:	102352578 102358135 102364135(A4GALT) 102367121

RTP:	109916623(a4galt)

DME:	Dmel_CG17223(alpha4GT1) Dmel_CG5878(alpha4GT2)

DER:	6541374 6554314

DSE:	6613189 6616976

DSI:	Dsimw501_GD11999(Dsim_GD11999) Dsimw501_GD21237(Dsim_GD21237)

DYA:	Dyak_GE14957 Dyak_GE23622

DAN:	6497573 6499569

DSR:

110183976

DPO:	Dpse_GA14400 Dpse_GA26016 Dpse_GA30827

DPE:	113565738 6589409 6589411

DMN:	108161990 108161991 108161994

DWI:

6642353

DGR:	6562020 6562021 6566712 6566713

DMO:	Dmoj_GI17430 Dmoj_GI17680 Dmoj_GI21097 Dmoj_GI21107 Dmoj_GI21149

DAZ:	108609667 108611322 108612040 108620613

DNV:	115563365 115563959

DHE:	111603754 111603769 111605531 111605535 115483235

DVI:	6627856 6627857 6627858 6629103 6629105 6629107 6629280

CCAT:

101455647

BOD:

106622044

MDE:

101898147

SCAC:

106082269

LCQ:

111687695

AGA:	AgaP_AGAP008258 AgaP_AGAP008259 AgaP_AGAP008260 AgaP_AGAP008261

ACOZ:

120955836 120955837

AARA:

120903323 120903324

AAG:	5565850 5572805 5572806

AALB:

109402519 109427936

CQU:	CpipJ_CPIJ001089 CpipJ_CPIJ001090 CpipJ_CPIJ001091 CpipJ_CPIJ019406 CpipJ_CPIJ019517

CPII:

120425038 120425084 120425089 120425090 120429786 120432453

CNS:	116343366 116346147 116346148 116346177 116346186 116346203 116346455 116347549 116348214 116351290

AME:	107965795 727510

ACER:

108001242 108001243 114577964

ALAB:

122719560

BIM:

100740409

BBIF:

117204463

BVK:

117233190

BVAN:

117153713

BTER:

100650768

BPYO:

122569170

CCAL:

108621932 108625680 108625708 108625772 108627168

OBB:

114871060

MGEN:

117222510

NMEA:

116425188

CGIG:

122395080

SOC:

105196183

MPHA:

105835340

AEC:

105145775

ACEP:

105624197 105624198

PBAR:

105430148 105430149

VEM:	105565147 105565148

HST:

105190591

DQU:

106752134

CFO:	105257223 105257248

LHU:

105678152

PGC:

109860132

PCF:

106792676

PFUC:

122518159

VPS:

122627604

NVI:

100115564

CSOL:

105359116

TPRE:

106649743 106651197

MDL:	103571850 103573985

CGLO:

123266288 123271667

FAS:

105265524

DAM:	107036410 107036540 107036541

AGIF:

122852499 122852895 122857547

CCIN:

107268984

TCA:

658448

DPA:	109537807 109543422

SOY:	115879082 115879084 115879186 115879188 115879227 115879248 115886044 115887748

ATD:	109596701 109602899 109608855

CSET:

123317327

AGB:

108914028

LDC:

111506093

NVL:

108558122

APLN:

108735466

PPYR:

116158876 116158877 116178097 116178530

OTU:	111413822 111413825 111418750 111419359 111420801 111421634 111424365 111426133

BMOR:

101745697

MSEX:

115448675

DPL:	KGM_210837

PMAC:

106707989 106716470

PPOT:

106102281 106109867

PXU:	106114144 106121085

PRAP:

111002820 123689406

ZCE:	119832516 119832562

HAW:	110376515 110376518 110376525 110376528

TNL:	113493751 113494791 113494792 113494827 113495305 113500611

SLIU:

111348404 111359776 111361926 111361951

OFU:	114361973 114361975

API:	100570817 100571406

DNX:

107166115

AGS:

114120620

RMD:

113556895

BTAB:

109031587 109033354 109033359 109033413 109034972 109043166

DCI:

103505501

CLEC:

106661801 106667625

HHAL:

106685363 106687390

NLU:

111043264

PHU:	Phum_PHUM591580

FOC:

113213782

ZNE:	110839021 110839023 110839024 110839025

CSEC:

111861228 111864855 111864876 111864880

DPX:

DAPPUDRAFT_111182 DAPPUDRAFT_224373 DAPPUDRAFT_227867 DAPPUDRAFT_239739 DAPPUDRAFT_239742 DAPPUDRAFT_246526 DAPPUDRAFT_25035 DAPPUDRAFT_25102 DAPPUDRAFT_25188 DAPPUDRAFT_255611 DAPPUDRAFT_262661 DAPPUDRAFT_305581 DAPPUDRAFT_308011 DAPPUDRAFT_316974 DAPPUDRAFT_316981 DAPPUDRAFT_32452 DAPPUDRAFT_328228 DAPPUDRAFT_330627 DAPPUDRAFT_3999 DAPPUDRAFT_4146 DAPPUDRAFT_4415 DAPPUDRAFT_49127 DAPPUDRAFT_49182 DAPPUDRAFT_49282 DAPPUDRAFT_60032 DAPPUDRAFT_63609 DAPPUDRAFT_63673 DAPPUDRAFT_67050 DAPPUDRAFT_72860

DMK:	116920953 116920959 116920960 116921665 116921825 116925995 116926000 116926053 116926060 116926826 116926830 116926831 116926836 116927014 116927015 116927016 116927619 116928054 116928377 116929717 116931330 116931449 116931451 116934336 123470428 123470455

PVM:	113807137 113816148 113818701 113818702 113819942 113819943 113826491 113829410 113830013 113830017

PJA:	122243879 122244468 122245385 122250879 122255275 122257961 122261205 122261206 122261650 122266598

PCHN:

125027724 125027902 125028862 125028863 125028864 125029140 125030804 125036716 125041817 125042062 125045356 125045357 125045374

HAME:

121855370 121857490 121859462 121859625 121859627 121859892 121866305 121869219 121869248 121872466

PCLA:

123745013 123754537 123759876 123761833 123761896 123764871 123765081 123766994 123770274

PTRU:

123503072 123508246 123509868 123520790

HAZT:

108665092 108665095 108668098 108668121 108672808 108673948 108674159 108681092 108681331 108682791

EAF:	111696522 111697478 111700658

LSM:	121116576 121119628 121126163 121127713 121127888 121128732 121129184 121129702

ISC:	IscW_ISCW001764 IscW_ISCW006262 IscW_ISCW006436 IscW_ISCW016806 IscW_ISCW023632 IscW_ISCW024908

DSV:	119439938 119440329 119441742 119446311 119449037 119457468 119462340 119465378

RSAN:

119373375 119373936 119375628 119381862 119385731 119386032 119386579 119386902 119391167 119391206 119401768 119401778

RMP:	119164302 119167885 119175991 119177826 119178731 119185556

CSCU:

111619600 111624323 111633299 111633300 111633301 111634269 111637798 111637802 111637815 111641513

PTEP:

107445145

SDM:

118194672

DGT:

114528755

ATH:	AT1G61050 AT2G38150 AT2G38152 AT3G09020 AT5G01250

ALY:	110224139 9309087 9315797 9317634 9318666 9322635

CRB:	17883816 17887713 17888432 17892042 17892158 17895616

CSAT:

104703696 104708969 104714434 104725095 104734178 104745062 104748339 104752773 104760592 104764595 104768340 104771514 104782249 104785659 104785660 104788923 104789876 104792610 104792613 109128472

EUS:	EUTSA_v10015400mg EUTSA_v10016818mg EUTSA_v10017675mg EUTSA_v10022431mg EUTSA_v10023465mg

BRP:	103838463 103847504 103848331 103867132 103867134 103870568

BNA:	106361585 106375187 106377506 106401051 106427911 106429327(BNAC04G07180D) 106429349 106435157 106435158 106435867 106435876 106448995 106452139 111199955 111205128 111205401 111215554 111215802

BOE:	106292917 106297793 106316533 106317240 106328068 106338355 106339612 106341154

RSZ:	108807329 108807593 108809947 108809965 108810169 108810529 108818126 108826946 108850990 108850991 108861212

THJ:	104805842 104806605 104806606 104807017 104809572 104816211

CPAP:

110807709 110813036 110814024

CIT:	102611987 102612578 102613019 102619808 107177427 112498639

CIC:	CICLE_v10011728mg CICLE_v10013378mg CICLE_v10013470mg CICLE_v10013606mg CICLE_v10013615mg CICLE_v10015246mg

PVY:	116108748 116119642 116119668 116133248 116133751 116133752

MINC:

123193698 123212707 123212780 123218616 123223281 123223316 123223542 123223569 123223594 123223678 123223723

TCC:	18596888 18597570 18597572 18597573

GRA:	105774702 105778472 105780720 105780980 105799938

GHI:	107889767 107890972 107899525 107899526 107924960 107930131 107930134 107937745 107963355

GAB:	108456221 108458268 108459467 108485691 108488674

DZI:	111278196 111294934 111295564 111297022 111297857 111311124 111311125 111318753

EGR:	104420130 104426383 104445309

GMX:	100781975 100789203 100809042 100812965

GSJ:	114375273 114388090 114415727 114419151

PVU:	PHAVU_006G188000g PHAVU_008G105700g PHAVU_010G003100g

VRA:	106770172 106775580

VAR:	108327324 108342513

VUN:	114167356 114184006 114189223

CCAJ:

109788418 109791649 109804301

APRC:

113850181 113852071 113862429

MTR:	MTR_2g013300 MTR_7g067510

CAM:	101490091 101507256

LJA:	Lj1g3v2311890.1(Lj1g3v2311890.1) Lj1g3v2311900.1(Lj1g3v2311900.1) Lj6g3v2044530.1(Lj6g3v2044530.1)

ADU:	107468484 107475176 107484863 107484864 107484865 107484866 107484867 107484868

AIP:	107619912 107622069 107625731 107636678 107637879 107637880 107637882 107639480 107639481

AHF:	112718119 112727967 112740477 112740478 112740483 112742850 112743612 112750088 112783364 112784177 112796992 112796993 112796995 112796996 112796997 112796998

LANG:

109329644

FVE:	101292321 101292329 101292620 101309514

RCN:	112166304 112193033 112193915 112194908

PPER:

18773272 18774761 18778355

PMUM:

103324721 103343036

PAVI:

110765067 110765068 110765069 110766754 110766813

PDUL:

117625067 117630533 117633120

MDM:	103433582 103434765 103450614 103450623

PXB:	103928093 103936603 103936613 103966356 103966366 103966368

ZJU:	107409623 107430777 107430781 107430783

MNT:	21395346 21398673 21398676

CSV:	101219707 101220697

CMO:	103486194 103486309

BHJ:	120090207 120091871

MCHA:

111010894 111014925

CMAX:

111470132 111481968 111495773

CMOS:

111434013 111441769 111452297

CPEP:

111790672 111800313

RCU:	8269398 8278556

JCU:	105646616 105649509

HBR:	110634787 110641684 110643007 110661946

MESC:

110604274 110620259 110622526

POP:	7485449 7487351 7487465 7494355

PEU:	105128072 105141779 105142080

PALZ:

118031690 118037451 118047339

JRE:	108981006 108982233 108994894 108995110

QSU:	112013126 112031691 112031696 112031697 112031698 112031710 112035503

QLO:	115952589 115953959 115965593 115992543

TWL:	119988360 119989915 120005245

VVI:	100247748 100853373 104878362

VRI:	117919693 117923299

SLY:	101250644 101265092 101267735

SPEN:

107001788 107010967 107029946

SOT:	102584175 102589435 102603042

CANN:

107846007 107859407

NTA:	107759048 107761292 107769309 107808382

NSY:	104235543 104241090

NTO:	104105601 104115402

NAU:	109207433 109232960

INI:	109159022 109159071

ITR:	116028636 116030528

SIND:

105161620 105167919 105174549 105175636

OEU:	111365245 111368426 111370115 111370560 111376052

EGT:	105951483 105953069 105969062 105970164

SSPL:

121742518 121769711 121790184 121798187 121802222 121809638

HAN:	110885588 110898814 110913099 110915918 110925514 110937858

ECAD:

122591662 122597107 122607652

LSV:	111890673 111891202 111891640 111903977

CCAV:

112512797 112518238 112523797 112526980

DCR:	108197433 108206582 108217871 108222688

CSIN:

114277353 114287504 114322533

BVG:	104900747 104904814 104905065

SOE:	110786576 110788017

CQI:	110685033 110693584 110706872

NNU:	104586450 104588792 104588883 104596957 104601237

MING:

122092467 122093560

TSS:	122640624 122670787

PSOM:

113306329 113310452 113323491

NCOL:

116252357 116254064

OSA:

4336475

DOSA:

Os04t0529700-01(Os04g0529700)

OBR:

102717891

BDI:

100831105

ATS:

109732097

TDC:	119359708 119361016

TAES:

123041651 123053927 123185722

SBI:

8082872

ZMA:

100283564

SITA:

101786409

SVS:

117863523

PVIR:

120642424

PHAI:

112899501

PDA:	103701621 103716220 103721120

EGU:	105042837 105042838 105053509 105055492

MUS:

103968640

DCT:

110109954

AOF:

109820034

ATR:	18423117 18437915

SMO:	SELMODRAFT_419460(GT32A2)

PPP:	112286443 112288960

» show all

Reference

1 [PMID:3099784]

Authors

Bailly P, Piller F, Cartron JP, Leroy Y, Fournet B.

Title

Identification of UDP-galactose: lactose (lactosylceramide) alpha-4 and beta-3 galactosyltransferases in human kidney.

Journal

Biochem Biophys Res Commun 141:84-91 (1986)
DOI:10.1016/S0006-291X(86)80338-2

Reference

2 [PMID:10747952]

Authors

Steffensen R, Carlier K, Wiels J, Levery SB, Stroud M, Cedergren B, Nilsson Sojka B, Bennett EP, Jersild C, Clausen H.

Title

Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.

Journal

J Biol Chem 275:16723-9 (2000)
DOI:10.1074/jbc.M000728200

Sequence

[hsa:53947]

Reference

3 [PMID:10748143]

Authors

Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.

Title

Molecular cloning of globotriaosylceramide/CD77 synthase, aglycosyltransferase that initiates the synthesis of globo seriesglycosphingolipids.

Journal

J Biol Chem 275:15152-6 (2000)
DOI:10.1074/jbc.M909620199