KEGG   ENZYME: 2.4.1.244
Entry
EC 2.4.1.244                Enzyme                                 
Name
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase;
beta1,4-N-acetylgalactosaminyltransferase III;
beta4GalNAc-T3;
beta1,4-N-acetylgalactosaminyltransferase IV;
beta4GalNAc-T4;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Reaction(KEGG)
(other) R07610(G) R07611(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
N-acetyl-beta-D-glucosaminyl group
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Comment
The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end. The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme-characterization experiments. Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
History
EC 2.4.1.244 created 2006
Pathway
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K09656  beta-1,4-N-acetylgalactosaminyltransferase 3
K09657  beta-1,4-N-acetylgalactosaminyltransferase 4
Genes
HSA283358(B4GALNT3) 338707(B4GALNT4)
PTR450920(B4GALNT4) 451738(B4GALNT3)
PPS100976376(B4GALNT4) 100989611(B4GALNT3)
GGO101147545(B4GALNT3)
PON100435319(B4GALNT3) 100457244(B4GALNT4)
NLE100602613(B4GALNT4) 105738882(B4GALNT3)
MCC114669831(B4GALNT4) 706259(B4GALNT3) 720768
MCF102115389(B4GALNT4) 102145263(B4GALNT3)
CSAB103218358(B4GALNT3) 103239139(B4GALNT4)
CATY105577189(B4GALNT4) 105582943(B4GALNT3)
PANU101000778(B4GALNT4)
TGE112606611(B4GALNT4) 112634023(B4GALNT3)
RRO104656676 104662541(B4GALNT3) 115893542(B4GALNT4)
RBB108519516(B4GALNT3) 108543532(B4GALNT4)
TFN117080293(B4GALNT4) 117090732(B4GALNT3)
PTEH111520323(B4GALNT3) 111520629(B4GALNT4)
CJC100407822(B4GALNT3) 100413834(B4GALNT4)
SBQ101037149(B4GALNT4) 101054201(B4GALNT3)
CSYR103266186(B4GALNT3)
MMUR105862186(B4GALNT3) 105874069(B4GALNT4)
LCAT123640206(B4GALNT3) 123642981(B4GALNT4)
OGA100944061(B4GALNT4) 100961561(B4GALNT3)
MMU330406(B4galnt3) 330671(B4galnt4)
MCAL110296670(B4galnt3) 110297886
MPAH110316578(B4galnt3) 110318245(B4galnt4)
RNO309105(B4galnt4) 500306(B4galnt3)
MCOC116099504(B4galnt3) 116103201(B4galnt4)
MUN110546049(B4galnt3) 110553927(B4galnt4)
CGE100756528(B4galnt3) 100758404(B4galnt4)
MAUA101831193(B4galnt3) 101836962(B4galnt4)
PLEU114693511(B4galnt4) 114700747(B4galnt3)
MORG121440001(B4galnt3) 121458064(B4galnt4)
AAMP119799909(B4galnt4) 119807981(B4galnt3)
NGI103739368(B4galnt3) 103751068(B4galnt4)
HGL101702463(B4galnt3) 101720559(B4galnt4)
CPOC100712778(B4galnt4) 100730678(B4galnt3)
CCAN109694620(B4galnt3) 109698146(B4galnt4)
DORD105991056(B4galnt3) 105998569(B4galnt4)
DSP122095036(B4galnt4) 122099585
NCAR124958321
OCU100351156(B4GALNT3)
OPI101516966(B4GALNT4) 101534838(B4GALNT3)
TUP102476308(B4GALNT4) 102477252(B4GALNT3)
CFA483398(B4GALNT4) 486751(B4GALNT3)
CLUD112663544(B4GALNT4) 112669004(B4GALNT3)
VVP112914603(B4GALNT4) 112917410(B4GALNT3)
VLG121480290(B4GALNT3) 121501378(B4GALNT4)
AML100474848(B4GALNT4) 100481474(B4GALNT3)
UMR103671083(B4GALNT4) 103675765(B4GALNT3)
UAH113248774(B4GALNT4) 113258033(B4GALNT3)
UAR123775533(B4GALNT4) 123777720(B4GALNT3)
ELK111149784 111159792
LLV125079652 125107316
MPUF101671138(B4GALNT4) 101673160(B4GALNT3)
ORO101362933(B4GALNT4) 101376959(B4GALNT3)
EJU114201512(B4GALNT4) 114222591(B4GALNT3)
ZCA113914397(B4GALNT4) 113923158(B4GALNT3)
MLX118015665(B4GALNT4) 118025451(B4GALNT3)
FCA101086091(B4GALNT4) 101097324(B4GALNT3)
PYU121022074(B4GALNT3) 121022812(B4GALNT4)
PBG122473889(B4GALNT3) 122484185(B4GALNT4)
PTG102950331(B4GALNT4) 102953154(B4GALNT3)
PPAD109259799(B4GALNT4) 109276235(B4GALNT3)
AJU106965465(B4GALNT3) 106987942(B4GALNT4)
HHV120223395(B4GALNT4) 120234496(B4GALNT3)
BTA100137759(B4GALNT4) 527026(B4GALNT3)
BOM102275891(B4GALNT3) 102283950(B4GALNT4)
BIU109558611(B4GALNT3)
BBUB102394198(B4GALNT3) 102409676(B4GALNT4)
CHX102172522(B4GALNT3) 102188023
OAS101105615(B4GALNT4) 101115274(B4GALNT3)
ODA120857852(B4GALNT3) 120874219(B4GALNT4)
CCAD122423417(B4GALNT3) 122430574(B4GALNT4)
SSC100623649(B4GALNT4) 110260758(B4GALNT3)
CFR102522276(B4GALNT4) 102523640(B4GALNT3)
CBAI105062438(B4GALNT4) 105076667(B4GALNT3)
CDK105102955(B4GALNT3) 105106170(B4GALNT4)
VPC102535991(B4GALNT4) 102539840(B4GALNT3)
BACU103000329(B4GALNT4) 103019272(B4GALNT3)
LVE103071788(B4GALNT4) 103084199(B4GALNT3)
OOR101269577(B4GALNT3) 101279166(B4GALNT4)
DLE111170320(B4GALNT4) 111176612(B4GALNT3)
PCAD102994651(B4GALNT4)
PSIU116757325(B4GALNT4) 116761376(B4GALNT3)
ECB100054676(B4GALNT4) 100056854(B4GALNT3)
EPZ103561349(B4GALNT4) 103565631(B4GALNT3)
EAI106825357(B4GALNT4) 106831525(B4GALNT3)
MYB102246590(B4GALNT4) 102254875(B4GALNT3)
MYD102756317(B4GALNT3)
MMYO118649013(B4GALNT4) 118651139(B4GALNT3)
MLF102429408(B4GALNT3)
MNA107542329(B4GALNT4) 107546417(B4GALNT3)
PKL118717962(B4GALNT4) 118729258(B4GALNT3)
HAI109375626(B4GALNT4) 109388940(B4GALNT3)
DRO112311132(B4GALNT3) 112317448(B4GALNT4)
SHON118982226(B4GALNT4) 119000001(B4GALNT3)
AJM119045231(B4GALNT3) 119062225(B4GALNT4)
PDIC114499180(B4GALNT4) 114513177(B4GALNT3)
PHAS123807341(B4GALNT4) 123813561(B4GALNT3)
MMF118624292(B4GALNT3) 118643193(B4GALNT4)
RFQ117029209(B4GALNT3) 117031317(B4GALNT4)
PALE102884317(B4GALNT4) 102884875(B4GALNT3)
PGIG120584649(B4GALNT4) 120607341(B4GALNT3)
PVP105297302(B4GALNT3) 105305950(B4GALNT4)
RAY107506918(B4GALNT3) 107506949(B4GALNT4)
MJV108386186(B4GALNT3) 108401884(B4GALNT4)
TOD119247842(B4GALNT3) 119248775(B4GALNT4)
SARA101546179(B4GALNT3) 101551635(B4GALNT4)
LAV100656658(B4GALNT4) 100665318(B4GALNT3)
TMU101350259 101357570
DNM101415099(B4GALNT3) 101445790(B4GALNT4)
MDO100020793(B4GALNT3)
GAS123248876(B4GALNT3)
SHR100918044(B4GALNT3) 100921988(B4GALNT4)
PCW110202986(B4GALNT4) 110204330 110218701(B4GALNT3)
OAA100080104(B4GALNT3) 100088024(B4GALNT4)
GGA418150(B4GALNT3) 770601(B4GALNT4)
PCOC116226858(B4GALNT3) 116237913(B4GALNT4)
MGP100539296(B4GALNT4) 100543657(B4GALNT3)
CJO107314272(B4GALNT4) 107315358(B4GALNT3)
NMEL110395311(B4GALNT3) 110401603(B4GALNT4)
APLA101794410(B4GALNT3) 101795425(B4GALNT4)
ACYG106031042(B4GALNT3) 106047061(B4GALNT4)
AFUL116487230(B4GALNT3) 116489412(B4GALNT4)
TGU100218099(B4GALNT4) 100221161(B4GALNT3)
LSR110472973(B4GALNT3) 110484970(B4GALNT4)
SCAN103820514(B4GALNT3) 103827051(B4GALNT4)
PMOA120501032(B4GALNT4) 120501516(B4GALNT3)
OTC121332794(B4GALNT3) 121334773(B4GALNT4)
PRUF121352308(B4GALNT4) 121362663(B4GALNT3)
GFR102034690(B4GALNT4) 102036024(B4GALNT3)
FAB101806677(B4GALNT4) 101814333(B4GALNT3)
PHI102109686(B4GALNT3) 102112024(B4GALNT4)
PMAJ107204887(B4GALNT3) 107206466(B4GALNT4)
CCAE111928420(B4GALNT3) 111930586(B4GALNT4) 111944590
CCW104684539(B4GALNT4) 104692236(B4GALNT3)
CBRC103614579(B4GALNT4) 103624718(B4GALNT3)
ETL114063268(B4GALNT4) 114068768(B4GALNT3)
ZAB102067994(B4GALNT4) 102069046(B4GALNT3)
ACHL103800365(B4GALNT4)
FPG101919553(B4GALNT4) 101920197(B4GALNT3)
FCH102051612(B4GALNT4) 102055264(B4GALNT3)
CLV102088828(B4GALNT4) 102090270(B4GALNT3)
EGZ104127888(B4GALNT4) 104129759(B4GALNT3)
NNI104011411(B4GALNT4) 104020250(B4GALNT3)
PLET104625129(B4GALNT3) 104625881
PCRI104035242(B4GALNT3)
ACUN113481121(B4GALNT4) 113487437(B4GALNT3)
TALA104357006(B4GALNT3) 116961597(B4GALNT4)
PADL103924499(B4GALNT3) 103925356(B4GALNT4)
ACHC115351887(B4GALNT4) 115352766(B4GALNT3)
HALD104321236(B4GALNT3)
CCRI104163071
CSTI104563214(B4GALNT3)
EHS104514665
CMAC104482300(B4GALNT3)
MUI104541194(B4GALNT3) 104546704(B4GALNT4)
FGA104073318(B4GALNT4) 104076689(B4GALNT3)
GSTE104263353(B4GALNT3)
LDI104344588
MNB103769379(B4GALNT3)
OHA104326525(B4GALNT4) 104330276(B4GALNT3)
AAM106488281(B4GALNT3) 106489126(B4GALNT4)
AROW112968267(B4GALNT3) 112973777(B4GALNT4)
NPD112948021(B4GALNT4) 112958331(B4GALNT3)
DNE112991580(B4GALNT4) 112993372(B4GALNT3)
ASN102384335(B4GALNT4)
AMJ102563895(B4GALNT3) 102569972(B4GALNT4)
CPOO109315923(B4GALNT3) 109318171(B4GALNT4)
GGN109296220(B4GALNT3) 109299254(B4GALNT4)
PSS102450592(B4GALNT3) 102454912(B4GALNT4)
CMY102944252(B4GALNT3) 102948034(B4GALNT4)
CPIC101946283(B4GALNT3) 101950465(B4GALNT4)
TST117877383(B4GALNT4) 117882408(B4GALNT3)
CABI116820558(B4GALNT4) 116834553(B4GALNT3)
MRV120395802(B4GALNT3) 120403836(B4GALNT4)
ACS100552264(b4galnt3) 100568220(b4galnt4)
PVT110074160(B4GALNT4)
SUND121919039(B4GALNT4) 121930897(B4GALNT3)
PBI103050876(B4GALNT3) 103061436(B4GALNT4)
PMUR107291100(B4GALNT4)
TSR106552382(B4GALNT4)
PGUT117655634(B4GALNT3) 117665151(B4GALNT4)
VKO123016517(B4GALNT3) 123021256(B4GALNT4)
PMUA114600280(B4GALNT4) 114605389(B4GALNT3)
ZVI118090793(B4GALNT3)
GJA107108372 107114683
STOW125425864(B4GALNT4) 125435322(B4GALNT3)
XLA108704576(b4galnt3.L) 108712580(b4galnt3.S) 108713824(b4galnt4.L) 108715202(b4galnt4.S)
XTR100036642(b4galnt4) 100488678(b4galnt3)
NPR108791998(B4GALNT4)
RTEM120917276(B4GALNT4) 120932697(B4GALNT3)
BBUF120980929(B4GALNT4) 121004272(B4GALNT3)
BGAR122920474(B4GALNT4) 122928496(B4GALNT3)
DRE553524(b4galnt3b) 559305(b4galnt4b) 565184(b4galnt4a)
SRX107705801 107707534 107709930 107730265
SANH107675269 107686572 107688567 107696636
SGH107558306 107562842 107564911 107596444 107600469
CCAR109045851 109054019 109083500 109097386
CAUA113043593 113067112 113100338 113106233 113118141
PPRM120464776(b4galnt3b) 120469310(b4galnt4b) 120473350(b4galnt4a)
MAMB125247077(b4galnt4a) 125253862(b4galnt3b) 125265129(b4galnt4b)
IPU108259196(b4galnt4b) 108264151(b4galnt3b) 108275076(b4galnt4a)
PHYP113529844(b4galnt4) 113540814
SMEO124380028(b4galnt4b) 124392673(b4galnt4a) 124395851(b4galnt3b)
TFD113636656(b4galnt4b) 113657294(b4galnt3b) 113659872(b4galnt4a)
AMEX103022890 103037724(b4galnt4) 103040627
EEE113570817 113579684 113581322(b4galnt4)
TRU101067924 101067926(b4galnt4)
TNGGSTEN00019775G001
LCO104918138 104920486(b4galnt4)
NCC104957600(b4galnt3) 104967977(b4galnt4)
CGOB115009853(b4galnt4) 115010263
ELY117262120(b4galnt3b) 117262290(b4galnt4a)
EFO125887637(b4galnt3b) 125887737(b4galnt4a)
PLEP121949667(b4galnt4a) 121950026(b4galnt3b)
SLUC116038542(b4galnt4a) 116045686(b4galnt3b)
ECRA117949490(b4galnt4a) 117949521(b4galnt3b)
ESP116694153 116694547(b4galnt4)
PFLV114559669(b4galnt4) 114560215
GAT120808958 120809787(b4galnt3b) 120812247
PPUG119195585(b4galnt4a) 119196592(b4galnt3b)
MSAM119893562(b4galnt3b) 119894206(b4galnt4a)
CUD121514681(b4galnt3b) 121515700(b4galnt4a)
ALAT119023889(b4galnt3b) 119025002(b4galnt4a)
MZE101471802(b4galnt4) 101485737
ONL100704589(b4galnt4) 100709042
OAU116313492(b4galnt3b) 116333275(b4galnt4a)
OLA101163791(b4galnt4) 101164306
OML112151753(b4galnt4a) 112152134(b4galnt3b)
XMA102221073(b4galnt4) 102223638
XCO114135595 114160760
XHE116734070(b4galnt4) 116735786
PRET103466150(b4galnt4) 103466673
PFOR103133797 103151601
PLAI106936817 106954927
PMEI106915345 106933230
GAF122835285(b4galnt4a) 122835521(b4galnt3b)
CVG107085425(b4galnt4) 107090556
CTUL119772420(b4galnt3b) 119776920(b4galnt4a)
GMU124855303(b4galnt4a) 124860987(b4galnt3b)
NFU107388842 107389008(b4galnt4)
KMR108230205(b4galnt3b) 108239976(b4galnt4a)
ALIM106514300(b4galnt3) 106515656(b4galnt4)
NWH119415703(b4galnt3b) 119416009(b4galnt4a)
AOCE111571948 111578077
MCEP125014775(b4galnt3b) 125014914(b4galnt4a)
CSEM103380088 103380379(b4galnt4)
POV109638984
SSEN122775446(b4galnt3b) 122775936(b4galnt4a)
HHIP117762992(b4galnt4a) 117763192
HSP118109172(b4galnt4a) 118109451
LCF108875136(b4galnt3) 108875398(b4galnt4)
SDU111228500 111228650(b4galnt4)
SLAL111653356 111661820(b4galnt4)
XGL120792688(b4galnt3b) 120793655(b4galnt4a)
HCQ109528077 109530471(b4galnt4)
BPEC110165926(b4galnt4)
MALB109967709 109973574
BSPL114857636(b4galnt4a) 114857690(b4galnt3b)
SASA106560716(b4galnt4) 106561254(b4galnt3)
OTW112218977(b4galnt3b) 112219203(b4galnt4a) 112252461
OMY110490617(b4galnt4a) 110496319 110521711
OGO124001623 124036033 124040915(b4galnt4a)
ONE115109478 115134198 115134636(b4galnt4)
SALP111961981(b4galnt4) 111962535
SNH120065861(b4galnt3b) 120066544(b4galnt4a)
CCLU121531187(b4galnt4a)
ELS105006820(b4galnt4) 105022210
SFM108934528 108936581 108942180(b4galnt4)
PKI111841532 111859463(b4galnt4)
AANG118215602(b4galnt4a) 118219072(b4galnt3b) 118228416 118231854
LOC102683937(b4galnt3) 102689842(b4galnt4)
PSPA121294830 121318539(b4galnt3b) 121320154 121330341
ARUT117416081 117420048(b4galnt3b) 117432458
LCM102348774(B4GALNT3) 102349555(B4GALNT4)
CMK103181837(b4galnt3b) 103186017
RTP109911271 109919635 109930789
NVE5501658 5518690
EPA110236390 110236544 110241297 110246555 110249064
ATEN116301396 116301860 116303567 116305195 116305287
ADF107326871 107341393 107342115 107344974
AMIL114947641 114967932 114967936 114973417
PDAM113667731 113669909 113672594 113682024 113685757
SPIS111320861 111321881 111323356 111335085 111336369
DGT114518197 114523273
XEN124452440
HMG100206963 100210795 100214956
TADTRIADDRAFT_24189
AQU100638711
MBRMONBRDRAFT_29432
SREPTSG_03250 PTSG_05319
 » show all
Reference
1  [PMID:12966086]
  Authors
Sato T, Gotoh M, Kiyohara K, Kameyama A, Kubota T, Kikuchi N, Ishizuka Y, Iwasaki H, Togayachi A, Kudo T, Ohkura T, Nakanishi H, Narimatsu H
  Title
Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.
  Journal
J Biol Chem 278:47534-44 (2003)
DOI:10.1074/jbc.M308857200
  Sequence
[hsa:283358] [mmu:330406]
Reference
2  [PMID:15044014]
  Authors
Gotoh M, Sato T, Kiyohara K, Kameyama A, Kikuchi N, Kwon YD, Ishizuka Y, Iwai T, Nakanishi H, Narimatsu H
  Title
Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine.
  Journal
FEBS Lett 562:134-40 (2004)
DOI:10.1016/S0014-5793(04)00219-4
  Sequence
[hsa:338707] [mmu:330671]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.244
IUBMB Enzyme Nomenclature: 2.4.1.244
ExPASy - ENZYME nomenclature database: 2.4.1.244
BRENDA, the Enzyme Database: 2.4.1.244
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