Entry
Name
diglucosyl diacylglycerol synthase (1,6-linking);
monoglucosyl diacylglycerol (1->6) glucosyltransferase;
MGlcDAG (1->6) glucosyltransferase;
DGlcDAG synthase (ambiguous);
UGT106B1;
ypfP (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol 6-glucosyltransferase
Reaction(IUBMB)
(1) UDP-alpha-D-glucose + 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl]-sn-glycerol + UDP [RN:
R04377 R12899 ];
(2) UDP-alpha-D-glucose + 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl]-sn-glycerol = 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl]-sn-glycerol + UDP [RN:
R10807 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:
C00029 ];
1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol [CPD:
C04046 ];
1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl]-sn-glycerol [CPD:
C06040 ]
Product
1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl]-sn-glycerol [CPD:
C06040 ];
UDP [CPD:
C00015 ];
1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl]-sn-glycerol [CPD:
C20860 ]
Comment
The enzyme is found in several bacterial species. The enzyme from Bacillus subtilis is specific for glucose [1]. The enzyme from Mycoplasma genitalium can incoporate galactose with similar efficiency, but forms mainly 1,2-diacyl-diglucopyranosyl-sn-glycerol in vivo [3]. The enzyme from Staphylococcus aureus can also form glucosyl-glycero-3-phospho-(1'-sn-glycerol) [2].
History
EC 2.4.1.315 created 2014
Pathway
Orthology
K03429 processive 1,2-diacylglycerol beta-glucosyltransferase
K19004 processive 1,2-diacylglycerol beta-glycosyltransferase
Genes
BLI : BL01366(ugtP) BL02574(ykoN)
BLD : BLi02330(ugtP) BLi03287(ykoN)
BLH : BaLi_c24180(ugtP) BaLi_c33690(ykoN)
BAZ : BAMTA208_07035(ugtP)
BSON : S101395_02276(ugtP) S101395_04017
BSTR : QI003_10850 QI003_14280
BCY : Bcer98_0433 Bcer98_1711
BMET : BMMGA3_02355 BMMGA3_09555 BMMGA3_10315(ugtP) BMMGA3_13970 BMMGA3_16560
BSM : BSM4216_2719 BSM4216_3241
BGY : BGLY_2585(ugtP) BGLY_3681
BFD : NCTC4823_01454(ykoN)
BSHI : LGQ02_13725 LGQ02_14110
BCO : Bcell_0723 Bcell_2692
BMQ : BMQ_1671(ugtP) BMQ_2967 BMQ_5025(ykoN)
BMD : BMD_1644(ugtP) BMD_2996 BMD_5013(ykoN)
BMEG : BG04_2018 BG04_3955 BG04_5499
OCN : CUC15_08030 CUC15_14555
GTM : GT3921_00300 GT3921_10220
GMC : GY4MC1_2153 GY4MC1_3597
GJF : M493_01380 M493_09605
GSR : GS3922_07230 GS3922_14610
GTH : Geoth_2225 Geoth_3710
PTL : AOT13_04365 AOT13_11655
PCAL : BV455_01525(ugtP_1)
PARG : PspKH34_20680(ykoN_1) PspKH34_36000(ykoN_2)
AAMY : GFC30_2324 GFC30_3318
ACAI : ISX45_05385 ISX45_09770 ISX45_17035
ASED : IRT44_00400 IRT44_06115
APAK : AP3564_09620 AP3564_12790 AP3564_18415
ACOP : RI196_04895 RI196_08175 RI196_12915
NMK : CHR53_12135 CHR53_12140 CHR53_24305
NDT : L1999_11530 L1999_14955
MSEM : GMB29_16080 GMB29_23675
BLEN : NCTC4824_00308(ykoN)
BCK : BCO26_2215 BCO26_2220
BCOA : BF29_1323 BF29_1327
MCUI : G8O30_06485 G8O30_13065
ECTO : MUG87_10610 MUG87_15085
TEI : QS257_03450 QS257_10960
ALKL : MM271_18425 MM271_20560
HYI : K2M58_01695 K2M58_01785 K2M58_07970 K2M58_09370
PUK : PU629_15170 PU629_17250 PU629_18460 PU629_21070
SUF : SARLGA251_09320(ugtP)
SAUT : SAI1T1_2007190(ugtP)
SAUJ : SAI2T2_1007210(ugtP)
SAUK : SAI3T3_1007200(ugtP)
SAUQ : SAI4T8_1007190(ugtP)
SAUV : SAI7S6_1007200(ugtP)
SAUW : SAI5S5_1007160(ugtP)
SAUX : SAI6T6_1007170(ugtP)
SAUY : SAI8T7_1007200(ugtP)
SDP : NCTC12225_02040(ugtP)
SPIC : SAMEA4384060_1943(ugtP)
SSH : NCTC13712_00960(ugtP)
SSIM : SAMEA4384339_0866(ugtP)
SSTE : SAMEA4384403_1842(ugtP)
GHA : NCTC10459_01239(ugtP)
BBE : BBR47_01830 BBR47_41080
BFM : BP422_16250 BP422_26330
BAGR : BA6348_01715 BA6348_10480
BCHS : JNE38_01235 JNE38_21310
BCOP : JD108_01150 JD108_06915
BPAB : PSE45_01215 PSE45_19165
BHUI : LOK74_03640 LOK74_21825
BAYD : BSPP4475_05495 BSPP4475_19820
BBOR : RFB14_07930 RFB14_25595
BRUM : NDK47_01280 NDK47_08205
BREH : HP435_01305 HP435_19740
PJD : Pjdr2_0466 Pjdr2_5001
GYM : GYMC10_3734 GYMC10_5150 GYMC10_5358
PPM : PPSC2_03160(ugtP1) PPSC2_07010(ypfP) PPSC2_12770(ugtP3) PPSC2_12780(ugtP5)
PPO : PPM_0574(ugtP1) PPM_1330(ypfP) PPM_2448(ugtP3) PPM_2450(ugtP5)
PPOL : X809_02595 X809_07665 X809_38170
PPQ : PPSQR21_006080 PPSQR21_014350 PPSQR21_044490
PPOY : RE92_04875 RE92_08780 RE92_23990 RE92_24000
PMS : KNP414_00359 KNP414_00729
PMQ : PM3016_312 PM3016_632
PTA : HPL003_10520 HPL003_15420
PLV : ERIC2_c01730(ugtP1) ERIC2_c03190(ugtP) ERIC2_c18570 ERIC2_c19190 ERIC2_c36710(ugtP2)
PSAB : PSAB_04915 PSAB_12250 PSAB_12960
PDU : PDUR_06180 PDUR_13910
PBD : PBOR_05740 PBOR_07720
PGM : PGRAT_05780 PGRAT_07425
POD : PODO_04855 PODO_06290 PODO_22210
PAEN : P40081_06015 P40081_07760
PAEF : R50345_04715 R50345_06715 R50345_22190
PAEQ : R50912_05325 R50912_06940
PSTE : PSTEL_05960 PSTEL_07360 PSTEL_14900 PSTEL_19215
PAEA : R70723_04760 R70723_06365
PAEE : R70331_04795 R70331_06355
PAEH : H70357_05655 H70357_07155
PAEJ : H70737_04985 H70737_06530 H70737_22530
PBJ : VN24_04360 VN24_21780
PIH : UB51_15915 UB51_17985
PSON : JI735_14295 JI735_15980
PPEO : ABE82_02830 ABE82_07155 ABE82_22085
PNP : IJ22_19840 IJ22_37410 IJ22_39630
POW : IJ21_10220 IJ21_43650 IJ21_47560
PBV : AR543_05190 AR543_09095
PXL : BS614_10250 BS614_12625
PYG : AWM70_02630 AWM70_06495 AWM70_21505
PSWU : SY83_08465 SY83_12700
PIB : BBD41_19320 BBD41_20170 BBD41_27040
PCX : LPB68_07670 LPB68_08850
PKB : B4V02_03355 B4V02_17860 B4V02_22190
PAIH : ASL14_04185 ASL14_09015
PVO : PVOR_20134 PVOR_27660 PVOR_28959
PLW : D5F53_03305 D5F53_04235 D5F53_11525
PLEN : EIM92_00750 EIM92_09485 EIM92_20370
PPSC : EHS13_07490 EHS13_08100 EHS13_28425 EHS13_28490
PLUT : EI981_03385 EI981_21190
PALB : EJC50_10295 EJC50_16975 EJC50_20880
PCHI : PC41400_04660 PC41400_04665 PC41400_04815 PC41400_05815
PBK : Back11_10860(ugtP_1) Back11_32040 Back11_40960(ugtP_2)
PPRT : ET464_12800 ET464_18915
PBAC : HUB98_23125 HUB98_25115
PRZ : GZH47_08435 GZH47_12530
PLYC : GXP70_04025 GXP70_08010
PSOP : KP014_08435 KP014_17060
PALO : E6C60_3214 E6C60_3391
PCEL : HUB94_05455 HUB94_16685 HUB94_23985
PTJ : JRJ22_04205 JRJ22_05620
PALR : HGI30_05770 HGI30_19460 HGI30_20740
PTHI : NDS46_23040 NDS46_25060 NDS46_28775
PKA : PQ456_02465 PQ456_06525
PMAH : PTQ21_11490 PTQ21_14040
PDY : QJQ58_07690 QJQ58_23585 QJQ58_27060 QJQ58_29150
PMAE : LMZ02_03310 LMZ02_09750 LMZ02_12700 LMZ02_13885
PWN : QNH46_03730 QNH46_07590 QNH46_19155
PAUN : MJA45_11905 MJA45_23165 MJA45_23200
PHK : SK066_16835 SK066_21145
PNK : AASFL403_12800 AASFL403_16645
PPAB : KET34_06950 KET34_09390
PKP : SK3146_03100(ugtP_1) SK3146_03992(ugtP_2)
PGLU : A3958_03405 A3958_04480 A3958_23440
PHEX : L0M14_01635 L0M14_02975 L0M14_03960
PLZH : C0638_00655 C0638_04735 C0638_11440 C0638_20360 C0638_20370
ATHE : K3F53_07795 K3F53_10535
ANEU : PP175_11395 PP175_11740 PP175_18910 PP175_22540 PP175_22545
COH : EAV92_06335 EAV92_06355 EAV92_07530 EAV92_15505
COHN : KCTCHS21_00130 KCTCHS21_08770(ugtP) KCTCHS21_11450
COHL : J4772_27610 J4772_29940
AAD : TC41_2008 TC41_2011(ugtP)
AFX : JZ786_00590 JZ786_03245 JZ786_04810
AACO : K1I37_13120 K1I37_13135
ACUR : JZ785_14580 JZ785_16145 JZ785_19700
ACYC : JI721_05680 JI721_14640 JI721_14655
ALIC : GI364_14355 GI364_14370 GI364_23555
KYR : CVV65_03985 CVV65_14285
EFF : skT53_27660(ugtP) skT53_27670
FFE : LSG31_00015 LSG31_02100 LSG31_02125 LSG31_04890 LSG31_13130
NTR : B0W44_06180 B0W44_12895
TVU : AB849_007390 AB849_010080
KPUL : GXN76_02280 GXN76_10530
KEB : GXN75_11815 GXN75_15330
PABS : JIR001_21220 JIR001_25830 JIR001_27580
CKL : CKL_2511 CKL_3719(murG2)
CLJ : CLJU_c02160(murG1) CLJU_c15830
CPAS : Clopa_0369 Clopa_1266 Clopa_4085
CPAT : CLPA_c02520(ugtP1) CLPA_c32970(ugtP2)
CPAE : CPAST_c02520(ugtP1) CPAST_c32970(ugtP2)
CLT : CM240_0996 CM240_2307
CCK : Ccar_02475 Ccar_21610
CTYK : CTK_C01240 CTK_C08060
CDRK : B9W14_07475 B9W14_25385
CCOH : SAMEA4530647_0147(ugtP)
CCAA : KQH81_12295 KQH81_13490
CMAH : C1I91_07060 C1I91_27860
CFB : CLFE_010150(ugtP_1) CLFE_042120(ugtP_2)
CINT : HZF06_02660 HZF06_19585
CTHD : CDO33_09505 CDO33_19565
CPRF : K7H06_05540 K7H06_12290
RPAY : P0092_00185 P0092_07730
CCEL : CCDG5_0987 CCDG5_1871
VCOP : MM50RIKEN_08410 MM50RIKEN_12510
TMEL : NOG13_07025 NOG13_08045
DDL : Desdi_0541 Desdi_3085
DMT : DESME_02680 DESME_13660 DESME_14920
DOR : Desor_2880 Desor_2921 Desor_3231 Desor_5560
DAI : Desaci_2799 Desaci_4338 Desaci_4660
DMI : Desmer_2043 Desmer_2497 Desmer_2786 Desmer_4596
DED : DHBDCA_p2632 DHBDCA_p2699 DHBDCA_p533
DEC : DCF50_p2643 DCF50_p2710 DCF50_p591
DRS : DEHRE_07050 DEHRE_12875 DEHRE_13305
FWA : DCMF_03190 DCMF_11840
TJR : TherJR_0474 TherJR_1332
EMT : CPZ25_002875 CPZ25_018220
ELIM : B2M23_07910 B2M23_17090
AWO : Awo_c16820(ugtP) Awo_c19680(murG2)
AWI : CHL1_001486 CHL1_001735
ALKA : J0B03_08425 J0B03_11935
SAY : TPY_3285 TPY_3607(ugtP)
SAP : Sulac_1312 Sulac_1626
STHR : BXT84_05895 BXT84_09820
CSCI : HDCHBGLK_02421(ugtP)
VGU : HYG85_07975 HYG85_07980 HYG85_13300
VPY : HZI73_04200 HZI73_04205
CSPO : QNI18_00710 QNI18_11470
PBIF : KXZ80_00125 KXZ80_11540
PSOR : RSJ16_00340 RSJ16_13250
CDF : CD630_00190 CD630_13440
PDC : CDIF630_00034(ugtP1) CDIF630_01500(ugtP2)
CDC : CD196_0019 CD196_1208
CDL : CDR20291_0008 CDR20291_1186
PDF : CD630DERM_00190 CD630DERM_13440
ROC : HF520_08555 HF520_13355
PHX : KGNDJEFE_00145(ugtP_1) KGNDJEFE_01463(ugtP_2)
TEM : JW646_09210 JW646_15305
TGC : L0P85_12340 L0P85_18555
TMY : TEMA_17260(ugtP_2) TEMA_29680(ugtP_3)
TPET : TPHSE_00360(ugtP_1) TPHSE_28260(ugtP_3)
IBR : NQ514_01060 NQ514_06900
EAC : EAL2_c00420(ugtP1) EAL2_c20400(ugtP2)
CST : CLOST_0597 CLOST_2388
BACG : D2962_03730 D2962_03885
PTRH : RsTaC01_0202 RsTaC01_1034
HPRF : HLPR_04170 HLPR_04180
SEDZ : JYG23_11680 JYG23_14600
VRM : 44547418_01438(ugtP)
VDN : NCTC11831_00465(ugtP)
DHO : Dia5BBH33_07300 Dia5BBH33_15690
SGBI : P3F81_03230 P3F81_04500
MANA : MAMMFC1_01917(ugtP_1) MAMMFC1_03909(ugtP_2)
STED : SPTER_18040(ugtP_1) SPTER_48330(ugtP_2)
PFAC : PFJ30894_01624(ugtP)
TUR : AT726_07540 AT726_09390
TSG : HLK68_02695 HLK68_06685 HLK68_09205
MNU : NCTC10166_00045(pgaC) NCTC10166_00159
PRV : G7070_04790 G7070_04795
FRI : FraEuI1c_3799 FraEuI1c_6904
PRUN : PCC7821_00742(ugtP)
OBG : Verru16b_01989(ugtP_1) Verru16b_02298(ugtP_2)
VBH : CMV30_10460 CMV30_13670
OBT : OPIT5_11645 OPIT5_24440
MIN : Minf_0951(murG) Minf_1632
MEAP : MTHMO_0783 MTHMO_1082
HBS : IPV69_00930 IPV69_05570
VAI : BU251_04265 BU251_04440
BPO : BP951000_0939(murG2)
BPJ : B2904_orf289 B2904_orf424
DPB : BABL1_gene_141(ugtP_2)
» show all
Taxonomy
Reference
Authors
Jorasch P, Wolter FP, Zahringer U, Heinz E
Title
A UDP glucosyltransferase from Bacillus subtilis successively transfers up to four glucose residues to 1,2-diacylglycerol: expression of ypfP in Escherichia coli and structural analysis of its reaction products.
Journal
Sequence
Reference
Authors
Jorasch P, Warnecke DC, Lindner B, Zahringer U, Heinz E
Title
Novel processive and nonprocessive glycosyltransferases from Staphylococcus aureus and Arabidopsis thaliana synthesize glycoglycerolipids, glycophospholipids, glycosphingolipids and glycosylsterols.
Journal
Sequence
Reference
Authors
Andres E, Martinez N, Planas A
Title
Expression and characterization of a Mycoplasma genitalium glycosyltransferase in membrane glycolipid biosynthesis: potential target against mycoplasma infections.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.315
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