KEGG   ENZYME: 2.4.1.316
Entry
EC 2.4.1.316                Enzyme                                 
Name
tylactone mycaminosyltransferase;
tylM2 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dTDP-alpha-D-mycaminose:tylactone 5-O-beta-D-mycaminosyltransferase
Reaction(IUBMB)
tylactone + dTDP-alpha-D-mycaminose = dTDP + 5-O-beta-D-mycaminosyltylactone [RN:R06450]
Reaction(KEGG)
R06450
Substrate
tylactone [CPD:C12000];
dTDP-alpha-D-mycaminose [CPD:C11933]
Product
dTDP [CPD:C00363];
5-O-beta-D-mycaminosyltylactone [CPD:C12001]
Comment
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. Activity is significantly enhanced by the presence of an accessory protein encoded by the tylM3 gene.
History
EC 2.4.1.316 created 2014
Pathway
ec00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15989  tylactone mycaminosyltransferase
Reference
1  [PMID:9031628]
  Authors
Gandecha AR, Large SL, Cundliffe E
  Title
Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome.
  Journal
Gene 184:197-203 (1997)
DOI:10.1016/S0378-1119(96)00595-1
  Sequence
[ag:CAA57472]
Reference
2  [PMID:15612702]
  Authors
Melancon CE 3rd, Takahashi H, Liu HW
  Title
Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis.
  Journal
J Am Chem Soc 126:16726-7 (2004)
DOI:10.1021/ja043900e
  Sequence
[ag:CAA57472]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.316
IUBMB Enzyme Nomenclature: 2.4.1.316
ExPASy - ENZYME nomenclature database: 2.4.1.316
BRENDA, the Enzyme Database: 2.4.1.316
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