KEGG   ENZYME: 2.4.1.38
Entry
EC 2.4.1.38                 Enzyme                                 

Name
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase;
UDP-galactose---glycoprotein galactosyltransferase;
glycoprotein 4-beta-galactosyl-transferase;
beta-N-acetyl-beta1-4-galactosyltransferase;
thyroid glycoprotein beta-galactosyltransferase;
glycoprotein beta-galactosyltransferase;
thyroid galactosyltransferase;
uridine diphosphogalactose-glycoprotein galactosyltransferase;
beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase;
GalT;
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide [RN:R04495]
Reaction(KEGG)
R04495 > R05989(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminylglycopeptide
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
Comment
Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides, glycoproteins and glycopeptides can act as acceptor. High activity is shown towards such residues in branched-chain polysaccharides when these are linked by beta-1,6-links to galactose residues; lower activity towards residues linked to galactose by beta-1,3-links. A component of EC 2.4.1.22 (lactose synthase).
History
EC 2.4.1.38 created 1972, modified 1976, modified 1980, modified 1986
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec00533  Glycosaminoglycan biosynthesis - keratan sulfate
ec01100  Metabolic pathways
Orthology
K07966  beta-1,4-galactosyltransferase 1
K07967  beta-1,4-galactosyltransferase 2
K07968  beta-1,4-galactosyltransferase 3
Genes
HSA: 2683(B4GALT1) 8703(B4GALT3) 8704(B4GALT2)
PTR: 100613700(B4GALT1) 456522(B4GALT2) 457451(B4GALT3)
PPS: 100974756(B4GALT1) 100980267(B4GALT2) 100980499(B4GALT3)
GGO: 101133326(B4GALT2) 101138982(B4GALT1) 101152694(B4GALT3)
PON: 100174763(B4GALT3) 100437696(B4GALT2) 100438031(B4GALT1) 100442932
NLE: 100597531(B4GALT1) 100598306(B4GALT2) 100600657(B4GALT3)
MCC: 703541(B4GALT1) 704038(B4GALT2) 719920(B4GALT3)
MCF: 102115300(B4GALT2) 102123574(B4GALT3) 102131044(B4GALT1)
CSAB: 103219294(B4GALT1) 103223692(B4GALT3) 103224947(B4GALT2)
CATY: 105589253(B4GALT3) 105590081(B4GALT1) 105594621(B4GALT2)
PANU: 101001587(B4GALT3) 101011230(B4GALT2) 101022281(B4GALT1)
RRO: 104665338(B4GALT3) 104669045(B4GALT2) 104674271(B4GALT1)
RBB: 108518246(B4GALT1) 108521170(B4GALT3) 108535685(B4GALT2)
TFN: 117069449(B4GALT1) 117074758(B4GALT3) 117075850 117092715(B4GALT2)
PTEH: 111529202(B4GALT1) 111543897(B4GALT3) 111548740(B4GALT2)
CJC: 100385157(B4GALT1) 100413633(B4GALT3) 100896540(B4GALT2)
SBQ: 101039415(B4GALT2) 101048901(B4GALT3) 101054125(B4GALT1)
MMUR: 105873539(B4GALT3) 105874372(B4GALT1) 105877433(B4GALT2)
MMU: 14595(B4galt1) 53418(B4galt2) 57370(B4galt3)
MCAL: 110292610(B4galt2) 110292819(B4galt1) 110300448(B4galt3)
MPAH: 110321517(B4galt3) 110322866(B4galt2) 110338771(B4galt1)
RNO: 24390(B4galt1) 313536(B4galt2) 494342(B4galt3)
MCOC: 116095826(B4galt1) 116096507(B4galt2) 116103395(B4galt3)
MUN: 110552917(B4galt2) 110554442(B4galt3) 110561670(B4galt1)
CGE: 100689346(B4galt3) 100689430(B4galt1) 100689434(B4galt2)
PLEU: 114685432(B4galt3) 114703257(B4galt1) 114709360(B4galt2)
NGI: 103741594(B4galt1) 103743868(B4galt2) 103745954(B4galt3)
HGL: 101698779 101702700(B4galt3) 101718811(B4galt2) 101721414(B4galt1)
CCAN: 109681413 109689965 109693205(B4galt3) 109695495(B4galt2)
OCU: 100345726(B4GALT1) 100351419(B4GALT2) 100358436(B4GALT3)
TUP: 102470655(B4GALT1) 102489782(B4GALT2) 102501629(B4GALT3)
CFA: 476397 481579(B4GALT1) 482527(B4GALT2) 488650(B4GALT3)
VVP: 112910047(B4GALT3) 112914817(B4GALT2) 112927554(B4GALT1) 112931239
VLG: 121472037(B4GALT3) 121478852 121481279(B4GALT2) 121494980(B4GALT1)
AML: 100471634(B4GALT2) 100477164(B4GALT1) 100479119 100482718(B4GALT3)
UMR: 103657308 103667105(B4GALT1) 103670800(B4GALT2) 103672017(B4GALT3)
UAH: 113246729(B4GALT3) 113247273 113254774(B4GALT2) 113260528(B4GALT1)
ORO: 101362571(B4GALT1) 101364688(B4GALT2) 101366805(B4GALT3)
MPUF: 101673173(B4GALT3) 101674375 101682229(B4GALT2) 101693610(B4GALT1)
EJU: 114199189(B4GALT3) 114199572 114218153(B4GALT1) 114224318(B4GALT2)
MLX: 118014013(B4GALT3) 118018025(B4GALT1) 118019513(B4GALT2)
FCA: 101084809(B4GALT2) 101089738(B4GALT3) 101100927(B4GALT1)
PYU: 121015477(B4GALT3) 121027002(B4GALT2) 121034567(B4GALT1)
PBG: 122475074(B4GALT1) 122476526(B4GALT3) 122480394(B4GALT2)
PTG: 102955088(B4GALT2) 102959538(B4GALT1) 102965736(B4GALT3)
PPAD: 109252046(B4GALT1) 109254800(B4GALT2) 109257290(B4GALT3)
AJU: 106970225(B4GALT2) 106976144(B4GALT1) 106978533(B4GALT3)
HHV: 120236082(B4GALT2) 120241405(B4GALT3) 120241747(B4GALT1)
BTA: 100125390(B4GALT2) 281781(B4GALT1) 515771(B4GALT3)
BOM: 102269762(B4GALT1) 102273575(B4GALT3) 102283249(B4GALT2)
BIU: 109556391(B4GALT2) 109563168(B4GALT1) 109578355(B4GALT3)
BBUB: 102389487(B4GALT1) 102398964(B4GALT3) 102408682(B4GALT2)
CHX: 100860927(B4GALT1) 102191101(B4GALT2) 102191287(B4GALT3)
OAS: 100620048(B4GALT1) 101103686(B4GALT3) 101114825(B4GALT2)
ODA: 120855549(B4GALT3) 120856268(B4GALT2) 120860345 120866179
CCAD: 122430506(B4GALT3) 122431686(B4GALT1) 122437085(B4GALT2)
SSC: 100154856(B4GALT3) 100511655(B4GALT1) 100514465 100736821(B4GALT2)
CFR: 102516080(B4GALT2) 102517623(B4GALT1) 102523348(B4GALT3)
CBAI: 105064116(B4GALT2) 105065926 105069546(B4GALT3) 105078745(B4GALT1)
CDK: 105085573(B4GALT1) 105090897(B4GALT2) 105100111(B4GALT3)
BACU: 102999260(B4GALT1) 103001417(B4GALT2) 103014433(B4GALT3)
LVE: 103083911(B4GALT3) 103086401(B4GALT1) 103086978(B4GALT2)
OOR: 101278293(B4GALT3) 101285364(B4GALT1) 101285582(B4GALT2)
DLE: 111163203(B4GALT1) 111167059(B4GALT3) 111175715(B4GALT2) 111181131
PCAD: 102981888(B4GALT1) 102991108(B4GALT2) 102991770(B4GALT3)
ECB: 100065936 100066144(B4GALT3) 100066149(B4GALT2) 100068209(B4GALT1)
EPZ: 103540622 103548278(B4GALT2) 103555031(B4GALT1) 103559988(B4GALT3)
EAI: 106822347 106827571(B4GALT3) 106841463(B4GALT1) 106847911(B4GALT2)
MYB: 102240062(B4GALT1) 102245477(B4GALT3) 102248727(B4GALT2)
MYD: 102751484(B4GALT1) 102755410 102770964(B4GALT3) 102774860(B4GALT2)
MMYO: 118649278 118667396(B4GALT1) 118673347(B4GALT3) 118675840(B4GALT2)
MNA: 107526700(B4GALT2) 107531762 107535094(B4GALT3) 107544980(B4GALT1)
HAI: 109371790(B4GALT1) 109376935(B4GALT3) 109383427(B4GALT2)
DRO: 112298941(B4GALT3) 112304428(B4GALT1) 112314589(B4GALT2)
SHON: 118979093(B4GALT3) 118979827(B4GALT1) 119003348(B4GALT2)
AJM: 119052444(B4GALT2) 119052625(B4GALT3) 119060005(B4GALT1)
MMF: 118626982(B4GALT2) 118629472(B4GALT1) 118637263(B4GALT3) 118638845
PALE: 102878748(B4GALT1) 102884318(B4GALT2) 102897413(B4GALT3)
PGIG: 120584209(B4GALT3) 120612917(B4GALT1) 120619485(B4GALT2)
RAY: 107499511(B4GALT2) 107502798(B4GALT1) 107504675(B4GALT3)
MJV: 108385572 108394555(B4GALT3) 108404111(B4GALT1) 108404461(B4GALT2)
TOD: 119232854(B4GALT1) 119235997(B4GALT2) 119241378(B4GALT3)
LAV: 100657659(B4GALT2) 100659897(B4GALT1) 100666904 100671768(B4GALT3)
MDO: 100010600(B4GALT1) 100028240 100032749(B4GALT3) 100617718(B4GALT2)
SHR: 100917085(B4GALT3) 100918732(B4GALT2) 100929465(B4GALT1) 100934965
PCW: 110194785(B4GALT1) 110197965(B4GALT3) 110200216(B4GALT2) 110220169
OAA: 100075607 100075703(B4GALT1) 100092000(B4GALT2) 114807990(B4GALT3)
GGA: 107049101(B4GALT3) 396121(B4GALT1) 396122(B4GALT2) 418342(B4GALT3)
PCOC: 116233877(B4GALT2) 116239317(B4GALT3) 116239467(B4GALT1) 116242432
MGP: 100543545(B4GALT1) 100543680(B4GALT2) 100548019
CJO: 107306674(B4GALT1) 107307393 107317480(B4GALT2) 107320437
NMEL: 110389893(B4GALT1) 110390460 110399414 110402248(B4GALT2)
APLA: 101792630(B4GALT3) 101792817(B4GALT1)
ACYG: 106037599(B4GALT3) 106040136(B4GALT1) 106049039(B4GALT2)
TGU: 100219809 100223491(B4GALT3) 100223650(B4GALT1) 100230857(B4GALT2)
LSR: 110469509(B4GALT2) 110474049(B4GALT1) 110479050(B4GALT3) 110480886
SCAN: 103815164(B4GALT2) 103821842(B4GALT1) 103827099
PMOA: 120503204(B4GALT2) 120506482 120506565(B4GALT3) 120513595(B4GALT1)
GFR: 102034619 102036032(B4GALT2) 102041517(B4GALT1)
FAB: 101805871(B4GALT2) 101807052(B4GALT1) 101809643
PHI: 102104795(B4GALT3) 102106294(B4GALT2) 102108330 102109081(B4GALT1)
PMAJ: 107198186(B4GALT1) 107206030(B4GALT3) 107208264(B4GALT2)
CCAE: 111933140(B4GALT2) 111939118 111941228(B4GALT1)
CCW: 104687054(B4GALT3) 104689823(B4GALT1) 104695261(B4GALT2)
ETL: 114055095 114057877(B4GALT1) 114061818(B4GALT2) 114072102(B4GALT3)
FPG: 101910439(B4GALT3) 101915824 101916596(B4GALT2) 101918852(B4GALT1)
FCH: 102046112(B4GALT1) 102051290 102056545(B4GALT2) 102057757(B4GALT3)
CLV: 102088289(B4GALT1) 102088677(B4GALT2) 102093948 102094059(B4GALT3)
EGZ: 104125508(B4GALT2) 104126496(B4GALT3)
NNI: 104008640 104012591(B4GALT3) 104015428(B4GALT2) 104022647(B4GALT1)
ACUN: 113483103(B4GALT2) 113485122(B4GALT3) 113490200(B4GALT1)
PADL: 103921076(B4GALT1) 103922311(B4GALT3)
AAM: 106484931(B4GALT2) 106486901(B4GALT1) 106490693 106500494(B4GALT3)
AROW: 112960464 112972486(B4GALT3) 112975301(B4GALT1) 112975984(B4GALT2)
NPD: 112942436(B4GALT2) 112948927(B4GALT1) 112950642(B4GALT3) 112951789
DNE: 112981279(B4GALT2) 112989410 112989803(B4GALT1) 112990044(B4GALT3)
ASN: 102370415 102371026 102372956(B4GALT1) 102376584(B4GALT2) 102388067(B4GALT3)
AMJ: 102558168(B4GALT2) 102559129(B4GALT1) 102572436 102575172 106737239(B4GALT3)
CPOO: 109307391(B4GALT2) 109319253(B4GALT3) 109323453(B4GALT1)
GGN: 109286748(B4GALT2) 109298077(B4GALT1) 109304648(B4GALT3)
PSS: 102448865(B4GALT3) 102450039 102459690(B4GALT1) 102461193
CMY: 102937186 102937222(B4GALT3) 102941864(B4GALT2) 102942662(B4GALT1)
CPIC: 101932379(B4GALT1) 101933315 101945883(B4GALT2) 101952944 101953612(B4GALT3)
TST: 117869500(B4GALT3) 117870594 117870597 117878876(B4GALT1) 117881649(B4GALT2) 117886855
CABI: 116816139(B4GALT3) 116816411(B4GALT2) 116825980 116829702(B4GALT1) 116833689
ACS: 100553459 100557158 100557558(b4galt2) 100558708(b4galt3) 100561064(b4galt1)
PVT: 110073738(B4GALT2) 110074017 110081027(B4GALT3) 110087350(B4GALT1) 110089672
PBI: 103050267 103063173(B4GALT3) 103065477(B4GALT1) 103068003 103068203(B4GALT2)
PMUR: 107283468(B4GALT2) 107285615(B4GALT1) 107287654 107288004 107300024(B4GALT3)
TSR: 106544528 106546760(B4GALT2) 106549006 106550798(B4GALT3) 106557055(B4GALT1)
PGUT: 117659979(B4GALT3) 117661724(B4GALT1) 117662142 117664107(B4GALT2) 117669303
PMUA: 114587210(B4GALT3) 114587454(B4GALT1) 114595808 114599120(B4GALT2)
ZVI: 118075850(B4GALT3) 118085305 118087362 118088949(B4GALT2) 118097645(B4GALT1)
GJA: 107106046 107110573(B4GALT1) 107120293(B4GALT2) 107121751(B4GALT3) 107122018
XLA: 100190782(b4galt2.S) 108696936(b4galt3l2.L) 108704693(b4galt1l.S) 108706812(b4galt1.1.S) 108706813(b4galt1.2.S) 108709275(b4galt3l1.S) 108712215(b4galt1.1.L) 108712216(b4galt1.2.L) 108712940 108712957(b4galt1l.L) 108714282(b4galt2.L) 379106(b4galt3.L) 414540(b4galt3.S) 446718(b4galt3l2.S) 496041(b4galt3l1.L)
XTR: 100145518(b4galt1.1) 100485024(b4galt1l) 100486704(b4galt3) 100492356(b4galt2) 116406683 448369(b4galt3l1) 549418(b4galt1.2) 733985(b4galt3l2)
DRE: 100148828(b4galt2) 550425(b4galt1) 556544(si:dkey-199f5.8) 561756(b4galt3) 768123(b4galt1l)
PHYP: 113530669(b4galt3) 113540104(b4galt1) 113540513(b4galt2)
PLEP: 121946371(si:dkey-199f5.8) 121947292(b4galt3) 121948152(b4galt1l) 121951595(b4galt2) 121960985 121960986
SLUC: 116046231(b4galt2) 116051105 116060258(b4galt1l) 116060298(si:dkey-199f5.8) 116062138(b4galt3)
ECRA: 117938145 117941477 117946023(si:dkey-199f5.8) 117948212(b4galt3) 117954208(b4galt2)
GAT: 120810580(si:dkey-199f5.8) 120811611 120816058(b4galt2) 120817303(b4galt1l) 120829516(b4galt3)
MSAM: 119884175 119897191(si:dkey-199f5.8) 119901943(b4galt2) 119905708(b4galt3) 119908413
CUD: 121513435(si:dkey-199f5.8) 121516558(b4galt1l) 121517984(b4galt3) 121519912(b4galt2) 121527509 121527692 121527693
OAU: 116315312(b4galt2) 116325514(si:dkey-199f5.8) 116328309 116330844(b4galt3) 116332053(b4galt1l) 116332060
OLA: 100301598(b4galt2) 101159351(b4galt3) 101162708 101171148(b4galt1)
OML: 112136663(si:dkey-199f5.8) 112147730(b4galt2) 112153596(b4galt1l) 112159005(b4galt3)
CTUL: 119776087 119781275 119784322(b4galt3) 119784548(b4galt1l) 119784620 119787615 119787995 119798287(si:dkey-199f5.8)
KMR: 108235243(b4galt3) 108241697(b4galt2) 108243995 108248973(b4galt1l) 108249546 108250944 108251055(si:dkey-199f5.8)
SDU: 111219126 111219224(b4galt3) 111230961(b4galt2) 111233512(b4galt1) 111235761 111237265
XGL: 120784194(si:dkey-199f5.8) 120785455(b4galt1l) 120790010 120799105(b4galt2) 120804247(b4galt3)
PKI: 111838658 111842288(b4galt3) 111846077(b4galt2) 111848718(b4galt1)
AANG: 118206549(si:dkey-199f5.8) 118208303 118211026(b4galt3) 118227568 118229995(b4galt2) 118231327(b4galt1l)
BBIF: 117210695
CGIG: 122398244
CCIN: 107268547
API: 100302475(NV135)
DNX: 107166054
AGS: 114128088
RMD: 113554920
NLU: 111053488
PVM: 113821378
CEL: CELE_Y73E7A.7(bre-4)
CBR: CBG22165(Cbr-bre-4)
 » show all
Reference
1  [PMID:6784450]
  Authors
Beyer TA, Sadler JE, Rearick JI, Paulson JC, Hill RL.
  Title
Glycosyltransferases and their use in assessing oligosaccharide structure and structure-function relationships.
  Journal
Adv Enzymol Relat Areas Mol Biol 52:23-175 (1981)
DOI:10.1002/9780470122976.ch2
Reference
2  [PMID:6816588]
  Authors
Blanken WM, Hooghwinkel GJ, Van Den Eijnden DH.
  Title
Biosynthesis of blood-group I and i substances. Specificity of bovine colostrum beta-N-acetyl-D-glucosaminide beta 1 leads to 4 galactosyltransferase.
  Journal
Eur J Biochem 127:547-52 (1982)
DOI:10.1111/j.1432-1033.1982.tb06906.x
Reference
3  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J Biol Chem 260:12927-34 (1985)
Reference
4  [PMID:5726898]
  Authors
Spiro MJ, Spiro RG.
  Title
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid galactosyltransferase.
  Journal
J Biol Chem 243:6529-37 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.38
IUBMB Enzyme Nomenclature: 2.4.1.38
ExPASy - ENZYME nomenclature database: 2.4.1.38
BRENDA, the Enzyme Database: 2.4.1.38
CAS: 37237-43-7
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