Entry
Name
nicotinate-nucleotide diphosphorylase (carboxylating);
quinolinate phosphoribosyltransferase (decarboxylating);
quinolinic acid phosphoribosyltransferase;
QAPRTase;
NAD+ pyrophosphorylase;
nicotinate mononucleotide pyrophosphorylase (carboxylating);
quinolinic phosphoribosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
beta-nicotinate-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
Reaction(IUBMB)
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate [RN:
R03348 ]
Reaction(KEGG)
Substrate
Product
pyridine-2,3-dicarboxylate [CPD:
C03722 ];
5-phospho-alpha-D-ribose 1-diphosphate [CPD:
C00119 ]
Comment
The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes [3].
History
EC 2.4.2.19 created 1972
Pathway
ec00760 Nicotinate and nicotinamide metabolism
Orthology
K00767 nicotinate-nucleotide pyrophosphorylase (carboxylating)
Genes
TOD : 119240176(QPRT) 119243942
PMUR : 107282743 107296375
SASA : 106564934 106588089 106596120
STRU : 115178478 115208659
SALP : 111961232 112080741
CCLU : 121534002 121534003
CSAT : 104710041 104779446 104793810
HSYR : 120133915 120211522
PCIN : 129321233 129321321
MEAN : 126680814 126680815
CILL : 122310405 122314466
NTA : 107820078(BYJ6) 107825849 107829122(QPT) 107829123(qpt1)
SSPL : 121779971 121782901
SMIL : 131014482 131014499
CSIN : 114261073 114299469
PSOM : 113310050 113320837
TAES : 123104753 123116830 123122559
MFLO : 136546716 136552281
PVIR : 120658363 120686350
SMO : SELMODRAFT_229197 SELMODRAFT_271353
NDI : NDAI_0G00870(NDAI0G00870)
TPF : TPHA_0G03620(TPHA0G03620)
TDL : TDEL_0D06310(TDEL0D06310)
LBG : 92205451(LODBEIA_P02550)
CAL : CAALFM_C107840WA(CaO19.5054)
YLI : 2912425(YALI2_E00155g)
NTE : NEUTE1DRAFT126722(NEUTE1DRAFT_126722)
SMP : 10810023(SMAC4_12623)
FPOA : FPOAC1_012111(BNA6)
TATV : 25777878(TrAtP1_012927)
TASP : 36615012(TrAFT101_009818)
PLJ : 28888216(PLICBS_003421)
CDET : 87944262(CDEST_07759)
BFU : BCIN_09g05800(Bcbna6)
PTRR : 6341601(PtrM4_069990)
CDEP : 91085212(L203_100998)
KMG : 30167420(I203_106330)
KNE : 92178232(IAR55_000973)
CCAC : CcaHIS019_0106290(BNA6)
ABP : AGABI1DRAFT120105(AGABI1DRAFT_120105)
ABV : AGABI2DRAFT203288(AGABI2DRAFT_203288)
SCM : SCHCO_02263611(SCHCODRAFT_02263611)
BLAC : 94345925(CCR75_002155)
ECOO : ECRM13514_0111(nadC)
ECOH : ECRM13516_0114(nadC)
ECW : EcE24377A_0111(nadC)
EDJ : ECDH1ME8569_0103(nadC)
ECOI : ECOPMV1_00110(nadC_1)
REE : electrica_04225(nadC)
RTG : NCTC13098_06178(nadC_2)
CLAP : NCTC11466_03813(nadC_2)
KIE : NCTC12125_02927(nadC)
AHN : NCTC12129_00891(nadC)
PSHI : SAMEA2665130_0408(nadC)
YPG : YpAngola_A1040(nadC)
YPI : YpsIP31758_3369(nadC)
SMW : SMWW4_v1c07650(nadC)
SFJ : SAMEA4384070_0803(nadC)
SOF : NCTC11214_00745(nadC)
SSAR : SSARUM_000708(nadC)
PAQU : DMB82_0017075(nadC)
PARL : PEC302110_33290(nadC)
DIC : Dpoa569_000621(nadC)
TPTY : NCTC11468_03074(nadC)
PRG : RB151_030270(nadC_2)
PHEI : NCTC12003_01264(nadC_2)
PRJ : NCTC6933_02740(nadC_2)
XFU : XFF4834R_chr26770(nadC)
XPH : XppCFBP6546_22500(nadC)
LLZ : LYB30171_00885(nadC)
VAU : VANGNB10_cI0474c(nadC)
VPL : SA104470976_00404(nadC)
PAEB : NCGM1900_2359(nadC)
PVD : CFBP1590__1071(nadC)
PPRC : PFLCHA0_c08650(nadC)
PMUD : NCTC8068_04501(nadC)
PFW : PF1751_v1c07650(nadC)
PPUU : PputUW4_00712(nadC)
PTRT : HU722_0005205(nadC)
PTAE : NCTC10697_00783(nadC)
PPSE : BN5_0672(nadC1) BN5_0675(nadC3) BN5_3622(nadC5)
MSHE : MAALD49_23720(nadC)
PSYC : DABAL43B_0716(nadC)
MCAT : MC25239_00804(nadC)
SCAA : TUM17387_03810(nadC)
SALH : HMF8227_02454(nadC)
CBS : COXBURSA331_A0184(nadC)
LLG : 44548918_01712(nadC)
LJR : NCTC11533_01886(nadC)
LCJ : NCTC11976_02783(nadC)
LWA : SAMEA4504053_1138(nadC)
LSS : NCTC12082_00771(nadC)
LADL : NCTC12735_01403(nadC)
LANT : TUM19329_13670(nadC)
MISZ : MishRS11D_40300(nadC)
TIB : THMIRHAM_13240(nadC)
TSE : THMIRHAS_11390(nadC)
TZO : THMIRHAT_12380(nadC)
TLR : Thiosp_02270(nadC_1)
TFRI : Thiofri_02229(nadC_1)
TWG : Thiowin_00903(nadC_1)
TNI : TVNIR_2339(nadC_[H])
THIC : TspCOW1_17120(nadC)
HAAH : HALA3H3_590082(nadC)
HSR : HSBAA_48130 HSBAA_52850(nadC)
HMD : CTT34_14930 CTT34_16710
HSX : HNO51_04255 HNO51_14925
ALCA : ASALC70_01119(nadC_1)
MPRF : J8N69_04530 J8N69_15645(nadC)
MGEO : CFI10_06505 CFI10_14960
AEL : NCTC12917_03766(nadC)
CDIZ : CEDIAZO_00555(nadC)
NMM : NMBM01240149_1692(nadC)
NMS : NMBM01240355_0402(nadC)
NMQ : NMBM04240196_0404(nadC)
NMZ : NMBNZ0533_1853(nadC)
NMX : NMA510612_2362(nadC)
NWE : SAMEA3174300_1138(nadC)
NCZ : NCTC10294_00102(nadC)
ECOR : SAMEA4412678_2136(nadC)
RPF : Rpic12D_2326 Rpic12D_2781 Rpic12D_4960
REH : H16_A3037(nadC) H16_B0560(h16_B0560)
CNC : CNE_1c29930(nadC) CNE_2c05070(nadC1) CNE_2c21250(nadC2)
CUH : BJN34_16225 BJN34_24420
REU : Reut_A2736 Reut_B3748
CTI : RALTA_A2512(nadC) RALTA_B0358
CBW : RR42_m3463 RR42_s0086
CPAU : EHF44_08670 EHF44_27055(nadC)
COX : E0W60_07830(nadC) E0W60_24255
CCAM : M5D45_06945(nadC) M5D45_13730(nadC)
CUK : KB879_16015 KB879_20255(nadC) KB879_27600
BMV : BMASAVP1_A2650(nadC)
BML : BMA10229_A1025(nadC)
BPM : BURPS1710b_1132(nadC)
BPL : BURPS1106A_0979(nadC)
BVI : Bcep1808_2583 Bcep1808_4270
BMJ : BMULJ_02470(nadC) BMULJ_03709(nadC)
BMK : DM80_2457(nadC) DM80_4023(nadC)
BUM : AXG89_09365 AXG89_16660
BUI : AX768_02995 AX768_26355
PHS : C2L64_03215 C2L64_49430
PMEG : FNZ07_23510(nadC) FNZ07_26560(nadC)
PSPU : NA29_11675 NA29_24000
PNR : AT302_02675 AT302_20355
PANN : PanNE5_13520(nadC_1) PanNE5_24290(nadC_2)
PANX : OYT13_00085(nadC) OYT13_19365(nadC)
PLG : NCTC10937_00986(nadC)
LMIR : NCTC12852_01022(nadC)
BUO : BRPE64_ACDS05860(nadC)
BTRM : SAMEA390648700622(nadC)
AXX : ERS451415_00709(nadC)
OUE : I6G29_03085 I6G29_11490
RHF : EUB48_12525(nadC) EUB48_15485(nadC)
ACID : CBP33_04180 CBP33_05495
ACIP : CBP36_04605 CBP36_05945 CBP36_20420
ACIN : CBP34_04125 CBP34_05330
ACIS : CBP35_13000 CBP35_14335 CBP35_20500
DEL : DelCs14_1657 DelCs14_4992
HTN : KI616_03565(nadC) KI616_06955(nadC)
SMIO : CATMQ487_26430(nadC)
HFR : G5S34_06810(nadC) G5S34_12090
CFU : CFU_1382(nadC) CFU_4303(nadC2)
CPRA : CPter91_2661(nadC) CPter91_3596(nadC)
MASW : AM586_14990 AM586_27425 AM586_27610 AM586_27675
MVAR : MasN3_27560(nadC_1) MasN3_30250(nadC_2)
URU : DSM104443_02447(nadC)
UPL : DSM104440_02201(nadC)
THAG : CKCBHOJB_02129(nadC)
FPHO : SHINM1_003950(nadC)
BEBA : BWI17_02245 BWI17_14990
ERW : ERWE_CDS_00010(nadC)
ERG : ERGA_CDS_00010(nadC)
MLO : mll5833 mll6272 mll9102
MAMO : A6B35_09195 A6B35_30440
MHUA : MCHK_12015 MCHK_12805
MOH : IHQ72_31685 IHQ72_32475
AMIS : Amn_10290 Amn_24770
RBS : RHODOSMS8_00279(nadC)
SMEL : SM2011_c02598(nadC)
SFD : USDA257_c08210(nadC)
SAME : SAMCFNEI73_Ch1163(nadC)
EAK : EKH55_0735 EKH55_5939
AVV : RvVAT039_32640(nadC)
AVF : RvVAR031_19600(nadC)
ASAL : CFBP5507_18500(nadC)
ALEG : CFBP4996_21590(nadC)
REC : RHECIAT_PA0000362(nadC)
REL : REMIM1_PC00214(nadC-1) REMIM1_PD00462(nadC-2)
REP : IE4803_PA00398(nadC)
REI : IE4771_PC00411(nadC)
RTR : RTCIAT899_PC03290(nadC)
RHL : LPU83_pLPU83d1490(nadC)
RGA : RGR602_CH01079(nadC)
RPHA : AMC79_PB00371(nadC)
RLW : RlegWSM1455_31520(nadC)
BSEP : HAP48_0041080(nadC)
BCAN : BcanWSM471_11790(nadC)
TRB : HB776_01020 HB776_17435
XDI : EZH22_01200 EZH22_05160(nadC)
MAQU : Maq22A_1p30175(nadC)
MTUN : MTUNDRAET4_0436(nadC)
FIL : BN1229_v1_0092(nadC)
FIY : BN1229_v1_0095(nadC)
LABT : FIU93_00295(nadC1) FIU93_07120(nadC2)
BVY : NCTC9239_00421(nadC)
TSV : DSM104635_02607(nadC)
RLI : RLO149_c031710(nadC)
PHP : PhaeoP97_00731(nadC)
PPIC : PhaeoP14_02521(nadC)
LMD : METH_01950 METH_16995
MALG : MALG_00032 MALG_03671
TPRO : Ga0080559_TMP3754 Ga0080559_TMP5096
PABY : Ga0080574_TMP2115 Ga0080574_TMP275
SINL : DSM14862_00117(nadC)
SPSE : SULPSESMR1_04444(nadC)
AHT : ANTHELSMS3_04941(nadC)
LVS : LOKVESSMR4R_00084(nadC)
AALK : LGT41_0003540(nadC)
LVR : T8T21_00465(nadC) T8T21_19405(nadC)
NDR : HT578_08875(nadC) HT578_13235(nadC)
NOL : NSDW_00180(nadC) NSDW_22700
SPHR : BSY17_2172(nadC) BSY17_4181(nadC)
SHYD : CJD35_07800(nadC) CJD35_19405(nadC) CJD35_19650(nadC)
SPAG : sphantq_01265(nadC_1) sphantq_04514(nadC_2)
SFLA : SPHFLASMR4Y_03243(nadC)
BLAS : BSY18_3648 BSY18_510(nadC)
POT : E2E27_02615(nadC) E2E27_18205(nadC)
TLU : R1T41_00600(nadC) R1T41_09730(nadC)
THGO : M9H61_11755(nadC) M9H61_18390(nadC)
HPO : HMPREF4655_20259(nadC)
HPX : HMPREF0462_0051(nadC)
HCL : NCTC13205_00479(nadC)
HSH : NHP194022_02770(nadC)
HPUL : NCTC13154_00493(nadC)
CFV : CFVI03293_0928(nadC)
CAMP : CFT03427_0815(nadC)
GEC : GEO60473_13870(nadC)
GBN : GEOBRER4_21740(nadC)
PPOR : JCM14722_01290(nadC)
DMM : dnm_048350(nadC1) dnm_069510(nadC2)
DAX : FDQ92_00085(nadC) FDQ92_15020(nadC)
BAZ : BAMTA208_13665(nadC)
BSON : S101395_01576(nadC)
BFD : NCTC4823_03825(nadC)
BKW : BkAM31D_04630(nadC_1)
BLEN : NCTC4824_02213(nadC)
SPIC : SAMEA4384060_1151(nadC)
LMOC : LMOSLCC5850_2086(nadC)
LMW : LMOSLCC2755_2077(nadC)
LMX : LMOSLCC2372_2091(nadC)
LMZ : LMOSLCC2482_2080(nadC)
LMON : LMOSLCC2376_1979(nadC)
LMOS : LMOSLCC7179_1996(nadC)
LMOO : LMOSLCC2378_2040(nadC)
LMOY : LMOSLCC2479_2088(nadC)
LMOT : LMOSLCC2540_2098(nadC)
LMOA : LMOATCC19117_2036(nadC)
BAYD : BSPP4475_20060(nadC)
PPQ : PPSQR21_000600(nadC)