KEGG   ENZYME: 2.4.2.38
Entry
EC 2.4.2.38                 Enzyme                                 
Name
glycoprotein 2-beta-D-xylosyltransferase;
beta1,2-xylosyltransferase;
UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase;
UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
UDP-alpha-D-xylose:N4-{beta-D-GlcNAc-(1->2)-alpha-D-mannosyl-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] 2-beta-D-xylosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-xylose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = UDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] [RN:R06016]
Reaction(KEGG)
R06016(G)
Substrate
UDP-alpha-D-xylose [CPD:C00190];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
Product
UDP [CPD:C00015];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
Comment
Specific for N-linked oligosaccharides (N-glycans).
History
EC 2.4.2.38 created 2001
Pathway
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03714  glycoprotein 2-beta-D-xylosyltransferase
Genes
SPU105445658
APLC110987877
SKO102800701
BTAB109042524
LGILOTGIDRAFT_128470 LOTGIDRAFT_153919 LOTGIDRAFT_233310
PCAN112571639
BGT106080300
GAE121367301 121367478 121367479
HRF124121880 124123094 124130879 124153091
HRJ124270140
CRG105319840 105333687 105339030
MYI110443248 110455369 110458688
PMAX117331275 117338533 117338575
MMER123522824 123523389 123523772 123524440 123528726 123530332 123534390 123544387 123545584 123550581 123550583 123550584 123552856 123561823 123563735
OBI106875510 106877045
OSN115209328 115210847
LAK106163443 106172208 112041729
EPA110252249
PDAM113666318 113666319
SPIS111332657 111332658
ATHAT5G55500(XYLT)
ALY9302172
CRB17876330
CSAT104726096 104731892 104761588
EUSEUTSA_v10013238mg
BRP103856986
BNA106345988 111211577
BOE106328005
RSZ108826879 108847859
THJ104811644
CPAP110820842
CIT102626878
CICCICLE_v100081212m
PVY116137382
MINC123202120 123220484
TCC18593385
GRA105768513 105781371
GHI107903431 107917941 107922453 107932716
GAB108450816 108480423
DZI111275629 111301565
EGR104448163 104450279 104451373 108960314
GMX100810186 100812319 100816008 100816533
GSJ114396417 114396542 114423486 114423487
PVUPHAVU_006G051000g
VRA106776281
VAR108343439
VUN114188267
CCAJ109789838
APRC113855059
MTRMTR_3g055690
CAM101507410
ADU107465751
AIP107624152
AHF112720198 112790609
LANG109330108
FVE101314264
RCN112165880 112168443
PPER18778489
PMUM103326601
PAVI110758283
PDUL117625897
MDM103407929 103448450
PXB103928133 103940105 103951441 103954513 103954547
ZJU107404289 107433180
MNT21392859
CSV101217309
CMO103501220
BHJ120086722
MCHA111010335
CMAX111477326
CMOS111442689
CPEP111797708
RCU8277560
JCU105633042
HBR110633648 110665200
MESC110601951
POP7485076
PEU105116937
PALZ118056802
JRE108984915
QSU112022592 112022622
QLO115957363 115986275
TWL119988741 119990155
VVI100232898(XT1)
VRI117909098
SLY101253606
SPEN107024140
SOT102594653(xt1)
CANN107878772
NTA107760241(xylt) 107795800(xylt)
NSY104214329
NTO104116748
NAU109241583
INI109178158
ITR116020120
SIND105176760
OEU111367061 111367063 111395759 111395762
EGT105962061
SSPL121784918 121807308
HAN110926525
ECAD122592692
LSV111882303
CCAV112505019 112514878
DCR108223942
CSIN114277880 114323605 114323606
BVG104891804
SOE110774679
CQI110705963
NNU104606563
MING122089671 122094180
TSS122640508 122642953
PSOM113336852 113348483
NCOL116258686
OSA4345969
DOSAOs08t0503800-01(Os08g0503800)
OBR102707144
BDI100843487
ATS109773455
TDC119329564 119337345
TAES123151121 123156485 123164878
SBI8055192
ZMA732746
SITA101770206
SVS117860921
PVIR120678493 120712775
PHAI112898424
PDA103723962
EGU105038937
MUS103992376
DCT110091925 110106140
PEQ110029936 110038399
AOF109834768
ATR18446655
SMOSELMODRAFT_168165(XylT)
PPP112291590
CRECHLRE_09g391282v5
OTAOT_ostta02g00040
FCYFRACYDRAFT_249126
PIFPITG_14483
PSOJPHYSODRAFT_481680 PHYSODRAFT_486427
SPARSPRG_04092
 » show all
Reference
1  [PMID:9395463]
  Authors
Zeng Y, Bannon G, Thomas VH, Rice K, Drake R, Elbein A.
  Title
Purification and specificity of beta1,2-xylosyltransferase, an enzyme that contributes to the allergenicity of some plant proteins.
  Journal
J Biol Chem 272:31340-7 (1997)
DOI:10.1074/jbc.272.50.31340
Reference
2  [PMID:10781814]
  Authors
Strasser R, Mucha J, Mach L, Altmann F, Wilson IB, Glossl J, Steinkellner H
  Title
Molecular cloning and functional expression of beta1, 2-xylosyltransferase cDNA from Arabidopsis thaliana.
  Journal
FEBS Lett 472:105-8 (2000)
DOI:10.1016/S0014-5793(00)01443-5
  Sequence
[ath:AT5G55500]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.38
IUBMB Enzyme Nomenclature: 2.4.2.38
ExPASy - ENZYME nomenclature database: 2.4.2.38
BRENDA, the Enzyme Database: 2.4.2.38
CAS: 141256-56-6
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