Entry
Name
S-methyl-5'-thioinosine phosphorylase;
MTIP;
MTI phosphorylase;
methylthioinosine phosphorylase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
Reaction(IUBMB)
S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate [RN:
R09668 ]
Reaction(KEGG)
Substrate
S-methyl-5'-thioinosine [CPD:
C19787 ];
phosphate [CPD:
C00009 ]
Product
hypoxanthine [CPD:
C00262 ];
S-methyl-5-thio-alpha-D-ribose 1-phosphate [CPD:
C04188 ]
Comment
No activity with S-methyl-5'-thioadenosine. The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC
3.5.4.31 , S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine [1].
History
EC 2.4.2.44 created 2011
Pathway
ec00270 Cysteine and methionine metabolism
Orthology
K19696 5'-methylthioinosine phosphorylase
Genes
XFU : XFF4834R_chr31650(deoD)
XPH : XppCFBP6546_04755(XppCFBP6546P_04755)
PPUU : PputUW4_03513(mtnP)
TNI : TVNIR_1603(mtnP_[H])
PIV : NCTC13079_00723(mtnP)
SBU : SpiBuddy_1534 SpiBuddy_1733
SGP : SpiGrapes_0255 SpiGrapes_3280
SASS : MUG09_08500 MUG09_09655
» show all
Taxonomy
Reference
Authors
Guan R, Ho MC, Almo SC, Schramm VL
Title
Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.44
ExPASy - ENZYME nomenclature database: 2.4.2.44
LinkDB
All DBs