Entry
Name
xylosyl alpha-1,3-xylosyltransferase;
XXYLT1 (gene name)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-xylose:[EGF-like domain protein]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine 3-alpha-D-xylosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine = UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine [RN:
R12637 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-xylose [CPD:
C00190 ];
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
Product
UDP [CPD:
C00015 ];
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
Comment
The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.
History
EC 2.4.2.62 created 2020
Pathway
ec00514 Other types of O-glycan biosynthesis
Orthology
K23800 xylosyl alpha-1,3-xylosyltransferase
Genes
CCAN : 109692776 109692777(Xxylt1)
NCAR : 124990173 124992852
GVR : 103586811(XXYLT1) 103601767
BOM : 102265999(XXYLT1) 102282131
AMJ : 102576451(XXYLT1) 109286051
SANH : 107677510 107685961
SGH : 107551790(xxylt1) 107581703
CCAR : 109076241 109098340
CAUA : 113055328 113110938
CGIB : 127968555 128022176
MASI : 127425914 127427752
TNG : GSTEN00019852G001 GSTEN00019874G001 GSTEN00024527G001
MSAM : 119881901 119900612(xxylt1) 119903385 119915313
AOCE : 111569259(xxylt1) 111585648
SASA : 106573863 106613663(xxylt1)
CCLU : 121533634(xxylt1) 121576837
PSPA : 121307632 121323443 121327319(xxylt1)
ARUT : 117416976(xxylt1) 117423164
SPU : 115918677 115918680 575308 575517
LPIC : 129276233 129276595
DSI : Dsimw501_GD29218(Dsim_GD29218)
VCAN : 122418328 122418762
DMK : 116929617 116933696 123474008
AFRA : 136024864 136024975 136025179 136026673 136029992 136031624 136033497 136042292
EAF : 111697990 111699263 111699268 111699566 111708450 111709088 111709097 111711480 111712451 111714345 111715508 111715934
PPOI : 119096272 119096274
DSV : 119444486 119444958 119445983 119450235
RSAN : 119383281 119383282 119390457
CSCU : 111613684 111620252 111620253
PTEP : 107452048 107453466
ABRU : 129964262 129983754
LPOL : 106457140 106461570
DPOL : 127841067 127841694 127842085
» show all
Taxonomy
Reference
Authors
Minamida S, Aoki K, Natsuka S, Omichi K, Fukase K, Kusumoto S, Hase S
Title
Detection of UDP-D-xylose: alpha-D-xyloside alpha 1-->3xylosyltransferase activity in human hepatoma cell line HepG2.
Journal
Reference
Authors
Sethi MK, Buettner FF, Ashikov A, Krylov VB, Takeuchi H, Nifantiev NE, Haltiwanger RS, Gerardy-Schahn R, Bakker H
Title
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch.
Journal
Sequence
Reference
Authors
Yu H, Takeuchi M, LeBarron J, Kantharia J, London E, Bakker H, Haltiwanger RS, Li H, Takeuchi H
Title
Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.62
ExPASy - ENZYME nomenclature database: 2.4.2.62
LinkDB
All DBs