KEGG   ENZYME: 2.4.2.64
Entry
EC 2.4.2.64                 Enzyme                                 
Name
tRNA-guanosine34 queuine transglycosylase;
QTRT1 (gene name);
QTRT2 (gene name);
TGT (ambiguous);
guanine insertion enzyme (ambiguous);
tRNA transglycosylase (ambiguous);
Q-insertase (ambiguous);
queuine34 transfer ribonucleate ribosyltransferase;
transfer ribonucleate glycosyltransferase (ambiguous);
tRNA guanine34 transglycosidase (ambiguous);
queuine tRNA-ribosyltransferase;
[tRNA]-guanine34:queuine tRNA-D-ribosyltransferase;
transfer ribonucleic acid guanine34 transglycosylase (ambiguous)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
Reaction(IUBMB)
guanine34 in tRNA + queuine = queuine34 in tRNA + guanine [RN:R03789]
Reaction(KEGG)
R03789
Substrate
guanine34 in tRNA;
queuine [CPD:C01449]
Product
queuine34 in tRNA;
guanine [CPD:C00242]
Comment
Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eukaryotes and a small number of prokaryotes queuine is salvaged and incorporated into tRNA directly via a base-exchange reaction, replacing guanine. cf. EC 2.4.2.29, tRNA-guanosine34 preQ1 transglycosylase.
History
EC 2.4.2.64 created 2020 (EC 2.4.2.29 created 1984, modified 2007, modified 2012, part transferred 2020 to EC 2.4.2.64)
Orthology
K00777  queuine tRNA-ribosyltransferase catalytic subunit
Genes
HSA81890(QTRT1)
PTR455717(QTRT1)
PPS100975608(QTRT1)
GGO101154454(QTRT1)
PON100444443(QTRT1)
NLE100599300(QTRT1)
MCC715940(QTRT1)
MCF102115330(QTRT1)
CSAB103234362(QTRT1)
CATY105601458(QTRT1)
PANU101001059(QTRT1)
TGE112612045(QTRT1)
RRO104670464(QTRT1)
RBB108539970(QTRT1)
TFN117075432(QTRT1)
PTEH111527758(QTRT1)
CJC100411867(QTRT1)
SBQ101053078(QTRT1)
CSYR103276681(QTRT1)
MMUR105885579(QTRT1)
LCAT123634371(QTRT1)
OGA100962192(QTRT1)
MMU60507(Qtrt1)
MCAL110302073(Qtrt1)
MPAH110328125(Qtrt1)
RNO64016(Qtrt1)
MCOC116073357(Qtrt1)
MUN110552450(Qtrt1)
CGE100771664(Qtrt1)
MAUA101829997(Qtrt1)
PLEU114695225(Qtrt1)
MORG121451629(Qtrt1)
MFOT126490566
AAMP119809686(Qtrt1)
NGI103747548(Qtrt1)
HGL101725775(Qtrt1)
CPOC100723403(Qtrt1)
CCAN109689054(Qtrt1)
DORD105999079(Qtrt1)
DSP122119748(Qtrt1)
NCAR124969378
OCU100348707(QTRT1)
OPI101522668(QTRT1)
TUP102486268(QTRT1)
CFA476711(QTRT1)
CLUD112666512(QTRT1)
VVP112908096(QTRT1)
VLG121496227(QTRT1)
AML100474205(QTRT1)
UMR103678719(QTRT1)
UAH113243000(QTRT1)
UAR123777745(QTRT1)
ELK111162451
LLV125084743
MPUF101675482(QTRT1)
ORO101380771(QTRT1)
EJU114197726(QTRT1)
ZCA113917224(QTRT1)
MLX118005240(QTRT1)
NSU110593909(QTRT1)
FCA101096292(QTRT1)
PYU121013991(QTRT1)
PBG122486874(QTRT1)
LRUF124524743
PTG102951486(QTRT1)
PPAD109254095(QTRT1)
AJU106980302(QTRT1)
HHV120244470(QTRT1)
BTA505497(QTRT1)
BOM102269615(QTRT1)
BBUB102409777(QTRT1)
CHX102190121(QTRT1)
OAS101119045(QTRT1)
ODA120863961(QTRT1)
CCAD122440413(QTRT1)
SSC100524546(QTRT1)
CFR102505536(QTRT1)
CBAI105068391(QTRT1)
CDK105087626(QTRT1)
VPC102531876(QTRT1)
BACU103013206(QTRT1)
LVE103085623(QTRT1)
OOR101281016(QTRT1)
DLE111166172(QTRT1)
PCAD102991187(QTRT1)
PSIU116750442(QTRT1)
ECB100057666(QTRT1)
EPZ103562421(QTRT1)
EAI106846634(QTRT1)
MYB102252641(QTRT1)
MYD102769901(QTRT1)
MMYO118658971(QTRT1)
MLF102430916(QTRT1)
MNA107533291(QTRT1)
PKL118731161(QTRT1)
HAI109391578(QTRT1)
DRO112301579(QTRT1)
AJM119055687(QTRT1)
PDIC114502771(QTRT1)
PHAS123828525(QTRT1)
MMF118616312(QTRT1)
RFQ117037460(QTRT1)
PALE102891985(QTRT1)
PGIG120610846(QTRT1)
PVP105305609(QTRT1)
RAY107515117(QTRT1)
MJV108398216(QTRT1)
TOD119240954(QTRT1)
SARA101551416(QTRT1)
LAV100661071(QTRT1)
TMU101353820
DNM101426637
MDO100011778(QTRT1)
GAS123232059(QTRT1)
SHR100917837(QTRT1) 116422291
PCW110214224(QTRT1)
OAA100083698(QTRT1)
GGA107050606(QTRT1)
CJO107307222(QTRT1)
APLA113841493
AFUL116500051(QTRT1)
TGU115491767(QTRT1)
LSR116184701(QTRT1)
PMOA120506296(QTRT1)
OTC121338550(QTRT1)
PRUF121362651
PHI102103890(QTRT1)
TALA116961338(QTRT1)
ACHC115338391 115348220
ASN102388013(QTRT1)
AMJ106737059(QTRT1)
PSS102456523(QTRT1)
CMY102938523(QTRT1)
CPIC101937222(QTRT1)
CABI116824833(QTRT1)
MRV120390808(QTRT1)
ACS100556886(qtrt1)
PVT110078025(QTRT1)
SUND121923757(QTRT1)
PBI103056797(QTRT1)
PMUR107298152(QTRT1)
CTIG120319626(QTRT1)
TSR106539654(QTRT1)
PGUT117677557(QTRT1)
PMUA114587719(QTRT1)
ZVI118097945(QTRT1)
GJA107109759(QTRT1)
STOW125436811(QTRT1)
XLA734584(qtrt1.S)
XTR394694(qtrt1)
NPR108797847(QTRT1)
RTEM120933308(QTRT1)
BBUF120986406(QTRT1)
BGAR122929305(QTRT1)
DRE393985(qtrt1)
SRX107711213 107744982
SANH107661875 107670462
SGH107602698(qtrt1)
CCAR109052182 109052203
CAUA113067690(qtrt1)
PPRM120489707(qtrt1)
MAMB125254266(qtrt1)
IPU108257001(qtrt1)
PHYP113546205(qtrt1)
SMEO124375703(qtrt1)
TFD113661944(qtrt1)
AMEX103032114(qtrt1)
EEE113587306(qtrt1)
TRU101077169(qtrt1)
TNGGSTEN00019772G001
LCO104918590(qtrt1)
NCC104945819(qtrt1)
CGOB115011687(qtrt1)
ELY117268125(qtrt1)
EFO125879771(qtrt1)
PLEP121956924(qtrt1)
SLUC116059448(qtrt1)
ECRA117958758(qtrt1)
ESP116703679(qtrt1)
PFLV114568915(qtrt1)
GAT120827309(qtrt1)
PPUG119221139(qtrt1)
MSAM119896507(qtrt1)
CUD121503420(qtrt1)
ALAT119013481(qtrt1)
MZE101473634(qtrt1)
ONL100699104(qtrt1)
OAU116317623(qtrt1)
OLA101166387(qtrt1)
OML112146674(qtrt1)
XMA102224740(qtrt1)
XCO114160384(qtrt1)
XHE116735107(qtrt1)
PRET103468778(qtrt1)
PFOR103151994(qtrt1)
PLAI106963582(qtrt1)
PMEI106932482(qtrt1)
GAF122821459(qtrt1)
CVG107093409(qtrt1)
CTUL119785326(qtrt1)
GMU124862892(qtrt1)
NFU107378302(qtrt1)
KMR108241278(qtrt1)
ALIM106529591(qtrt1)
NWH119421713(qtrt1)
AOCE111573688(qtrt1)
MCEP124998036(qtrt1)
CSEM103392727(qtrt1)
POV109634183(qtrt1)
SSEN122785861(qtrt1)
HHIP117765745(qtrt1)
HSP118122971(qtrt1)
LCF108902618
SDU111227167(qtrt1)
SLAL111653685(qtrt1)
XGL120784707(qtrt1)
HCQ109521451(qtrt1)
BPEC110169370(qtrt1)
MALB109965920(qtrt1)
BSPL114861089(qtrt1)
SASA100380392(qtrt1)
STRU115171570
OTW112226207(qtrt1)
OMY110486728 110538676
OGO123998940 124015239
ONE115104349 115110827
SALP111980241(qtrt1)
SNH120039798 120040744
CCLU121551310(qtrt1)
ELS105013084(qtrt1)
SFM108935758(qtrt1)
PKI111849217(qtrt1)
AANG118217055(qtrt1)
LOC102685045(qtrt1)
PSPA121304585(qtrt1)
ARUT117409793 117965604
LCM102359857(QTRT1)
CMK121851130(qtrt1)
RTP109917346(qtrt1)
BFO118420668
BBEL109482463
CIN100185001
SCLV120340874
SPU115929337 579235
APLC110976306
SKO100367470
DMEDmel_CG4947(Tgt)
DER6541571
DSE6617358
DSIDsimw501_GD23082(Dsim_GD23082)
DYADyak_GE17440
DAN6497987
DSR110185801
DPO4817617
DPE6595637
DMN108161767
DWI6642855
DGR6561468
DMODmoj_GI14537
DAZ108611522
DNV115562151
DHE111595851
DVI6627534
CCAT101452272
BOD106616812
RZE108373113
MDE101892666
SCAC106088630
LCQ111685970
LSQ119605572
HIS119654187
AGAAgaP_AGAP003622
ACOZ120950974
AARA120898064
ASTE118507061
AAG5574217
AALB109411099 115267336
CQUCpipJ_CPIJ016028
CPII120417058
CNS116345409
BCOO119071704
AME411719
ACER108000110
ALAB122713554
BIM100749941
BBIF117211923
BVK117231520
BVAN117166578
BTER100643128
BPYO122572995
CCAL108624278
OBB114881519
MGEN117226484
NMEA116427286
CGIG122397108
SOC105205254
MPHA105829745
AEC105143843
ACEP105627565
PBAR105430955
VEM105563264
HST105180601
DQU106747870
CFO105253869
FEX115240018
LHU105677019
PGC109856713
OBO105284038
PCF106793939
PFUC122520590
VPS122632590
NVI100123579
CSOL105363287
TPRE106657556
FAS105265619
DAM107037004
AGIF122848451
LHT122502922
CCIN107268374
TCA660689
DPA109539966
SOY115886310
ATD109601487
CSET123309315
AGB108913061
LDC111503940
NVL108563655
APLN108739203
PPYR116171061
OTU111427950
BMOR101736624
BMAN114252148
MSEX115441050
DPLKGM_214144
BANY112058236
NIQ126781415
PMAC106714358
PPOT106099863
PXU106122114 106127509
ZCE119829306
HAW110379412
HZE124645906
TNL113501016
SLIU111352441
OFU114364115
API100169167
DNX107162526
AGS114126904
RMD113553103
BTAB109044776
DCI103509002
CLEC106665703
HHAL106688439
NLU111044753 120350473
PHUPhum_PHUM463850
FOC113213693
TPAL117646933
ZNE110830643
CSEC111866193
FCD110845705
DPXDAPPUDRAFT_188045
DMK116929059
PVM113802034
PJA122263196
PCHN125032417
HAME121870378
PCLA123770458
PTRU123520184
HAZT108680340
EAF111700950
LSM121114269
PPOI119103769 119106840
ISCIscW_ISCW007214
DSV119436978
RSAN119397369
RMP119161445
VDE111247326
VJA111269431 111273412
TUT112538462
DPTE113791888
DFR124495260
CSCU111626352
PTEP107439662
SDM118196504
CELCELE_ZK829.6(tgt-1)
CBRCBG_06200(Cbr-tgt-1)
BMYBM_BM7559(Bma-tgt-1)
LOALOAG_08521
TSPTsp_06742
HROHELRODRAFT_111078
LGILOTGIDRAFT_205064
PCAN112574329
BGT106060177
GAE121383944
HRF124148959
HRJ124257604
MYI110464409
PMAX117322052
MMER123539291
OBI106879987
OSN115210075
LAK106153059 106177051
SMMSmp_192000
NVE5502103
EPA110252722
ATEN116293781
ADF107332948
AMIL114947758
PDAM113681669
SPIS111326609
DGT114530376
XEN124439556
HMG100211412
TADTRIADDRAFT_20956
THJ104806793
CPAP110816734
CIT102616659
CICCICLE_v10001423mg
PVY116132986
MINC123202606
TCC18592107
GRA105785282
GHI107921348 107962241
GAB108483369
DZI111312422 111315562
EGR104447993
GMX100806874 100819664
GSJ114409258 114415295
PVUPHAVU_009G033100g
VRA106759993
VAR108330897
VUN114164313
CCAJ109787925
APRC113852921
MTR11429357
CAM101493451
LJALj1g3v1515820.1(Lj1g3v1515820.1) Lj1g3v4103630.1(Lj1g3v4103630.1) Lj1g3v4103630.2(Lj1g3v4103630.2)
ADU107466345 107490590
AIP107605417 107613448
AHF112711296 112755781 112770842
LANG109327395
FVE101304001
RCN112192092
PPER18792123
PMUM103319572
PAVI110751923
PDUL117630196
MDM103436462
PXB103962272
ZJU107420738
MNT21396375
CSV101206917
CMO103503686
BHJ120084547
MCHA111023258
CMAX111476974
CMOS111443016
CPEP111796751
RCU8281696
JCU105630652
HBR110662862
MESC110609228
POP7461794
PEU105120388
PALZ118031596
JRE109001191
QSU111984978 112009438 112031247
QLO115973839
TWL120009261
VVI100250619
VRI117905324
SLY101265329
SPEN107016207
SOT102587790
SSTN125852381
CANN107867442
NTA107783638 107800823
NSY104244094
NTO104104993
NAU109241757
INI109170395
ITR116007800 116009998
SIND105158977
OEU111401390
EGT105959345 105963015
SSPL121784035 121787951
HAN110914548
ECAD122607471
LSV111910764
CCAV112511508
DCR108215784
CSIN114287940
SOE110804024
NNU104604272
MING122090667
TSS122670139
PSOM113330574 113332046 113357897
NCOL116261731
OSA4347331
DOSAOs09t0469900-01(Os09g0469900)
OBR102721303
BDI100831593
ATS109733234
TDC119287197 119301900 119310307
TAES123104043 123112271 123121793
TUA125509644
SBI8055996
ZMA100273014
SITA101765742
SVS117845654
PVIR120660706 120695694
PHAI112883542
PDA103707981
EGU105058456
MUS103969151 103991522
DCT110116707
PEQ110025016
AOF109832791
ATR18423249
SMOSELMODRAFT_110632 SELMODRAFT_430565
PPP112279168
CRECHLRE_12g558400v5
VCNVOLCADRAFT_55892
CSLCOCSUDRAFT_37402
CVRCHLNCDRAFT_140645
OLUOSTLU_12116
OTAOT_ostta01g03000
BPGBathy08g01520
MISMICPUN_89746
MPPMICPUCDRAFT_25109
CMECYME_CMN182C
GSLGasu_59630
CCPCHC_T00008745001
YLIYALI0F08921g
SLBAWJ20_1160
NCRNCU07015
NTENEUTE1DRAFT121512(NEUTE1DRAFT_121512)
SMPSMAC_07372
PANPODANSg3674
TTTTHITE_2122470
MTMMYCTH_2310216
CTHRCTHT_0038050
MGRMGG_04110
PPEIPpBr36_04594
TMNUCRPA7_5527
SSCKSPSK_05274
FGRFGSG_05638
FPUFPSE_06231
FVRFVEG_06848
FOXFOXG_09248
NHENECHADRAFT_95441
TRETRIREDRAFT_109602
TRRM419DRAFT_131615
MAWMAC_00019
MAJMAA_04847
CMTCCM_07337
PLJVFPFJ_01432
VALVDBG_08250
VDAVDAG_10445
CFJCFIO01_12570
CLUPCLUP02_15215
CHIGCH63R_04838
SAPOSAPIO_CDS7006
ELAUCREL1_6593
PFYPFICI_05625
SSLSS1G_08277
BFUBCIN_12g01320
MBEMBM_02087
PSCOLY89DRAFT_685500
GLZGLAREA_09228
AFMAFUA_4G04260
ACTACLA_054140
NFINFIA_029130
AORAO090206000067
ANGANI_1_1052124(An14g00580)
AFVAFLA_012958
ALUCAKAW2_40749A
ACHEACHE_31088S
APUUAPUU_80691S
PCSPc13g06450
PDPPDIP_15520
TMFPMAA_085440
TRGTRUGW13939_01959
CIMCIMG_08645
CPWCPC735_062490
PBLPAAG_08596
PBNPADG_08529
AJEHCAG_07998
BGHBDBG_07185
PNOSNOG_13685
PTEPTT_11067
BZECOCCADRAFT_8456
BSCCOCSADRAFT_36061
BORCOCMIDRAFT_9247
AALTCC77DRAFT_538496
ZTRMYCGRDRAFT_72208
PFJMYCFIDRAFT_47328
FFUCLAFUR5_08273
BCOMBAUCODRAFT_230243
NPAUCRNP2_42
SPOSPAC1687.19c
TVSTRAVEDRAFT_34533
DSQDICSQDRAFT_99183
SHSSTEHIDRAFT_102486
HIRHETIRDRAFT_476476
PSQPUNSTDRAFT_62843
ADLAURDEDRAFT_55378
FMEFOMMEDRAFT_108503
GTRGLOTRDRAFT_73874
LBCLACBIDRAFT_189073
CCICC1G_06854
ABPAGABI1DRAFT37677(AGABI1DRAFT_37677)
ABVAGABI2DRAFT69071(AGABI2DRAFT_69071)
PCUBJR316_0002320
MRRMoror_6296
MOREE1B28_000512
SCMSCHCO_02634555(SCHCODRAFT_02634555)
SLASERLADRAFT_368693
ECUECU06_0310
EINEint_060220
EHEEHEL_060240
EROEROM_060230
NCENCER_100145
MBRMONBRDRAFT_4956
SREPTSG_07157
DDIDDB_G0291802(qtrt1)
DPPDICPUDRAFT_51772
DFADFA_11372(qtrt1)
EHIEHI_035660(17.t00053)
EDIEDI_019130
EIVEIN_525060
ACANACA1_204960
PFAPF3D7_0717400
PFDPFDG_01403
PFHPFHG_03185
PREIPRSY57_0714700
PGABPGSY75_0717400
PYOPY17X_0617800
PCBPCHAS_0616800
PBEPBANKA_0615100
PVVPVVCY_0601540
PKNPKNH_0312400
PVXPVX_000560
PCYPCYB_032110
TANTA16175
TPVTP01_1072
TOTTOT_010001018
BEQBEWA_043910
BMICBMR1_03g01400
CPVcgd7_830
CHOChro.70102
TGOTGME49_316100
TETTTHERM_00494100
PTMGSPATT00020710001 GSPATT00021975001
SMINv1.2.005466.t1(symbB.v1.2.005466.t1)
PTIPHATRDRAFT_17628
FCYFRACYDRAFT_274254
TPSTHAPSDRAFT_31256
PIFPITG_12050
PSOJPHYSODRAFT_355889
SPARSPRG_04715
GTTGUITHDRAFT_85003
TBRTb927.6.3130
TBGTbgDal_VI2920
TCR507023.200 511751.30
LMALMJF_30_1800
LIFLINJ_30_1800
LDOLDBPK_301800
LMILMXM_29_1800
LBZLBRM_17_0880
LPANLPMP_301770
NGRNAEGRDRAFT_60345
TVATVAG_2v0054450 TVAG_2v0240130 TVAG_2v0536770
GLAGL50803_0095064
 » show all
Reference
1  [PMID:721832]
  Authors
Howes NK, Farkas WR.
  Title
Studies with a homogeneous enzyme from rabbit erythrocytes catalyzing the insertion of guanine into tRNA.
  Journal
J Biol Chem 253:9082-7 (1978)
Reference
2  [PMID:6986171]
  Authors
Shindo-Okada N, Okada N, Ohgi T, Goto T, Nishimura S
  Title
Transfer ribonucleic acid guanine transglycosylase isolated from rat liver.
  Journal
Biochemistry 19:395-400 (1980)
DOI:10.1021/bi00543a023
Reference
3  [PMID:19414587]
  Authors
Boland C, Hayes P, Santa-Maria I, Nishimura S, Kelly VP
  Title
Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase.
  Journal
J Biol Chem 284:18218-27 (2009)
DOI:10.1074/jbc.M109.002477
  Sequence
[mmu:106248]
Reference
4  [PMID:31481610]
  Authors
Yuan Y, Zallot R, Grove TL, Payan DJ, Martin-Verstraete I, Sepic S, Balamkundu S, Neelakandan R, Gadi VK, Liu CF, Swairjo MA, Dedon PC, Almo SC, Gerlt JA, de Crecy-Lagard V.
  Title
Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.
  Journal
Proc Natl Acad Sci U S A 116:19126-19135 (2019)
DOI:10.1073/pnas.1909604116
  Sequence
[ctr:CT_193]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.64
IUBMB Enzyme Nomenclature: 2.4.2.64
ExPASy - ENZYME nomenclature database: 2.4.2.64
BRENDA, the Enzyme Database: 2.4.2.64
CAS: 72162-89-1
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