KEGG   ENZYME: 2.5.1.100
Entry
EC 2.5.1.100                Enzyme                                 
Name
fumigaclavine A dimethylallyltransferase;
FgaPT1;
dimethylallyl-diphosphate:fumigaclavine A dimethylallyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
prenyl-diphosphate:fumigaclavine A prenyltransferase
Reaction(IUBMB)
fumigaclavine A + prenyl diphosphate = fumigaclavine C + diphosphate [RN:R10201]
Reaction(KEGG)
R10201
Substrate
fumigaclavine A [CPD:C20436];
prenyl diphosphate [CPD:C00235]
Product
fumigaclavine C [CPD:C20438];
diphosphate [CPD:C00013]
Comment
Fumigaclavine C is an ergot alkaloid produced by some fungi of the Trichocomaceae family. Activity does not require any metal ions.
History
EC 2.5.1.100 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K14135  fumigaclavine A dimethylallyltransferase
Genes
AFM: AFUA_2G17990
Reference
1  [PMID:16397874]
  Authors
Unsold IA, Li SM
  Title
Reverse prenyltransferase in the biosynthesis of fumigaclavine C in Aspergillus fumigatus: gene expression, purification, and characterization of fumigaclavine C synthase FGAPT1.
  Journal
Chembiochem 7:158-64 (2006)
DOI:10.1002/cbic.200500318
  Sequence
[afm:AFUA_2G17990]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.100
IUBMB Enzyme Nomenclature: 2.5.1.100
ExPASy - ENZYME nomenclature database: 2.5.1.100
BRENDA, the Enzyme Database: 2.5.1.100
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