brevianamide F prenyltransferase (deoxybrevianamide E-forming);
NotF;
BrePT;
brevianamide F reverse prenyltransferase;
dimethylallyl-diphosphate:brevianamide-F tert-dimethylallyl-C-2-transferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
prenyl diphosphate [CPD:C00235];
brevianamide F [CPD:C20563]
Product
diphosphate [CPD:C00013];
deoxybrevianamide E [CPD:C20636]
Comment
The enzyme from the fungus Aspergilus sp. MF297-2 is specific for brevianamide F [1], while the enzyme from Aspergillus versicolor accepts a broad range of trytophan-containing cyclic dipeptides [2]. Involved in the biosynthetic pathways of several indole alkaloids such as paraherquamides and malbrancheamides.
Ding Y, de Wet JR, Cavalcoli J, Li S, Greshock TJ, Miller KA, Finefield JM, Sunderhaus JD, McAfoos TJ, Tsukamoto S, Williams RM, Sherman DH
Title
Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp.
Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides.
