KEGG ENZYME: 2.5.1.160

ENZYME: 2.5.1.160

Entry

EC 2.5.1.160                Enzyme

Name

plant cystathionine gamma-synthase;
CGS1 (gene name)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

O-phospho-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase

Reaction(IUBMB)

O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate [RN:R13363]

Reaction(KEGG)

R13363

Substrate

O-phospho-L-homoserine [CPD:C01102];
L-cysteine [CPD:C00097]

Product

L-cystathionine [CPD:C02291];
phosphate [CPD:C00009]

Comment

A pyridoxal 5'-phosphate-dependent enzyme, found in plants, that participates in the plant L-methionine biosynthetic pathway. It differs from its bacterial counterpart, EC 2.5.1.48, cystathionine gamma-synthase, in being specific for O-phospho-L-homoserine (the bacterial enzyme is specific for O-succinyl-L-homoserine).

History

EC 2.5.1.160 created 2024

Pathway

ec00270

Cysteine and methionine metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K27857

plant cystathionine gamma-synthase

Genes

AJM:

119044706

ATH:	AT1G33320 AT3G01120(MTO1)

ALY:

9318266

CRB:

17891341

CSAT:

104705809 104709147 104713707 104735553 104741921 104744259 104757690 104763752 104772267 104777342

EUS:	EUTSA_v10013649mg EUTSA_v10015332mg EUTSA_v10020394mg

BRP:	103847532 103858929 103870949

BNA:	106369895 106388653 106438910 106453252 125587586

BOE:

106295730

RSZ:	108805200 108816558 108859429

THJ:	104802959 104821018

CPAP:

110825690

CIT:

102621879

CIC:	CICLE_v10011434mg

PVY:

116112084

MINC:

123197605

TCC:

18601561

GRA:	105766331 105780101

GHI:	107940600 107943482 107949182 107955507

GAB:	108460914 108487576

HSYR:

120131071 120146404 120147413

DZI:	111292121 111299630

EGR:

104419372

GMX:	100794584(CGS1) 548023(CGS2)

GSJ:	114396266 114425085

PVU:	PHAVU_008G038100g

VRA:

106759378

VAR:

108329333

VUN:

114184932

VUM:

124828362

CCAJ:

109802197

APRC:

113863926

MTR:	11406997 11427680

TPRA:

123888706 123905714

CAM:

101491511

PSAT:

127115522 127128575

VVO:	131594552 131608827

LJA:	130728540 130739388

ADU:	107471195 107486697

AIP:	107622851 107635351

AHF:	112716416 112744507 112782319 112797810

LANG:

109336012

PCIN:

129306558

QSA:	O6P43_004457 O6P43_004461 O6P43_009102

RCN:

112187617

PPER:

18782333

PMUM:

103330036

PAVI:

110755554

PDUL:

117621388

MDM:	103404615 103432045

MSYL:

126583738 126612033

PXB:

103951044

ZJU:

107406356

MNT:

21412898

CSAV:

115698867

CSV:

101212851

CMO:

103486979

BHJ:

120091054

MCHA:

111014185

CMAX:

111482275 111500161

CMOS:

111437871 111441806

CPEP:

111785529 111791156 111793706

RCU:

8283445

MEAN:

126677204

JCU:

105644089

HBR:	110640276 110663835

MESC:

110609102 110630068

POP:

7482488

PEU:

105133471

PALZ:

118049527

PNZ:

133671008

JRE:	108985953 109011873

CILL:

122302435 122307662

CAVE:

132181180

QSU:	111998624 136065900

QLO:

115976906

TWL:

120016145

VVI:

100267880

VRI:	117931395 117931396

SLY:	543920(CGS)

SPEN:

107011046

SOT:	102577796(CGS2) 102601571(CGS1)

SSTN:

125847060 125860583

SDUL:

129872402 129880150 129894274

CANN:

107858737 107868072

LBB:	132620399 132621300

NTA:	107762350 107771605 107774020 107803531 107814266 107822634(metB)

NSY:	104223192 104225689 104243701

NTO:	104089663 104097273 104119212

NAU:	109211558 109213315 109230850

INI:

109180562

ITR:

116013287

SIND:

105167647 105177271

OEU:	111372600 111376297

EGT:	105960948 105970821

SSPL:

121769486 121769894

SMIL:

130989577

APAN:

127240713 127258040

HAN:	110878986 110889434

ECAD:

122586603

LSV:

111893968

CCAV:

112515298

DCR:

108196318

CSIN:

114296518 114315886

RVL:

131335105

AEW:	130753353 130775551

BVG:

104887321

SOE:

110795484

CQI:	110688988 110735033

ATRI:

130801870

MOF:

131164159

NNU:

104598107

MING:

122064687 122076661

TSS:	122654147 122671282

PSOM:

113300382 113318095

OSA:	107276273 4332956 4348560 4348561

OBR:	102704742 102705012 102709311 102717509

OGL:	127753299 127753301 127753340 127767510 127776357

BDI:	100837599 100842309

ATS:	109769348 109769349 109769350 109769351 109773976

TDC:	119285889 119296170 119343815 119344617 119344680 119345168 119346144 119347801 119357507 119367033 119367034 119367037 119367040

TAES:

123038900 123040260 123040261 123040262 123040265 123048427 123048428 123048429 123055569 123086069 123092032 123097358 123177566 123184451 123184452 123184453 123184465

TUA:	125530992 125534839 125551509

LPER:

127329376 127332281 127335962

LRD:	124671488 124677648 124677829 124677843 124678318 124702512 124702527

SBI:	8059635 8080479

ZMA:	100191523 103645417 103645418 541650

MFLO:

136530790 136543734 136544423

SITA:

101759864 101760683 101776607

SVS:	117837167 117838468 117839653

PVIR:

120648660 120652218 120688069 120688976 120691777

PHAI:

112875885 112876249 112876355

PDA:	103702763 103716376

EGU:	105056640 105058567

MUS:	103987493 103991346

ZOF:	122002278 122006536 122042268 122046789

DCT:

110094736

PEQ:

110039508

AOF:	109833914 109848393

MSIN:

131233455

NCOL:

116259663

ATR:

18447928

SMO:	SELMODRAFT_143363 SELMODRAFT_155550

PPP:	112273301 112276080

CRE:	CHLRE_03g144627v5

VCN:	VOLCADRAFT_75793

CSL:	COCSUDRAFT_27251

CVR:	CHLNCDRAFT_24830

APRO:

F751_3191

OLU:	OSTLU_33390(CGS1)

OTA:	OT_ostta09g00970

BPG:	Bathy10g03490

MIS:	MICPUN_98339

MPP:	MICPUCDRAFT_25455

CME:	CYME_CMF156C

GSL:	Gasu_58810

CCP:	CHC_T00008547001

GTT:	GUITHDRAFT_159042

» show all

Reference

1 [PMID:9531508]

Authors

Ravanel S, Gakiere B, Job D, Douce R

Title

Cystathionine gamma-synthase from Arabidopsis thaliana: purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli.

Journal

Biochem J 331 ( Pt 2):639-48 (1998)
DOI:10.1042/bj3310639

Sequence

[ath:AT3G01120]

Reference

2 [PMID:10438597]

Authors

Steegborn C, Messerschmidt A, Laber B, Streber W, Huber R, Clausen T.

Title

The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity.

Journal

J Mol Biol 290:983-96 (1999)
DOI:10.1006/jmbi.1999.2935