KEGG   ENZYME: 2.5.1.34
Entry
EC 2.5.1.34                 Enzyme                                 
Name
4-dimethylallyltryptophan synthase;
dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase;
dimethylallyltryptophan synthetase;
dimethylallylpyrophosphate:tryptophan dimethylallyl transferase;
DMAT synthetase;
4-(gamma,gamma-dimethylallyl)tryptophan synthase;
tryptophan dimethylallyltransferase;
dimethylallyl-diphosphate:L-tryptophan 4-dimethylallyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
prenyl-diphosphate:L-tryptophan 4-prenyltransferase
Reaction(IUBMB)
prenyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-en-1-yl)-L-tryptophan [RN:R01657]
Reaction(KEGG)
R01657;
(other) R02943
Substrate
prenyl diphosphate [CPD:C00235];
L-tryptophan [CPD:C00078]
Product
diphosphate [CPD:C00013];
4-(3-methylbut-2-en-1-yl)-L-tryptophan [CPD:C04290]
History
EC 2.5.1.34 created 1984, modified 2010
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K14130  tryptophan 4-dimethylallyltransferase
Genes
MAW: 19251300(DMAW1_1)
MAJ: MAA_06736
MBRN: 26246265(dmaW)
GLZ: GLAREA_05930
AFM: AFUA_2G18040
ACT: ACLA_031240
AOR: AO090005001079
AFV: AFLA_003907
ACHE: ACHE_61019A ACHE_61023A
ABE: ARB_04649
TVE: TRV_01863
BSC: COCSADRAFT_185949
 » show all
Reference
1  [PMID:999297]
  Authors
Lee SL, Floss HG, Heinstein P.
  Title
Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58.
  Journal
Arch Biochem Biophys 177:84-94 (1976)
DOI:10.1016/0003-9861(76)90418-5
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.34
IUBMB Enzyme Nomenclature: 2.5.1.34
ExPASy - ENZYME nomenclature database: 2.5.1.34
BRENDA, the Enzyme Database: 2.5.1.34
CAS: 55127-01-0
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