Entry
Name
cystathionine gamma-synthase;
O-succinyl-L-homoserine succinate-lyase (adding cysteine);
O-succinylhomoserine (thiol)-lyase;
homoserine O-transsuccinylase (ambiguous);
O-succinylhomoserine synthase;
O-succinylhomoserine synthetase;
cystathionine synthase;
cystathionine synthetase;
homoserine transsuccinylase (ambiguous);
4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
Reaction(IUBMB)
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate [RN:
R03260 ]
Reaction(KEGG)
Substrate
O4-succinyl-L-homoserine [CPD:
C01118 ];
L-cysteine [CPD:
C00097 ]
Product
Comment
A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
History
EC 2.5.1.48 created 1972 as EC 4.2.99.9, transferred 2002 to EC 2.5.1.48
Pathway
ec00270 Cysteine and methionine metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K01739 cystathionine gamma-synthase
Genes
SCE : YJR130C(STR2) YLL058W(HSU1) YML082W
SEUB : DI49_3138 DI49_3476 DI49_4007
SPAO : SPAR_J03060 SPAR_L00060 SPAR_M00480
LTH : KLTH0D17930g KLTH0G00418g
CGR : 2888540(GVI51_H03971) 2891592(GVI51_M00451)
NCS : NCAS_0A06270(NCAS0A06270)
NDI : NDAI_0D03260(NDAI0D03260)
TPF : TPHA_0L00330(TPHA0L00330)
TBL : TBLA_0E04790(TBLA0E04790)
TGB : HG536_0A09580 HG536_0C06180
TDL : TDEL_0D00610(TDEL0D00610) TDEL_0E05710(TDEL0E05710)
KAF : KAFR_0B06830(KAFR0B06830)
KNG : KNAG_0M00330(KNAG0M00330)
ZMK : HG535_0C00260 HG535_0E01540
SLUD : SCDLUD_003176 SCDLUD_004363
LBG : 92208256(LODBEIA_P30600)
CAL : CAALFM_C103760CA(STR2)
YLI : 2911236(YALI2_D00783g)
SLB : AWJ20_127 AWJ20_4608(STR2)
NCR : NCU02430(met-7) NCU05093 NCU08117
NTE : NEUTE1DRAFT131251(NEUTE1DRAFT_131251) NEUTE1DRAFT70133(NEUTE1DRAFT_70133) NEUTE1DRAFT88452(NEUTE1DRAFT_88452)
SMP : 10801426(SMAC4_09398) 10801661(SMAC4_08318) 10804933(SMAC4_08048)
PAN : PODANSg09945 PODANSg2271 PODANSg9227
PBEL : QC761_106770 QC761_505460(STR2)
PPSD : QC762_106770 QC762_505460(STR2)
PPSP : QC763_106770 QC763_505460(STR2) QC763_507270
PPSA : QC764_106770 QC764_505460(STR2)
TTT : THITE_2050614 THITE_2116799 THITE_2143774
MTM : MYCTH_2141686 MYCTH_2309110 MYCTH_95546
CTHR : CTHT_0048260 CTHT_0049670 CTHT_0057200
PPEI : PpBr36_06722 PpBr36_07631 PpBr36_10098
PGRI : PgNI_00430 PgNI_06261
TMN : UCRPA7_1229 UCRPA7_1958
FGR : FGSG_00503 FGSG_08909 FGSG_09855
FPU : FPSE_04408 FPSE_07639 FPSE_08203
FPOA : FPOAC1_000522 FPOAC1_005063 FPOAC1_011780(MET7)
FVN : FVRRES_00675 FVRRES_05583 FVRRES_12840
FVR : FVEG_00960 FVEG_05093
FOX : FOXG_00553 FOXG_03640 FOXG_08167
NHE : NECHADRAFT_37948 NECHADRAFT_74897 NECHADRAFT_78174
FFC : NCS54_00100600 NCS54_00436800 NCS54_00510300 NCS54_01461700
FKR : NCS57_00098800 NCS57_00443500 NCS57_00471700 NCS57_00548600
FMU : J7337_001036 J7337_007127(MET7) J7337_008853
TRE : TRIREDRAFT_3641 TRIREDRAFT_68036
TRR : M419DRAFT_35200 M419DRAFT_87945
TATV : 25775513(TrAtP1_008043) 25775712(TrAtP1_006740)
TASP : 36608585(TrAFT101_005964) 36618872(TrAFT101_003318) 36618919(TrAFT101_008300)
MAW : 19244432(STR2) 19245420(J3458_004558)
MAJ : MAA_01033 MAA_04478 MAA_04959 MAA_05624
MBRN : 26238815(G6M90_00g011520) 26240148(met-7_0) 26242233(met-7_1) 26244345(G6M90_00g000980)
PCHM : VFPPC_03107 VFPPC_08189 VFPPC_16763
AMUS : LMH87_005794 LMH87_007863
PLJ : 28884430(PLICBS_005686) 28889186(PLICBS_008347) 28891783(PLICBS_004055) 28892515(PLICBS_006455)
PTKZ : JDV02_003679(STR2) JDV02_004643 JDV02_006299 JDV02_008047
VAL : VDBG_04545 VDBG_09679
VDA : VDAG_04090 VDAG_09420
CFJ : CFIO01_10243 CFIO01_13309
CHIG : CH63R_00764 CH63R_11888
CDET : 87939490(CDEST_02987) 87946649(CDEST_10147)
SAPO : SAPIO_CDS3342 SAPIO_CDS4544 SAPIO_CDS6153
ELA : UCREL1_1871 UCREL1_3408
PFY : PFICI_01107 PFICI_03498
BFU : BCIN_02g06470(BcStr2)
PSCO : LY89DRAFT_626074 LY89DRAFT_651065
GLZ : GLAREA_02912 GLAREA_04631 GLAREA_05111 GLAREA_12201
ACT : ACLA_033490 ACLA_078450
AOR : AO090003001113 AO090020000019 AO090120000144
ANG : An01g10010 An11g11160
AFV : AFLA_000556 AFLA_009359 AFLA_010632
ALUC : AKAW2_21044S AKAW2_80958S
ACHE : ACHE_50114A ACHE_50504A ACHE_70546S
APUU : APUU_10331S APUU_31498S
PDP : PDIP_01350 PDIP_07840
POU : POX_f08212 POX_g09137
TMF : EYB26_004452 EYB26_007564 EYB26_009118
TRG : TRUGW13939_01401 TRUGW13939_08756 TRUGW13939_11208 TRUGW13939_11580
CIM : CIMG_02107 CIMG_03169
CPW : CPC735_009930 CPC735_044800
URE : UREG_02299 UREG_06985
PNO : SNOG_00049 SNOG_15756 SNOG_15757
PTRR : 6341514(PtrM4_069140)
BOR : COCMIDRAFT_23820 COCMIDRAFT_26620
AALT : CC77DRAFT_1064519 CC77DRAFT_981232
ZTR : MYCGRDRAFT_106762 MYCGRDRAFT_87913
PFJ : MYCFIDRAFT_154091 MYCFIDRAFT_33225
FFU : CLAFUR5_08308 CLAFUR5_12684
CBET : CB0940_04460 CB0940_05601 CB0940_11996
BCOM : BAUCODRAFT_21946 BAUCODRAFT_62936
NPA : UCRNP2_4808 UCRNP2_5148
CDEP : 91085141(L203_100927)
KMG : 30162694(I203_101245)
KNE : 92179580(IAR55_002321)
CCAC : CcaHIS019_0212240(STR2)
TVS : TRAVEDRAFT_142870 TRAVEDRAFT_153079
DSQ : DICSQDRAFT_106505 DICSQDRAFT_140909
PCO : PHACADRAFT_115737 PHACADRAFT_137003 PHACADRAFT_88834
SHS : STEHIDRAFT_104336 STEHIDRAFT_145989 STEHIDRAFT_47912 STEHIDRAFT_75747 STEHIDRAFT_95871
HIR : HETIRDRAFT_473244 HETIRDRAFT_67186
PSQ : PUNSTDRAFT_132800 PUNSTDRAFT_69067
ADL : AURDEDRAFT_110467 AURDEDRAFT_111815 AURDEDRAFT_133175 AURDEDRAFT_156602 AURDEDRAFT_164075 AURDEDRAFT_164076 AURDEDRAFT_164078 AURDEDRAFT_181927 AURDEDRAFT_67455 AURDEDRAFT_93155
FME : FOMMEDRAFT_111174 FOMMEDRAFT_147931 FOMMEDRAFT_24166
GTR : GLOTRDRAFT_65239 GLOTRDRAFT_70613
LBC : LACBIDRAFT_235424 LACBIDRAFT_311699
CCI : CC1G_02540 CC1G_14611
ABP : AGABI1DRAFT115558(AGABI1DRAFT_115558) AGABI1DRAFT121903(AGABI1DRAFT_121903) AGABI1DRAFT73517(AGABI1DRAFT_73517)
ABV : AGABI2DRAFT194632(AGABI2DRAFT_194632) AGABI2DRAFT202594(AGABI2DRAFT_202594) AGABI2DRAFT224770(AGABI2DRAFT_224770)
MPR : MPER_02786 MPER_04401
MRR : Moror_17516 Moror_6234
MORE : E1B28_005197 E1B28_006175
SCM : SCHCO_02590818(SCHCODRAFT_02590818) SCHCO_02622795(SCHCODRAFT_02622795)
CPUT : CONPUDRAFT_104658 CONPUDRAFT_117236 CONPUDRAFT_52967 CONPUDRAFT_83744
SLA : SERLADRAFT_365904 SERLADRAFT_452185 SERLADRAFT_475678
UMA : UMAG_04053 UMAG_11720
PFP : PFL1_00893 PFL1_03865
MSYM : MSY001_1507 MSY001_2076
PGR : PGTG_08342 PGTG_15188
PTRC : PtA15_14A448 PtA15_6A669
MLR : MELLADRAFT_44095 MELLADRAFT_48480
EHI : EHI_142250(389.t00003) EHI_144610(132.t00018)
EHX : EMIHUDRAFT_42839 EMIHUDRAFT_43235
ECOO : ECRM13514_5056(metB)
ECOH : ECRM13516_4792(metB)
ECW : EcE24377A_4479(metB)
EDJ : ECDH1ME8569_3808(metB)
ECOI : ECOPMV1_04338(metB)
REE : electrica_04950(metB)
RTG : NCTC13098_07098(metB_1)
CAMA : F384_12945 F384_21640
CLAP : NCTC11466_04485(metB)
KIE : NCTC12125_03673(metB)
KAS : KATP_44210 KATP_47440
AHN : NCTC12129_04822(metB)
PSHI : SAMEA2665130_2844(metB)
YPG : YpAngola_A3807(metB)
YPI : YpsIP31758_0121(metB)
SMW : SMWW4_v1c47170(metB)
SERS : SERRSCBI_00240 SERRSCBI_22855
SFJ : SAMEA4384070_4720(metB)
SOF : NCTC11214_00706(mdeA_1) NCTC11214_01522(metB_2)
SSAR : SSARUM_004646(metB)
PAQU : DMB82_0000815(metB)
PARL : PEC302110_38260(metB)
DIC : Dpoa569_000172(metB)
EBI : EbC_01640(metB) EbC_34860
TPTY : NCTC11468_03681(metB)
PHEI : NCTC12003_03839(metB)
PRJ : NCTC6933_03864(metB)
HAV : AT03_00030 AT03_21450
LRI : NCTC12151_00108(metB)
HIW : NTHI477_01112(metI_2)
HIC : NTHIC486_00955(metI_2)
HIX : NTHI723_01630(metI_2)
HPIT : NCTC13334_01158(metI)
HHZ : NCTC10839_00989(metI_2)
HAEG : NCTC8502_02013(metB)
PDAG : 4362423_01287(metB)
ALIG : NCTC10568_00757(metB)
ASEG : NCTC10977_01922(metI_2)
AVT : NCTC3438_01090(metI_2)
RPNE : NCTC8284_03027(metB_2)
PAET : NCTC13378_00099(metB)
XFU : XFF4834R_chr16010(metB1)
XPH : XppCFBP6546_20585(XppCFBP6546P_20585)
XHD : LMG31886_13090(metB)
PSU : Psesu_0759 Psesu_2656
LHX : LYSHEL_18240(metB_2)
LCAS : LYSCAS_18240(metB_2)
LLZ : LYB30171_00762(metB)
THES : FHQ07_10865 FHQ07_11630
THEH : G7079_03470 G7079_04205
TCN : H9L16_01700 H9L16_02450
THEX : ICG51_001023 ICG51_002045
XBC : ELE36_01950 ELE36_15505(metB)
DJI : CH75_01355 CH75_24435
DYG : DYGSA30_17120(metB_2)
XBA : C7S18_18790 C7S18_21620(metB)
TAMN : N4264_05170 N4264_23175(metB)
VAU : VANGNB10_cI2432(metB)
VPL : SA104470976_00153(metB)
PPRC : PFLCHA0_c38680(mccB)
POJ : PtoMrB4_25520 PtoMrB4_53900(mdeA)
PTW : TUM18999_59000(mdeA)
SCAA : TUM17387_33550(metB)
RHEI : ATY27_07145 ATY27_17715
GAI : IMCC3135_10450(mgl_1) IMCC3135_28230(metC_2)
WOC : BA177_08545 BA177_09675
AEL : NCTC12917_03647(metB)
ZDF : AN401_17925 AN401_18005
SDF : ACG33_08115 ACG33_14640
CDIZ : CEDIAZO_00643(metB)
NMQ : NMBM04240196_1363(metC)
NMZ : NMBNZ0533_0851(metC)
NMX : NMA510612_1134(metB)
NCZ : NCTC10294_00448(metC)
NANI : NCTC12227_00321(metC)
VOX : LCH97_09850 LCH97_11545
BTRM : SAMEA390648702630(cysD1_3)
URU : DSM104443_03839(metB)
UPL : DSM104440_02076(metB)
THAG : CKCBHOJB_01065(metB)
SMEL : SM2011_c02595(metB)
SFD : USDA257_c48290(metB)
NEN : NCHU2750_43550(metB) NCHU2750_49230(metB)
VGO : GJW-30_1_00516(metB_1) GJW-30_1_01108(metB_2)
BVV : BHK69_02120 BHK69_07560
BOP : AXW83_04285 AXW83_17420
BOF : FQV39_23815 FQV39_30605
BOW : NWE53_01390 NWE53_15345
BOSE : RMR04_00760 RMR04_02320 RMR04_27530
MDI : METDI3626 METDI4488(metB)
MRD : Mrad2831_4408 Mrad2831_5099
MOR : MOC_5078(metB) MOC_5805
MAQU : Maq22A_1p33585(metC) Maq22A_c01125(metC)
MPHY : MCBMB27_03929 MCBMB27_04540
MEE : DA075_10845(metB) DA075_12955
METX : A3862_04515 A3862_05650 A3862_09325
METS : DK389_11010 DK389_28560(metB)
MMES : MMSR116_03305 MMSR116_18425(metB)
MTEA : DK419_07220(metB) DK419_19900
MIND : mvi_15660 mvi_52400(metB)
MTAD : M6G65_24560(metB) M6G65_30110
MTUN : MTUNDRAET4_0468(metB)
RHZ : RHPLAN_27160 RHPLAN_66180
BVY : NCTC9239_02661(metB)
TSV : DSM104635_02949(metB)
SINL : DSM14862_02009(metB)
RMM : ROSMUCSMR3_00339(metB)
AHT : ANTHELSMS3_03237(metB)
RSQ : Rsph17025_0780 Rsph17025_4330
LVS : LOKVESSMR4R_00264(metB)
MMR : Mmar10_1549 Mmar10_2620
SPHD : HY78_09785 HY78_28380
SPHM : G432_20080 G432_20200
SARI : H5J25_04275(metB) H5J25_20020
SPHT : K426_02960 K426_10600
SUFL : FIL70_23740(metB) FIL70_24755(metB)
CNA : AB433_02655 AB433_04400
NTD : EGO55_02925(metB) EGO55_10480(metB)
SVC : STVA_01700(metB) STVA_03910
SROE : JL101_013350 JL101_034605(metB)
GBN : GEOBRER4_20760(metC-1)
DWD : DSCW_13550(mdeA) DSCW_31590
ACP : A2cp1_1872 A2cp1_3333
AFW : Anae109_1737 Anae109_3196
ANK : AnaeK_1793 AnaeK_3252
AORY : AMOR_00750 AMOR_13910(metB_1)
MSD : MYSTI_01021 MYSTI_02247
MYM : A176_005034 A176_006007
MFB : MFUL124B02_05695 MFUL124B02_12125
MLAN : JY572_15475 JY572_21400
MFU : LILAB_03840 LILAB_17585
MMAS : MYMAC_000992 MYMAC_002011
PPAK : JY651_29105 JY651_34215
AGE : AA314_03253 AA314_06629
AVM : JQX13_30285 JQX13_52690
CFUS : CYFUS_004585 CYFUS_007363
SCU : SCE1572_00765 SCE1572_05020 SCE1572_12220 SCE1572_43925
BAZ : BAMTA208_11630(metI)
BSON : S101395_03563(metB)
BFD : NCTC4823_02000(metC) NCTC4823_03282(metB)
BSHI : LGQ02_01375 LGQ02_10985
GST : HW35_06655 HW35_17695
BACQ : DOE78_03110 DOE78_14610
BCO : Bcell_3347 Bcell_3359
BMQ : BMQ_1415(metB) BMQ_1886
BMD : BMD_1396(metB) BMD_1878
BMH : BMWSH_3372 BMWSH_3814
BMEG : BG04_3710 BG04_4218 BG04_5937
BKW : BkAM31D_10850(metI) BkAM31D_11425(mccB)
BCL : ABC0021 ABC1867(metI)
BLE : BleG1_2053 BleG1_4015
SHUA : PQ477_07695 PQ477_19145
BPF : BpOF4_15295(metC) BpOF4_15860(metB)
BON : A361_13075 A361_15535
CPSS : M5V91_05625 M5V91_08275
OON : NP440_06630 NP440_13295
PCAL : BV455_00945(metI_2)
PARG : PspKH34_29070(metI)
LYP : MTP04_18720 MTP04_21310
HHD : HBHAL_1693(metI) HBHAL_4915(metB2)
HMN : HM131_02840 HM131_20180
HNZ : P9989_03180 P9989_17875 P9989_20450
HSAN : MUN89_00410 MUN89_03895
HSHI : MUO14_02705 MUO14_07630 MUO14_10685
HAMY : MUO15_00875 MUO15_09695 MUO15_15175
VNE : CFK40_00415 CFK40_10590 CFK40_15745
LAO : AOX59_08380 AOX59_17555
FEC : QNH15_07150 QNH15_16505
SJE : AAV35_007865 AAV35_009465
PFRI : L8956_05845 L8956_09155
GRC : GI584_02835 GI584_15615
NCM : QNK12_05125 QNK12_25785 QNK12_27775
MSEM : GMB29_05310 GMB29_22070
BLEN : NCTC4824_02189(metB)
BBEV : BBEV_1549(mccB) BBEV_2860(metB)
SLMS : MM221_03910 MM221_11695
ALKL : MM271_13310 MM271_14040
PHJ : LC071_04065 LC071_17445
AHAL : FTX54_003300 FTX54_013345
STEA : C0679_03055 C0679_13795
SDP : NCTC12225_02681(metB1)
SSH : NCTC13712_00305(metI)
SSIM : SAMEA4384339_0316(metI)
SSTE : SAMEA4384403_2479(metI_2)
SHV : AAT16_00940 AAT16_02015
JEA : JEM45_06560 JEM45_07205
LMOC : LMOSLCC5850_1743(metC-2)
LMOG : BN389_17080(metI_2)
LMOL : LMOL312_1687(metC-2)
LMW : LMOSLCC2755_1692(metC-2)
LMX : LMOSLCC2372_1745(metC-2)
LMZ : LMOSLCC2482_1744(metC-2)
LMON : LMOSLCC2376_1639(metC-2)
LMOS : LMOSLCC7179_1653(metC-2)
LMOO : LMOSLCC2378_1701(metC-2)
LMOY : LMOSLCC2479_1743(metC-2)
LMOT : LMOSLCC2540_1763(metC-2)
LGZ : NCTC10812_01196(metI_2)
GMO : NCTC11323_01051(metI_2)
GHA : NCTC10459_01102(metI)
BBE : BBR47_30180 BBR47_38780(metI)
BFM : BP422_09775 BP422_14695
BHUI : LOK74_07035 LOK74_14155
BRUM : NDK47_09715 NDK47_12730
PPQ : PPSQR21_015370(metC)
PBJ : VN24_07060 VN24_16245 VN24_22310
PLUT : EI981_15635 EI981_20945
PBK : Back11_01110 Back11_29610
ACUR : JZ785_08870 JZ785_19165
AFAS : NZD89_16175 NZD89_21960
TUM : CBW65_06825 CBW65_20210
FFE : LSG31_02340 LSG31_18005
PLN : Plano_2133 Plano_2194
PRT : AUC31_05555 AUC31_15790 AUC31_16245
PANA : BBH88_08065 BBH88_16740
PDG : BCM40_04265 BCM40_04580 BCM40_12115
PHC : BBI08_07920 BBI08_08235 BBI08_16670
PMAR : B0X71_03560 B0X71_04265 B0X71_13095
PPLA : BBI15_00165 BBI15_06390 BBI15_06805
PLX : CW734_05915 CW734_12390
PMAT : BBI11_05390 BBI11_11825 BBI11_12270
PDEC : H1Q58_04535 H1Q58_11090 H1Q58_11555
PLAY : DNR44_008980 DNR44_017150
PSHE : QWY16_13950 QWY16_14270
KPUL : GXN76_11215 GXN76_11635
KEB : GXN75_12645 GXN75_13260
PABS : JIR001_14970 JIR001_22450
SMC : SmuNN2025_0442(metB)
SGG : SGGBAA2069_c17270(metB)
SSAH : HSISS4_00279(metB1)
SVB : NCTC12167_00378(metB)
SMEN : SAMEA4412692_1071(metI)
SFER : NCTC12278_01479(metB)
SAUP : NCTC3168_01258(metC)
SURN : NCTC13766_01695(metI_1)
SVF : NCTC3166_01490(metC)
SMIE : NCTC11169_00436(metB)
ECEC : NCTC12421_00450(metI)
CPAE : CPAST_c26360(metC4)
CRW : CROST_006800(mccB_1)
CAUN : CLAUR_023120(mccB_2)
STHR : BXT84_11885 BXT84_12285
CBAR : PATL70BA_2049(metB)
VRM : 44547418_00280(metB)
VDN : NCTC11831_00252(metB)
MANA : MAMMFC1_04120(mccB)
STED : SPTER_05850(mccB_1)
SSID : SPSIL_011060(metB) SPSIL_012330(mccB)
ERZ : ER308_05580 ER308_11695
EUZ : DVS28_a1508 DVS28_a1564 DVS28_a4725
MMAE : MMARE11_42080(metB)
MBAI : MB901379_03845(metB)
MHEK : JMUB5695_01318(metB)
MKY : IWGMT90018_16690 IWGMT90018_50560(metB)
MPHL : MPHLCCUG_04261(metB)
MTHN : 4412656_03581(metB)
MAUU : NCTC10437_04396(metB_2)
MFLV : NCTC10271_01074(metB)
MKR : MKOR_17310 MKOR_40190(metB)
MSAL : DSM43276_01065(metB)
MTER : 4434518_01011(metB)
CGL : Cgl2446(Cgl2446) Cgl2786(Cgl2786)
CGU : WA5_2360(MetB) WA5_2688
CGM : cgp_2687(metB) cgp_3086
CGQ : CGLAR1_11570 CGLAR1_13360
CMIN : NCTC10288_00521(metB)
CRL : NCTC7448_00262(metB)
CSUR : N24_2524(metB) N24_2873
CCYS : SAMEA4530656_0377(metB)
BFV : C628_11835 C628_13810
NFR : ERS450000_05088(metB)
NAD : NCTC11293_06180(metB)
NHU : H0264_10810 H0264_22495
NYA : LTV02_08800 LTV02_21905
RCR : NCTC10994_01581(metB)
STRC : AA958_03355 AA958_22340
SAMB : SAM23877_4774(metB)
SRW : TUE45_01471(metB_1) TUE45_05492(metB_3)
SLE : sle_27290(sle_27290)
SAUO : BV401_00660 BV401_27905
SGV : B1H19_19875 B1H19_25925
SHAW : CEB94_04650 CEB94_25985
SFIC : EIZ62_03765 EIZ62_11835
SRIM : CP984_14500 CP984_37570
SPLA : CP981_03625 CP981_24775
SDW : K7C20_03485 K7C20_23565
SAUH : SU9_002740 SU9_022040
SANU : K7396_13385 K7396_31995
SNIG : HEK616_60620 HEK616_75380
SXT : KPP03845_104716(metB_2)
STUD : STRTU_002514 STRTU_006569
SENG : OJ254_04450 OJ254_23455
SHAU : K9S39_16965 K9S39_17420
SINN : ABB07_14215 ABB07_39640
STPB : QR97_16950 QR97_20885
SRPA : HEP86_05135 HEP86_25820
LXL : KDY119_02365(metB) KDY119_02718
PSIC : J4E96_15065 J4E96_16235
MSUW : GCM10025863_00330(metB_1) GCM10025863_32970(metB_2)
FSB : GCM10025867_39230(metB)
AGY : ATC03_03385 ATC03_04900
AGF : ET445_00115 ET445_00880
AARC : G127AT_04175 G127AT_10470
AMAU : DSM26151_00730(metB_1) DSM26151_05250(metB_2)
ASOI : MTP13_00345 MTP13_01235
AMAV : GCM10025877_21930(metB_1) GCM10025877_24770(metB_2)
ALAV : MTO99_17865 MTO99_18885
AIL : FLP10_04530 FLP10_05595
AUT : AINA4_09200(metB_1) AINA4_10180(metB_2)
MHUM : NNL39_03515 NNL39_09450
AGG : C1N71_03005 C1N71_06930
AGRO : JSQ78_02805 JSQ78_11705
PSEV : USB125703_01621(metB)
GMN : GMOLON4_1093(metB) GMOLON4_1158(metB) GMOLON4_2102(metB)
HOM : OF852_08240 OF852_11955
NAEI : GCM126_04200 GCM126_16160(metB)
ARR : ARUE_c08420(metB1) ARUE_c31860(metB2)
ARL : AFL94_02405 AFL94_03210 AFL94_12365
ARE : AL755_02625 AL755_19180
AAQ : AOC05_13195 AOC05_18475
ARW : MB46_13880 MB46_19020
ARH : AHiyo8_26120 AHiyo8_48850
ARY : ATC04_05605 ATC04_14630 ATC04_15510
ARU : ASPU41_01200 ASPU41_09125
ARQ : BWQ92_06795 BWQ92_16110
ARN : CGK93_04515 CGK93_17270
ARX : ARZXY2_3141(metB) ARZXY2_641(metB)
ACRY : AC20117_01950 AC20117_10290
ARTH : C3B78_03400 C3B78_14580
ARTP : E5206_00005 E5206_06680
AAGI : NCTC2676_1_00441(metB_1) NCTC2676_1_02400(metB_2)
AJG : KKR91_02365 KKR91_13810
ASUN : KG104_02120 KG104_14750
ASUF : MNQ99_04860 MNQ99_16110
ARTY : AHiyo4_07970 AHiyo4_37880
APOA : J0916_12580 J0916_16785
AWW : G8758_10500 G8758_16735
ACAO : NF551_02375 NF551_13125
AZH : MUK71_02455 MUK71_13060
AGEG : MUG94_02045 MUG94_14090
AOD : Q8Z05_02195 Q8Z05_11520
AKO : N9A08_02565 N9A08_12695
AZX : N2K95_02405 N2K95_13000
AJR : N2K98_02265 N2K98_13705
ARTM : MN0502_05210 MN0502_26200(metB)
ARTU : E7Y32_02770 E7Y32_08880
ARTZ : FCN77_04040 FCN77_19445
ARI : UM93_10425 UM93_15935
AAU : AAur_0889(metB) AAur_3037(metB)
PUE : FV140_04535 FV140_16490
PNV : JMY29_03930 JMY29_14650
PAYJ : HMI59_05710 HMI59_17365
PAGO : IRJ34_03995 IRJ34_15180
ARZ : AUT26_03765 AUT26_14905
APN : Asphe3_07570 Asphe3_28900
PSUL : AU252_06615 AU252_16405
PSNI : NIBR502771_01170 NIBR502771_10440
PSEY : GU243_10040 GU243_20035
PDEL : JCQ34_03430 JCQ34_13960
POK : SMD14_03720 SMD14_14880
PSLS : KTR40_03585 KTR40_13730
AAI : AARI_05210(metB) AARI_07010(metB) AARI_24010(metB)
GAR : AOZ07_02710 AOZ07_03875 AOZ07_12390
GCR : GcLGCM259_0412 GcLGCM259_0543(metB) GcLGCM259_2138
GLU : F0M17_02695 F0M17_03600 F0M17_11820
GPR : JQN66_02815 JQN66_03665 JQN66_12315
GMI : NMP99_03230 NMP99_04140 NMP99_12395
GMY : XH9_05190 XH9_06160 XH9_13625
GNC : QQS42_02795 QQS42_03775 QQS42_12185
GLM : N6V40_07635 N6V40_16345
RSA : RSal33209_0400 RSal33209_0897
KRH : KRH_18800 KRH_20930(metB)
KPL : KPaMU14_00925 KPaMU14_02070
KFV : AS188_05155 AS188_06315
KII : KocCE7_10085 KocCE7_11350
KRS : EQG70_14005 EQG70_15325
KOD : HBK84_10025 HBK84_11295
KVR : CIB50_0000949(metB) CIB50_0001210(mccB_2)
MLU : Mlut_17590 Mlut_20810
MICK : B1A86_00008780 B1A86_00010385
MYU : M8233_08415 M8233_10075
MPOR : KW076_03060 KW076_05225
MTEU : R3I42_07780 R3I42_12435 R3I42_13505
MICU : SOY78_02110 SOY78_03675
SATK : SA2016_0770 SA2016_3102
CCYC : SCMU_07770 SCMU_30850(metB)
NAE : BHE16_06165 BHE16_11175
AUL : DCC27_000070 DCC27_001850
AIG : QDX25_01180 QDX25_12040
CIG : E7744_02115 E7744_03695
CMUA : P8192_01790 P8192_03515 P8192_11060
PAEY : KUF55_02130 KUF55_03475 KUF55_12640
DNI : HX89_09850 HX89_11085
DAY : FV141_08945 FV141_10310
DERM : H7F30_06970 H7F30_08480
LMOI : VV02_09115 VV02_11550
YIM : J5M86_03370 J5M86_04840
ALX : LVQ62_15820 LVQ62_17325
BEI : GCM100_03920(metB_1) GCM100_23700(metB_2) GCM100_28440
XYL : ET495_00325 ET495_01015
XYA : ET471_02000 ET471_17335
IVA : Isova_2102 Isova_2469
CET : B8281_08480 B8281_10230
CCEU : CBR64_00935 CBR64_02805
CPRT : FIC82_007330 FIC82_009155
CGA : Celgi_1153 Celgi_1364
CELZ : E5225_06070 E5225_13295
CEJ : GC089_06325 GC089_13975
CELH : GXP71_01065 GXP71_09435
CIRA : LFM56_06535 LFM56_13650
CPAL : F1D97_13225 F1D97_14355
CELC : K5O09_04110 K5O09_05645
CDON : KKR89_04610 KKR89_11590
CWAN : KG103_04950 KG103_11690
CFEN : KG102_03270 KG102_11645
CWN : NP075_04850 NP075_12055
CCHE : NP064_04190 NP064_05475
CXIE : NP048_04840 NP048_11650
OEK : FFI11_010120 FFI11_018480
ICA : Intca_0990 Intca_2324
ARS : ADJ73_06385 ADJ73_15135
JTE : ASJ30_04805 ASJ30_12180
JLI : EXU32_02210 EXU32_09995
JME : EEW87_003110 EEW87_010110
JAY : H7A72_04740 H7A72_12580
JCR : O9K63_01235 O9K63_08450
PEI : H9L10_01605 H9L10_08220
TED : U5C87_10220 U5C87_19275
ORN : DV701_08790 DV701_10470
ORZ : FNH13_00180 FNH13_12120
OCP : NF557_10325 NF557_16600
OFA : NF556_08025(metB) NF556_12315 NF556_20255
BLIN : BLSMQ_3187 BLSMQ_3522
BRI : FDF13_05110 FDF13_06460
BCAU : I6G59_00410 I6G59_02165
BSPO : L1F31_14980 L1F31_16735
BREB : PGC08_15885 PGC08_17525
DCO : SAMEA4475696_0532(metB)
PAUS : NCTC13651_02336(metB)
MPH : MLP_20990 MLP_44110(metB)
MIK : FOE78_16030 FOE78_20205
MICG : GJV80_10005 GJV80_12605
BRT : J4N02_02585 J4N02_12875(metB)
NDK : I601_2022(metB_1) I601_2500(metB_2)
NOY : EXE57_16000 EXE57_18440
NOI : FCL41_03315 FCL41_05405
NOO : FE634_05865 FE634_14915
NSN : EXE58_01070 EXE58_03185
NBE : Back2_22870 Back2_24650
NANO : G5V58_05635 G5V58_17560
NMES : H9L09_13820 H9L09_16520
NARO : CFH99_06910 CFH99_17260
NPI : G7071_01005 G7071_17765
NAQU : ENKNEFLB_01350(metB_1) ENKNEFLB_03763(metB_2)
NRO : K8W59_03710 K8W59_13695
NOQ : LN652_06030 LN652_08555
NCQ : K6T13_11855 K6T13_13895
NPC : KUV85_00255 KUV85_02400
NPS : KRR39_00555 KRR39_04260
NMAR : HPC71_04635 HPC71_06965
NFC : KG111_05160 KG111_13775
NRN : SHK17_14150 SHK17_16555
NBI : SHK19_04710 SHK19_07450
AER : AERYTH_10145 AERYTH_11340
AEZ : C3E78_06185 C3E78_10720
AEB : C6I20_04740 C6I20_09475
AEF : GEV26_05975 GEV26_10620
ASEZ : H9L21_05235 H9L21_06445
ADB : NP095_05180 NP095_06430
AWN : NQV15_06020 NQV15_10555
MGG : MPLG2_0128(metB) MPLG2_1064(metB)
MUZ : H4N58_04440 H4N58_06970
SGRG : L0C25_01070 L0C25_04810
KQI : F1D05_06510 F1D05_12405
KSL : OG809_03090 OG809_40090
KRI : OX958_08740 OX958_12640
STRR : EKD16_03360(metB) EKD16_05950(mdeA1)
ACTW : F7P10_27845 F7P10_30120
NOA : BKM31_29430 BKM31_51085
NCX : Nocox_14195(mdeA3) Nocox_37310(metB)
NFS : OIE67_29450 OIE67_54165
NAK : EH165_01360 EH165_03625
NAKA : H7F38_08745 H7F38_23135
SACC : EYD13_00265(metC) EYD13_17660(metB)
AMD : AMED_0062(metB) AMED_8104(metB)
AMM : AMES_0059(metB) AMES_7982(metB)
AMZ : B737_0060(metB) B737_7983(metB)
AOI : AORI_0053(metB) AORI_6927(metB)
AJA : AJAP_00290 AJAP_04470(metB)
AMQ : AMETH_0072(metB) AMETH_5887(metB)
AMYC : CU254_33040 CU254_39630
AMYB : BKN51_27845 BKN51_34295
AAB : A4R43_23715 A4R43_29060
AMYY : YIM_00260(metC) YIM_05040(metB)
AORI : SD37_06050 SD37_41545
AACD : LWP59_00200 LWP59_33670
APRT : MUY14_36345 MUY14_43695
AROO : NQK81_25915 NQK81_31400
ATHM : L1857_02730 L1857_32425
ARHD : VSH64_29850 VSH64_37430
AMOG : QRX60_11180 QRX60_18850
ACYN : ORV05_02290 ORV05_32495
ACOR : LCL61_06685 LCL61_13015
SSYI : EKG83_03700 EKG83_32360
KPHY : AOZ06_06225 AOZ06_36215
ACTA : C1701_07880 C1701_25105
PMAD : BAY61_00265 BAY61_26700
ACTU : Actkin_00708(metB_1)
UME : RM788_01900 RM788_29460
ASE : ACPL_1038(megL) ACPL_964(metB)
ACTS : ACWT_0847 ACWT_0920
AIH : Aiant_15140(metB) Aiant_51270
ANE : ATCC27039_22420(metB)
AHW : NCTC11636_01552(metI)
ASLA : NCTC11923_00371(metI)
AVC : NCTC10951_02179(metI)
ACAP : MANAM107_09510(metB)
FSL : EJO69_04140 EJO69_04315
BDE : BDP_0671 BDP_0672(metB)
BBI : BBIF_1301(metB) BBIF_1569
BBF : BBB_1323(metB) BBB_1603(mdeA)
EKE : EK0264_12860 EK0264_14070
JTL : M6D93_02825 M6D93_05425
JCY : M6B22_14040 M6B22_15590
BALA : DSM104299_05618(metB)
SBAE : DSM104329_00278(metB)
ATQ : GH723_10030 GH723_15660
SYX : SynWH7803_0586(metB)
SYH : Syncc8109_2098(metC)
SYNW : SynWH8103_00772(metB)
PMA : Pro_0404(metC_metB) Pro_0405(metC_metB)
PMN : PMN2A_1742 PMN2A_1743
PMI : PMT9312_0403 PMT9312_0404
PMB : A9601_04581 A9601_04591(metB)
PMH : P9215_04841 P9215_04851(metB)
PMJ : P9211_04061 P9211_04071(metB)
MPRO : BJP34_06990 BJP34_10520 BJP34_12105
RRS : RoseRS_1055 RoseRS_4472
CHL : Chy400_1581 Chy400_2028
HAU : Haur_0506 Haur_2807 Haur_4016
CALL : OZ401_002236 OZ401_003857
CAP : CLDAP_04670(metB) CLDAP_15990(metC)
THUG : KNN16_03285 KNN16_11300
PMET : G4Y79_14995 G4Y79_16725
MHD : Marky_0572 Marky_0634
OBG : Verru16b_01465(metB)
OLE : K0B96_02290 K0B96_15390
AAQW : K1X11_016335 K1X11_017135
LUI : llg_37370(metC_metB)
SOA : G3M56_008685 G3M56_008690
FPES : NXS98_04505 NXS98_04510
PIR : VN12_12685(mdeA) VN12_17065(metC_1)
RML : FF011L_15170(mdeA) FF011L_15180(metC)
MFF : MFFC18_35360(mdeA_2)
RUV : EC9_24740(mdeA) EC9_30430(mccB)
RCF : Poly24_23730(mccB) Poly24_34400(mdeA)
LCRE : Pla8534_54540(mdeA_2)
SMAM : Mal15_01800(metC_1) Mal15_01810(metC_2)
SNEP : Enr13x_78810(metC_1)
LPAV : PLANPX_0606 PLANPX_2292
AMUC : Pan181_41790(metC_2)
BGOK : Pr1d_18540(metC) Pr1d_18550(mdeA)
FMR : Fuma_00391(metB) Fuma_04489(metC)
SDYN : Mal52_48190(metB_2)
PVAR : SH412_004709 SH412_005680
CCOP : Mal65_26500(metB) Mal65_26510(metC)
SCOR : J3U87_28095 J3U87_28100
FPOL : ERS445057_00719(mccB)
MGOT : MgSA37_02973(metC_2)
SRD : SD10_13845 SD10_17720
SPIR : CWM47_04295 CWM47_18795
SPIK : EXU85_07190 EXU85_12355
SPIB : G8759_18110 G8759_18280
STAE : HNV11_09535 HNV11_13505
SRHO : HH216_01765 HH216_18330
SFOL : H3H32_14900 H3H32_21195
SENF : GJR95_00965 GJR95_01140
PSEZ : HME7025_02473(metB)
FDV : JJC05_06045 JJC05_06055
PROC : Ptc2401_00866(metC)
RMG : Rhom172_0166 Rhom172_1119
RLO : GQ464_005845 GQ464_012560
TVO : TVG1061416(TVG1061416)
FAC : FACI_IFERC01G0923 FACI_IFERC01G1268
SULA : BFU36_07395 BFU36_10545
ABRI : DFR85_06130 DFR85_14800
» show all
Taxonomy
Reference
Authors
Flavin M, Slaughter C.
Title
Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine.
Journal
Reference
Authors
Kaplan MM, Flavin M.
Title
Cystathionine gamma-synthetase of Salmonella. Catalytic properties of a new enzyme in bacterial methionine biosynthesis.
Journal
J Biol Chem 241:4463-71 (1966)
Reference
Authors
Wiebers JL, Garner HR.
Title
Homocysteine and cysteine synthetases of Neurospora crassa. Purification, properties, and feedback control of activity.
Journal
J Biol Chem 242:12-23 (1967)
Reference
Authors
Wiebers JL, Garner HR.
Title
Acyl derivatives of homoserine as substrates for homocysteine synthesis in Neurospora crassa, yeast, and Escherichia coli.
Journal
J Biol Chem 242:5644-9 (1967)
Reference
Authors
Clausen T, Huber R, Prade L, Wahl MC, Messerschmidt A.
Title
Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.48
ExPASy - ENZYME nomenclature database: 2.5.1.48
LinkDB
All DBs